Gene VRK2 (Mouse)
VRK2
Sequence
Protein domains of VRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | VRK2.AA | VRK | 29-292 | 61 | 1.4e-204 | 660.35 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 29-292 Range on HMM: 1-284/284 Sequence Identity: 61% (174 aa) WALGKMIGSGGFGLIYLAFP-TNKPN-KDARHVIKLE-YQENGPLFSELKFYQRAAKRECIQKWIQQRK------------LDYLGIPVFYGFGLTDFKG |.|||.||.||||.||||.| |.||. |||..|.|.| ..||||||.|..|||||||.|.||||....| |..||||...|||..||.| WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG RSYRFMVMERLGIDLQKLLD-QNGG-FKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF-TNPDRVYLADYGLSYRYCPNGNHKQYQEDPRKGH ..||||||.|.|.||||... |||. |.. |||||..||||||||.||||||||||||||.||.| .|||.|||.||||.|||||||.|.||.||||..| EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRCH NGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLD--DPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYL |||.||||.|||||.|||||||.|||||||..||.|.|||...|. ||..||.||....|..||...|..|....|.|..||. NGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
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Kinase | VRK2.AA | CK1 | 29-309 | 25 | 5.1e-86 | 292.09 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 29-309 Range on HMM: 1-339/339 Sequence Identity: 25% (86 aa) WALGKMIGSGGFG-LIYLAFP---TNKPNK----DARHVIKLEYQ-ENGPLFSELKFYQRAAKRECIQKWIQ----QRKLDY---LGIPVFYGFGLTDFK | ..|.||.|||| ||.... ....|. . . ..|.| ..|........||. .| ....|| . . |... .|.| . .. .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE GRSYRFMVMERLGIDLQKLLD---Q-NGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF--------------TNPDRVYLADYGLSY-RY .. |..|||..|| .|..|.. . |. | . |.|...|.||..|||.|.. ..| |||..|.... . ..||. |.|.. .| DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY CPNGNHK----------QYQEDPR----KGHNG-TIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGK--LPWEAKLD-----DPVAVQTAKTNLLDEL .....|. |. . .. ||. | |....|...|.|. ..|| |.. ..|....|| |. ||| | |. |. .| . || RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEK PESV-LKWAPSGS----SCSELVKYLMYVHNLAYDDKPDYQKL . |. .. .. .. . .|. |.. |...| |.|.|||... KMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | VRK2.AA | CK1-A | 112-309 | 32 | 1.4e-26 | 90.85 | In-house | 65-261 (261) | Show / Hide |
Range on Protein: 112-309 Range on HMM: 65-261/261 Sequence Identity: 32% (66 aa) KGRSYRFMVMERLGIDLQKLLDQ-NGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFT-NPDRVYLADYGLS--YRYCPNGNHKQYQEDPR ... | |||. || | | . | ||| | |. .||.|| ..| ||| | |. ...| |.||. || | .|.|| CEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYRED-- KGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQ | ||. . |..|| |. ||| |.| .||.|. . ||||| . . | . | |. . .|. |. |. || ....||| KNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMK---AMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYM KL | YL |
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Kinase | VRK2.AA | CK1-Unclassified | 29-250 | 33 | 2.3e-25 | 71.84 | In-house | 1-216 (244) | Show / Hide |
Range on Protein: 29-250 Range on HMM: 1-216/244 Sequence Identity: 33% (77 aa) WALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEY--QENGPLFSELKFYQRAAKRE-CIQKWIQQRKLDYLGIPVFYGFGLTDFKG--RSYRFMVMER ... ||.| || ||.. .|. .. |||| ... |. | |..|. ... | . .||| | .| . . | .|||. YRVIEKIGQGSFGEIYKC--INMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNC-DNF------I-KGIPKMYWCG----QEEQGDYNIMVMDL LGIDLQKLLDQNG-GFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLD--FTNPDRVYLADYGLSYRYC---PNGNHKQYQEDPRKGHNGTIEFT || .| .|. . | ||| .. |.. .||.|.. ..| ||| | | | ..||. |.||| || .|.| .|.|. |. || .. LGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYREN--KNLTGTARYA SLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPW |. ||.|. ||| | | |||... | |.||| SINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW |
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Kinase | VRK2.AA | CK1 | 29-250 | 31 | 7.8e-25 | 82.55 | In-house | 1-216 (271) | Show / Hide |
Range on Protein: 29-250 Range on HMM: 1-216/271 Sequence Identity: 31% (73 aa) WALGKMIGSGGFGLIYLAFPTNKPNK-DARHVIKL--EYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKG--RSYRFMVMER .|. ||.| || |||. . . .. . ||| . ... | | |.|.. ...| . ||| | .| . . | .|||. YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNC-DN-------QCHGIPHMYWCG----QEEQGDYNIMVMDL LGIDLQKLLDQNG-GFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF--TNPDRVYLADYGLSYRY--CPNGNHKQYQEDPRKGHNGTIEFTS || .| .|.. . | ||| .. |.. .||.|.. ..| ||| | | . ..||. |.||. || ...| .|.|. |. || ..| LGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYREN--KNLTGTARYAS LDAHKGVAPSRRSDVEILGYCMLHWLFGKLPW . .| |. ||| | | |||... | |.||| INTHLGIEQSRRDDMESLGYVLMYFLRGSLPW |
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Kinase | VRK2.AA | TTBKL | 29-190 | 22 | 3e-23 | 75.42 | In-house | 1-156 (288) | Show / Hide |
Range on Protein: 29-190 Range on HMM: 1-156/288 Sequence Identity: 22% (40 aa) WALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLG----IPVFYGFGLTDFKGRSYRFMVMERL | ||||.|||| .|.. .. .|. . . | | ..... . .... .. ... . . .| ... | .. .|.||||. . WMIVKMIGEGGFGQVYHV--WDMKDKKDCAAMKEE------------KNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRK----DYNFMVMTLC GIDLQKLLDQNGGFK---KLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFT---NPD--RVYLADYGLS | .||.| .. .| . |.. .||. |..| ..|.. ..| |.| .| .... ... .||| |.|.. GPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMA |
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Kinase | VRK2.AA | CK1-D | 116-250 | 37 | 2.9e-22 | 75.24 | In-house | 69-205 (261) | Show / Hide |
Range on Protein: 116-250 Range on HMM: 69-205/261 Sequence Identity: 37% (52 aa) YRFMVMERLGIDLQKLLDQ-NGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF-TNPDRVYLADYGLSYRYCPNG--NHKQYQEDPRKGHN | |||. || | | . | ||| |. |. .|||| ....| ||| | |. . ||. |.||. || | | |. | YNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYREN--KNLT GTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPW || . |. |.|. ||| |.| ||| .. . | ||| GTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPW |
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Kinase | VRK2.AA | Worm6 | 116-309 | 23 | 1.1e-13 | 45.71 | In-house | 77-279 (279) | Show / Hide |
Range on Protein: 116-309 Range on HMM: 77-279/279 Sequence Identity: 23% (49 aa) YRFMVMERLGIDLQKLLDQNGGFKKLTV---LQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF------TNPDRVYLADYGLSY--RYCPNGNHKQYQE ....||. .| .|. | .|... |...| .|. .| | . ..| |.|..| . ..|. |.|.. .|| .|| . . FNYIVMTLVGKNLWDLRKNRP-DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPR DPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCS-ELVKYLMYVHNLAYDDK .. | || . .| .||| .|. |.| | |.... |.||| ....|. .|. | ... . ... | . |... . |. ...| |. WTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPW-RHMKDHDHVEKHKKWCRRRTRA-PMMRMFFGPCPKEEFNDIMDYIDQYSYWDR PDYQKL |||... PDYKFI |
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Kinase | VRK2.AA | CK1-G | 99-250 | 32 | 5.1e-12 | 36.93 | In-house | 57-208 (266) | Show / Hide |
Range on Protein: 99-250 Range on HMM: 57-208/266 Sequence Identity: 32% (51 aa) GIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQNG-GFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLD---FTNPDRVYLADYGLS--YR ||| | || | |||. || | | | . | ||... | |.. .||.|. . . .|.| | | .. ... |.|. |. GIPQVYYFGQCGK----YNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYI YCPNGNHKQYQEDPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPW . . | | | .| || . | | | ||| | | || . | |.||| DPETKQHIPYRE--HKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPW |
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Kinase | VRK2.AA | S_TKc | 29-402 | 12 | 4.7e-11 | -14.87 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-402 Range on HMM: 1-231/231 Sequence Identity: 12% (50 aa) WALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGI-- . ... ||.|.|| |.. .. . . || . ..|| | .. . | .|.. . .. .|||| .. YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------------EHIRREIQ---ILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDL -DLQKLLDQNGG------FKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPRKGHNGTIEFTSL || ......|. | .. . ... |||.|.. .| |.| .|.||| .. ..| ||. .. . || .. . GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAP DAHKGVAPSR-RSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKILNPDGV .. ..|. .| .. | |. |.. .. . . . EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------------------------------------------ PLGPLEFSTKVQSVHVRTPAQQKVDSPKATRKPANEFPAKFPKKVHRETRARQREEQEDSQPT-----MLQ----SRPAAPENSR---TRKIHEYS ... .|| || | | . |.|.. ----------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | VRK2.AA | TTBK | 116-309 | 28 | 1.4e-10 | 33.59 | In-house | 70-257 (257) | Show / Hide |
Range on Protein: 116-309 Range on HMM: 70-257/257 Sequence Identity: 28% (58 aa) YRFMVMERLGIDLQKL--LDQNGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAAN--LLLDFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPRK--G . .|||. .| | | | | | |.||. .|. .| ||. . | ||| | . . . ..|. |.|| .| | . ||. | FNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYT---NACGEVRPPREVAG HNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKL ||. . | ||. |. | | | . . | ||| |. | | | . || | .|. .. .. | | |.|||| . FRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWR-KIKDKDQVGEMKEKYDHRM---LLKHCP-----HEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | VRK2.AA | Pkinase | 114-190 | 26 | 3e-06 | 23.24 | Pfam | 72-159 (293) | Show / Hide |
Range on Protein: 114-190 Range on HMM: 72-159/293 Sequence Identity: 26% (23 aa) RSYRFMVMERLGI-----DLQKLLD--QNGGF--KKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLD--FTNPDRVYLADYGLS ... |||| .. || .. ..|.| .. .| |||.|.. .| |.| .|.|.| .....| ..| ||. KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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Kinase | VRK2.AA | CK1 | 286-307 | 40 | 3e-06 | 17.58 | In-house | 250-271 (271) | Show / Hide |
Range on Protein: 286-307 Range on HMM: 250-271/271 Sequence Identity: 40% (9 aa) SELVKYLMYVHNLAYDDKPDYQ .|.. || |. .| ...||||. NEFAMYLNYCRQLHFEEKPDYM |
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Kinase | VRK2.AA | CK1-D | 286-309 | 54 | 1.5e-05 | 15.39 | In-house | 238-261 (261) | Show / Hide |
Range on Protein: 286-309 Range on HMM: 238-261/261 Sequence Identity: 54% (13 aa) SELVKYLMYVHNLAYDDKPDYQKL || ..|. |..|| .|||||| | SEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | VRK2.AA | Worm6 | 29-63 | 34 | 4.2e-05 | 14.64 | In-house | 1-34 (279) | Show / Hide |
Range on Protein: 29-63 Range on HMM: 1-34/279 Sequence Identity: 34% (12 aa) WALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLE | ..| ||.|||| .|.. . . .| . ..|.| WKVTKKIGEGGFGAVYKVEDKSDKKK-KQFAMKCE |
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Kinase | VRK2.AA | CK1-G | 287-309 | 39 | 4.2e-05 | 13.15 | In-house | 244-266 (266) | Show / Hide |
Range on Protein: 287-309 Range on HMM: 244-266/266 Sequence Identity: 39% (9 aa) ELVKYLMYVHNLAYDDKPDYQKL .. .|| || .| ....||| | QFATYLRYVRRLDFFECPDYDYL |
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Kinase | VRK2.AA | TyrKc | 29-313 | 17 | 0.000124 | -147.72 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 29-313 Range on HMM: 1-280/280 Sequence Identity: 17% (57 aa) WALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKREC---IQKWIQQ----RKL--DYLGIPVFYGFGLTD---FKGRSY |||..|.| || .|.. . .| | | .. .. .|| . | .|| ... | ITLGKKLGEGAFGEVYKGTWK---------------------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP RFMVMERL-GIDLQKLLDQNGGFKKLTVLQLGIRMLDV---LEYIHENEYVHGDIKAANLLLDFTNPDRVYLADYGLSYRYCPNG-----NHKQYQEDPR ..||| . ||.. | ... |.. .| .... ||.|.. ..| |. | | |.. . .| .| ||| |. .. ... | . LMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLS-RDIYDDDQQGESKDYYRKKEH KGHN--GTIEFTSLDAHKGVAPSRRSDV--------EILGYCMLHWLFGKLPWEA----KLDDPVAVQTAKTNLLDELPESVLKWAPSGS----SCSELV || . | ... . . . ||| ||. | |. |.. .... ... |. . |.... | .|. KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY-------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P--MSFVCCPDEMY KYLMYVHNLAYDDKPDYQKLKKIL . . .| | . ..... QIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | VRK2.AA | TTBKL | 294-313 | 30 | 0.000881 | 8.73 | In-house | 269-288 (288) | Show / Hide |
Range on Protein: 294-313 Range on HMM: 269-288/288 Sequence Identity: 30% (6 aa) YVHNLAYDDKPDYQKLKKIL ....| | | |||... ... HLRSLRYYDRPDYEMIYECF |
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Kinase | VRK2.AA | CK1-D | 29-45 | 52 | 0.0025 | 7.41 | In-house | 1-17 (261) | Show / Hide |
Range on Protein: 29-45 Range on HMM: 1-17/261 Sequence Identity: 52% (9 aa) WALGKMIGSGGFGLIYL . .|. |||| || ||. YRIGRKIGSGSFGDIYH |
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Kinase | VRK2.AA | TTBK | 29-44 | 62 | 0.003508 | 7.13 | In-house | 1-16 (257) | Show / Hide |
Range on Protein: 29-44 Range on HMM: 1-16/257 Sequence Identity: 62% (10 aa) WALGKMIGSGGFGLIY | | || |||| || WKVVKKIGGGGFGEIY |
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Kinase | VRK2.AA | CK1-A | 29-46 | 55 | 0.007866 | 5.63 | In-house | 1-18 (261) | Show / Hide |
Range on Protein: 29-46 Range on HMM: 1-18/261 Sequence Identity: 55% (10 aa) WALGKMIGSGGFGLIYLA . | . |||| || |||. YRLVRKIGSGSFGDIYLG |
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Kinase | VRK2.AA | CK1-G | 29-45 | 41 | 0.016042 | 4.26 | In-house | 1-17 (266) | Show / Hide |
Range on Protein: 29-45 Range on HMM: 1-17/266 Sequence Identity: 41% (7 aa) WALGKMIGSGGFGLIYL .. || || | || ... YRVGKKIGCGNFGELFE |
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Kinase | VRK2.AA | Pkinase | 29-46 | 44 | 0.472965 | 4.8 | Pfam | 1-18 (293) | Show / Hide |
Range on Protein: 29-46 Range on HMM: 1-18/293 Sequence Identity: 44% (8 aa) WALGKMIGSGGFGLIYLA . .|. ||||.|| |.. YHIGRKIGSGSFGCVYKC |