Gene chk-2 (Nematode worm)

chk-2

Species: Nematode worm
Alias: aSWK068, chk-2, CE27297, Y60A3.b, Y60A3.bx=aneg..phfs, Y60A3A.12
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 19908074-19908075, WormBase Genetic Map location: n/a,

Classification

Group: CAMK
Family: RAD53

Sequence

Name Sequence Type Origin Length Description Download
chk-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
chk-2.AA Protein Genbank 476 None Fasta, JSON

Protein domain

Protein domains of chk-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FHA chk-2.AA FHA 66-144 24 5.5e-12 49.38 Pfam 1-73 (73) Show / Hide 
Range on Protein: 66-144
Range on HMM: 1-73/73
Sequence Identity: 24% (21 aa)

FVCGRGSDDAPTNFNFSQVAKDVGLYRF-ISKIQFSI-DRDTETRRIYLHD--HSRNGTLV--NQEMIGKGLSRELMNGDLISIG
.. ||.   .  .. ..         .. .|. .. |  .| .  | |..|  .|.||| |  | . |..| ...| .|| |..|
WTIGRD---PDCDIVLD-------NDPSFVSRHHCEIRRYDNG--RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG
FHA chk-2.AA FHA 65-127 19 0.000879 19.29 SMART 1-49 (49) Show / Hide 
Range on Protein: 65-127
Range on HMM: 1-49/49
Sequence Identity: 19% (13 aa)

HFVCGRGSDDAPTNFNFSQVAKDVGLYRFISKIQFSIDRDTETRRIYLHDHS---RNGTLVNQEMI
 .. ||.|            .  .   ..||. .. |    ..   |..|..   .||| || . .
TWTIGRHS------------CDIQLPHPSISRHHCQIR--DGD---YIIDLGEHSTNGTYVNGRRV
Kinase chk-2.AA RAD53 170-436 42 1.5e-192 579.42 In-house 1-305 (305) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-305/305
Sequence Identity: 42% (129 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFST-RCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVA-KYSYMVIEYVGGGEFFSKVVDSK
...|. ||.|.||.|.|.|.|.....||||........ ||...|.|.....||||..|||.||.|..|||..... ||.|||.|...|||.|.|.|..|
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

YNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERC---------------ILKLTDFGMAKNSVNR--MKTRCGTPSYNAPEIVAN
...||..|. .||...|..||..|||..||||||.|||||||....|.|               ..|.||||..|.....  ||| ||||.|.|||....
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

EG-------------VEYTPKVDIWSLGCVLFITFSGYPPFSEEYTD----MTMDEQVLT-GRLIF-HAQWRRITVETQNMIKWMLTVEPSNRPSAVELM
.|             |.||.|||.||.||.|.|...||||||..||.    |...||... |.. | | .|.||. |....|||||.|.| .|....|..
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

STQWM
...||
NHPWM
Kinase chk-2.AA CAMK 175-436 23 1.7e-97 314.74 In-house 1-425 (425) Show / Hide 
Range on Protein: 175-436
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

SLGKGGFGKVLLGYKKSDR------------SVVAIKQLN-----------------TQFSTRCSRAIA----KTRDIRNEVEVMKKLS-------HPNI
 ||.|.|||| |.. |..               |||| ..                  ..|. ..|.      . . .|.|.|.||||.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAIYDWIT------------VAKY--------SYMVI---EYVGGG----EFFSKVVDSKYNR-----------MGLGESLGKYFAFQLIDAILYLHSVG
. .|...               ..         |||    ||. ||    . |...|. ....             . |.  ...  |...|. |.|| .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ICHRDIKPENILCSDK--------------AERCILKLTDFGMAKNSVN--------------------------RMKTRCGTPSYNA-PEIVANEG---
|.|||.||||||..|.               ... .|..|||.|.                               |||.||||.| | ||..  .|   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------VEYTPKVDIWSLGCVLFITFSGYPPFSEEY------------TDMTMDEQVLTGRLIFHAQ-------------WRRITVE--------TQ
           |.||.|.||.|..|.|  .||||| ...            .|  . |....|.  |                | .|. |         .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NMIKWMLTVEPSNRPSAVELMSTQWM
..|..||.|.|..|... . .. .||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase chk-2.AA S_TKc 170-436 31 1.7e-81 277.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGG--GEFFSKVVDSK
      .|||.|||| ....|..  .||||...              ..||.|....||  ||||| .||..   .. ||| ||..|  |. |.  .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

Y--NRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRMKTRCGTPSYNAPEIVANEGVEYTP-KVDIWSL
.  .| .. |   .... |...|. |.|| ||.|||.||||||...      .|..|||.|.      .| |||| | |||..      |.. |.|.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-----GYGKCKCDWWSC

GCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMS-------TQWM
||.|.. ..|||||.         .. .. ..|        . |  ..|. .|...|..||.| |..         .|.
GCILYEMLCGYPPFP---------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase chk-2.AA Pkinase 170-436 31 2.3e-78 271.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGG----EFFSKVVD
 ..   .|.|.||.| ....|... .||.|... . .....  ....|   .|...||.|.||||| .||| .  .. ||| ||..||    . |. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

SKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERC--ILKLTDFGMAK---NSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVD
...... . |   | .. |.. .. |.|| ||.|||.||||||.. .   .  ..|..||| ||   .  |.|.|.|||| | |||..  .| .|.||||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR-GGQYYGPKVD

IWSLGCVLFITFSGYPPFSEE-----YTDMTMDEQVLTGRLIFH-AQWRRIT-----------------VETQNMIKWMLTVEPSNRPSAVELMSTQWM
.||.||.|.. ..|.|||...     ...| | .... ..| |.  .|..|                   | .  |||.|.. |. ||.| ...   |.
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase chk-2.AA CAMKL 169-436 30 1.3e-74 237.48 In-house 1-297 (297) Show / Hide 
Range on Protein: 169-436
Range on HMM: 1-297/297
Sequence Identity: 30% (93 aa)

YHVTSHSLGKGGFGKVLLGYK-KSDRSVVAIKQLN--TQFSTRCSRA-------IAKTRDIRNEVEVMKKLS---HPNIVAIYDWITVAKY------SYM
| .    ||||.|||| |.   .  .  |||| ..        ....        ..   || |.. ||.|.   ||||. .|. |.  ..       |.
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VIEYVGGGE--FFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMA-------KNSVNRMKTRCGTP
| ||..|||   | ..|  .. |  . |.  . .  |...|. |.|| ||.|||||||||| ...  .  .|..|||..       ... . .||.||.|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

SYNAPEIVAN-EGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYT-----DMTMDEQVLTGRLIFHA-QWRRITVETQNMIKWMLTVEPSNRPSAVELMST
.| ||||..  .   . |||||||.| .|.    || || ..       | .  .   . .. ..   | ..  . ...|..||.| |. ||.. ..|. 
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

QWM
 ||
PWM
Kinase chk-2.AA AGC 176-436 22 2.1e-67 172.37 In-house 7-395 (395) Show / Hide 
Range on Protein: 176-436
Range on HMM: 7-395/395
Sequence Identity: 22% (91 aa)

LGKGGFGKVLLGYKK------SDRSVVAIKQLNTQF-STRCSR-AIAKT-RD--------IRNEVEVMKKLS----------HPNIVA-IYDWITVAKY-
.|||.|||| |  ||      .   . |.| |. .    .  .  ...| .         ...| ....|..          ||.||   .      .. 
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-SYMVIEY---------VGGG-EFFSKVVDSKYNRMGLGESLGKYFAFQ-------LIDAILYLHS-VGICHRD-IKPENILCSDKAERCILKLTDFGMA
  |.| ||         .||| |.|.   . . ..  . |.  ...| .       .. |. ||||  || ||| .||||||  ..     .||||||..
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRR-KEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLC

KNSVN-----------------------------------------------------RMKTRCG--TPSYNAPEIVANEGVEYTPKVDIWS--LGCVLF
|  .|                                                     | .| ||  || | ||||.      |.. .|.||  |||...
KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCLMY

ITFSGYPPFSEE---------YTDMTMDEQVL------TGRLIFH-------AQWRRITVETQNMIKWMLTVEPSNRPS----------AVELMSTQWM
   .|||||. .         .. | | ....      . .. |          .| ...| .. || .|...|..|.           | |...  | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase chk-2.AA Ciliate-E2 170-436 21 7.6e-60 204.1 In-house 1-365 (365) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-365/365
Sequence Identity: 21% (83 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQF--------------------STRCSRAIAKTRDIRNEVE----------VMKKLSHPNIVAIYD
      .|.|.||.| .. .....  .|||. . |                     . .  ..| .  .| .|..          ....|.||||. .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

WIT--VAKYSYMVIEYVGGGEFFSKVVDSK---------------YNRMGLGESLGK-------YFAFQLIDAILYLHSVG-ICHRDIKPENILCSDKAE
.      .. |.| ||. ||. |.   ..|               . .  . . . .       ... ..|.|. |||| . |.||||||||||      
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

RCILKLTDFGMAKNSV----------------------------------NRMKTRCGTPSYNAPEIVANEGVE-------YTPKVDIWSLGCVLFITFS
   .|..|||..|.                                    |  .| |||| | ||||. ... .       |. |.||||||..|..  .
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYPPFSEEYTDMTMDEQVLTGRLIFHAQ---------------WRRITVETQNMIKW----MLTVEPSNRPS-AVELMSTQWM
|.|||          .| . . . |  .               |  .. |....||     || ..|..|.. . ...  .|.
GKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase chk-2.AA CAMK-Unique 170-436 24 1.1e-55 182.18 In-house 1-363 (363) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-363/363
Sequence Identity: 24% (89 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAI-----------AKTRD--IRNEVEVMKKLSHPNIVAIYDW----ITVAK-------
. .  ..|.|.||.|. .  .. .   |.| .. |   . .. .            | ||   ..|....|...||||. .|||       .|       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YSYMVIEYVGGGEFFSKVVD-SKYN---------------RMGLGE--SLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAE-----
        | |.| ||. ||. |..... ...                .  . |  ..     ..|  |. |.|| .| |||.|.|||. .         
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------RCILKLTDFGMAKNSV-NRMK----TRCGTPSYNAP--------------EIVANEGVEYTPKV----DIWSLGCVLFITFSGYPPFSEEYT
        .  .||.|||...    |.|     |.||||.| ||              |.... .  |  ..    |||||| .... ..|.||| .|  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQC--YDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

D-------MTMDEQVLTGRL-IF-HAQWRR---ITVETQNMIKWMLTVEPSNRPSAVELMSTQWM
|           |  . |..  |   .|..   |..|  . .|  .||.|. | || || . || 
DRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase chk-2.AA CAMK1 284-436 36 1.8e-52 150.78 In-house 116-276 (276) Show / Hide 
Range on Protein: 284-436
Range on HMM: 116-276/276
Sequence Identity: 36% (59 aa)

QLIDAILYLHSVGICHRDIKPENILCSDKAERCILK--LTDFGMAKNSV-N--RMKTRCGTPSYNAPEIVAN-EGVEYTPKVDIWSLGCVLFITFSGYPP
|...|. |.|| ||.|||.||||.|..|| |  ..|  . ||| .|    .   |||.||||.| |||.... .   |  ..|.|| |....|   ||||
QILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPP

FSEEYTDMTMDEQVLTGRLIFHAQ-WRRITVE-TQNMIKWMLTVEPSNRPSAVELMSTQWM
| .|  |... |... . . |.   |  |  .   . || ||.|.|..|... .     | 
FYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase chk-2.AA MARK 176-436 33 2e-52 169.73 In-house 7-262 (262) Show / Hide 
Range on Protein: 176-436
Range on HMM: 7-262/262
Sequence Identity: 33% (90 aa)

LGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAI-AKTRDIRNEVEVMKKLSHPNIVAIYDWIT--VAKY-SYMVIEYVGGGEFFSKVVDS--KYN
.|.|...|| |.  |  .  |||| ..     . .     . . .. |.|.||||.||||.  .. |     .   |.. ||..||| .. ..     . 
IGHGSYAKVKLACHKHTGRKVAIKIYE-----KFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR-

RMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRM--KTRCGTPSYNAPEIVANEGVEYT-PKVDIWSLGC
   | |.. . .  |.. |. |.|| .|.||||||||||  ..  .   |..|||..    . .  .| ||||.| ||||.  .. .|. ||||||||| 
---LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNH-NIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIF--LKKPYDGPKVDIWSLGV

VLFITFSGYPPFSEEY-TDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQWM
||..  .|| || .   .. .. ...|.|.  .      . .| .|.|...||| |. ||.. |.|.  ||
VLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH---VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase chk-2.AA Ciliate-E2-Unclassified 170-436 22 3e-52 179.55 In-house 1-352 (352) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-352/352
Sequence Identity: 22% (78 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLS-------------------HPNIVAIYDWITVAKYSYMV
    . .|.|||||| . ..|..  . |.|... . .        |  .| || . |....                   ||.||  ... .  .. |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

