Gene F28B12.3 (Nematode worm)

F28B12.3

Species: Nematode worm
Alias: aSWK116, F28B12.3, CE02704
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 5921924-5924790, WormBase Genetic Map location: II:-0.88,

Classification

Group: CK1
Family: VRK

Sequence

Name Sequence Type Origin Length Description Download
F28B12.3.AA Protein Genbank 610 None Fasta, JSON
F28B12.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F28B12.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F28B12.3.AA VRK 32-286 41 6.2e-169 544.62 In-house 1-281 (284) Show / Hide 
Range on Protein: 32-286
Range on HMM: 1-281/284
Sequence Identity: 41% (116 aa)

FIVGKQFATGGFGRIHTC----TEEG-KSQQMVMKIEP-STNGPLLTEVVVFNRILKKELIESYKKKKK------------ISWIGLPYLIANGYFTYES
...||....||||.|...    .... |..|.|.|||| ..||||.||.....|..|.|.|....||.|            ..|.|.||....||.....
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG

EKMRYMIIPKYATSLEAVRE-TNGGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNN----VDKPDKKRAH
||.|.|..|.....|....| .||....||..|..|...||.||||||..|.|.|.|||||||..........|||.|||.|...|    ..|.|..|.|
EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRCH

NGTCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGTLPWMALES--SPEKVFDAKQKFIAGLPGTLQNVLK-NESSAVVG
||||.|||.|||.|..||.|.|.|||.|..|||..|.||||...   .||||.||||||....|...|.... ...... |
NGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIG
Kinase F28B12.3.AA CK1 32-309 20 1e-56 194.72 In-house 1-339 (339) Show / Hide 
Range on Protein: 32-309
Range on HMM: 1-339/339
Sequence Identity: 20% (69 aa)

FIVGKQFATGGFG-RIHTC-----TEEGKS-----QQMVMKIEPS-TNGPLLTEVVVFNRILKKELIESYKK----KKKISW---IGLPYLIANGYFTYE
. |.|. ..||||  |. .     . .  .     ....||.||  ..|.. .. .......|.. .... |    |.| ..    | |. .. .| . |
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE

SEKMRYMIIPKYATSLEAVRE--TN-GGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEK-------------QGVYSTAVLVDFGLAH-RT
 .. .||... .  .|| .|.  .. .. . || .| .| ..|.||||.|.  . | |.|..|...               .. . . ...|||.|. . 
DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY

TNN--------------VDKPDK----KRAHNG-TCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGT--LPWMALES-----SPEKVFDAKQKFIAG-
...              . .| .    |. . | |. ..| ..|.|  .. | |.. ..| |. |  ||  |||. ...      .. | ..|..||.  
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEK

LPGTLQNVLKNESS--AVVGCIASMFDISMKTNYTDKVDMGKL
.. |... |.  ..   .  .   .... .. .| |. |  ..
KMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F28B12.3.AA CK1-D 140-251 30 1.4e-11 36.97 In-house 93-208 (261) Show / Hide 
Range on Protein: 140-251
Range on HMM: 93-208/261
Sequence Identity: 30% (35 aa)

AMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPD----KKRAHNGTCIFTSTDAHRGNNPSFRGDIEILA
..|  | .|  ..  .||.|  .. | |.|  | |.      ..  ..||||| |      .       ..   ||  . |   |.|   | | |.| | 
SLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLG

YNLMMWATGTLPWMAL
| || .. |.|||  |
YVLMYFNRGSLPWQGL
Kinase F28B12.3.AA CK1-A 140-257 29 3.1e-11 35.8 In-house 93-214 (261) Show / Hide 
Range on Protein: 140-257
Range on HMM: 93-214/261
Sequence Identity: 29% (36 aa)

AMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPD----KKRAHNGTCIFTSTDAHRGNNPSFRGDIEILA
.||  | .|  ..  .||.||  . | |.|  | |.          |.||||| .   .  .      . .   ||  . | .|| |   | | |.| ..
TMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMG

YNLMMWATGTLPWMALESSPEK
| .| .  |.|||  ..    |
YVMMYFNRGKLPWQGMKAMTKK
Kinase F28B12.3.AA DAPK 151-194 33 3.2e-10 24.04 In-house 112-156 (264) Show / Hide 
Range on Protein: 151-194
Range on HMM: 112-156/264
Sequence Identity: 33% (15 aa)

ILDALEYLHESDYAHADVKAANILLEKQGVYST-AVLVDFGLAHR
||... |||  . .| | |  ||.|   ..      ..||||...
ILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRK
Kinase F28B12.3.AA AGC 150-192 44 3.4e-10 21.05 In-house 161-202 (395) Show / Hide 
Range on Protein: 150-192
Range on HMM: 161-202/395
Sequence Identity: 44% (20 aa)

CILDALEYLHE-SDYAHAD-VKAANILLEKQGVYSTAVLVDFGLA
||. ||||||.  .. | | .|  |||| ..       |.||||.
CIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLC
Kinase F28B12.3.AA S_TKc 32-313 13 3.5e-10 -27.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-313
Range on HMM: 1-231/231
Sequence Identity: 13% (43 aa)

FIVGKQFATGGFGRIHTCTEEGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKELIESYKKKKKISWIGLPYLIANGYFTYESEKMRYMIIPKYAT---SL
. ....   |.||. . |.. .  ... .|| .              . ...| |.  ||       . |...   .. ..  .  ||.     .   .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRRE-IQILKK-------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDL

EAVRETNGG-----TLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGN
  . . .|.      .   .   ..  |..||||.|.    | |.| .|||| .     .  . ||||| .                             
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------------------

NPSFRGDIEILAYNLMMWATGTLPWMALESSPEKVFDA------------------KQKFIAGLPGTLQNVLKNESSAVVGCIASMFDISMKTNYTDKVD
                .   ||. .|| |      ..                   .  |    . .. ....  |. .   |  ...   .  .|    
----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EA

MG-----KLKKLV
.      |.   .
LQDEWDIKCHPWF
Kinase F28B12.3.AA DAPK 151-194 40 3.6e-10 25.42 In-house 112-156 (264) Show / Hide 
Range on Protein: 151-194
Range on HMM: 112-156/264
Sequence Identity: 40% (18 aa)

ILDALEYLHESDYAHADVKAANILLEKQGVYS-TAVLVDFGLAHR
|||.. ..|    .| | |  || |   .| .    ..|||||||
ILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHR
Kinase F28B12.3.AA YSK 151-201 43 4.1e-10 26.27 In-house 108-155 (257) Show / Hide 
Range on Protein: 151-201
Range on HMM: 108-155/257
Sequence Identity: 43% (22 aa)

ILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDK
|| .|.|||.    | |.||||.|| ..|      | ||| | . |... |
ILKGLDYLHSERKIHRDIKAANVLLSEHG---DVKLCDFGVAGQITDTQIK
Kinase F28B12.3.AA STE 146-192 37 8.1e-09 27.4 In-house 155-194 (359) Show / Hide 
Range on Protein: 146-192
Range on HMM: 155-194/359
Sequence Identity: 37% (18 aa)

TVASCILDA-LEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLA
...  || . |.|||.  . | |.|.|||||        . |.|||..
YICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVC
Kinase F28B12.3.AA CAMK 151-537 4 1.2e-08 23.28 In-house 188-280 (425) Show / Hide 
Range on Protein: 151-537
Range on HMM: 188-280/425
Sequence Identity: 4% (20 aa)

ILDALEYLHESDYAHADVKAANILLEKQGVYS--------------TAVLVDFGLAHRTTNN-----------------VDKPDKKRAHNGTCIFTSTDA
|..|..|.|. . .| | |  |||| . .  |              .  ..|||.| . . .                 .                    
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW--------------------

HRGNNPSFRGDIEILAYNLMMWATGTLPWMALESSPEKVFDAKQKFIAGLPGTLQNVLKNESSAVVGCIASMFDISMKTNYTDKVDMGKLKKLVTDAIQK
                                                                                                    
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TSSDGKKTPTRQKKLAEEDKNAVTPKRSTRRLAVKEESDNKDNDEVEVKPEKKATPRKRTTRKAVEVNNDSDDNEEQYENPKSKSSRTQTKSKRAKEEDV
                                                                                                    
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DDEEEIIIPKSSRSRSKVQLSGEGSDVTTPSSAASTSRSRSIRLGLTSSTASSNKVAKKIEQKYKRLSMNKSSLVPVTISVASDKSPTTSTPSSSSGLRS
                                                                                                    
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KRKSSEDVGEGITLKTQV
      ...||  .||..
-----TTPTEGQKMKTFC
Kinase F28B12.3.AA Pkinase 110-192 25 3.8e-07 26.37 Pfam 68-159 (293) Show / Hide 
Range on Protein: 110-192
Range on HMM: 68-159/293
Sequence Identity: 25% (24 aa)

TYESEKMRYMIIPKYATSLEAVRETN-------GGTL--AMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVY-STAVLVDFGLA
..|...  ||. .     |. | .         .|..   ...   ..  || .|||.|.    | |.| .|||. ..|.  ..  . |||||
WFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA