Gene atl-1 (Nematode worm)
atl-1
Sequence
Protein domains of atl-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FATC | atl-1.AA | FATC | 2015-2021 | 42 | 34.431228 | 0.4 | Pfam | 27-33 (33) | Show / Hide |
Range on Protein: 2015-2021 Range on HMM: 27-33/33 Sequence Identity: 42% (3 aa) IGWRAFY ||| ... IGWCPWW |
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| Kinase | atl-1.AA | PI3Kc | 2219-2513 | 23 | 4e-109 | 369.75 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2219-2513 Range on HMM: 1-336/336 Sequence Identity: 23% (80 aa) RLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTS------------------------ ..|.|..||| .|.. .|....|....||...| .......|..||.|...|.||.. .... . ..|...... AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM GEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEA-GQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVH-TTGKCIHVDFDM ..|......|......| ..|..|||....|...| |. .||. ..|.. . |...|. |..|.|......||.|.||||. |.|.. .||.|.|.||.. MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH IFNKGETLGTP-----ELVPFRLTQNMINGMG----EVALDGEFRTVCEQALRVFRENSYEIEKYIADLPNLVADFPSNKR-APKDFDMSEAKRL-VSGR ||..|... .. |.||||||..|...|| . ..|.||| |..|.|..|..| .| ... . . .. .. .... .. .| . IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE LRGQIMTA----KLYRSNPISHPMQVSQLASSLIEL .. | ... ||.... |..... ... . .. EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | atl-1.AA | PI3_PI4_kinase | 2217-2461 | 24 | 5e-90 | 310.2 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2217-2461 Range on HMM: 1-300/300 Sequence Identity: 24% (74 aa) IVRLICKKDDDLS--KDYHFTKMV-----------------------EMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMG ....|.|..||| .| . .|. ...|....|| .| ..|....|..||.|.. |.||... .|.| | ... | WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV MTSGEWLEKLKFWNTHMKPMGKE----ERTKYFREVACKNTPVVMGKWFRIQYPEA-GQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMV---HTTG . . ....| ......|.|. .. .....|.....|...... .||. ..|.| . |...|. |..| |.|.|..||.|.|||| |.|| .||| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KCIHVDFDMIFN--KGETLGTPELVPFRLTQ------NMINGM------GEVALDGEFRTVCEQALRVFRENSYEIEKYI--------ADLPNLVADFPS ...|.||...|. |.... ||.||||.|. .|...| .. .|.||..|..|.|..|... . .. . . . ...| HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | atl-1.AA | ATR | 2188-2452 | 35 | 2.8e-62 | 210.88 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 2188-2452 Range on HMM: 2-267/267 Sequence Identity: 35% (95 aa) LIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLD | | | |..| | || | | |.. ..|| ||| || .. |. | ...|| . | . . ||.|||| | .|||... . || YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD KLMGMTSGEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHT-TGKCI || . | . |. | ||| | . || ..|.. ||..||. . .|.||....||| ||||||| |... .| |. KLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECV HVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADL |||. .|||.||.. ||.||||||.||..||| . .| || || ....|.. .| .. HVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | atl-1.AA | PIKK | 2188-2441 | 29 | 2.2e-56 | 193.63 | In-house | 1-279 (290) | Show / Hide |
Range on Protein: 2188-2441 Range on HMM: 1-279/290 Sequence Identity: 29% (81 aa) LIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLD | . . | |. ...|| | . |.. . || .|| .| ..| .| || ... . ...||||||.. . |.|| .. .. | .. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK KLMG---------MTS-------GEWLEKLK-----FWNTHMKPMGK--EERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIG ... .. .|| .. .|.. .. .|. . |||.. . | . ||| | . .|...|. .. |.|||.. | QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFN-KGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFREN || ||||||. |.|. .||...|.|| .|. ....| .||.||||||.||.|.|| ..| || ||......|.. YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQH |
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| Kinase | atl-1.AA | ATM | 2346-2444 | 43 | 2.9e-27 | 83.85 | In-house | 133-231 (304) | Show / Hide |
Range on Protein: 2346-2444 Range on HMM: 133-231/304 Sequence Identity: 43% (43 aa) WFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYE || | . .| | |..||| |||||| .|... .|.| . | .| | ||| |||||| .. ||| .| || ||. . | | || | WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMR-NSQE |
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| Kinase | atl-1.AA | FRAP | 2346-2441 | 42 | 3.8e-24 | 85.66 | In-house | 133-230 (251) | Show / Hide |
Range on Protein: 2346-2441 Range on HMM: 133-230/251 Sequence Identity: 42% (42 aa) WFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVH-TTGKCIHVDFDMIFN---KGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFREN || | . .| |.||..||| |||||| |.| ||| .|.|| | . | . ||..||||| ..| | ..| .| .|| ..| ||. WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKF--PEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREH |
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| Kinase | atl-1.AA | SMG1 | 2346-2404 | 48 | 4.1e-18 | 56.48 | In-house | 183-242 (242) | Show / Hide |
Range on Protein: 2346-2404 Range on HMM: 183-242/242 Sequence Identity: 48% (29 aa) WFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVH-TTGKCIHVDFDMIFNKGETLGTPE |. . .|.||||||..||| |||||| | .. ||| .|.|. | || | || WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | atl-1.AA | DNAPK | 2350-2439 | 35 | 1e-13 | 46.15 | In-house | 187-278 (301) | Show / Hide |
Range on Protein: 2350-2439 Range on HMM: 187-278/301 Sequence Identity: 35% (33 aa) RKLFAKSTAVMSVIGYIFGLGDRHTKNLMV-HTTGKCIHVDFDMIFN-KGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFR | |. . || . ..| | |||| | || .| | .|| | . | ||| ||||| || | . | .. . ... || REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFR |
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| Kinase | atl-1.AA | ATM | 2219-2279 | 37 | 3.4e-12 | 34.85 | In-house | 1-61 (304) | Show / Hide |
Range on Protein: 2219-2279 Range on HMM: 1-61/304 Sequence Identity: 37% (23 aa) RLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGV | . | ||| .| .. ||| || . || |.| || |.|| . |..|. |. RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT |
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| Kinase | atl-1.AA | FATC | 2499-2531 | 39 | 1.5e-10 | 36.86 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2499-2531 Range on HMM: 1-33/33 Sequence Identity: 39% (13 aa) HPMQVSQLASSLIELATSEEKLSEMYLGWMATL .|. |.| .. ||. ||..| |. || ||.. . EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | atl-1.AA | FRAP | 2219-2273 | 25 | 0.045906 | 3.56 | In-house | 3-57 (251) | Show / Hide |
Range on Protein: 2219-2273 Range on HMM: 3-57/251 Sequence Identity: 25% (14 aa) RLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGII . | .|. | . . | || . .|. . . ||.||| . |.| HFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLI |
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| Kinase | atl-1.AA | SMG1 | 2196-2280 | 24 | 0.05427 | 2.21 | In-house | 1-85 (242) | Show / Hide |
Range on Protein: 2196-2280 Range on HMM: 1-85/242 Sequence Identity: 24% (21 aa) VKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVT . .| ||| . |. . | .|| | . . . | . . | ||| ||| |.| ...| | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGAT |
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