IEYVGGGEFFSKVVD-------------SKYNRMGLGESLGK-----YFAFQLIDAILYLHSVG-ICHRDIKPENILCSDKAERCILKLTDFGMAK----
 ||. ||. .    .             ....|  . |   |     ... |..... |||. . |.|||||||||| ... ..  .|..||| .|    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

--------------NSVNRMKTRCGTPSYN----APEIVANEGVEYT--PKVDIWSLGCVLFITFSGYPPFS--EEYT-------------DMTMDEQVL
              .. ..|.|.||||.|     |||.  ... . .   |.||||||..|.    ||.||.   ..              .. . .. .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TGRL-IFHAQW----RRITVETQNMIK----WMLTVEPSNRPSAVELMSTQWM
 . . .... |     ..  | ...|.     || . |..|... ...  .|.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase chk-2.AA STE 170-436 21 1.1e-50 174.75 In-house 1-359 (359) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

HVTSHSLGKGGFGKVLLGYKKS---------------DRSVVAIKQLNTQFS-------TRCSRA-----IAKTRDIRNEVEVMKKLS--HPNIVAIYDW
      .|||.||.| .....                   ..||||.| . .       .  .       . .  .| .|...|||..  |||||  |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

ITVA-------KYSYMVIEYVGGGEFFSKVVDSKYNRMGLG-----------ESLGKYFAFQLIDA-ILYLHSVGICHRDIKPENILCSDKAERCILKLT
  .         . ... ||..||  .......|| . .             ||. .|...|.. .   |||| .| |||||| |||          ||.
YFKEGHNHKNDDELWICMEYMDGG-SLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLC

DFGMAKNSVN-------------------RMKTRCGTPSYNAPEIVANEG----VEYTPKVDIWSLGCVL------FITFSGYPPFSEEYTDMTM-----
||| ... ..                   . .| .||| . |||.. ..|     .|. |.|||||||..         .. ..|..  .  ...     
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

----------DEQVLTGRLIFHAQWR-----------RITVETQNMIKWMLTVEPSNRPSAVELMS--TQWM
          .   |  .|    . .           . . | .. |.  |. .|..||.| .|..    . 
QFEQLCIVNGPPPPLPDHLSQNEM-ISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase chk-2.AA CAMK1 169-265 29 3.2e-18 49.51 In-house 1-101 (276) Show / Hide 
Range on Protein: 169-265
Range on HMM: 1-101/276
Sequence Identity: 29% (32 aa)

YHVTSHSLGKGGFGKVLLGYKKS---DRSVVAIKQLNTQFSTRCSRAIAKTRD-----IRNEVEVMKK---LSHPNIVAIYDWITVAKYSYMVIEYVGGG
| ...  .|.| |..| |. .|.   .   .||| ..        ....| ..     ..||.|.|||   ..||||...|.|    .. |.| |.| ||
YEFGKE-IGRGAFSEVYLCTHKETQTNGKQYAIKCIDK------KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGG

EFFSKVVD
| | ..|.
ELFDRIVE
Kinase chk-2.AA TyrKc 170-436 22 1.3e-15 29.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 170-436
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKL--SHPNIVAIYDWITVA-------KYSYMVIEYVGGGEFF
 .  . || | ||.| .|  |     ||.| |.              .|...| ..|.||  .|||||..|  .|         .  ..| ||. .|   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

SKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNR--------MKTRCGTPSYN--------A
.   ... .   |  .   .|..|  .   |||| .. |||.   |.| ...    . | .|||....  .         ...  .. . .        |
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEIVANEGVEYTPKVDIWSLGCVLFITFS-GYPPFSEE----YTDMTMDEQVLTG-RLIFHAQ-----WRRITVETQNMIKWMLTVEPSNRPSAVELMST
||   |.|. .|.| |.|| | ...  |. | .| ...     ..  . |.| .| |.   .        . . |  ...|.    .|..||.  |.   
PECI-NYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

QWM
. .
ECF
Kinase chk-2.AA Pkinase_Tyr 171-257 30 1.6e-10 36.26 Pfam 2-92 (270) Show / Hide 
Range on Protein: 171-257
Range on HMM: 2-92/270
Sequence Identity: 30% (29 aa)

VTSHSLGKGGFGKVLLGYKK----SDRSVVAIKQLNTQFSTRCSRAIA-KTRDIRNEVEVMKKL-SHPNIVAIYDWIT-VAKY--SYMVIEYVGGG
.  . ||.| ||.| .|. |    ...  ||.| |.       .   . . .|  .|...||.| .|||||  |  .|   .    |.| ||. .|
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG