Gene daf-11 (Nematode worm)
daf-11
Sequence
Protein domains of daf-11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | daf-11.AA | RGC | 433-703 | 28 | 9.6e-89 | 301.14 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 433-703 Range on HMM: 1-300/300 Sequence Identity: 28% (88 aa) DQVYVLADKYVMR---DKLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKAS-----HMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKG ....|.. |...| ... ... . .|.||. .||||||| |.|. || . .|.|.| | ||||.|... .. . | . |.|||.|| EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMR-QLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN--DDIKMDWMFKYSFIRDIVKG LEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQI----------FTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQFG ..|.|.| | .||||. .||. ||.| ||...||.|..|..| ..||| ....|.. .. ...... | . ..|........ . .|... MQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGP-HRQTQRGT KKCDMYSFGVILHEIILKKKFVEQLFD---------SPREEDDSVLIDDENDAIASRFPLPIIIPEG--IEMHNDLIKMLENCFG---SVRPD-IALARK .|.|.||||.|..|||..| .... . ||.|. . |.. .... ... .|. . . || ||....|......|. ..||| . || QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK IIDT . | QLKT |
|||||||||
| Kinase | daf-11.AA | RGC | 433-703 | 28 | 9.6e-89 | 301.14 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 433-703 Range on HMM: 1-300/300 Sequence Identity: 28% (88 aa) DQVYVLADKYVMR---DKLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKAS-----HMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKG ....|.. |...| ... ... . .|.||. .||||||| |.|. || . .|.|.| | ||||.|... .. . | . |.|||.|| EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMR-QLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN--DDIKMDWMFKYSFIRDIVKG LEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQI----------FTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQFG ..|.|.| | .||||. .||. ||.| ||...||.|..|..| ..||| ....|.. .. ...... | . ..|........ . .|... MQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGP-HRQTQRGT KKCDMYSFGVILHEIILKKKFVEQLFD---------SPREEDDSVLIDDENDAIASRFPLPIIIPEG--IEMHNDLIKMLENCFG---SVRPD-IALARK .|.|.||||.|..|||..| .... . ||.|. . |.. .... ... .|. . . || ||....|......|. ..||| . || QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK IIDT . | QLKT |
|||||||||
| Kinase | daf-11.AA | TK-Unique | 460-558 | 18 | 6.3e-10 | 30.53 | In-house | 56-178 (294) | Show / Hide |
Range on Protein: 460-558 Range on HMM: 56-178/294 Sequence Identity: 18% (23 aa) QMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQ--RG-------------TATRFEG-LF-------LRDILKGLEYIHA--SAID .||. .| |. ...|..... ..||. .| .|.| ... |. .. .. ... .. . . .| .|.||.. | MMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI- FHGNLTLHNCMLDSHWIVKLSGFG .|..| .|..| .. ..|...|| VHRDLCARNVLLTEDKVCKICDFG |
|||||||||
| Kinase | daf-11.AA | TK | 465-566 | 8 | 1.3e-08 | 24.14 | In-house | 100-351 (486) | Show / Hide |
Range on Protein: 465-566
Range on HMM: 100-351/486
Sequence Identity: 8% (21 aa)
LQHDNLNSFVGITIDKA-----------SHMYIIWNQCFRGS----LHDHIFTKERQRGTATRFEGL---------------------------------
..|.|. ...|. ... ...|. . |. |.|. .. . . . .
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD
---------------------------------------FLRDILKGLEYIHASAID-----FHGNLTLHNCMLDSHWI-----------VKLSGFG---
. ..| .|.||.|. . |..| .||..... . .|.. ||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
--------------------------------------------VNRLLVKW
.| ..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW
|
|||||||||
| Kinase | daf-11.AA | S_TKc | 436-705 | 17 | 7.1e-07 | -76.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 436-705
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)
YVLADK---------YVMRDKL-----------RYDKIDINLLYQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFR--GSLHDHIFTKERQRG---TA
| . .| | |.| . . |..| . .|.|. . .. | .|.|.. | |.|.|.| . |...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP
TRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQIFTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALIT
... |...|||.| | | | | .||. .|.. ||. |.| | || . |.
E-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----------------------
PQFGK-KCDMYSFGVILHEIILKKKFVEQLFDSPREEDDSVLIDDENDAIASRFPLPIIIPEGIEMHNDLIKMLENCFG---SVRPDIALARK-----II
..|| |||..|.|.|| | . . . .. .... ... ....|. . || . | . .
-GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC
DTVL
. .
HPWF
|
|||||||||
| Kinase | daf-11.AA | TKL-Unique | 463-558 | 22 | 1e-06 | 19.76 | In-house | 50-162 (290) | Show / Hide |
Range on Protein: 463-558 Range on HMM: 50-162/290 Sequence Identity: 22% (26 aa) SHLQ-HDNLNSFVGITID---KASHMYIIWNQCFRGSLHDHIFT--------KERQRGTATRFEGLFLRDILKGLEYIHASA--IDFHGNLTLHNCMLDS . |. |.|. ..|...| ....|.|. | .|||.|.. . .. . .. ... || .|..|.| . | |..|. | .|. KKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAI-DIAQGMYYLHHCEPPI-IHRDLKSSNFLVDN H-----WIVKLSGFG . | .|...|| NSNIAEWNIKICDFG |
|||||||||
| Kinase | daf-11.AA | TKL | 461-558 | 19 | 4.2e-05 | 14.32 | In-house | 78-199 (364) | Show / Hide |
Range on Protein: 461-558 Range on HMM: 78-199/364 Sequence Identity: 19% (26 aa) MKSHLQHDNLNSFVGITIDKAS------------HMYIIWNQCFRGS-LHDHIFTKERQRGTATRFE--GLFLRDILKGLEYIHASAI-------DFHGN |.| |.|.|. .|.|. .. . ...|. | .|| ||... .. . .|| .|..| |.. | . MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD LTLHNCMLDSHWI--------------VKLSGFG |. .|...|..| .|.. || LKSKNILVDENWTNVSNYMYNPNADWCCKICDFG |
|||||||||
| Kinase | daf-11.AA | TKL | 612-630 | 52 | 8.6e-05 | 13.19 | In-house | 265-283 (364) | Show / Hide |
Range on Protein: 612-630 Range on HMM: 265-283/364 Sequence Identity: 52% (10 aa) QFGKKCDMYSFGVILHEII .. .|||.||||..| ||. EYSEKCDVYSFGIVLWEIL |
|||||||||
| Kinase | daf-11.AA | LISK-DD1 | 617-639 | 43 | 9.2e-05 | 13.42 | In-house | 212-234 (290) | Show / Hide |
Range on Protein: 617-639 Range on HMM: 212-234/290 Sequence Identity: 43% (10 aa) CDMYSFGVILHEIILKKKFVEQL || .|||. | |.|. || .. . CDVFSFGMVLLELITRKKPDKRM |
|||||||||
| Kinase | daf-11.AA | MLK | 615-630 | 50 | 0.00011 | 12.32 | In-house | 215-230 (291) | Show / Hide |
Range on Protein: 615-630 Range on HMM: 215-230/291 Sequence Identity: 50% (8 aa) KKCDMYSFGVILHEII .|||..|.||.| |.. EKCDVWSWGVVLWEML |
|||||||||
| Kinase | daf-11.AA | Ciliate-E2-Unclassified | 430-558 | 17 | 0.000493 | 9.91 | In-house | 13-192 (352) | Show / Hide |
Range on Protein: 430-558
Range on HMM: 13-192/352
Sequence Identity: 17% (31 aa)
ATVDQVYVLADKYV------MRDKLRYDKID------INLLYQMKSH----------------LQHDNLNSFVGITID-KASHMYIIWNQCFRGSLHDHI
..| ... .|.. . . . .|. .| . .|... |.|.... . . .. . ..||. .| |.|...|
GKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYI
-------------FTKERQRGTATRFEGL------FLRDILKGLEYIHASA-IDFHGNLTLHNCMLDSHW---IVKLSGFG
| . .|| | .. . ... ||.||||.| . | | .... | ..|. .|...||
KKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNI-IHRDIKPENILFDNNGKNYYIKIIDFG
|
|||||||||
| Kinase | daf-11.AA | UTK | 517-563 | 24 | 0.001478 | 8.04 | In-house | 123-178 (296) | Show / Hide |
Range on Protein: 517-563 Range on HMM: 123-178/296 Sequence Identity: 24% (14 aa) FLRDILKGLEYIHASAIDFHGNLTLHNCMLDSH-------WIVKLSGFG---VNRLL . .|| |..|.| . |..| || ...| ...|...|| |.. MAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRV |
|||||||||
| Kinase | daf-11.AA | TKL-Unique | 612-630 | 52 | 0.002822 | 7.62 | In-house | 204-222 (290) | Show / Hide |
Range on Protein: 612-630 Range on HMM: 204-222/290 Sequence Identity: 52% (10 aa) QFGKKCDMYSFGVILHEII |. .|.| ||||..| ||. QYSEKSDVYSFGIVLWEIA |
|||||||||
| Kinase | daf-11.AA | Ciliate-E2-Unclassified | 615-633 | 47 | 0.003288 | 7.01 | In-house | 249-267 (352) | Show / Hide |
Range on Protein: 615-633 Range on HMM: 249-267/352 Sequence Identity: 47% (9 aa) KKCDMYSFGVILHEIILKK .|||..|.||||.|.. . YKCDIWSLGVILYEMLFGY |
|||||||||
| Kinase | daf-11.AA | UTK | 607-629 | 45 | 0.020183 | 4.1 | In-house | 210-233 (296) | Show / Hide |
Range on Protein: 607-629 Range on HMM: 210-233/296 Sequence Identity: 45% (11 aa) ALITP-QFGKKCDMYSFGVILHEI ||. .| | |..|||| ..|| ALTHHTRFTTKSDVWSFGVVCWEI |
|||||||||
| Kinase | daf-11.AA | TK | 610-629 | 36 | 0.14858 | 0.11 | In-house | 363-387 (486) | Show / Hide |
Range on Protein: 610-629 Range on HMM: 363-387/486 Sequence Identity: 36% (9 aa) TPQ-----FGKKCDMYSFGVILHEI ... | | |..|||| ..|| SEAEKYGKFTTKSDVWSFGVLMWEI |
|||||||||
| CYCc | daf-11.AA | CYCc | 739-940 | 36 | 4.9e-96 | 326.27 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 739-940 Range on HMM: 1-231/231 Sequence Identity: 36% (85 aa) KEQEKGDQLLMELLPKSVANDLKNGI-AVDPKVYENATILYSDIVGFTSLCSQSQPMEVVTLLSGMYQRFDLIISQQGGYKVILNRIMETIGDAYCVAAG .|..| |.||...||..|||.||.| .|.|. |...|||..||||||.|||...||.||..| ..| ||| ||.. |.|.. . ..|||||||.|. | MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHN-YCYKVETIGDAYMVVSG LPVVME-------------------KDHVKSICMIALLQRDCLHHFEIPHR----PGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSG .| ..| .| . |...|| ..|...|...|. |.. |..|.|...|||..||.|...||| .||..| .||.|||.| CPTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTG VEDRIQMTLASQQLL------EENFPQFVCSN . ..|... . ...| . ...||.... DPGQIHVSEETYWCLCLDQFERRRCGQFEFEP |
|||||||||
| Guanylate_cyc | daf-11.AA | Guanylate_cyc | 766-959 | 32 | 1.3e-51 | 182.57 | Pfam | 1-214 (214) | Show / Hide |
Range on Protein: 766-959 Range on HMM: 1-214/214 Sequence Identity: 32% (72 aa) VDPKVYENATILYSDIVGFTSLCSQSQ----PMEVVTLLSGMYQRFDLIISQQ--GGYKVILNRIMETIGDAYCVAAGLPVV-----MEKDHVKSICMIA | .. |.. ||. .||||||..||.. ||..|..| .| .|| ...| |.||| .||||.|....|||. .| .. .| VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKV------KTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMA LLQRDCLHHFEIPHRPGTF-----LNCRWGFNSGPVFAGVIG--QKAPRYACFGEAVILASKMESSGVED--RIQMTLASQQLLEENF-PQFVC--SNRG | . .. . ..| ... .. | | ..|||.||||| |. |||. .| | .||.||| || .|... . ..|.. . .||.| ..|| LDMMEYCQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRG GRTIEGIGR---ILTYWLEG . . | |. . ||.|.| EIPVKGKGKMGEMETYFLHG |
|||||||||
| HNOBA | daf-11.AA | HNOBA | 734-760 | 55 | 4.9e-07 | 27.02 | Pfam | 208-234 (234) | Show / Hide |
Range on Protein: 734-760 Range on HMM: 208-234/234 Sequence Identity: 55% (15 aa) TAELEKEQEKGDQLLMELLPKSVANDL ..|||.| |.|.|| . .|||||| | HRELEEEKKKTDDLLYSMFPKSVANRL |
|||||||||