Gene F22F1.2 (Nematode worm)

F22F1.2

Species: Nematode worm
Alias: aSWK153, F22F1.2, CE04444
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 8154464-8153422, WormBase Genetic Map location: X:-0.59,

Classification

Group: CK1
Family: Worm8

Sequence

Name Sequence Type Origin Length Description Download
F22F1.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
F22F1.2.AA Protein Genbank 299 None Fasta, JSON

Protein domain

Protein domains of F22F1.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F22F1.2.AA Worm8 11-271 75 1.5e-265 777.48 In-house 1-261 (261) Show / Hide 
Range on Protein: 11-271
Range on HMM: 1-261/261
Sequence Identity: 75% (196 aa)

YILEKKLGEGSYGDVYFCRDERNNKWSVIKLIHKEINGVRDETWRRETFALTALAEVRGISRMYDYGATDIHNYIVMEPLLDDLTNIARRNGIKGFSKST
|.|||.||.|.||||..|.|.|||.|.|.||||||.||.||||||.|||||||||.|.|..||.|||.||.||.||||.|.|||.||..||..|.|||.|
YTLEKVLGRGMYGDVHLCQDDRNNEWRVMKLIHKEHNGHRDETWRHETFALTALADVNGVPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKPT

GFHILWQLVKILQDVHSFGIAHGDIKADNLMISGSNKTFMLSLVDFGLSRSFKDHNGNRTPPIPFPSGCINLIHTPARTANGKPHMEAEDLMQVAYLACI
|..|.|||||||||.|||||.||||||||||.|.||..|||.|||||.|..|||||||||||.||||.|..||||||.||||.||||||||||||||.||
GYQIMWQLVKILQDIHSFGIVHGDIKADNLMVSHSNRMFMLVLVDFGCSCWFKDHNGNRTPPAPFPSNCMHLIHTPAHTANGHPHMEAEDLMQVAYLSCI

CRKLAPWEDIDGHKMTKLKKAFAEKPKKFLGEHQDLKPIIKIIAKQKHGKEPNYKEIMDLL
||...||.|||.|||||.|..||..||||||||||||||||..|||||.|||.||||||||
CRQYMPWKDIDEHKMTKMKMKFAKNPKKFLGEHQDLKPIIKMLAKQKHYKEPDYKEIMDLL
Kinase F22F1.2.AA CK1 11-267 18 3.1e-58 199.78 In-house 1-339 (339) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-339/339
Sequence Identity: 18% (64 aa)

YILEKKLGEGSYG-DVYFC-----RDERNN-----KWSVIKLIHKEINGV-----RDETWRRETFALT---------------ALAEVRGISRMYDYGAT
. ..||.|||..| ..| .     .|. ||     .. ..|. .|. .|      ... . ... ...               ....  .. ..|  .  
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

DIHNYIVMEPLLDDLTNIAR--RNGIKGFSKSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISG-------------SNKTFMLSLVDFGLSR-SFK
| .||.||. |  .|  . .  |.. . ||..|...| .|... |...|. |. | |||.||....              .|.   . ..|||..|  ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DHNGNR---------TPPIPFPS--------GCINLIHTPARTANGKPHMEAEDLMQVAYLACICRKLA---PWEDIDGHKM-------TKLKKAFAEKP
| .|..           ..|...        ||  . ... .. .||...   ||  ..|. . . |     || ... ...        . .. ..||.
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGC-TARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

KKFLGE----------HQDLKPIIKIIAKQKHGKEPNYKEI
......          .|.. .|.|.| ..|....|.|..|
MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F22F1.2.AA TTBKL 11-173 23 6.2e-17 53.78 In-house 1-170 (288) Show / Hide 
Range on Protein: 11-173
Range on HMM: 1-170/288
Sequence Identity: 23% (40 aa)

YILEKKLGEGSYGDVYFCRDERNNKWSVIKLIHKEINGVRDETWRRETFALTALA--EVRGISRMYDYGATDIHNYIVMEPLLDDLTNIARRNGIKG-FS
.  .|..||| .| ||  .|  . |   .. ..|  ..  | .   |   |..|.    . . .....| ..  |..||. . ..|  . ...  |  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

KSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISGSNKT----FMLSLVDFGLSRSFKDHNGNR-TPPI
..|   |  |... |...|. |. | |.|  | ..  . ..      . |.|||..| .....|..   ||
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNG-PI
Kinase F22F1.2.AA CK1-A 11-166 30 2.3e-15 50.59 In-house 1-152 (261) Show / Hide 
Range on Protein: 11-166
Range on HMM: 1-152/261
Sequence Identity: 30% (49 aa)

YILEKKLGEGSYGDVYFCRDERNNKWSVIKLIHKEINGVRDETWRRETFALTALAEVRGISRMYDYGATDIHNYIVME---PLLDDLTNIARRNGIKGFS
| | .|.| ||.||.|     .| .   ||.   | | .|      |.   . |.   || .|  ||    .| .||.   | |.|| |. .|     |.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKM---ESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRR----FT

KSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISGSNKTFMLSLVDFGLSRSFKDHN
  |   .  |..  .  ||  .  | ||| || ..        | |.||||.. ..|..
MKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSR
Kinase F22F1.2.AA CMGC 11-165 19 6.4e-15 44.57 In-house 1-257 (513) Show / Hide 
Range on Protein: 11-165
Range on HMM: 1-257/513
Sequence Identity: 19% (50 aa)

YILEKKLGEGSYGDVYFCRD--------------ERNNKWSVIKLIHKEINGVRDET--------WR---RETFALTALA----------------EVRG
|   ||.|||.|| || |||               ..|.   || | ..    ...         ..   ||   |  |                     
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ISRMYDYGATDI-----------------HNYIVMEPLLDDLTNIARRNG--IKG--FSKSTGFH---------------IL------WQLVKILQ--DV
| ..||.  ..                  | |.|.| .  || .. ..|    .|    . .  |               ..      .|. . |     
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFG--IAHGDIKADNLMISGSNKT-----------------FMLSLVDFGLSRSFKDH
|| .  | | |.|  |..|.  ..                  . | . ||||.|.. .|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase F22F1.2.AA Ciliate-E2 11-170 20 5.1e-14 44.51 In-house 1-214 (365) Show / Hide 
Range on Protein: 11-170
Range on HMM: 1-214/365
Sequence Identity: 20% (46 aa)

YILEKKLGEGSYGDVYFCRDERNNK-------------------WSVIKLIHKEINGVRDETWRRETFALTALAEVRG-----------------ISRMY
|.. ||.|.|..|.|| |.. ...|                     . .   | ..    | . .|   .  . .  .                 | .||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC--FYKKINEKNILEQLNHPNIIKMY

DYGA--TDIHNYIVMEPLLD-DLTNIARRNGIKGFSK---------STGFHILWQLVK---------------ILQDVHSFG-IAHGDIKADNLMISGSN
..    .| . |.||| .   ||  . . | .| ...             .| .|...                |.  || . | | ||| .|...    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KTFMLSLVDFGLSRSFKDHNGNRT
    . ..|||||. ..| | |||
----IKIIDFGLSKKYDDDNQNRT
Kinase F22F1.2.AA CK1 11-168 27 1.1e-13 43.69 In-house 1-166 (271) Show / Hide 
Range on Protein: 11-168
Range on HMM: 1-166/271
Sequence Identity: 27% (48 aa)

YILEKKLGEGSYGDVYFCRDERNNKWS---VIKLIHKEINGVRDETWRRETFALTALAE------VRGISRMYDYGAT--DIHNYIVMEPL---LDDLTN
| ...|.|.|| ||.| . .  .|..     |||   | |  .     .|   .. |          || .|| .|      .|..||. |   |.|| |
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKL---EKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN

IARRNGIKGFSKSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISG-SNKTFMLSLVDFGLSRSFKD-HNGN
.  |     ||  |   |  |... .. ||. .. | ||| || ..    ..  .. ..||||.  ..|  ...
FCNRK----FSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQ
Kinase F22F1.2.AA S_TKc 11-292 17 1.2e-13 23.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-292
Range on HMM: 1-231/231
Sequence Identity: 17% (55 aa)

YILEKKLGEGSYGDVYFCRDERNNKWSVIKLIHKEINGVRDETWRRETFALTALAEVRGISRMYDYGATDIHNYIVMEPLLD---DLTNIARRNGIKG--
| . .|.|.|..| || ||. . ..   || |.        |. |||   |        | ..||.  .  | |.||| .     ||  . ...| .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FSKSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISGSNKTFMLSLVDFGLSRSFKDHNGNRTPPIPFPSGCINLIHTPA-----RTANGKPHMEA
  |.  .  ....|... |.  || || | |.| .|....       . . ||||.| .                   .. ||                 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL---------

EDLMQVAY-----------LACICRKLAPWEDIDGHKMTKLKKAFAEKPKKFLGEHQDLKPIIKIIAKQKHGKEPNYKEIMDLLQEMLT-------SSGG
    .  .           |.  .    |..  . ..| |. .                                  .|  |... .|.       .   
----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

GFA--GDSLKAQFV
 ..   |  . ...
ALQDEWDIKCHPWF
Kinase F22F1.2.AA Worm6 11-171 25 7.7e-12 39.07 In-house 1-174 (279) Show / Hide 
Range on Protein: 11-171
Range on HMM: 1-174/279
Sequence Identity: 25% (46 aa)

YILEKKLGEGSYGDVYFCRDERNNK--WSVIKLIHKEI--NGVRDETWRRETFALTALAEVR--GISRMYDYGATDI--HNYIVMEPLLDDLTNIARRNG
. ..||.|||..|.|| . |. ..|    ..|.   |    .      ..| . |.|..  .  .  .. |.| .|    |||||. .  .| .. .   
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKC---EKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP

IKGFSKSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISG-----SNKTFMLSLVDFGLSR--SFKDHNG-NRTP
 . || .|| .|  |  . ..|.|..|  | |.|. |  |       .|.   . ..|||..|   ......  |||
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTP
Kinase F22F1.2.AA Pkinase 11-170 25 1.6e-10 38.28 Pfam 1-169 (293) Show / Hide 
Range on Protein: 11-170
Range on HMM: 1-169/293
Sequence Identity: 25% (45 aa)

YILEKKLGEGSYGDVYFCRDERNNKWSVIKLIHKEINGVRDETWRRETF--ALTALAEVRG--ISRMYDYGATDIHNYIVMEPLLD-----DLTNIAR--
| ...|.|.||.| || |..  ..|  ..| | |.  . ... ... .    .  .....   | |.||.  .. | |.||| .       ||  . .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-RNGIKGFSKSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISGSNKTF--MLSLVDFGLSRSF-KDHNGNRT
 ....  ||  .  ....|... |.  || || | |.| .|..|. .| .   .. . ||||.. |   .|.  |
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase F22F1.2.AA CK2 115-159 40 6.1e-08 18.99 In-house 101-143 (288) Show / Hide 
Range on Protein: 115-159
Range on HMM: 101-143/288
Sequence Identity: 40% (18 aa)

LWQLVKILQDVHSFGIAHGDIKADNLMISGSNKTFMLSLVDFGLS
. .| | |   || || | |.|  | ||  ...   |.|.| ||.
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKR--KLRLIDWGLA
Kinase F22F1.2.AA CAMKL 126-168 31 2.5e-07 19.26 In-house 144-186 (297) Show / Hide 
Range on Protein: 126-168
Range on HMM: 144-186/297
Sequence Identity: 31% (14 aa)

HSFGIAHGDIKADNLMISGSNKTFMLSLVDFGLSRSFKDH-NGN
|| ||.| |||..|.... ...   . ..|||.|  .... .|.
HSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGP
Kinase F22F1.2.AA CAMKL 11-45 36 3.1e-07 18.98 In-house 1-36 (297) Show / Hide 
Range on Protein: 11-45
Range on HMM: 1-36/297
Sequence Identity: 36% (13 aa)

YILEKKLGEGSYGDVYFCRDERN-NKWSVIKLIHKE
|...| ||.||.| |  ....|. ..   || |.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKK
Kinase F22F1.2.AA CK2 11-42 32 5e-06 13.27 In-house 1-34 (288) Show / Hide 
Range on Protein: 11-42
Range on HMM: 1-34/288
Sequence Identity: 32% (11 aa)

YILEKKLGEGSYGDVYFCRDERNNKWS--VIKLI
| ...|.| | | .|.  .. .||.    |||..
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKIL
Kinase F22F1.2.AA TyrKc 11-232 16 0.000581 -158.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-232
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

YILEKKLGEGSYGDVYFCRDERNNKWSV-IKLIHKEINGVRDETWRRETFALTAL-AEVRGISRMYDYGATD-------IHNYIVME-----PLLDDLTN
  |.|||||| .| || ..        | .| ....      |  .||   .. |  .   | |.| .  ..          .||||      |.| | .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IARRNGIKGFSKSTGFHILWQLVKILQDVHSFGIAHGDIKADNLMISGSNKTFMLSLVDFGLSRSFKDH-------NGNRT-----PP--IPF-------
  ..     .. ..  .. ||  .  .  || .. | |. | | ...  .        ||||||  .|.          |.         .|        
HRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

-----------------------------PSGC----INLIHTPARTANG-KPHMEAE--------DLMQVAYLACICRKLAPWEDIDGHKMTKLKKAF
                             ..|     .. ..  ..  .|  .   ..            .  .   | .  |    |   .. ... |
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE---DRPTFSEIHECF
Kinase F22F1.2.AA TTBKL 216-271 14 0.042648 2.96 In-house 227-288 (288) Show / Hide 
Range on Protein: 216-271
Range on HMM: 227-288/288
Sequence Identity: 14% (9 aa)

PWEDIDGHK-MTKLKKAFAEKPKKFLGEH-------QDLKPIIKIIAKQKHGKEPNYKEIMDLL
||.... .. . ..||.   | ... ...       . . .. | .   .  ..|.|  |. ..
PWTNMEDKMEIEHMKKNM--KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase F22F1.2.AA Worm6 216-267 21 0.214195 1.19 In-house 220-279 (279) Show / Hide 
Range on Protein: 216-267
Range on HMM: 220-279/279
Sequence Identity: 21% (13 aa)

PWEDIDGHKMTK-LKKAFAEKP-----KKFLGEHQ--DLKPIIKIIAKQKHGKEPNYKEI
||  ...|.  . .||.   .      . |.|. .  ... | ..| . .   .|.|| |
PWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI