Gene F21F3.2 (Nematode worm)
F21F3.2
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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F21F3.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 281 | Kinase domain by global Sugen HMM | Fasta, JSON |
F21F3.2.AA | Protein | Genbank | 440 | None | Fasta, JSON |
Protein domains of F21F3.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | F21F3.2.AA | GSK | 23-303 | 32 | 2.8e-168 | 518.58 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 23-303 Range on HMM: 1-328/328 Sequence Identity: 32% (106 aa) IEEVHLHSCGVFSNVYKGILREP--YEKKI-----AIKKSWPEKGER-NFEFIFLTGRERAKHKNVIHMIFAFSHSYDT-----KVCESYVFDFMPNTLA .|| ... .|.|..||......| ..|.| |||| |..| . |.|. .... ....|.|.......|...|.. ..|...|...||.||. YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY EVIR------QKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVK--GKANNFYQVTRFYRPPELLMKAMEYNSTV .||| |......|.||..|.| ||.||..|...|||.||.|||||.||..|||.||||||.... ...|..|...|.||.|||......|.... QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI DVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEK--LEKEYWKFTKGFG------------------------LQRLVNDISPD ||||.||.||||.|... |||..| .||.......| |....|..|. .. ...||.|.. .. ... ......| DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD QLQFIKRILVYAPEKRLRGKQLLQDDFF ....|...|||.|.|||.. ......|| WIDLISKCLVYDPKKRLSPLEACAHPFF |
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Kinase | F21F3.2.AA | CMGC | 23-303 | 17 | 1.5e-84 | 277.62 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 23-303 Range on HMM: 1-513/513 Sequence Identity: 17% (88 aa) IEEVHLHSCGVFSNVYKGILRE-------------PYEKKIAIKKSWPEKGERN----------------FEFIFLTGRERAK--------------HKN | . .| ...|||.. .. .....|||| . .. . . | .| ... |.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VIHMIFAFSHSYDTKV-------------CESYVFDFMPNTLAEVIRQ-----------KLTDLD------------IRLYT------WQIFSGLK--YL ..... | |. ... . ||..|...|...|.. .|.. |. .. .||. ||| |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC EEHK--VVHRDLKPVNILVDHDTAF-------------------LKISDFGSAKIIVKG----------------------KANNFYQVTRFYRPPELLM |. ..|||||| |||..|.. ||| |||.|... . ... | |||.||.||.|. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL KA---------MEYNSTVDVWSAGCIMAEMVKR--------HVVFPGRDS-----------AHQLKLYCRCFGAPN---------------EQDISAMKG . |.|....|.||.|||.|||. . . |||... .||.. .. .| |. |... |.. GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK EKLEKE------------YWK--------------FTKGFGLQRLVND-----------------------------------ISPDQLQFIKRILVYAP . .|. .. ...|. . ..|. . ..|..|.| | LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP EKRLRGKQLLQDDFF .||. .| || ..| DKRITAEQALQHPYF |
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Kinase | F21F3.2.AA | S_TKc | 23-303 | 22 | 1.4e-56 | 195.21 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 23-303 Range on HMM: 1-231/231 Sequence Identity: 22% (68 aa) IEEVHLHSCGVFSNVYKGILREPYEKKIAIKKSWPEKGERNFEFIFLTGRERAKHKNVIHMIFAFSHSYDTKVCESYVFDFMPN---TLAEVIRQK---- | . . | |. |||.. .. .. |||. |. | . . .|.|..... .| . .... |...... .| ..|... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD---DHLY--MVMEYCDGDLGDLFDYIKKRGRHG ----LTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNFYQVTRFYRPPELLMKAMEYNS-TVDVWSAGCIM .. ..| |..||...|.|. .|...|||||| |||.|. .||.|||.|... . . .|..|..||.| |. .|.|| |||. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL AEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEKLEKEYWKFTKGFGLQRLVNDISPDQLQFIKRILVYAPEKRLRGKQLLQ-------DDFF .||. . || .. ... .. ||. ..||...|.. ||||. ..|| . .| YEMLCGYPPFP-----QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | F21F3.2.AA | CDK | 100-303 | 29 | 2.4e-54 | 172.21 | In-house | 96-284 (284) | Show / Hide |
Range on Protein: 100-303 Range on HMM: 96-284/284 Sequence Identity: 29% (66 aa) VFDFMPNTLAEVIRQKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTA----FLKISDFGSAKIIV-----KGKANNFYQ---VTRFYRP ||..|. |..... |. |.||. .|| |. .....|||||| |||.... ||| ||| |.. . . |. | ||. ||. VFEYMDHDLKKYMD-------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRA PELLMKAMEYN--STVDVWSAGCIMAEMVK---RHVVFPGRDSAHQLKLYCRCFGAPNEQD---ISAMKGEKLEKEYWKFTKGFGLQRLVNDISPDQLQF ||||. . .|. ..|.||.|||.|||. | |||. .||.. .| .| |.|.. .. . . .. PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DL IKRILVYAPEKRLRGKQLLQDDFF . . |.| |.||. .| ||...| LNKMLCYDPKKRISAEQALQHPYF |
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Kinase | F21F3.2.AA | Pkinase | 32-303 | 23 | 3.9e-49 | 174.36 | Pfam | 10-293 (293) | Show / Hide |
Range on Protein: 32-303 Range on HMM: 10-293/293 Sequence Identity: 23% (74 aa) GVFSNVYKGILREPYEKKIAIKKSWPEKGERNF--------EFIFLTGRERAKHKNVIHMIFAFSHSYDTKVCESYVFDFMPN-----TLAEVIR----Q | |. |||.. . ..|. |.|. . .. . .. | . . |.|.. .. .| ..... |...... |...|. GSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYISTWRHG KL--TDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAF---LKISDFGSAKI--IVKGKANNFYQVTRFYRPPELLMKAMEYNSTVDVWSAG .. .. ... | .||..||.|. .....|||||| |||.|.. .||.|||.|| . .. .. . .|..|..||..... .| . ||.||.| CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG CIMAEMVKRHVVFPGR----DSAHQLKLYCRCFGAPNEQDISAM----------KGEKLEKEYWKFTKGFGLQRLVNDISPDQLQFIKRILVYAPEKRLR ||..||. .. |||. . . |....|| |.|.. |.. . . | .... .|.. ..|||..| . |.||. CILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT GKQLLQDDFF .|.||...| AEQILQHPWF |
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Kinase | F21F3.2.AA | CDK7 | 76-303 | 35 | 1.9e-46 | 121.44 | In-house | 60-288 (288) | Show / Hide |
Range on Protein: 76-303 Range on HMM: 60-288/288 Sequence Identity: 35% (85 aa) KHKNVIHMIFAFSHSYDTKVCESYVFDFMPNTLAEVIRQK---LTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVK .| ||| .| .| | | . |||||. | .||. | || .| |. .. || |. . . |||||| | |.. . ||| ||| |. . QHDNVIGLIDIFMH----KSNIQLVFDFMDWDLEVVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQ-LKIADFGLARFY-- GKANNFYQ---VTRFYRPPELLMKAMEYNSTVDVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQD---ISAMKGEKLEKEYWKFTKGFG-- | | | |||.|| |||| | | . ||.|| |||.|| | .|| ||. .. | |.|.. ...| ..| ||.. | GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCM------MDYIKFKDFPGYS ---LQRLVNDISPDQLQFIKRILVYAPEKRLRGKQLLQDDFF |. . | | | ...... | ||. | |. ..| RTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF |
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Kinase | F21F3.2.AA | ERK7 | 65-303 | 32 | 3.4e-42 | 141.93 | In-house | 48-292 (292) | Show / Hide |
Range on Protein: 65-303 Range on HMM: 48-292/292 Sequence Identity: 32% (80 aa) EFIFLTGRERAKHKNVIHMIFAFSHSYDTKVCESYVFDFMPNTLAEVIR--QKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKIS | .|| .| .| |.|..| . . | . ||.|| | ||| . | | . .|.. .||. .|.|||||| |||.| . ..|. EIMFL--QEFHCHPNIIRLINVIRADNDRDIY--LVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSE-CMVKVC DFGSAKIIVKGK-------ANNFYQVTRFYRPPELLMKAMEYNSTVDVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEKLEK- ||| | | . . . | || || || |. . .| || || |||..||.. .||| .|. . . . | ..|| |.. . . DFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNM -EYWKFTKGFGLQRLVNDISPDQLQFIKRILVYAPEKRLRGKQLLQDDFF | . .| |. .. . ..| . .||.||..|.||| .| || . LEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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Kinase | F21F3.2.AA | MAPK | 100-303 | 30 | 7.3e-42 | 142.45 | In-house | 94-328 (328) | Show / Hide |
Range on Protein: 100-303 Range on HMM: 94-328/328 Sequence Identity: 30% (73 aa) VFDFMPNTLAEVIR-QK-LTDLDIRLYTWQIFSG--LKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNF---------------YQ |...| | .|. |. |.| |. ..|| | |||. |.|||||| ||||. . ||| ||| | .| . . | VMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNEN-CDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYV VTRFYRPPELLMK--AMEYNSTVDVWSAGCIMAEMVK-RHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEKLEKEYWKFTKGFG---------LQRL .||.|| ||... .|.|. .||.||.|||.|||.. |.. |||.|. .|..| | | |..|. .. ...... ...| .. . ATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICM---SEHARNYIQSLGNLPKYPKKPWEKM VND----ISPDQLQFIKRILVYAPEKRLRGKQLLQDDFF . .|. . .... || |.||. .. || .| FPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | F21F3.2.AA | p38 | 100-303 | 32 | 5.7e-37 | 123.71 | In-house | 86-289 (289) | Show / Hide |
Range on Protein: 100-303 Range on HMM: 86-289/289 Sequence Identity: 32% (67 aa) VFDFMPNTLAEVIRQK-LTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNFYQVTRFYRPPELLMKAMEYN | || | ..... |.| |.. || |||| ..|||||| || | | |.| ||| | . . | .|| || || . |.|. VTHFMGADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCE-LRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYT STVDVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEKLEKEYWK---FTKGFGLQRLVNDISPDQLQFIKRILVYAPEKRLRGK |||.|| ||||||.. . . ||| | .||. . | | | .. .. |. . | . .. .... .| . . ..|. |.||. . QTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEA-RNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAE QLLQDDFF . .| ..| EAMQHPYF |
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Kinase | F21F3.2.AA | CCRK | 100-303 | 35 | 1.3e-36 | 123.85 | In-house | 77-285 (285) | Show / Hide |
Range on Protein: 100-303 Range on HMM: 77-285/285 Sequence Identity: 35% (75 aa) VFDFMPNTLAEVIR---QKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNF-YQV-TRFYRPPELLMKA ||.|| ||||.| . |.. .. | . |. . | ..|||||| |.|. .. ||| ||| |.. . . || ||.|| |||| | VFEFMLSDLAEVVRHAQRPLAEAQVKSYMQMLLKGVAHCHENNIMHRDLKPANLLI-SESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGA MEYNSTVDVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKG-EKLEKEYWKFTKGFGLQRLVNDISPDQLQFIKRILVYAPEKRLR .| ||.|. |||| |.. .|||. || | | |... || | .| | ..| |.||. | .|. ||| | .|. RQYDQGVDLWAVGCIMGELLNNSPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIA GKQLLQDDFF | | ..| ASQALLHQYF |
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Kinase | F21F3.2.AA | ERK5 | 100-303 | 34 | 2.7e-36 | 126.9 | In-house | 82-295 (295) | Show / Hide |
Range on Protein: 100-303 Range on HMM: 82-295/295 Sequence Identity: 34% (74 aa) VFDFMPNTLAEVI--RQKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVK---GKANNF---YQVTRFYRPPELL ||| | | .| | .| || . .|| ||||. .|.|||||| |.|| ||| ||| |. . | | | ||.|| |||. VFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCE-LKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELM MKAMEYNSTVDVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEKLEKEYWK---FTKGFGLQRLVNDISPDQLQFIKRILVYAP . .| .|||| |||. ||. |. .|||. |||.| | | . | |. ... . | . .... . |. . |.|.. | FSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEP EKRLRGKQLLQDDFF .|. . || | SERITVNKALQHPFL |
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Kinase | F21F3.2.AA | CDC2 | 110-222 | 34 | 6.4e-36 | 107.5 | In-house | 94-211 (301) | Show / Hide |
Range on Protein: 110-222 Range on HMM: 94-211/301 Sequence Identity: 34% (41 aa) EVIRQKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNFYQ---VTRFYRPPELLMKAMEYNSTVDVWSA .. ..... .. |..|| .|. .. ....|||||| |||.| . . .||.||| |. . . . . ||. ||.||.|. . |. .||.|| IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSI GCIMAEM---VKRHVVFPG |||.||| | .. |.| GCIFAEMFMDVTKKPLFHG |
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Kinase | F21F3.2.AA | TyrKc | 23-302 | 18 | 2.2e-10 | -54.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 23-302 Range on HMM: 1-280/280 Sequence Identity: 18% (59 aa) IEEVHLHSCGVFSNVYKGILREPYEKKIAIKKSWPEKGERNF--EFIFLTGRERA--KHKNVIHMIFAFSHS-----YDTKVCESYVFDFMP--NTLAEV |. . .| | ||||... . |.|. ... .. | | .. . .|.|.. .. . ... |. .. |. .|| . . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMC---KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI--VMEYMPHGDLKDYL IRQK--LTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKG----KANNFYQV-----TR-----FYRPPELLMKAM . . |. | . ||| .| ||......|||| |.||... |||||| .. | . . | . .. .|| . . RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG EYNSTVDVWSAGCIMAEMVKRHVVFPGR-----DSAHQLKLYCRCFGAPNEQDI----SAMKGEKLEKEYWKFTKGFGLQRLVNDISPDQLQFIKRILVY .... |||| | | |. . . |. .. | . . . . | | ... | .|. . KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------F------VCCPDEMYQIMKQCWHE APEKRLRGKQLLQDDF ||.| . ... ..| DPEDRPTFSEI-HECF |
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Kinase | F21F3.2.AA | Pkinase_Tyr | 113-205 | 32 | 1.6e-09 | 32.86 | Pfam | 105-199 (270) | Show / Hide |
Range on Protein: 113-205 Range on HMM: 105-199/270 Sequence Identity: 32% (32 aa) RQKLTDLDIRLYTWQIFSGLKYLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNFY-QVTR------FYRPPELLMKAMEYNSTVDVWS .|.|| |. . ||| .|. |||... .|||| |.||... . ||.||| |. | | ... . .|| .. ... |||| KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWS |
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Kinase | F21F3.2.AA | CDC2 | 264-303 | 22 | 4.2e-05 | 11.04 | In-house | 253-301 (301) | Show / Hide |
Range on Protein: 264-303 Range on HMM: 253-301/301 Sequence Identity: 22% (11 aa) GLQRLVND---------ISPDQLQFIKRILVYAPEKRLRGKQLLQDDFF .|.... . . |. .. ....|.| |.||. |. || .| DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF |