Gene VACAMKL (Mouse)
VACAMKL
Group:
CAMK
Family:
CAMK-Unique
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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VACAMKL.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 263 | Kinase domain by global Sugen HMM | Fasta, JSON |
VACAMKL.AA | Protein | Sugen | 512 | None | Fasta, JSON |
VACAMKL.NA | RNA | Sugen | 3031 | None | Fasta, JSON |
Protein domains of VACAMKL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | VACAMKL.AA | CAMK-Unique | 24-286 | 33 | 2.5e-150 | 499.61 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-363/363 Sequence Identity: 33% (120 aa) YDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQK-RDGRKVRKA------------------AKNEIGILKMVKHPNILQLVDV----FVTRK------- |.....|....|.......|..|||...||...| ..|.|..|. .|.|..|.|||.||||..|.|. |..|| YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------EYFIFLELATGREVFDWILD--------------------QGYYSE--RDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLK----- ...|..|...|...||||.. ||..|| .||.......|.||||.||..||||.|||||.......| IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH --------NSKIVISDFHLAKLENGLIKEP-----CGTPEYLAP--------------EVVGRQRYGRPV----DCWAIGVIMYILLSGNPPFYEEVEED |..|...||.|....|. .... ||||.|.|| ||...|.|.... |.|..|||||..|.|.|||..|.|.. RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR DYENHDKNLFRKILAGDY-EFDSPYWDD---ISQAAKDLVTRLMEVEQDQRITAEEAISHEWI |||||||..|..|..||| .||...|.. |||.|||.|...|.|..|.|..|.|...|.|| DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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Kinase | VACAMKL.AA | CAMK | 29-286 | 23 | 5.4e-110 | 355.74 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 29-286 Range on HMM: 1-425/425 Sequence Identity: 23% (101 aa) VIKTEEFCEIFRAKDK-TTG-----------KLHTCKKFQKRD---------------------------GRKVRKAAKNEIGILKM-------VKHPNI .. . |.. .....| ||| . .| |. | || ..|| |.|. ..|||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LQLVDVFVT-------------------RKEYFIFL---ELATGR----EVFDWILDQ---------------GYYSERDTSNVVRQVLEAVAYLHSLKI ..| .|. . .|...... |...| ..||.| .. |...||... ..||...||.|.||..| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VHRNLKLENLVYYNRLKNS--------------KIVISDFHLAKLENG--------------------------LIKEPCGTPEYLA-PEVVGRQR---- ||| ||.||. . .. ..| .| |.|| .|. .. . |..|||||| | |||. ... VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM ----------YGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYE-----NHDKNLFRKILAGDYEFDSPY------------WDDISQA--------AKD ||...|.|..|||.||.|.| ||||.. .....| ..|..||.||..|.|.|..|| |||||. .|| QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD LVTRLMEVEQDQRITAEEAISHEWI |. ....|. ..|.|.|.. .|.|. LIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | VACAMKL.AA | CAMK1 | 53-286 | 43 | 1.6e-108 | 316.56 | In-house | 38-276 (276) | Show / Hide |
Range on Protein: 53-286 Range on HMM: 38-276/276 Sequence Identity: 43% (108 aa) KKFQKRDGR-KVRKAAKNEIGILKMV---KHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKL ||| | . . | ..| .|||.|.| | .|||| .. ... . ... . .|| || | || |.. |.|.|.| .....|.|.|| |.||. |||| || KKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKP ENLVYYNRLKNSKIV--ISDFHLAKLEN-G--LIKEPCGTPEYLAPEVVGR---QRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKI ||| ||. .|||. |.|| |.| .. . | | .||||.| ||||. . . |. ..|.| |||| |||| | ||||. || |..||.|| ENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYD-------ENVDNELFEKI LAGDYEFDSPYWDDISQA-AKDLVTRLMEVEQDQRITAEEAISHEWI . ..|||.||.||.|| |||... ..||. .|.|.|... | || KKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | VACAMKL.AA | PSK | 24-286 | 40 | 1.2e-87 | 280.14 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-258/258 Sequence Identity: 40% (109 aa) YDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTS || .| . | . | ..| . | .. | .|.. || ||. |.||.| ||. || |. .. .|.||| | || | .| ..||| YDIKALIGKGSFSRVVRVEHRVTRQPYAIKMVETKC-REGREFCENELNILRRVRHPYIIQLMEVFETQDRVYMVMEMATGGEMFDRIVAKGRFTERDAT NVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLA----KLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPP .| . ||... |||.|.| ||.|| ||| || ..|||.| || || | .. . |. |||||| |||| | | || ||.||| |||.|| | RVLQMVLDGMRYLHALRITHRDLKPENLLYYHPGNESKIMITDFGLAYQRKKSNDWMMKTTCGTPEYIAPEVLLRKPYTQSVDMWAVGVIAYILMSGIMP FYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI | .|| |.|.|| | | . .| ..|..||| . .|.|..| .|.|| |. |.|. F-----DDDCRTR---LYRHILTGKYNYYGQPWPSVSHLAKDFIDKLLEINQGERMTASQAMKHPWV |
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Kinase | VACAMKL.AA | S_TKc | 24-286 | 28 | 2.5e-83 | 284.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-231/231 Sequence Identity: 28% (80 aa) YDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATG--REVFDWILDQGY----- |.....| | . .....| ||.. .|. . ...|| |||. .|||| .| |||.. .......|.. | ..|| | ..|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -YSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGR-PVDCWAIGVIMYILL ..| .. ...|...|..|.||..|.|| || ||. . | |.|| ||.. . ||||.|.||||. ||. ..| |..|.|.|..| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAIS-------HEWI .| |||. ... .|.||. |. |||.. ...... ..|.|| || |.|. CGYPPFP----------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | VACAMKL.AA | DCAMKL | 24-286 | 35 | 3.8e-83 | 258.44 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-279/279 Sequence Identity: 35% (100 aa) YDLGQVIKTEEFCEIFRAKDKTTG------KL---------HTCKKFQKRDGRKVR---KAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGR |..| .| | .. .....|| | | ||. | ||.. . ||. |.. .|||.| ||.... |...|.. .|...| YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG EVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLEN-LVYYNRLKNSKIVISDFHLAKLENG---LIKEPCGTPEYLAPEVVGRQRYGRPV || | . ..||| . .... .| |||.. |||| .|.|| ||. . . . || ||. || .. |||| | |||. || | DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCKV DCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI | ||.||| |||| | ||| . .| || .|..|..||..||||.|| .||||......|....| |||. .| |. DIWAAGVILYILLCGFPPFRSP------DNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
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Kinase | VACAMKL.AA | RAD53 | 40-286 | 33 | 2.1e-74 | 220.91 | In-house | 17-305 (305) | Show / Hide |
Range on Protein: 40-286 Range on HMM: 17-305/305 Sequence Identity: 33% (97 aa) RAKDKTTGKLHTCKKFQK-------RDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTR-KEYFIFLELATGREVFDWILDQGY----YSERDTSNVVR .|..|.|.. | . | .. .| .. ||. ||| ..||.| .. |.|.| | |.. |||.|| | |. | .... ..| . . LAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFY QVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNS---------------KIVISDFHLAK-LENG-LIKEPCGTPEYLAPEVVGRQ--------------- | ..|| |||.. |.|| || || . . .. .| |.|| |.| ...| . | |||| |.||||. . QMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQV RYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILA-GDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI |.. |||| .|.| ||.|.| ||| .. . | | ..|| .|. | |.|..||||.||. ||||. .. |. . |.|..||..| |. GYTKKVDCWSMGCILYICLCGYPPFSDDYTQ---EMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM |
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Kinase | VACAMKL.AA | MAPKAPK | 64-286 | 33 | 1.2e-71 | 220.99 | In-house | 40-292 (292) | Show / Hide |
Range on Protein: 64-286 Range on HMM: 40-292/292 Sequence Identity: 33% (84 aa) RKAAKNEIGILKMVK-HPNILQLVDVFVT----RKEYFIFLELATGREVFDWILD--QGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNR |. | .| ...... ||||.|..|.| .| .. .|. | | |. | . .....|| | ..... .||..|||. | || ||.||. . . RQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDT LKNSKIVISDFHLAKL-------ENG----LIKEPCGTPEYLAPEVVGRQR----YGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENH--------D .|. . ..|| .|| . . . ||.||.| ||||||... | | | .||||||.|.| |||| . . | . NHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQ KNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI . .|..| .| ||| .. |..||..||||. .| .. ||.|.|. ..| || NMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI |
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Kinase | VACAMKL.AA | Pkinase | 39-286 | 29 | 5.9e-71 | 246.83 | Pfam | 16-293 (293) | Show / Hide |
Range on Protein: 39-286 Range on HMM: 16-293/293 Sequence Identity: 29% (84 aa) FRAKDKTTGKLHTCKKFQKRDGRK-VRKAAKN--EIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGR----EVFDWIL--DQGYY--SERDTSNVVR .....| |||. .|.. ||. .. ..... . || |.|...||||..| |.| ..... . .|.. | . ||.| ..| . ||.. .... YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY QVLEAVAYLHSLKIVHRNLKLENLVYYNRLKN-SKIVISDFHLA----KLENGLIKEPCGTPEYLAPEVVG-RQRYGRPVDCWAIGVIMYILLSGNPPFY |.|....|.|| .|.|| ||.||. . |. . ... |.|| || |. . .||||.|.||||. .| ||..|| |..|.|.|..|.|.|||. QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP EEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDIS-----------------QAAKDLVTRLMEVEQDQRITAEEAISHEWI ... .| . .. ....|. ....||.|.|..|| ...||..... .. .|.|||.. |.|. GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | VACAMKL.AA | RSK | 61-286 | 29 | 8.7e-70 | 238.16 | In-house | 35-278 (278) | Show / Hide |
Range on Protein: 61-286 Range on HMM: 35-278/278 Sequence Identity: 29% (73 aa) RKVRKAAK------NEIGILKMVK-HPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGY---YSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLEN .|.....| |. ||.... ||.| .| ..| | .. .. .|. | | |. .. ... ||.. . . ... || .||...|.|| ||.|| AKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPEN LVYYNRLKN-SKIVISDFHLAKL----ENGLIKEPCGTPEYLAPEVVG---RQR-YGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKIL .| .. | |...|| ..|. .|.. . .|.| ||.|||.. .|. ... .| | ||.|| .|.|.|||. ..| |. | ....|. ILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG--PND---NNRKEIMKRIQ AGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRIT-----AEEAISHEWI |.. ...| |. .||.||||........ .|.. ||| .|.|. KGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | VACAMKL.AA | Ciliate-E2 | 24-286 | 20 | 1.5e-67 | 230.75 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-365/365 Sequence Identity: 20% (78 aa) YDLGQVIKTEEFCEIFRAKD-----------------------KTTGKLHTCKKFQKRDGRKVRKAAK--NEIG----------ILKMVKHPNILQLVDV |.. ..| . | ....|. |...|. | ..|.. . . . . .|| ||. ..||||...... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FV--TRKEYFIFLELATGREVFDWILDQ-----------GYYSERDTSNVVRQVLE---------------AVAYLHSLK-IVHRNLKLENLVYYNRLKN | ... ... .|.. | . ||.| .. .|..|. ... .|.|. |. |||| . |.||..|.||... FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ SKIVISDFHLAKLEN-------------GLIKEP----------------------CGTPEYLAPEVVG---------RQRYGRPVDCWAIGVIMYILLS | |.|| |.| . .. ||||.|.|||... ...|. .| |..|||.|..|. --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSP--------------YWDDISQAAKDLVTR----LMEVEQDQRIT-AEEAISHEWI |.||| ...|. ....|..| |...|| .||| . ........||| .|... |.|. GKPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | VACAMKL.AA | Ciliate-E2-Unclassified | 24-286 | 21 | 4.2e-63 | 215.95 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-352/352 Sequence Identity: 21% (76 aa) YDLGQVIKTEEFCEIFRAKDKTTGKLH----TCKKFQKRDGRKVRKA--------AKNEIG-------------ILKMVKHPNILQLVDVFVTRKEYFIF | ....| . |........| .. . . ||.|... ..... . |.. ||.. .||.|. ....| ... .| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LELATGREVFDWILDQ-----------------GYYSERDTS-----NVVRQVLEAVAYLHSLK-IVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENG .|.. | . ...| .. .|. .. . .|.|.. |||. . |.||..|.||... | || .| |.|| ..| . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ L------------------IKEPCGTPEYL----APEVVGRQRYGRP----VDCWAIGVIMYILLSGNPPFYEEVEED-----------DYENHDKNLFR .. ||||.|. |||| ..| |. . .|.|. |||.| .| |..||| . .|. . .|.|.. NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA---YRKQLYQ KILAGDYEFDSPYW----DDISQAAKDLVT----RLMEVEQDQRITAEEAISHEWI .|......|.. | ...|. |||... ..... ...|||.|... | |. NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | VACAMKL.AA | TyrKc | 24-286 | 17 | 7.6e-10 | -63.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 24-286 Range on HMM: 1-280/280 Sequence Identity: 17% (53 aa) YDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMV--KHPNILQLVDVFVTR-------KEYFIFLELATGREVFDWILDQ ||... .|.|..... | |. .. |.. .|. |.... .||||..|. | .. . ..| .|.. . | . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH GY-YSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGL--------IKEP----CGTP----EYLAPEVVGRQRY . . .| . |. . .|||| ...|| | | . ... . |||| |.. . . .| .|||. .. RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF GRPVDCWAIGVIMY-ILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPY-----WDDISQAAKDLVTRLME----VEQDQRITAEEAISHEWI | |. || |. |. | .| ...... .. ..... .|.. |. . ... . .|. . ..| | .| || . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF |