Gene SGK196 (Mouse)

SGK196

Species: Mouse
Alias: SGK196, 4930444A02Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
SgK196.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON
SgK196.NA RNA Sugen 1879 None Fasta, JSON
SgK196.AA Protein Sugen 349 None Fasta, JSON

Protein domain

Protein domains of SgK196.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK196.AA Other-Unique 83-328 11 4.5e-33 109.63 In-house 1-249 (249) Show / Hide 
Range on Protein: 83-328
Range on HMM: 1-249/249
Sequence Identity: 11% (29 aa)

LKRVGEGAVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLEETLNLSKYQD---VNTWQHRLQ
.| .|.|. .||........|  ..  |.  .. . ... .. .. |..|.. . . |... | ....|............. . |..    ...|....
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKRE-QIYHYQ-IIH-CIFYWT-MNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCE

LAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSI---------VANDLDALPLVDHDSGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDD
. |... .|..||| . .  ..||.|   . ..|  .  ....           ...   ..  . . .. .. .. .... . ... ... .. ..| .
HWMNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYH

LMPSYNEKVDIWKIPDVSSFLLG--HVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLD
.. ..........| . ... ..  ..| ...  ..|. ... |.... ....  .|...
FGCYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase SgK196.AA TKL-Unique 82-194 24 4e-12 39.21 In-house 1-129 (290) Show / Hide 
Range on Protein: 82-194
Range on HMM: 1-129/290
Sequence Identity: 24% (31 aa)

QLKRVGEGAVKRVFLSEWKEHKVALSRLT-----RLEMKEDFLHGLQMLKSLQ-SEHVVTLVGYCE----EDG--TILTEYHPLGSLSNLEE-TLNLS--
 .. .|||.. .|.  .|.  .||. ..      ..||...|   .  .| |. .. .|...|||       .   | .|| |.||| ..    .|..  
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KYQDVNTWQHRLQLAMEYVSIINYLHHS
 .    ...| |...|   ..  .||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHC
Kinase SgK196.AA TKL 86-192 16 9.8e-12 38.54 In-house 1-149 (364) Show / Hide 
Range on Protein: 86-192
Range on HMM: 1-149/364
Sequence Identity: 16% (27 aa)

VGEGAVKRVFLSEWKEHK----------VALSRLTRLE-----------------------------MKEDFLHGLQMLKSLQSEHVVTLVGYCEEDG--
.|.|.   |.  .|. .           ||  .. . .                             ... .   . |...|. ...| ..||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------TILTEYHPLGS-LSNLEETLNLSKYQDVNTWQHRLQLAMEYVSIINYLH
              | .||.| || |..|              |..|...|..  . .||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLH
Kinase SgK196.AA TK 80-156 15 1e-05 14.31 In-house 1-146 (486) Show / Hide 
Range on Protein: 80-156
Range on HMM: 1-146/486
Sequence Identity: 15% (23 aa)

VRQLKRVGEGA---VKRVFLSEWKEH---------------------------KVALSRLT---RLEMKEDFL----------------HGLQMLKS--L
.. .|  |||.     .|.. ||...                           .||   |.     ...| |.                . ..|...  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QSEHVVTLVGYCEEDGT--------------ILTEYHPLGS----L
. ...| |.|.| ....              |..|| |.|.    |
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSL
Kinase SgK196.AA SgK493 124-197 28 3.5e-05 10.71 In-house 64-138 (234) Show / Hide 
Range on Protein: 124-197
Range on HMM: 64-138/234
Sequence Identity: 28% (21 aa)

MLKSLQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLEETLNLSKYQDVN-TWQHRLQLAMEYVSIINYLHHSPLG
.|. | . |.| |.|||  | .   .    |     |    ....| |  .|  |.. .|.      .| |||.|
YLRQLRHPHIVQLYGYCYRDDNGSPDIRDQGITTVVELGKPVHMHQLVQTMWEQRFRYCMDLGRLLHHLEHSPMG
Kinase SgK196.AA TyrKc 80-330 13 5e-05 -141.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 80-330
Range on HMM: 1-280/280
Sequence Identity: 13% (48 aa)

VRQLKRVGEGAVKRVFLSEWKEHKVA--LSRLTRLEMKEDFLHGLQMLKSL--QSEHVVTLVGYCE---------EDGTILTEYHPLGSLSNLEETLNLS
.. .|  ||||  .|.. .||  .||    .      .|||.. ......|  . ...| |.|.|          |   |..|| |.|.| .      | 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY-----LR

KYQDVNTWQHRLQLA------MEYVSIINYLH----------HSPL-------------GTR--------VMC-----DSND-LP---------KTL---
|...  .... |. .      ||| .  |. |          ....             .          .       .... ||         ..    
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

--------------------SQYLL-----TSNFSIVANDLDA--LPLVDHD---SGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDI
                    . |        ||. ....  .   .|  ..|   |                                            
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------------

WKIPDVSSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLDAY
                .      ...| | |    |..||| ... .  
----------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SgK196.AA Pkinase_Tyr 114-158 29 5.1e-05 17.61 Pfam 46-96 (270) Show / Hide 
Range on Protein: 114-158
Range on HMM: 46-96/270
Sequence Identity: 29% (15 aa)

MKEDFLHGLQMLKSL-QSEHVVTLVGYCE-EDGT----ILTEYHPLGSLSN
..|||.. ....|.| . ...| |.| |  ...     | .|| |.|.| .
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase SgK196.AA S_TKc 80-334 12 6.2e-05 -104.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 80-334
Range on HMM: 1-231/231
Sequence Identity: 12% (40 aa)

VRQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCE-EDGTILTEYHPL--GSLSNLEETLNL----SKYQD
 . |. .|.||  .|..  .|.  ..||. ..      |...  .|.||. . ...|.| .... ..  . .|| .   |.|  . .  .     ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

VNTWQHRLQLAMEYVSIINYLHHSP-----------------------LGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRE
  ..    |.    .. ..|.|                          | ...                                             . 
-HARFYMYQI----CCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------------------------TT

LHG--DFVAPEQLWPYGE------------------DTPFQDDLMPSYNEKVDIWKIPDVSSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVL
. |  ...||| | .||                    .||. ...  ..  .                         . |. . |    |..||||  .|
FCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

DAY-----QRVF
 .         |
QDEWDIKCHPWF
Kinase SgK196.AA UTK 80-159 25 0.000125 11.76 In-house 1-100 (296) Show / Hide 
Range on Protein: 80-159
Range on HMM: 1-100/296
Sequence Identity: 25% (25 aa)

VRQLKRVGEGAVKRVFLSEW-------KEHKVALSRLTRLEMKEDFLH----------GLQMLKSLQ-SEHVVTLVGYC--EEDGTILTEYHPLGSLSNL
|..... |.||   |.. ..       .| .||.  . . ......            .|||.| ..  ..|. |||.|  ||   |.||| . |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY
Kinase SgK196.AA Dicty4-Unclassified 80-140 28 0.00015 11.46 In-house 1-67 (263) Show / Hide 
Range on Protein: 80-140
Range on HMM: 1-67/263
Sequence Identity: 28% (19 aa)

VRQLKRVGEGAVKRVFLSEWKEHKVALSRL------TRLEMKEDFLHGLQMLKSLQSEHVVTLVGYC
.. .. .|.|.  .|    ||   ||   .       | || .||.    .| |.|    |.. |||
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYC
Kinase SgK196.AA SrcA 80-156 35 0.000154 9.75 In-house 1-80 (250) Show / Hide 
Range on Protein: 80-156
Range on HMM: 1-80/250
Sequence Identity: 35% (28 aa)

VRQLKRVGEGAVKRVFLSEWK-EHKVALSRLTRLEMK-EDFLHGLQMLKSLQSEHVVTLVG-YCEEDGTILTEYHPLGSL
.|  .|.|.|    |..  |  . |||.  |    |  | ||.  |..| |. . .| |     ||   | |||   |||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSL
Kinase SgK196.AA TK-Unique 115-156 39 0.000244 11.01 In-house 47-92 (294) Show / Hide 
Range on Protein: 115-156
Range on HMM: 47-92/294
Sequence Identity: 39% (18 aa)

KEDFLHGLQMLKSLQ-SEHVVTLVGYCE---EDGTILTEYHPLGSL
| |||  .||.|.|   ...|...|.|    |.  |. || | |.|
KQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNL
Kinase SgK196.AA MLK 80-159 18 0.000521 9.95 In-house 1-100 (291) Show / Hide 
Range on Protein: 80-159
Range on HMM: 1-100/291
Sequence Identity: 18% (19 aa)

VRQLKRVGEGAVKRVFLSEWKEHK-----VALSRLT------------RLEMKEDFLHGLQMLKSLQ-SEHVVTLVGYCEEDGT---ILTEYHPLGSLSN
 . .. .|.|.   |.. .|.        ||. | .            . ...... | | .|. .  .  .. ..| | ...    |..|| . |||.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRH-LRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

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