Gene B0495.2 (Nematode worm)

B0495.2

Species: Nematode worm
Alias: aSWK168, B0495.2, CE01761, YP62_CAEEL
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 7699211-7701910, WormBase Genetic Map location: II:0.51,

Classification

Group: CMGC
Family: CDK
Subfamily: PITSLRE

Sequence

Name Sequence Type Origin Length Description Download
B0495.2.AA Protein Genbank 719 None Fasta, JSON
B0495.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 292 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of B0495.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase B0495.2.AA PITSLRE 356-647 70 2.5e-241 807.98 In-house 1-295 (295) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-295/295
Sequence Identity: 70% (209 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKME--KEKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRRN
..|.||..|||.|||||.|||||||||||||||||  |||||||||.||||||.|.|..||||||||||..|||||||||.||.||||.|||...|.|||
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

KRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEF
..|..||.|.|.||||.|.||||..||.||||||||||.||||||||.|||||||||.|.|..|..|||||||.||||||...|||||||||||||.|||
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALT-FEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWF
|..||||.|..|..||..||.|||||||.||||.|||..||... |..||||.||||| |.....||||.|||..||..||||..|..||.|.||
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase B0495.2.AA CDK 356-647 43 2.8e-167 539.41 In-house 1-284 (284) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-284/284
Sequence Identity: 43% (141 aa)

YECVNRVDEGTFGVVYRGKDKRTD-----EIVALKRLKMEK-----EKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMD---------KIYMAME
||..... |||.||||...||.|.     .|||||...||.     |||||||||.|||..| .   |||||..... ...|||         |.|| .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGI-----LKIADFGLAREYGD------PLKKFTSIVVTLWY
...|| |...|              |....|||.|....|. ||.|||||..|.|....|.     ||||||||||..|       |....|. ||||||
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RSPELLLGTRLYS--TPVDMWSVGCIMAEFIL---LKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYNQLRKRFLAGRLLNDTG
|.||||||.. ||  ||.||||||||.||...    ||||||. |..|..|||  .|||||..|||||.| ..                           
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

FKLLNGLLTLDPKNRFSATQALDHEWF
  |||..|..|||.|.||.|||.|..|
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase B0495.2.AA CMGC 356-647 25 1.3e-134 445.16 In-house 1-513 (513) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YECVNRVDEGTFGVVYRGKDKRTD--------------EIVALKRLK---MEK------EKEGFPITALREINMLLKAG----------------NHPNI
||..... |||.||||...||||.              ||||.|..|   .|       ||.||||.||||| .| .                  .|.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVKEILLGSNMD---------------KIYMAMEFVEHDMKSLLDTMSR-----RNKRFSIGE------------QKTLL------QQLLSGIE--HMH
|. ..|.  .|.|               ..|. .|...|| . ... ...     |.. .|  .             | ..      .|.| |..  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KLW--ILHRDLKTSNLLMSHK--------------------GILKIADFGLAREYGDP---------------------LKKFTSIVVTLWYRSPELLLG
. |  |.||||| .|.|..|.                    |.|||.|||||| |...                     .. .|. |||.|||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

TRLYS---------TPVDMWSVGCIMAEFIL--------LKPLFPGRGE-----------LEQIKKIFMEMGTPT---------------ESIWPGVTEL
 . |.         ||.||||||||.|| ..        .||||||. |           ..|..|||  .||||               | .||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

DGWKA-------------LT------------FEKYPYNQLRKRFLAGRL--------------------------------LNDTGFKLLNGLLTLDPK
....              ..            | ..|.. ... |   .                                 ... .. ||...|..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

NRFSATQALDHEWF
.| .| |||.|..|
KRITAEQALQHPYF
Kinase B0495.2.AA CDC2 356-647 43 1e-126 391.63 In-house 1-301 (301) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-301/301
Sequence Identity: 43% (134 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEG--FPITALREINMLLKAGN-HPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRR
|...... |||.||||..||..|..|||||. . | | ||  .| ||.|||  .||. . |||||  ....      |.||  |....| | ..|     
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREI-SCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPK

NKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFT--SIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIM
|| ..    | .. |.|.|... |   |.||||| .|.| . || .|||||||||  | |... |    |||||||.||.||| . |||||||||.|||.
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AEF---ILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYNQLRKRFLA------GRLLNDTGFKLLNGLLTLDPKNRFSATQA
||.   .  ||||.|  | .|. |||  .|||.|..|||||.|  .|. || ... ..|.| .           |...|. ||. .| .|| .| || .|
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEA

LDHEWF
|.| .|
LQHPYF
Kinase B0495.2.AA CDK7 356-647 39 5.4e-123 329.5 In-house 1-288 (288) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-288/288
Sequence Identity: 39% (117 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLK----MEKEKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSR
|| .  . ||.|..||.. |. |..||| |. |     .  | |   ||.|||  .|.   |.|...   |.     . |.. ..| . |.       | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREI-KILQEMQHDNVIGLIDIF--MHKSNIQLVFDFMDWDLEVVIKDKSI

RNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMA
  .   |   |    ..| |.|..|. ||||||||  ||||.  |.|||||||||| || | . .|. ||| |||.|||| | | | | |||||||||.|
ILTPAHI---KAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFA

EFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPY---NQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWF
| .|  | .|| ... |...||  .|||||. ||.....     ..| ..|      ||..| |.    |    |. |..|..| .| ..||.| .. |
ELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTAA---SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase B0495.2.AA CDK5 356-647 41 3.4e-118 375.21 In-house 1-287 (287) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-287/287
Sequence Identity: 41% (123 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKR
|| .... |||.|.||....| | ||||||| ... | || | ||.|||  |||   |.|||    ..   .  |. .  ||.  |.|  .| .      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREI-CLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNG---E

FSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEFI-
 .    | .. ||| |..  |.  .||||||  ||| . .|.|| ||||||| .| | . ... ||||||| |  |.| ..|||..||||.|||.|| . 
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMAN

LLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWK--ALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWF
 ..||||| .. .| |.||  ||||.|. ||..|.|  .|  .  ...|| .|  .    .  |. .|  ||...| ..|. | || .|| | .|
AGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK--LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase B0495.2.AA CDK10 356-647 47 2.2e-115 389.62 In-house 1-285 (285) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-285/285
Sequence Identity: 47% (140 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKR
.| .||| |||.|.||| .| |.|||||||. .|.|||.| || .|||| |||.   |.|||...|.  |  .| |.. |.. | |. |||| |.   . 
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREI-MLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMP---QP

FSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEFIL
|.  . | .  |.| |.  .|. ...||||| |||||. || .|.||||||| || | |  |  .|||||| ||||||.|   | .||| ||||..| ..
FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLV

LKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWF
 |||.||  |. ||  |   .||| |.|||| ..|   .  | .| ||| |...|    .| ..| .||| |.  .|| |  | ..|. ..|
HKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF---HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase B0495.2.AA CRK7 356-647 37 1e-107 364.18 In-house 1-343 (343) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-343/343
Sequence Identity: 37% (131 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKE---KEGFPITALREINMLLKAGNHPNIVNVKEILLG------SNMDK--IYMAMEFVEHDMKS
|| .. . |||.| ||  |.|.| |.||||...|. |   |||||||| |||  .|.  ||.|||| ||| .       .. .|  .||  | . ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREI-KILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

LLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPL--KKFTSIVVTLWYRSPELLLGTRLY-----
||.  |   . || .. | .. ||| |.. .||  .||||.| ||.||  .|..||||||||| |      ...|  |.||||| ||||||.  |     
LLE--SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------STPVDMWSVGCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYN
                                  . .||||.|||..|    ||.|.|. |..|. ||.  .|.|.   || |..| .|...   .    
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNR

QLRKRFL---AGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWF
 ||. |       ..    . || ..|.|||| ||.|...|.|.||
RLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase B0495.2.AA S_TKc 356-647 26 5.2e-93 316.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-231/231
Sequence Identity: 26% (81 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGNHPNIVNVKEILLGSNMDKIYMAMEFVEH---DMKSLLDTMSRR
|| .. . .|.||.||....|.|..|||.|..|         ....|||..| |  .|||||. ...      |..|| ||....   |...... . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

NKR--FSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYST-PVDMWSVGCI
 .|  |.  . . ...|.....|..|...|.||||| .|.|...   .||.||||||..       |....|.||..||.|     |.. ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALD------
..|..  .|.||   ..... |. .                                           . .  .....|. ||..| .| .||       
LYEMLCGYPPFP---QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HEWF
 |.||
CHPWF
Kinase B0495.2.AA Pkinase 356-647 31 5.2e-89 306.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALR--EINMLLKAGNHPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTM----
|... .. .|.||.||....| | .|||.|..| ..||.....|..|  || ....  ||||||  ...      |.||| ||..|.. . ..| .    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIS

SRRNKRF--SIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGIL----KIADFGLAREY-GDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVD
 .|...|  |  | |  . |.|.|.|..|. .|.||||| .|.|....| .    ||.|||||. .   .   .|....|.||..||...| . |...||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

MWSVGCIMAEFILLKPLFPGR----GELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSA
|||.|||..|... .|.|||.    . ..|...|.. ||.|... ||   .    . ... . .    . . .   ...... ......|..||| | .|
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

TQALDHEWF
.|.| |.||
EQILQHPWF
Kinase B0495.2.AA CDK4 356-647 37 8.5e-80 271.41 In-house 1-290 (290) Show / Hide 
Range on Protein: 356-647
Range on HMM: 1-290/290
Sequence Identity: 37% (114 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKE--GFPITALREINML--LKAGNHPNIVNVKEILLGSNMDK----IYMAMEFVEHDMKSLLD
|.||. . || .| |||  |  |  .||||. .   . |  | |.  .||| ..  |.. .|||||  ...   .  |     | | .| .. | . .||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

TMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVG
 . .     .    | .  |||.|..  |   | |||||  |.| .  | .|.|||||||.|.    ..|..|||||||.|| ||    | |||||||||
KCPP--PGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVG

CIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWP-GVTELDGWKALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEW
||.||    .|||.|  | .|  |||  ||.|.|  ||  |       .|  . .|  . |.       .   |  ||.  |. ... | || |.| | .
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDV-------SLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPY

F
|
F
Kinase B0495.2.AA CDK9 356-608 39 3.3e-71 242.88 In-house 1-277 (340) Show / Hide 
Range on Protein: 356-608
Range on HMM: 1-277/340
Sequence Identity: 39% (113 aa)

YECVNRVDEGTFG-----------VVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINML--LKAGNHPNIVNVKEI-------LLGSNM-DKIYMA
|| ....  ||||            |.. . |..  .||.|.  || ||||||||||||| ||  ||   |.|.||  ||         ..     .|. 
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLK---HENVVNLIEICRTKATAYNRYKDRATFYLV

MEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREY----GDPLKK--FTSIVVTLWYRSP
..| |||.  ||   |  | .|| |. |...|.|..|   .|.  |||||.|  | | .  |||| ||||||| .    .|      .|  ||||||| |
FDFCEHDLAGLL---SNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPP

ELLLGTRLYSTPVDMWSVGCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKAL---TFEKYPYNQLRK
||||| | | .|.|||  ||||||     |   |  |  | . |    |  |. .||.. ... |...        | .| ||
ELLLGDRNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRK
Kinase B0495.2.AA TyrKc 356-590 19 3.7e-13 -9.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 356-590
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAG-NHPNIVNVKEILLGS-----NMDKIYMAMEFVEHDMKSLLDTM
 .      || ||.||.|. |   . || | || ..         .||.... | | .|||||.   . . .       . ... ||...|   .|.|  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYL

SRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDP--------LKKF----TSI-VVTLWYRSPELLLGTRL
 .. ....  .      |  .| |. |.  . |||| . | | ..... ||.||||.|. .|          ..      .  .. .   .|| .  .. 
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

YSTPVDMWSVGCIM------------------AEFILLKPLFPGRGELEQIKK--------IFMEMGTPTESIWPG-----------VTEL
..|  | || |  |                   . . .  .   .. ..| .            || .  .. |             . ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase B0495.2.AA Pkinase_Tyr 364-507 32 2.5e-11 39.01 Pfam 9-159 (270) Show / Hide 
Range on Protein: 364-507
Range on HMM: 9-159/270
Sequence Identity: 32% (51 aa)

EGTFGVVYRGKDK----RTDEIVALKRL---KMEKE--KEGFPITALREINMLLKAGNHPNIVNVKEILL--GS-NMDKIYMAMEFVEHDMKSLLDTMSR
|| ||.||.|. |     |.  || | |    |...  .| |    .||.... . |.|||||.   . .  |  |  .||. ||...|   .|||   .
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHG--DLLDYLRK

R---NKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAR
.   ...... .     .|  .| |. .   . |||| . | | ..... ||.||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase B0495.2.AA CDK9 618-647 43 1.5e-09 28.83 In-house 311-340 (340) Show / Hide 
Range on Protein: 618-647
Range on HMM: 311-340/340
Sequence Identity: 43% (13 aa)

DTGFKLLNGLLTLDPKNRFSATQALDHEWF
...  |.. ||..||| |  . .|||| ||
QQACHLIDKLLNIDPKKRMDSDEALDHDWF