Gene C46C2.1 (Nematode worm)

C46C2.1

Species: Nematode worm
Alias: CE03080, aSWK261, C46C2.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 9201298-9212206, WormBase Genetic Map location: IV:4.11,

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
C46C2.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
C46C2.1.AA Protein Genbank 1851 None Fasta, JSON

Protein domain

Protein domains of C46C2.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C46C2.1.AA WNK 344-607 77 3e-222 724.86 In-house 1-261 (261) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-261/261
Sequence Identity: 77% (206 aa)

LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFKR
.|||||.||||||||.|||||||.|.|||||||..||.|.|||||.|||||||.|||||||||||||||. ||||. .||||||||||||||.||||||.
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESV-LCGKK-CIVLVTELMTSGTLKTYLKRFKK

INIKVVLKSWCRQILKGLSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGDLGLA-TLKNKSFAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEM
...| ||.||||||||||.|||||.| |.||||||||||||||||||||||||||| ||||.||||||||||||||||||||.|||||||||||||.|||
MKPK-VLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEM

VTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFF
.|.|||||||.|.|.|||||..|.||..|..|..  ||..|||..|||...|||....||| .|||
ATSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQN--PEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase C46C2.1.AA S_TKc 344-607 24 4.3e-66 226.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTS--GTLKMYLKRF
 .. ...|.|.| .|... ...||  ||  ..          ...| | ..||  .|||||..||....       ... .|.|..    |.|. |.|. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

KR------INIKVVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDE-SVDVYAF
.|      ..   . .....||...| ..| ..  .|||||| .||...     .||.| |||..      ....|||..||||.    |.  ..|....
GRHGLRFPFPE--HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSC

GMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLV-------DDFF
| .| ||..|. |..   .......|.                || ...|..| ..  |.| |. ..|        . .|
GCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C46C2.1.AA STE 344-607 20 1.7e-61 210.64 In-house 1-359 (359) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-359/359
Sequence Identity: 20% (76 aa)

LKFDEELGRGSFKTVFRGLDT------ETG-----------VAVAWCELQESKL-------------NKTERQRFREEAEMLKDLQ--HPNIVRFYDYWE
... |..|.|.| ||.....       .||           .|.   .|....              |..|.|.. .| ...|...  |||||..|.. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SADL-CGKRKYIVLVTELMTSGTLKMYLKRFKRINI-------------KVVLKSWCRQILKG-LSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLG
  .  .. . .. .. |.|  |.|   .|. . ..                ...  ||||||| |..||  .  .||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATLKNKS------------------FAKSVIGTPEFMAPEMYEEM-------YDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVIS--------
...  ..|                    ....||| .||||. . .       ||...|.. .| ...||.||..|...  ..  .... ..        
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GVKPECFSRIP----------------AQYPEIREIIDRCIRVRREERSTVKQLLV--DDFF
      |  |   ...                    || .. |..| .   ..| |..|||     |.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase C46C2.1.AA Pkinase 344-607 25 6e-59 206.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFRE--EAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSG----TLKMY
... . .|.||| .|... .  ||  ||  ..  .. .. ..|. |   |....| |.||||||.||..|.      ...| .|.|..  |     |. |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

LK-RFKRIN--IKVVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSV----KIGDLGLAT---LKNKSFAKSVIGTPEFMAPEM--YEEMY
.. . ..       ..|....|||.|| ..| .   .|||||| .||.|   .| .    ||.| |||    . |.| .... |||..||||     ..|
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

DESVDVYAFGMCLLEMVTGEYPYSEC-----MNPATIYRKVIS-GVKPECFSRIPAQY----------------PEIREIIDRCIRVRREERSTVKQLLV
. .||....|  | ||..|. |....     ...  ..... .  .. ...  ..  |                .| ...|..|...  ..| | .|.| 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

DDFF
...|
HPWF
Kinase C46C2.1.AA CAMK 349-607 19 6.1e-52 165.28 In-house 1-425 (425) Show / Hide 
Range on Protein: 349-607
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

ELGRGSFKTVFRGLDTETG------------VAVAWCELQESKLNKTE--------------------------RQRFREEAEMLKDLQ-------HPNI
.|||||| .|... ...|.            . ||   .  .|| . .                          |...| | |..| ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDYWESAD-------------LCGK-RKYIVLVT---ELMTSG----TLKMYLKRF---------------KRINIKVVLKSWCRQILKGLSFLHTR
...|...|...              . . .|....|.   |... |     |  |...                .|.. . . . . |||. .. ..| .
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA-RRYFRQICSAVHYCHSH

NPPVIHRDLKCDNIFITGTT----------------GSVKIGDLGLATLKNKS-------------------------FAKSVIGTPEFMA-PEMYEEM-
|  ..|||||..|| ..                   . .|| | |.|. ....                           | . ||||.|| ||. .   
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

--------------YDESVDVYAFGMCLLEMVTGEYPYSEC------------MNPATIYRKVISGV---KPECFSRIPAQY-----------------P
              |....|. . |  |  |..|..|. .             ||.  ...|...|     |. || |.. |                 .
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQ

EIREIIDRCIRVRREERSTVKQLLVDDFF
| .  | .. .|  |.| |..| | . ..
ECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase C46C2.1.AA TKL 350-602 20 1.9e-48 167.24 In-house 1-361 (364) Show / Hide 
Range on Protein: 350-602
Range on HMM: 1-361/364
Sequence Identity: 20% (75 aa)

LGRGSFKTVFRG-LDTET-------GVAVAWCELQESKLNKTER-------------------------QRFREEAEMLKDLQHPNIVRFYDYWESAD--
.|.|.| .|..| .  ..       |  ||   . .   .....                         ....||. |.. |.|||||.|. |  . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-LCGK----RKYIVLVTELMTSGTLKMYLKRFKRINIKVVL-KSWCRQILKGLSFLHTRN------PPVIHRDLKCDNIFITG-------------TTGS
  |..     ... .|.|..  |.|  ||           .  .|...| .|...||..|      ||.|||||| .||..                .. 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VKIGDLGLATLKNKSF---------------------AKSVIGTPEFMAPEMYE-----------------EMYDESVDVYAFGMCLLEMVTGEYPYSEC
.||.|.||.. ...|.                       ...||| .||||. .                 . |.|..|||.||..| |..|.. ||.. 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

MNPATI---------YRKVISGVKPECFSRIP--------AQYPE-IREIIDRCIRVRREERSTVKQLL
...  |         .  .  | .|.. .. .         . |. ..... .|     |.| . ...|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEIL
Kinase C46C2.1.AA Ciliate-E2 344-607 17 1.7e-47 161.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-365/365
Sequence Identity: 17% (70 aa)

LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTE---------------------RQRFREEAEM---------------LKDLQHPNIVRFY
 || . .|.|.| .|... . ...  .|    .  |. .                       .| ..|. .|               |. |.||||...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DYWESADLCGKRKYIVLVTELMTSGTLKMYLK------------RFKRINIKVVL-------K-------SWCRQILKGLSFLHTRNPPVIHRDLKCDNI
..... |    ...| ||.|.   |.|. |.|              |....| ..       .        ....|...| .|| .|. .||||.| .||
ECFQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENI

FITGTTGSVKIGDLGLATLKNKS---------------------------------FAKSVIGTPEFMAPEMYEEM----------YDESVDVYAFGMCL
..      .|| |.||..  ...                                  .....|||..||||...            ||...|....|..|
LF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

LEMVTGEYPYSECMNPATIYRKVISGVKPECFSRI-PAQYPEIR-----------------------EIIDR----CIRVRREERST-VKQLLVDDFF
 ||..|..|.                   .      . ..|.                          .| .    .. .  |.| |  .|.|   .|
YEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase C46C2.1.AA NEK 348-607 26 6.7e-45 155.49 In-house 5-286 (286) Show / Hide 
Range on Protein: 348-607
Range on HMM: 5-286/286
Sequence Identity: 26% (76 aa)

EELGRGSFKTVFRGLDTETGVA-----VAWCELQESKLNKTERQRFR-EEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMT-SGTLKMY---
...|.||| .|..  ....|       ..| . . ....  |.|    .|.  || |.|||||..||    . .  .  ..  | |     |.|      
KKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYD----SFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKRFK----RINIKVVLKSWCRQILKGLSFLHTR-NP--PVIHRDLKCDNIFITGTTGS---VKIGDLGLATLKNKS--FAKS-VIGTPEFMAPEMY-EE
.|. |     .  ..... |. |....| ..| | .|   ..|||.|. |||.|    .   |||||.|.. . |..  .|.. ..||| .|.||.  ..
IKKQKQKGKYFEEEQIWD-WFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

MYDESVDVYAFGMCLLEMVTG--EYP-YS-ECMNPATIYRKVISGVKPECFSRIPAQ--Y-PEIREIIDRCIRVRREERSTVKQLLVDDFF
 |.. .|. ..| .| ||.|   . | ..   ||    | |.. |   . ...|| .  | .. ...| .....  |.| ...|.| . | 
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWD-MNMPSLYMKIMKG---PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase C46C2.1.AA Ciliate-E2-Unclassified 345-607 18 2.9e-42 144.38 In-house 2-352 (352) Show / Hide 
Range on Protein: 345-607
Range on HMM: 2-352/352
Sequence Identity: 18% (67 aa)

KFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRF-----REEAEMLKD----------------LQHPNIVRFYDYWESADLCGKRKYIV
|. . .|.|.| .|..  . ... . |  ..  .. .|   ...     .|. || .                 |.||.... .....  |    ...| 
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQD----KQNIY

LVTELMTSGTLKMYLKRF-----------------KRINIKVVL----KSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTG--SVKIGDLGLATL
.|.|..  |.|. |.| .                 |..  . ..    | ...|||.||..||  |  .||||.|..||...   .   .|| |.|..  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

KN-----------------KSFAKSVIGTPEFM----APEMYEE-MYDES----VDVYAFGMCLLEMVTGEYPYS-ECMNP--------------ATIYR
 .                 .  .....|||..|    |||....  ||.|    .|....|..| ||..|.||.. .. .                 .|.
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

KVISG-VKPECFS------RIPAQYPEIRE-IIDRCIRVRREERSTVKQLLVDDFF
. . . ..  .|.      ... .. .. . .. ... .. ..| | .|.|   .|
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase C46C2.1.AA ULK 344-607 21 8.7e-41 141.83 In-house 1-324 (324) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-324/324
Sequence Identity: 21% (71 aa)

LKFDEELGRGSFK-TVFRGLDTET---GVAVAWCELQESKLNKTERQ--------RFREEAEMLKDLQ---HPN--IVRFYDYWESADLCGKRKYIVLVT
   ...|| |||  .|..| . .|   ...||    . .|.|| . .         .. | . .| |    |||  ||..||. |...     ..| ...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH----NNIYIIM

ELMTSGTLKMYLKRFKRINIKV---------VLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGS-----------VKIGDLGLATLKNK-SF
|.   |.|. |.|. |. .  .           .. ..||. |. .|| .|  .||||.| .|| |.  ...           .||.| |.|   .. ..
EYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNM

AKSVI----------GTPEFMAPEMYEEM-----YDES-VDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKP-------ECFSRIPAQ------
.. ..          ||| .|||.  ...     |... .|.. .|. . ||..|.||.... .  .. . ... ..        ..   |. .      
EQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDP

--YPEIREIIDRCIRVRREERSTVKQLLVDDFF
   ||....| |.. . ...| .  ...   .|
KISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase C46C2.1.AA ULK 344-607 20 4.8e-40 137.51 In-house 1-329 (329) Show / Hide 
Range on Protein: 344-607
Range on HMM: 1-329/329
Sequence Identity: 20% (70 aa)

LKFDEELGRGSFKTVFRGLDTET----GVAVAWCELQESKLNKTERQR--------FREEAEMLKDL--------QHPNIVRFYDYWESADLCGKRKYIV
   ...|| ||| .|..| . .|    ...||   .. .|.|. . ..        .. | . .| |        .|||||..||. |...     ..| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSN---H-NNIY

LVTELMTSGTLKMYLKRFKRINIKV---------VLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGS-----------VKIGDLGLATLKNK
...|.   |.|. |.|. |. . ..           .. ..||| |. .|| .|  .||||.| .|| |.  ...           .||.| |.|   ..
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

S-----FAKSVI------GTPEFMAPEMYEEM-----YDES-VDVYAFGMCLLEMVTGEYPYSECMNPATI----YRKVISGVKPE---CFSRIPAQ---
.      ...        ||| .|||.  ...     |... .|.. .|. . ||..|..|.... .  ..    .. .  . ...   .   .  .   
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

-----YPEIREIIDRCIRVRREERSTVKQLLVDDFF
      ||....| |.. . ...| .  .|.   .|
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase C46C2.1.AA TKL-Unique 346-551 25 1.5e-39 137.17 In-house 1-237 (290) Show / Hide 
Range on Protein: 346-551
Range on HMM: 1-237/290
Sequence Identity: 25% (62 aa)

FDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQ-HPNIVRFYDYWESADLCG----KRKYIVLVTELMTSGTLKMYLK-
| . .|.|.. .|..|    . ||.   .. .........| |..|   .| |. |||||... |      |     . ..  .|.| .  |.|  .|  
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGY------CMDHQVYPPNMCIVMEYCPGGSLYDVLHQ

---------RFKRINIKVVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTT----GSVKIGDLGLATLKNKS---FAK--------SVIGTPEF
         . . .| ....|   ..| .|. .||...||.||||||  |. ..        ..|| | ||.....|.   ...        ...|..  
NNNNNNNNNNNCKLNMQQRVK-MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRW

MAPEMYEE---MYDESVDVYAFGMCLLEMVTGEY------PYSEC
||||. .    .|.|..|||.||..| |..|..       ||...
MAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM
Kinase C46C2.1.AA TyrKc 344-606 25 2.4e-24 88.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 344-606
Range on HMM: 1-280/280
Sequence Identity: 25% (78 aa)

LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDL--QHPNIVRFYDYWESADLCGKR-------KYIVLVTELMTSGTL
......||.| | .|..|  .   . ||   |.|..     |. |..||.... |  .||||||.| .      | .        . . .|.|.|  | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGV------CTQQGRNFMYIEPLMIVMEYMPHGDL

KMYLKRFKR-INIKVVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKS----FAKSVIGT-----PEF------MAP
| ||.. .. .. |  | |.| || .| ..|| .  ..||||| . |. ..     |||.| ||.           .|... .       .      |||
KDYLRKHRPKLCMKDLL-SFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EMYEEM-YDESVDVYAFGMCLLEMVT-GEYPYSEC----MNPATIYRKVISGVKPECFSR--------IPAQYPEIREIIDRCIRVRREERSTVKQLLVD
|   .  . .  ||..|| |. |. | |. ||..     |... ....| .|  ...            |   .|. .|. .| .   |.| | ... ..
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP---DEMYQIMKQCWHEDPEDRPTFSEI-HE

DF
.|
CF
Kinase C46C2.1.AA Pkinase_Tyr 344-498 33 9.8e-23 77.62 Pfam 1-158 (270) Show / Hide 
Range on Protein: 344-498
Range on HMM: 1-158/270
Sequence Identity: 33% (56 aa)

LKFDEELGRGSFKTVFRGLDT----ETGVAVAWCELQESKLNKTE--RQRFREEAEMLKDL-QHPNIVRFYDYWESADLCGKRKY--IVLVTELMTSGTL
..|...||.|.| .|..|  .    .|.. ||   | | .  . .  |. | .||...| | .||||||.|          ...   | .|.|.|  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-----DQGEPNQIYIVMEYMPHGDL

KMYLKR----FKRINIKVVLKSWCRQILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLA
. ||..     .....|  | ..|.|| ||...|. .|   ||||| . |. .| .   |||.| |||
LDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase C46C2.1.AA Pkinase_Tyr 530-564 31 0.031925 8.15 Pfam 196-232 (270) Show / Hide 
Range on Protein: 530-564
Range on HMM: 196-232/270
Sequence Identity: 31% (12 aa)

DVYAFGMCLLEMVT-GEYP-YSECMNPATIYRKV-ISG
||..|| .. |..| || | | ..  .. .|...  .|
DVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
OSR1_C C46C2.1.AA OSR1_C 633-671 56 1.3e-16 63.92 Pfam 1-38 (38) Show / Hide 
Range on Protein: 633-671
Range on HMM: 1-38/38
Sequence Identity: 56% (22 aa)

IQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVV
|...||..|.||||. ..||||..||.||||.|.|.||.
INLWLRMRDPKKRKG-KHKENEAIQFEFDIEKDTPEEVA
FRWNK_Wnk1 C46C2.1.AA FRWNK_Wnk1 610-705 32 2.2e-15 53.09 In-house 1-92 (92) Show / Hide 
Range on Protein: 610-705
Range on HMM: 1-92/92
Sequence Identity: 32% (31 aa)

EDLIGIRVEIKNRDADLNDLNVEIQMQLRVYDEKKRKQYRFKENEGLQFAFDIENDSPDEVVQQMIEQQHIPDEDTRMITKLIKDKVDAFRRDRDH
.   |.|||    |   ..    |   |.. | || |. ..|.|| ..| ||.|.| |.||.| |.|.. . ..| ... | |.| | . .. |  
QEDTGVRVELAEEDDGEKS---AIKLWLWMEDPKKLKG-KYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
FRWNK_Wnk2.hmm C46C2.1.AA FRWNK_Wnk2.hmm 658-680 43 0.000898 10.16 In-house 18-40 (63) Show / Hide 
Range on Protein: 658-680
Range on HMM: 18-40/63
Sequence Identity: 43% (10 aa)

FAFDIENDSPDEVVQQMIEQQHI
| ||.. |.|.|. | |.|.. |
FKFDLDGDNPEEIAQYMVENDFI
FRWNK_Wnk2.hmm C46C2.1.AA FRWNK_Wnk2.hmm 973-1033 30 6.4e-07 20.76 In-house 2-63 (63) Show / Hide 
Range on Protein: 973-1033
Range on HMM: 2-63/63
Sequence Identity: 30% (19 aa)

ALVSCRLDT-SHKSVTFQFAPGTDKPCTIATKLLAEDCLLKVHVHIVEAQLGEVIQLINSDG
  | | |.|  || |||.|    |.|  ||. .  .| .|... .   .|. ..||  .. .
RMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
OSR1_C C46C2.1.AA OSR1_C 988-1001 35 32.599925 0.92 Pfam 25-38 (38) Show / Hide 
Range on Protein: 988-1001
Range on HMM: 25-38/38
Sequence Identity: 35% (5 aa)

FQFAPGTDKPCTIA
|.| ...|.|  .|
FEFDIEKDTPEEVA