Gene Slob (Mouse)
Slob
Sequence
Protein domains of Slob.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PX | Slob.AA | PX | 32-122 | 32 | 6.1e-21 | 74.34 | Pfam | 21-120 (120) | Show / Hide |
Range on Protein: 32-122 Range on HMM: 21-120/120 Sequence Identity: 32% (32 aa) SHTEYIIRVQRGIS--AENSWQIVRRYSDFDLLNNSLQITGL---SLPLPPKKLIGN---MDREFIAERQRGLQNYLNVIMANHVLSN-CELLKKFLDPN .|..|...... . . .|.. |||||| | |. . |||||...|. .|.||| .|...|..||. .. . .|.| ||....|| |. MHYYYVYEIHMNTNPFQKKEWHVWRRYSDFHWLHKQLKRHFPMCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQYLQRVCQHPELCNHCEVFHDFLHPD |
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| PX | Slob.AA | PX | 17-122 | 21 | 6.5e-19 | 70.08 | SMART | 1-142 (142) | Show / Hide |
Range on Protein: 17-122 Range on HMM: 1-142/142 Sequence Identity: 21% (30 aa) TVPLTAAVEASQ------SLQSHTEYIIRVQRGISA-ENSWQIVRRYSDFDLLNNSLQITGLSL-------PLPPKKLIGN------------------M . .. ..| . . .|. |....... . . |.. |||||| | . |. . . |||||..... . DHIFIITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEKRMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFNNF DREFIAERQRGLQNYLNVIMANHVLSN----CELLKKFLDPN |..|| .|.|||..||. .. . ...| ||....|.... DEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS |
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| Kinase | Slob.AA | Slob | 152-393 | 49 | 6.8e-167 | 560.74 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 152-393 Range on HMM: 1-268/268 Sequence Identity: 49% (133 aa) LKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPD----KYLSDKDFQCLIKLLPSCVHPYIYRVT----FATASESSALLIRAFNEKGTLKDLIYKAKP |..||||.||....||...||.|..|.||.|.||| |.|..|..||..|.|.|| |||||.|. |..........||.||..|.|||.|||||| LDHIGWRHRKNWCMMKNDMQPGEECVQSWIDYGPDCCPWKMLNEKECQCFMKILMSCHHPYIYPVINLVFFINHKHNYCCVIRFFNKRGSLKDFIYKAKP KDPFLKKYCN----------------PKKTQGLELQQIKTYGRQILEALKFLHDKGFPYGHLHAANVMLDG--NTCRLLDLENSLLGLPSFYRSYFTQFR |.|...|||| .||..||...|...|.|||||||.|||.|||||||||..|||.|. ..|||.|.||.|||.|.||..|....| KMPWARKYCNKQPKSSSSSSSSSSSSHKKQNGLPMKQVQKYCRQILEALIFLHSKGFPYGHLHSGNVMIDDSNDCCRLSDIENCLLGMPPFYNDYIMWHR KINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPASSLAVVAVLESTLSCEACKNGMPTVSRLLQM ||...|.|||.||||.||||..|.|.....|..|||....|.....|..||||.||..|||...|||| KIHEIENVDVYCFGHCLYEMCCGYPMQNHSVRNFPPCPFIALFCDKEHILSCEICKHCMPTMRQLLQM |
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| Kinase | Slob.AA | SRPK | 258-282 | 40 | 3e-06 | 10.59 | In-house | 124-148 (554) | Show / Hide |
Range on Protein: 258-282 Range on HMM: 124-148/554 Sequence Identity: 40% (10 aa) QGLELQQIKTYGRQILEALKFLHDK ||. . ..|. ||.|..|..||.| QGMPMHCVKQIARQVLIGLDYLHRK |
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| Kinase | Slob.AA | CLK | 254-281 | 39 | 4e-06 | 13.72 | In-house | 105-132 (350) | Show / Hide |
Range on Protein: 254-281 Range on HMM: 105-132/350 Sequence Identity: 39% (11 aa) PKKTQGLELQQIKTYGRQILEALKFLHD | | .......|. ..|..||.||||| PNKYIPYPIDHIRHMAYQLCEAVKFLHD |
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| S_TKc | Slob.AA | S_TKc | 146-396 | 15 | 6e-06 | -90.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 146-396
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)
WEVVEPLKD-------IGWRIR-KKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCVHPYIYRVTFATASESSALLIRAFNEK--GTLK
.|..... .. .. .... .|| . .... |..| . ||.| . . . .. .. . . |.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF
DLIYKAKPKDPFLKKYCNPKKTQGLELQQIKTYGRQILEALKFLHDKGFPYGHLHAANVMLDGNTCRLLDLENSLLGLPSFYRSYFTQFRKINTL-----
|.| ||. ... ... ... | .||..||...|..|. . | .|..|| . . | . . .|.
DYI----------KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------------TTFCGTPW
----------E-SVDVHCFGHLLYEMTYGRPPDSVPVDSFPPASSLAVVAVLESTLSCEAC--------KNGM--PTVSRLLQ-------MPLF
..|. .| .|||| .|.|| . .. .. | ||. |. ||. .|| .| |
YMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Slob.AA | CDC2 | 248-283 | 31 | 2.3e-05 | 11.89 | In-house | 86-123 (301) | Show / Hide |
Range on Protein: 248-283 Range on HMM: 86-123/301 Sequence Identity: 31% (12 aa) LKKYCN-PKKT-QGLELQQIKTYGRQILEALKFLHDKG |||| ... . ...| .| | |||... |.| .. LKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRR |
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| Kinase | Slob.AA | CMGC | 262-284 | 29 | 0.000147 | 9.88 | In-house | 181-205 (513) | Show / Hide |
Range on Protein: 262-284 Range on HMM: 181-205/513 Sequence Identity: 29% (8 aa) LQQIKTYGRQILEALK--FLHDKG--F . .|. | .|||..|| ..| .. . I-HIR-YMYQILRGLKLKYCHSHWGNI |
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| Kinase | Slob.AA | SLK | 258-296 | 28 | 0.000165 | 10.99 | In-house | 92-130 (259) | Show / Hide |
Range on Protein: 258-296 Range on HMM: 92-130/259 Sequence Identity: 28% (11 aa) QGLELQQIKTYGRQILEALKFLHDKGFPYGHLHAANVML ..|. .||. .....|||..||.. . | | |... HPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILM |
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| Kinase | Slob.AA | RAD53 | 264-283 | 45 | 0.000185 | 8.62 | In-house | 110-129 (305) | Show / Hide |
Range on Protein: 264-283 Range on HMM: 110-129/305 Sequence Identity: 45% (9 aa) QIKTYGRQILEALKFLHDKG ..|.| .|...|.| |||.| TCKYYFYQMCDAVKYLHDNG |
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| Kinase | Slob.AA | ULK | 248-283 | 23 | 0.000322 | 10.94 | In-house | 104-146 (324) | Show / Hide |
Range on Protein: 248-283 Range on HMM: 104-146/324 Sequence Identity: 23% (10 aa) LKKYCNPKKT-------QGLELQQIKTYGRQILEALKFLHDKG |..| . .|. . |. |... . .||....|.||... LEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN |
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| Kinase | Slob.AA | Delta | 261-297 | 37 | 0.000329 | 11.05 | In-house | 98-134 (259) | Show / Hide |
Range on Protein: 261-297 Range on HMM: 98-134/259 Sequence Identity: 37% (14 aa) ELQQIKTYGRQILEALKFLHDKGFPYGHLHAANVMLD ... . |. |. .|.||| || | | ||.|| DEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLD |
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| Kinase | Slob.AA | ULK | 248-283 | 25 | 0.00046 | 10.18 | In-house | 107-150 (329) | Show / Hide |
Range on Protein: 248-283 Range on HMM: 107-150/329 Sequence Identity: 25% (11 aa) LKKYCNPKKT--------QGLELQQIKTYGRQILEALKFLHDKG |..| . .|. . |. |... . .|||...|.||... LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN |
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| Kinase | Slob.AA | Delta | 331-351 | 52 | 0.048457 | 3.08 | In-house | 179-199 (259) | Show / Hide |
Range on Protein: 331-351 Range on HMM: 179-199/259 Sequence Identity: 52% (11 aa) ESVDVHCFGHLLYEMTYGRPP .||| || |.||| | | HSVDWWSFGVLMYEMLIGQSP |
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| Kinase | Slob.AA | ULK | 341-351 | 54 | 0.16767 | 1.17 | In-house | 241-251 (324) | Show / Hide |
Range on Protein: 341-351 Range on HMM: 241-251/324 Sequence Identity: 54% (6 aa) LLYEMTYGRPP ..||| ||..| IFYEMLYGKYP |
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| Kinase | Slob.AA | ULK | 341-351 | 63 | 0.168123 | 1.11 | In-house | 245-255 (329) | Show / Hide |
Range on Protein: 341-351 Range on HMM: 245-255/329 Sequence Identity: 63% (7 aa) LLYEMTYGRPP ..||| ||.|| IFYEMLYGKPP |
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