Gene VRK3 (Mouse)
VRK3
Sequence
Protein domains of VRK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | VRK3.AA | VRK | 145-411 | 44 | 2.3e-171 | 552.49 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 145-411 Range on HMM: 1-284/284 Sequence Identity: 44% (127 aa) WTLGALQIRDDQGILYEAEPTSAVPSESRTQKWRFSLKLDSKDGRLFNEQNFFQRVAKPLQVNKWKKQFL------------LPLLAIPTCIGFGIHQDK | || . .. .|..|.| |.. |.|. |. .... ....|.||.|..|.||.|||.|..||.|.. ||.|.||.|.|||.|... WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEP-PHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFN ---YRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNP-EDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSP |||.|.|..||.||....|...|..|...|||.|||.||.||||||||||||...|.|..... .. .||.||.||..|||||.|||..|||..|.. GEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRC HDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLP--NTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYL |.|..||.|||.||||.|||||||..|||||..||||.|||..||. ..||....|||..|....... |..|.........|. HNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
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| Kinase | VRK3.AA | CK1 | 181-428 | 18 | 1.8e-56 | 193.94 | In-house | 40-339 (339) | Show / Hide |
Range on Protein: 181-428 Range on HMM: 40-339/339 Sequence Identity: 18% (56 aa) LKLDSKDGR--LFNEQNFFQRVAKPLQVNKWKK-------QFLLPLLAIPTCIGFGIHQ---DKYRFLVFPSLGRSLQSALD--DNPKHVVSERCVLQVA .|. .|. . .. .. ..|...|. . .|| | .|. .....| .. ...|. |.|...| . ||..|.. .. .... | ...|..| MKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIA CRLLDALEYLHENEYVHGNLTAENVFVNP--------------EDLSQVTLVGYGFTY-RYCPGGKHV----------AYKEGSR----SPHDG-DLEFI ...|.||||.|.. ..| .. ..|. . ... || .. .|. .|.. ..|. ... . .. | ... IQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYC SMDLHKGCGPSRRSDLQTLGYCMLKWLYGS--LPWTNCLPNTE-K---ITRQKQKYLDSPERLVGLCGRWNK-----ASETLREYLKVVMALNYEEKPPY |.. |.|. ..|| || ...|... || |. |||.|. ... | . ..|... | .. .. .. .. . . ...|....|.|...|.| SINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDY ATL . . EMI |
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| Kinase | VRK3.AA | CK1-D | 220-428 | 25 | 7.6e-13 | 41.49 | In-house | 57-261 (261) | Show / Hide |
Range on Protein: 220-428 Range on HMM: 57-261/261 Sequence Identity: 25% (53 aa) IPTCIGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVN-PEDLSQVTLVGYGFTYRYCPGG-- ||. .| | | .| || || | . | . || .| .. .||.| ....| . .| . . | .. .| . || IPEIRWCGQEGD-YNVMVMDLLGPSLE-DLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTH KHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMA .|..|.| | . |. |.| ||| || ||| .. . ||||| | . .. .. || . .. .|. . QHIPYRE--NKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSE---FQQYMNYCRN LNYEEKPPYATL | ...|| |. | LKFDDKPDYCYL |
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| Kinase | VRK3.AA | Ciliate-E6 | 231-293 | 30 | 9.9e-11 | 30.72 | In-house | 22-86 (154) | Show / Hide |
Range on Protein: 231-293 Range on HMM: 22-86/154 Sequence Identity: 30% (20 aa) DKYRFLVFPSLGRSLQSALD--DNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFV ..| | |.......|| . .| | . ....| |. |.|||| . ||..|.| .| |. ENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFL |
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| Kinase | VRK3.AA | CK1-A | 220-428 | 25 | 2.6e-09 | 28.91 | In-house | 57-261 (261) | Show / Hide |
Range on Protein: 220-428 Range on HMM: 57-261/261 Sequence Identity: 25% (55 aa) IPTCIGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNPE-DLSQVTLVGYGFT--YRYCPGG ||. .| .| | .| || || | | . . || .| .. .||.|| ..| . .| . . .. |. .| . || IPHMRWYGCEKD-YNVMVMDLLGPSLE-DLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTR KHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMA .|. |.| | . |.. | | ||| |. .||.|. . |.||| .| | | . || . |.. . . QHIPYREDKN--LTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLC---KGFPAEFCMYMNYCRN LNYEEKPPYATL | .||.| | | LRFEEQPDYMYL |
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| Kinase | VRK3.AA | Jak | 258-293 | 30 | 5.7e-08 | 24.33 | In-house | 116-151 (299) | Show / Hide |
Range on Protein: 258-293 Range on HMM: 116-151/299 Sequence Identity: 30% (11 aa) SERCVLQVACRLLDALEYLHENEYVHGNLTAENVFV .| ...|.| ......||... |.||.. | |. | TEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILV |
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| Kinase | VRK3.AA | UTK | 244-294 | 26 | 2.6e-07 | 21.08 | In-house | 96-152 (296) | Show / Hide |
Range on Protein: 244-294 Range on HMM: 96-152/296 Sequence Identity: 26% (15 aa) SLQSALDDNPK------HVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVN .|.| | .... | ..... |. | ....|||. .||..| | |..|. DLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVH |
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| Kinase | VRK3.AA | Ciliate-C3 | 263-306 | 31 | 1e-06 | 19.88 | In-house | 99-140 (140) | Show / Hide |
Range on Protein: 263-306 Range on HMM: 99-140/140 Sequence Identity: 31% (14 aa) LQVACRLLDALEYLHENEYVHGNLTAENVFVNPEDLSQVTLVGY ||.. .| |..|||| ||| . .|. .| .| .. .. . LQISKQILQAIDYLHEHNIVHGDIKFSNILINSKD--EIKIIDF |
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| Kinase | VRK3.AA | S_TKc | 150-452 | 8 | 3e-06 | -85.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 150-452 Range on HMM: 1-231/231 Sequence Identity: 8% (30 aa) LQIRD-----DQGILYEAEPTS--------AVPSESRTQKWRFSLKLDSKDGRLFNEQNFFQRVAKPLQVNKWKKQFLLPLLAIPTCIGFGIHQDKYRFL .| . | | . .. .. .. .| . .. . .. |. . .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK----------HHPNIVKLYDVFQD--------DHLYM VFPSLGR---SLQSALDDNPKHV----VSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNPEDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSPH |. .. .| . ......| .| . ... ...||||.|.. .| | ||.... .. . |. .. . VMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTF DGDLEFISMDLHKGCGPSR-RSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATL | ..... . | .. ..| .| .. |.| |. . ... .. . CGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------------------------SPEA RNSLEALLQ---DMRVSPYDPLD-------LQMV .. .. .|| . | . . | . . KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | VRK3.AA | CK1-G | 262-369 | 25 | 2.5e-05 | 13.93 | In-house | 98-208 (266) | Show / Hide |
Range on Protein: 262-369 Range on HMM: 98-208/266 Sequence Identity: 25% (29 aa) VLQVACRLLDALEYLHENEYVHGNLTAENVFV---NPEDLSQVTLVGYGFT--YRYCPGGKHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLG |..|| ... .||.|. . . . .| . .| . .. .| |. . ..|..| | . | . | | | ||| |. || VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--HKSLTGTARYMSINTHLGREQSRRDDMEALG YCMLKWLYGSLPW . | ||||| HMFMYFLRGSLPW |
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| Kinase | VRK3.AA | Worm6 | 341-428 | 18 | 0.000157 | 12.56 | In-house | 193-279 (279) | Show / Hide |
Range on Protein: 341-428 Range on HMM: 193-279/279 Sequence Identity: 18% (16 aa) HKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATL |||. .|. |. . | |. .. | ||| .. .. ..|... . ... . . . | ... .... ..|...| |... HKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFG-PCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | VRK3.AA | Worm6 | 231-283 | 25 | 0.000922 | 9.77 | In-house | 73-127 (279) | Show / Hide |
Range on Protein: 231-283 Range on HMM: 73-127/279 Sequence Identity: 25% (14 aa) DK--YRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVH |. ....| . .|..|. . |. | .. |..|. |.|.| || . ..| DNRGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIH |
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| Kinase | VRK3.AA | CK1-G | 410-428 | 42 | 0.005317 | 5.91 | In-house | 248-266 (266) | Show / Hide |
Range on Protein: 410-428 Range on HMM: 248-266/266 Sequence Identity: 42% (8 aa) YLKVVMALNYEEKPPYATL ||. | |...|.| | | YLRYVRRLDFFECPDYDYL |
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