Gene gcy-17 (Nematode worm)

gcy-17

Species: Nematode worm
Alias: gcy-24, aSWK283, W03F11.2, gcy-17, CE30700
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 2233192-2223308, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-17.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
gcy-17.AA Protein Genbank 1280 None Fasta, JSON

Protein domain

Protein domains of gcy-17.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-17.AA ANF_receptor 212-327 22 7.7e-15 53.33 Pfam 30-151 (364) Show / Hide 
Range on Protein: 212-327
Range on HMM: 30-151/364
Sequence Identity: 22% (28 aa)

DFDEC---NEILGAGKTVDLLEVKKVDVIFGPTCSRPALISSALATYYNIPIFEWGLTSTRQLTD--VKRFPTTLPFSVNSYSL-AMAILGTLKQ-FQWT
|.|.|       ... .....  |.|..|.||.||  . . . .|...|||.. || |... |||   .|.|...    .. .. . |..  ..  |.|.
DDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPC-LTDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWK

EFVFLYCNDGDDEKCESL---KDDVQ
.....| .|  . .....    ...|
WVAVIYDDDDYY-YWRGGCYFMEAFQ
ANF_receptor gcy-17.AA ANF_receptor 329-501 15 5e-09 32.77 Pfam 194-342 (364) Show / Hide 
Range on Protein: 329-501
Range on HMM: 194-342/364
Sequence Identity: 15% (30 aa)

IIVACVASGNGS--KRTLMQAVALENANNSEYVYIMAETNSRGFVVEEVGGKWHYLWEGKFDDSDTFSTEDSRTSMANLLFLVDNMGMNNVVT----PQY
.|| |  .  ..  .| .||... .. .. .||.|.... . ....                            .....  ... |..  ..|    | .
VIVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W----------------------WYDDDMDNDKFREAMKGVLGFTMHPSPEF

LNFSKNVIEMMKDEPFNCVEDCVGEEYSSVAKYAGQLADAFYAYAVAVNRLLTANPQAEIRN-------GTMILRNI-G-MTFEGVGG
 .| ... .                . ...  ||... ||.|.|| |....|...|..  ..       |. .|. .   ..|||| |
QEFMQRWKK----------------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTG
Kinase gcy-17.AA RGC 671-697 20 0.189174 1.14 In-house 1-29 (300) Show / Hide 
Range on Protein: 671-697
Range on HMM: 1-29/300
Sequence Identity: 20% (6 aa)

QNEVVAANKHDFRPQLTDVER--SELRQV
....|.. || .|... ...   |..|..
EGDWVWIKKHNQRNLFRHWDFTRSMMREL
Kinase gcy-17.AA RGC 671-697 20 0.197403 1.14 In-house 1-29 (300) Show / Hide 
Range on Protein: 671-697
Range on HMM: 1-29/300
Sequence Identity: 20% (6 aa)

QNEVVAANKHDFRPQLTDVER--SELRQV
....|.. || .|... ...   |..|..
EGDWVWIKKHNQRNLFRHWDFTRSMMREL
Kinase gcy-17.AA RGC 773-1013 35 4.4e-123 415.2 In-house 1-300 (300) Show / Hide 
Range on Protein: 773-1013
Range on HMM: 1-300/300
Sequence Identity: 35% (106 aa)

KVRQIGVLTPTSMPYLKPKLSYFSSMHH---MRSLDHDNLNKFIGLCLNSQ------QLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGF
. ... .     .......    | |..   || |.|||||||||.|....      .....|.||||||| |........||..|..|.||||..|. .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLN----------------------EVR-GMDKLSTENMLWWAPEVLR-GLEQRSKE-----------AD
.|.|....|| |.|..|..|.||.|||.|||||                      ..|  ... . ..|||.|||.||  .......           .|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFGIICSEVITRSSAFDLE-----------NRKEKPEEIIYQLKKGGFNAIRPSLLTDEA---LEINPALVHLIRDCWTEKPSERPP-IDQVRSLLRG
.||||||..|.|||....|||           ...|..||..|..|||| . .|||. .||.   .|.||.|.||.||||.|.|.|||. .||.|..|..
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-17.AA RGC 773-1013 35 4.4e-123 415.2 In-house 1-300 (300) Show / Hide 
Range on Protein: 773-1013
Range on HMM: 1-300/300
Sequence Identity: 35% (106 aa)

KVRQIGVLTPTSMPYLKPKLSYFSSMHH---MRSLDHDNLNKFIGLCLNSQ------QLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGF
. ... .     .......    | |..   || |.|||||||||.|....      .....|.||||||| |........||..|..|.||||..|. .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLN----------------------EVR-GMDKLSTENMLWWAPEVLR-GLEQRSKE-----------AD
.|.|....|| |.|..|..|.||.|||.|||||                      ..|  ... . ..|||.|||.||  .......           .|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFGIICSEVITRSSAFDLE-----------NRKEKPEEIIYQLKKGGFNAIRPSLLTDEA---LEINPALVHLIRDCWTEKPSERPP-IDQVRSLLRG
.||||||..|.|||....|||           ...|..||..|..|||| . .|||. .||.   .|.||.|.||.||||.|.|.|||. .||.|..|..
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-17.AA TKL 800-1011 20 4.4e-34 119.54 In-house 78-364 (364) Show / Hide 
Range on Protein: 800-1011
Range on HMM: 78-364/364
Sequence Identity: 20% (61 aa)

HMRSLDHDNLNKFIGLCLNSQQ-------------LLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGFIHTSML-------HFHGYLSSRS
.|..|.|.|. .|.| |.....             |  .  ||..||| ...           ......||| |. . |..           |  | |. 
MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

CLIDDRWQ--------------VKISDFGLNEVRGMDK---------------------LSTE--NMLWWAPEVLRGL---------------EQRSKEA
.|.|. |.              .||.||||  .  ...                     ..|.  .  | |||||||                .. |. .
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DIYSFGIICSEVITRSSAFD-LENRKEKPE----EIIYQLKKGGFNAIRPSLLT-----DEALEINPALVHLIRDCWTEKPSERPPIDQVRSLL
|.|||||.  |..||   .. . .. ...     |....  . |    .|.             . | .  |. ||| ..|..||  ... . |
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase gcy-17.AA TKL-Unique 801-942 27 8.7e-27 91.59 In-house 49-224 (290) Show / Hide 
Range on Protein: 801-942
Range on HMM: 49-224/290
Sequence Identity: 27% (49 aa)

MRSLD-HDNLNKFIGLCL----NSQQLLSIWRYCSRGSLADVIS---------RSSMQMDSFFMLSLIRDIANGLGFIHTSML-HFHGYLSSRSCLIDDR
|  |. |.|. ...| |        ..  .  ||..||| ||..         .... ..   ......||| |. ..|..     |. | |.. |.| .
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

-----WQVKISDFGLNEVRG--MDKLSTEN--------M---LWWAPEVLRGL-EQRSKEADIYSFGIICSEVITR
     |..||.||||  ..   ... ..|.        .   .| ||||||.. .|.|. .|.|||||.  | .||
SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase gcy-17.AA TK 792-1011 13 5.8e-25 79.96 In-house 86-486 (486) Show / Hide 
Range on Protein: 792-1011
Range on HMM: 86-486/486
Sequence Identity: 13% (55 aa)

LSYFSSMHHMRS--LDHDNLNKFIGLCLNS------------QQLLSIWRYCSRGS----LADVISRSSM------------------------------
|.  . |  |..  ..|.|. ...| |. .            . .. .  |.. |.    | |   ...                               
LEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDIT

---------------------------------------------QMDSFFMLSLIRDIANGLGFIHTSML-----HFHGYLSSRSCLIDDRWQ------
                                             |..   .|   ..||.|. ..|           |. |  | ||.... .      
YSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFD

-----VKISDFGLN------EVRGMDK--------------------------------LSTENMLWWAPEVLRGLEQRSKE--------ADIYSFGIIC
     .||.||||         | ...                                       | |||.|.. . ...|         |..|||. .
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

SEVIT---RSSAFDLENRKEKP----EEIIYQLKKG-----------GFNAIRPS-LLTDE----ALEINP-----ALVHL-IRDCWTEKPSERPPIDQV
 |. |      . .. |..       .|.. .|..|           |    .|   .  .    .    |     ..... ...|| ..|..||  .|.
WEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQL

RSLL
.. |
HEQL
Kinase gcy-17.AA DRK 801-942 36 7e-19 60.61 In-house 51-198 (258) Show / Hide 
Range on Protein: 801-942
Range on HMM: 51-198/258
Sequence Identity: 36% (54 aa)

MRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGFIHTSM-LHFHGYLSSRSCLIDDRWQVKISDFGLNE--
|  | | |   |.| |.|.   . .  | .||||. .    |..||   |...  |.| |. . | .     |  | |   |.|. ||||..||||    
MCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRF

VRGMDKLSTENML----WWAPEVLRGLEQRSKE-ADIYSFGIICSEVITR
 .  ..  .  |     | ||||||  .||  | ||.|||.|.  |..||
KKHKQHKFAMTMCGTPCWTAPEVLR--NQRYTEKADVYSFAIVLWECVTR
Kinase gcy-17.AA TK-Unique 800-935 19 4.3e-17 55.58 In-house 56-228 (294) Show / Hide 
Range on Protein: 800-935
Range on HMM: 56-228/294
Sequence Identity: 19% (34 aa)

HMRSLD-HDNLNKFIGLCLNSQ-QLLSIWRYCSRGSLADVISRSSMQ-------------------------MDSFFMLSLIRDIANGLGFIHT--SMLH
.|..|. | |. ...| |  |. . . |. ||..|.| . . .. ..                          ....... . .||.|. ...    .  
MMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI-

FHGYLSSRSCLIDDRWQVKISDFGLNE-------VRGMDKLSTENMLWWAPEVLR-GLEQR-SKEADIYSFGII
.|. |..| .|. .. ..||.|||. .       .  |.. ..    | |||.|.   ..  . . |..|||..
VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVL
TyrKc gcy-17.AA TyrKc 771-1011 18 7.1e-13 -14.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 771-1011
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

LLKVRQIG-------------------VLTPTSMPYLKPKLSYFSSMHHMRSL--DHDNLNKFIGLCLNS-------QQLLSIWRYCSRGSLADVISRSS
. . ...|                   .| . .      .    . .  |..|  .|.|. ...| |. .       ..|. .  |.. |.| | . .. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

MQMDSFFMLSLIRDIANGLGFIHTSMLHFHGY----LSSRSCLIDDRWQVKISDFGL--NEVRG--------MDKL----STENML---WWAPEVLRGLE
 .     .||   .||.|  ..|       ..    |  | ||.... .||||||||  .   .        . .     ..  ||   | |||..    
PKLCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---N

QR--SKEADIYSFGIICSEVITRSSAFDLE---NRKEKPEEIIYQLKKGGFNAIRPSLLTDEAL---EINPALVHLIRDCWTEKPSERPPIDQVRSLL
 .  . . |..|||. . |. |.      .   . . ...|.| ..|.|.   . |. .  . .   .  ...  ....|| |.|..||   ......
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase gcy-17.AA UTK 801-895 23 4.1e-12 37.74 In-house 63-174 (296) Show / Hide 
Range on Protein: 801-895
Range on HMM: 63-174/296
Sequence Identity: 23% (26 aa)

MRSLD-HDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSSM----QMDSFF---MLSLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDR-------
|  .. | |. ...|.|....... ...|...|.|...  |..     . ...    .|.  .|||.|. ..| |.   |. |  | ||...        
MKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH-SCGFVHRDLAARNCLVHMHRMMWHCM

WQVKISDFG---L
...||.|||   .
MVCKIADFGRGGM
Kinase gcy-17.AA MLK 800-942 25 4.4e-11 34.82 In-house 58-232 (291) Show / Hide 
Range on Protein: 800-942
Range on HMM: 58-232/291
Sequence Identity: 25% (45 aa)

HMRSLDHDN----LNKFIGLCLNSQQ-LLSIWRYCSRGSLADVI-SRSS------------MQMDSFFMLSLIRDIANGLGFIHTSMLH--FHGYLSSRS
| | |.| |      .| | ||.... .. .  ||. |||..|. ...|              .|  ....   ..|.|. . |    .   | .| |. 
HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN

CLIDD------RWQVKISDFGLNEVRGMDKL---STE---NMLWWAPEVL--RGLEQRSKEADIYSFGIICSEVITR
 |||.        ..||.|||.  .| . .     .    .  | ||||.     |. |. .|..|.|..  |..||
ILIDEICHDMHHGTLKICDFGT--SRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
S_TKc gcy-17.AA S_TKc 771-1011 17 8.5e-10 -33.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 771-1011
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)

LLKVRQIG----------VLTPTSMPY----LKPKLSYFSSMHHMRSLDHDNLNKFIGLCLNSQQLLSIWRYCSR--GSLADVISRSSMQ-----MDSFF
  ..|.||          . . |   .    .|   .  . .  ... .|.|. |... . . . |  .  ||.   |.| |.| .   .     ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

MLSLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLNEVRGMDKLSTENMLWWAPEVLRGLEQRSK-EADIYSFGIICSEVITRSSAFDL
  .... |...| ..|      |  |     |.|.  ..||.||||  .  .    |    . |||||    . .| ..|..|.|.|  | ...   |. 
ARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGT--PWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-

ENRKEKPEEIIYQLKKGGFNAIRPSLLTDEALEINPALVHLIRDCWTEKPSERPPIDQVRS---------LL
       .. .... .                   | . ..|| |..  |..|| . ..            .
------QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gcy-17.AA TESK 801-900 29 1.9e-09 25.51 In-house 47-149 (292) Show / Hide 
Range on Protein: 801-900
Range on HMM: 47-149/292
Sequence Identity: 29% (31 aa)

MRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGFIHTSMLHFHGYLSSRSCLID----DRWQVKISDFGLN
|  | | |  .| | |    ||  .  | . |.| .. . |.. .     . |  ||| |. ..|     ||  | |. ||.     . ..  . |||| 
MNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLAYDIARGMSYLHSKGV-FHRDLTSKNCLVRQRDNNQYEAVVGDFGLA

EVRG
 | |
RVLG
Kinase gcy-17.AA Pkinase 913-1011 16 3e-09 33.81 Pfam 179-293 (293) Show / Hide 
Range on Protein: 913-1011
Range on HMM: 179-293/293
Sequence Identity: 16% (20 aa)

APEVLRGLEQRSKEADIYSFGIICSEVITRSSAFDLEN----RKEKPEEIIYQLKKGGFNAIRPSL-------------LTDEALEINPALVHLIRDCWT
||||.|| .  ....|..|.|.|. |....   |. .     .   . ..|.. ... .   .| .             ..    ...... ..|..|..
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLC

EKPSERPPIDQVRSL--L
 .|..|| ..|.     .
KDPKKRPTAEQILQHPWF
Kinase gcy-17.AA TESK 911-945 54 2.4e-08 21.99 In-house 202-235 (292) Show / Hide 
Range on Protein: 911-945
Range on HMM: 202-235/292
Sequence Identity: 54% (19 aa)

WWAPEVLRGLEQRSKEADIYSFGIICSEVITRSSA
| ||||||| |.  ..||..||||.  |.| |  |
WMAPEVLRG-EWYDEKADVFSFGIVLCEIIARIQA
Kinase gcy-17.AA TKL-Unique 981-1011 32 4e-06 17.67 In-house 260-290 (290) Show / Hide 
Range on Protein: 981-1011
Range on HMM: 260-290/290
Sequence Identity: 32% (10 aa)

EINPALVHLIRDCWTEKPSERPPIDQVRSLL
.... . .||..||.  ||.||  |.... |
HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase gcy-17.AA MLK 981-1011 25 2.5e-05 14.61 In-house 261-291 (291) Show / Hide 
Range on Protein: 981-1011
Range on HMM: 261-291/291
Sequence Identity: 25% (8 aa)

EINPALVHLIRDCWTEKPSERPPIDQVRSLL
.... .  |. .|| ..|..||  .|. . |
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase gcy-17.AA TK-Unique 989-1011 39 5.1e-05 13.4 In-house 272-294 (294) Show / Hide 
Range on Protein: 989-1011
Range on HMM: 272-294/294
Sequence Identity: 39% (9 aa)

LIRDCWTEKPSERPPIDQVRSLL
|.. ||...|.||| ..|... |
LMKSCWQWEPEERPSFRQIKHRL
Kinase gcy-17.AA Pkinase_Tyr 984-1011 25 9.1e-05 16.77 Pfam 243-270 (270) Show / Hide 
Range on Protein: 984-1011
Range on HMM: 243-270/270
Sequence Identity: 25% (7 aa)

PALVHLIRDCWTEKPSERPPIDQVRSLL
. . .|...|| ..|..||   .... |
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase gcy-17.AA UTK 985-1011 25 0.000144 11.55 In-house 270-296 (296) Show / Hide 
Range on Protein: 985-1011
Range on HMM: 270-296/296
Sequence Identity: 25% (7 aa)

ALVHLIRDCWTEKPSERPPIDQVRSLL
..  | ..||.  |.||| ...... .
PVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase gcy-17.AA DRK 989-1013 36 0.000522 9.51 In-house 234-258 (258) Show / Hide 
Range on Protein: 989-1013
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LIRDCWTEKPSERPPIDQVRSLLRG
|. ||| | |. ||  ...   |  
LMNDCWNEDPQHRPSMQECLERLEA
Kinase gcy-17.AA Pkinase_Tyr 801-895 26 0.001799 12.38 Pfam 57-157 (270) Show / Hide 
Range on Protein: 801-895
Range on HMM: 57-157/270
Sequence Identity: 26% (27 aa)

MRSL-DHDNLNKFIGLCL-NSQQ--LLSIWRYCSRGSLADVISRS---SMQMDSFFMLSLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDRWQVKISDF
|..| .|.|. ...| |.  ...  .. .  |.  |.| |   .      . .   .|.  ..||.|. . . |.   |  |  | ||...  .|||.||
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNVVKICDF

GL
||
GL
Kinase gcy-17.AA UTK 911-942 37 0.009411 5.25 In-house 205-236 (296) Show / Hide 
Range on Protein: 911-942
Range on HMM: 205-236/296
Sequence Identity: 37% (12 aa)

WWAPEVLRGLEQRSKEADIYSFGIICSEVITR
| |||.|   .. .   |..|||. | |. |.
WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase gcy-17.AA Pkinase 880-895 45 4.962809 1.19 Pfam 139-158 (293) Show / Hide 
Range on Protein: 880-895
Range on HMM: 139-158/293
Sequence Identity: 45% (9 aa)

CLIDDRWQV----KISDFGL
.|||.. ..    ||.||||
ILIDNNGHIDACVKICDFGL
Kinase gcy-17.AA Pkinase 801-865 20 7.528103 0.55 Pfam 54-125 (293) Show / Hide 
Range on Protein: 801-865
Range on HMM: 54-125/293
Sequence Identity: 20% (15 aa)

MRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRG----SLADVIS-RSSMQM--DSFFMLSLIRDIANGLGFIH
|..|.|.|  .... . ... .  .  ||  |    .|.|.|| ...  .  .     . .. |. || ..|
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH
CYCc gcy-17.AA CYCc 1050-1233 41 5.5e-84 286.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 1050-1233
Range on HMM: 1-231/231
Sequence Identity: 41% (96 aa)

EEQKKSDVLLYRMLPKTVAEKLKAGI-SIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQND-----VYKVETIGDGYLCVSGL
.|..| | ||..|||. ||. ||.|  ...|.... ||| |.|.| ||.|.|.|||.||| .|||.|| ||.||....     .||||||||.| .|||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PHRNGH-------------------DHIKHIARMSLAFLSSLAEFRVAHMP----------------SSVVAGVVGLTMPRYCLFGDAVNTASRMESNGK
|.||.|                   .|.. || ..|  .... .| | | .                 .||.||||..|||||.|||.||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PGRIHVSSEANHLL------THVVGGFRTEE
||.||||.|. ..|      ..  |.|..|.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc gcy-17.AA Guanylate_cyc 1077-1252 39 1.1e-72 252.53 Pfam 1-214 (214) Show / Hide 
Range on Protein: 1077-1252
Range on HMM: 1-214/214
Sequence Identity: 39% (84 aa)

IEPETFELVTIFFSDVVQFTTLASKCT----PLQVVQLLNDLYTIFDSIIEQN--DVYKVETIGDGYLCVSGLPHR-----NGHDHIKHIARMSLAFLSS
.... .. |||.|.|.| || ..|.|.    |.|.|..|||.|| ||....|.  ..|||.|||| |.|||||| .     .. .|.  .| |.|... .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

LAEFRVAHMP--S---------------SVVAGVVG--LTMPRYCLFGDAVNTASRMESNGKPG--RIHVSSEANHLLTHVVG-GFRT--EERGEVIIKG
. ...| | .                  .|||||.|  . |||||..|| ||.||||||.|.||  .|||| |.  .|.   .  |..  ..|||. .||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGV---MNTYWLLG
||    | ||.| |
KGKMGEMETYFLHG
HNOBA gcy-17.AA HNOBA 1045-1071 59 3.9e-08 31.0 Pfam 208-234 (234) Show / Hide 
Range on Protein: 1045-1071
Range on HMM: 208-234/234
Sequence Identity: 59% (16 aa)

TKELVEEQKKSDVLLYRMLPKTVAEKL
..|| || ||.| ||| |.||.||..|
HRELEEEKKKTDDLLYSMFPKSVANRL