Gene MINK (Mouse)

MINK

Species: Mouse
Alias: Map4k6-pending, MINK, ZC3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MSN

Sequence

Name Sequence Type Origin Length Description Download
MINK.AA Protein Sugen 1340 None Fasta, JSON
MINK.NA RNA Sugen 5058 None Fasta, JSON
MINK.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of MINK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MINK.AA MSN 25-289 90 1.1e-209 698.97 In-house 1-265 (265) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-265/265
Sequence Identity: 90% (240 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA
||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.|.|||.|||||||||||||||.|||..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAI
||||.||||||||||||||||.||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||.||.|||||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
|||||.|||||||||||||||||||||.|||||||||| .|...||||.|..|| |||.||.|||
EMAEGQPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase MINK.AA STE20 25-289 53 1.1e-171 576.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-288/288
Sequence Identity: 53% (156 aa)

FELVEVVGNGTYGQVYKGRHVKTGQL----AAIKVMDVTE-----DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTD
.||.|..|.|.||.|||..|..||..    .|||.|.. .     ||.|.|..||...|..  | || .|||...|....  ||.||.|||.||.||.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTC--DDELWIVMEYCGGGSLTD

LVKN--TKGN-----ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR----TVG-RRNTFIGTPYWMAPEVIACD
..|.  ..|.      ..|..|||||||.|.||..||....||||||..|.||||..||||.||||.|||..    | . .||||.|||||||||||.|.
IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

ENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIP--RNPPPRLK---SKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
|.||  |||..||||||||||||||| ||..|||||||.|.||  .||||.||   ..|||..| ||.|.|| | .  || ..|||| |||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MINK.AA STE 25-289 38 2.4e-141 475.85 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-359/359
Sequence Identity: 38% (140 aa)

FELVEVVGNGTYGQVYKGRHVK---------------TGQLAAIKVMDVTE------------------DEEEEIKQEINMLKKYSH-HRNIATYYGAFI
.|..|..|.|..|.|||....|               ||.. |||.|.. .                  .|...|..||...||..| | || .|||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KKSPP-GNDDQLWLVMEFCGAGSVTDLVKN--TKGNALK----------EDCIAYICREILRG-LAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSA
|.... .|||.||..||....||..|..|.   .|. |.          |. ||||||.||.| |..|| |..||||||..|.||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLDR---------------TVG-RRNTFIGTPYWMAPEVIACDENP-DATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN-----------
||.                | . .||||.||| ||||||| ..... |  ||...||||||.|.||||.| ||..|||||||.|.||.|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPRLKS------------------KKWSKKFIDFIDTCLIKTYLSRPPTEQLLK--FPFI
    |||.|..                  .|||..|.|||. ||.| .  || ..||||   |||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MINK.AA NinaC 25-289 53 4.1e-133 448.54 In-house 1-267 (267) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-267/267
Sequence Identity: 53% (143 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKG
.| .| .| |||| |.|    . ||.||.|...  .| .|||  | | |..|. | |.  .|| . .|. . | ||||.|||.|  |||||.||     |
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMY-YKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCG

NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT
  ..|. |||| .| ..|| ||| ..|||||.|| |.||| .  |||.||||||||| | .|||| .|||.||||||||| .  | .|| | |.||||||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
|||.. | ||. |||||||.| |||||||.|    .|...| |||  ||.| |  ||   ..|. |||
AIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase MINK.AA YSK 25-289 48 7.4e-132 399.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-257/257
Sequence Identity: 48% (130 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE--EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG
|   |..| | .| ||||  ..|..  |||. |  ..|.  | | |||. |       .|  |||.. |      |  || .||.|| ||. || |    
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSP-YITKYYGSYLK------DTKLWIIMEYCGGGSCLDLMKPKYV

NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC--DENPDATYDYRSDIWSLG
... |  || | |||| ||  ||  ..||||||  ||||.|. .||| ||||..|.  |. .||||.||||||||||| .  ..     ||.  ||||||
GQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY-----YDFKADIWSLG

ITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
|||.||| | ||.||.||||..|||| |.||.|. ...|| |..|.. || |.   ||  ..|||. ||
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MINK.AA MST 25-289 49 3e-115 367.79 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-254/254
Sequence Identity: 49% (133 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSHHRNIATYYGAFI--KKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK
|..||  | | ||.|||  | .||.. |||.. |  .|  .||. ||....      .| .||| ..  |      . ..|.|||.||.||| |..| |.
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQC-KSKYIVKYYGSYFDAK------NNHCWIVMEYCGMGSVCDIMKITQ

GNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGI
   | |. || |..  |.||. ||  | ||||||  | || .  | || |||||.||  | . |||.||||||||||||         ||.  |||||||
-RTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ-----EIKYDCKADIWSLGI

TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
|||||||| ||. | |||||.|.|| .||| .|   .||  |.||.  ||.|    |.  ||||. |||
TAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase MINK.AA KHS 25-289 47 1.1e-104 353.03 In-house 1-258 (258) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-258/258
Sequence Identity: 47% (129 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN
.||.  || ||||.||| |......|||.||. .  ... . |.||| |.|.  .| ||  |.|.....      |.||..||.||.||. |. . |   
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKD-CRHPNIVAYFGSYLRR------DKLWICMEYCGGGSLQDIYHVT--G

ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITA
 |.|  |||.|||.|.||..||... .|||||| |.|||.. .||| |||||||.  |...|  |||||||||||| | . .    |.   |||..||||
PLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK--GGYNQLCDIWAVGITA

IEMAEGAPPLCDMHPMRALFLIPRNP--PPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
||.||  ||. |.||||||||. .    ||.|| | |||..| .|. ..|.|    ||  |.||. ||.
IELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase MINK.AA PAKA 25-289 41 2.7e-101 342.82 In-house 1-260 (260) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-260/260
Sequence Identity: 41% (112 aa)

FELVEVVGNGTYGQVYKGRHVKTGQL--AAIKVMDVTEDEEE-EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK
.. .| .| |  |.||..  .||.|    |||.|.. ..     |. || ..|. ..| ||  |. ...       ||.||.|||. ..|. ||..... 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKE-CKHKNIVNYIDSYLV------DDELWVVMEYMEGGCLTDVITQCC

---GNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWS
    | ..|. |||.|||.|.||  .|....||||||  |.||  ...||. |||  ||| .   .|||  |||||||||||   .     ||.  ||||
NIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-----YDEKVDIWS

LGITAIEMAEGAPPLCDMHPMRALFLIPRN-PPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
||| ||||.|| ||  .. | ||..||  |  |...   |||..| || |.|| .   .|. ...||..||.
LGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase MINK.AA PAKL 25-289 43 4.8e-96 325.38 In-house 1-256 (256) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-256/256
Sequence Identity: 43% (117 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTED-EEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN
||. |  | | || |||. |  |.   ||||. ..|  | ..|  ||..|||     ||  |.|    |      ...|  |..| .||. |. . . . 
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKK-CKCPNIVSYFGSIQQKL-----NHYWILMDYCSLGSINDMMESC-CK

ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG-RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT
 |.|  |. | .  |.||  ||   .||||||  |.||.| . ||. ||||| ||. . .   |  ||||||||||.|       . |..  ||||||||
TLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINK-----QNYNNKCDIWSLGIT

AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
|||||.| ||. || ||||.  ||. ||| ..  |.||. | ||...|. |    |.   .||  |||
AIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase MINK.AA S_TKc 25-289 31 2.2e-94 320.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-231/231
Sequence Identity: 31% (89 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGA--GSVTDLVKNTKG
.|.....| |..|.|||.||.|||.. |||...      | |..||..|||  || || ..|..|         | |..|||.|.   |.. |. |. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR

NA----LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDY-RSDIW
.     . |  .......|...|...| |..||||.| .|.||.|  ..|. |||...||       .||.|||..|||||.         |.. ..|.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWW

SLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLK-------FPFI
|.|.. .||. | || .  .... . .|             |. ..|||. || |    ||   ..|.        |..
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MINK.AA SLK 25-289 42 1.1e-90 306.15 In-house 1-259 (259) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-259/259
Sequence Identity: 42% (114 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN
.|..  .|.| .|.||| .|  ....|| |.... ..|| |.   ||..| .   | ||   |.|.        |..||...|||. | | | .    . 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYYY------DNKLWMMIEFCDGGAV-DNIMVELEH

ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITA
.|.|| |.|.|.... .| .|| .||||||.|  |.|.| . .|.| ||||||.. .|. .| |||||||||||||..|.   |. |||..|||||||| 
PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITL

IEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI
||||.. ||  .| ||| |. | .  ||.|.   .|||.| ||.  || |    |..|.||.. ...
IEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase MINK.AA Pkinase 25-289 27 2e-79 274.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQ-----EINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAG----SVTD
.......| |..|.|||..|..||.. |.|.... ...... ..     || ..|.  .| || ..|..|        .| ...|||.|. |    .  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

LVKNTKGNAL--KEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEV----KLVDFGVSAQL-DRTVGRRNTFIGTPYWMAPEVIACDENPDA
...  .....   |. .  ....|||||...|....||||.| .|.|. .| ..    |. |||...|.     .  .|| |||..||||||      . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQ

TYDYRSDIWSLGITAIEMAEGAPPLCDM----HPMRALFLIPRNPPPRLKSKKW----------------------SKKFIDFIDTCLIKTYLSRPPTEQ
 |....|.||.|.. .||. | || ..     . .. ...| |. .|.|..  .                      |. ..|||. || |   .||  ||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLKFPFI
.|. |..
ILQHPWF
Kinase MINK.AA Pkinase_Tyr 25-245 26 1.7e-36 124.21 Pfam 1-228 (270) Show / Hide 
Range on Protein: 25-245
Range on HMM: 1-228/270
Sequence Identity: 26% (63 aa)

FELVEVVGNGTYGQVYKGRHV----KTGQLAAIKVM--DVTEDE--EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDL
 .. .. | | .|.||||.      .|..  |.|..  . ....   |.  .|....|.. || ||  .||. .... |.   |...|||..  |.  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDY

VKNT--KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRT-VGRRNTFIGTPYWMAPEVIACDENPDATY
 ..    ...|.   .  .|..| .|...|.... ||||.   |.|.|||  ||  ||| .  .   |   . | ..      |||||.|.  .     .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGK-----F

DYRSDIWSLGITAIEMAE-GAPP-LCDMHPMRALFLI
   ||.|| |..  |.   |. |   .| . . . .|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase MINK.AA TyrKc 25-287 22 1.2e-17 62.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKY-SHHRNIATYYGAFIKK-----SPPGNDDQLWLVMEFCGAGSVTDLVK
 .| .. |.| .|.||||.     .  |.|..      .|.. .|.....|.  || ||   ||. ...     .    ...|..|||..  |.  |  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY----IEPLMIVMEYMPHGDLKDYLR

NTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT--------VGRRNTFIGTP-----YWMAPEVIACDEN
..... |. .   ..|  | .| ..|| ...||||.   |.|..||  ||  ||| |  ..          . |  .  |.       |||||.|     
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----

PDATYDYRSDIWSLGITAIEMAE-GAPPLCD-----MHPMRALFLIPRN---PPPRL----KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFP
 . ..   ||.|| |..  |.   |..|  .     | . ... .. .    |.|       .   ...  . . .|      .||  ... .. 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
CNH MINK.AA CNH 1022-1320 27 1.1e-116 394.82 SMART 1-375 (375) Show / Hide 
Range on Protein: 1022-1320
Range on HMM: 1-375/375
Sequence Identity: 27% (103 aa)

YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQ------GKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK------------IL
........|.|..|||..|||||| |...|....|      |... ...||....|.|.|..|.|..||||. .|....|.||..|             .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

HNDPEVEKKQGW-TTVGDMEG-CGHYRV-VKYER--IKFLVIALKSSVEVYAWAPKPYHKFMAFKS----------------FADLPHRPLLVDLTVEEG
.|.  |..|..| |...| .| | |..| ....|  |.||. |...||..|.....|.|||| .||                |. . . |..|...... 
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

QRLKVIYGSSA------GFHAVDVD-------------SGNSYDIYIPVHIQSQI------TPHAIIFLPNTDG---MEMLLCYEDEGVYVNTYG---RI
.|.....|..       |||.|...             . | .|.... ..|. .      .||........||   .. ||||...||.||.||   | 
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

IKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHL-DGVFMHK---RAQRLKFLCE---RNDKVFFASVR
 ....|.|..||...||.  ..||......|.||...||.. ....|..   .......||.   |..|.|..| .
WRNPILHWEFMPEYFAYHY-PYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH MINK.AA CNH 1031-1311 23 3.3e-86 297.52 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1031-1311
Range on HMM: 1-336/336
Sequence Identity: 23% (80 aa)

LCAALWGVNLLVG-TENGLMLLDR------SGQGKVYGLIGRRRFQQMDVLEGLNLLITI--SGKRNKLRVYYLSWLRNKILHNDPEVEKKQ--------
.|.. ||..|||| |. ||.....      .......... | |..|..|.| .|.||.|  ..| ..|.|..|.|| .|...... . .|.        
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSR-RVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIER

-------GWTTVGDMEGCGHYR--VVKYERIKFLVIALKS-----SVEVYAWAP--KPYHKF-------MAFKSFAD-LPHR----PLLVDLTVEEGQRL
       .|....|  .| ...  ...|.....|..|.|.     .. .| |..  |..||.       ..|. | . . .     .. ..... . ...
IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKP

KVIYGSSAGFHAVDVD-SGNSYDIYIPVHIQS----------QITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGR-IIK--DVVLQWGEMPTSVAYICS
|...|.. |||.|..| .| ..... ... .|          ...|.... ...  . |.||||....||||..|. . .  |....| .||.|.|. |.
KLCVGCQKGFHIVNLDGTGQPWWLH-DPADHSVQQDFMARRENCKPICMHRINDD-E-EFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFAC-CY

NQIMGWGEKAIEIRSVETG-HLDGVFMHKRAQRLKFLCERN
...... ...||||.|||| ..|..... ..|...||....
PYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS