Gene gcy-2 (Nematode worm)

gcy-2

Species: Nematode worm
Alias: R134.2, CE25080, gcy-2, aSWK299
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 9511999-9507508, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 228 Kinase domain by global Sugen HMM Fasta, JSON
gcy-2.AA Protein Genbank 1118 None Fasta, JSON

Protein domain

Protein domains of gcy-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-2.AA ANF_receptor 56-435 19 2.7e-66 231.38 Pfam 1-364 (364) Show / Hide 
Range on Protein: 56-435
Range on HMM: 1-364/364
Sequence Identity: 19% (78 aa)

VCGGAVPMAIERLREFGYVKDFDFEFIVDYTEC----DQGSVVRAGIEFIKTHKVDVIIGPPCAQALRVMSFLAENYKKPVLGWGFVSDTDLSD--VIRF
 |..|..||||..   . . ...... .....|    |    | |. .... ..|..|||| | .. . .. .|. ...|...|| .... |.|   .|.
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWG-CTCPCLTDKAKNRY

PYLTTVIPNSLML-GYAASKMLTV-YNWGRVAMLYYYSDIKYCSGV---MNDVEATFNNPSTPNVNI--VIKAEIYLNDNETTDIVFQS-VKSRARIIFW
||.. ..|..... |.|.....   ..| .||..|. .| .|. |.   |.... ... .  ..|..  | . . . .| .. . . .  .|..||.|..
PYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVM

CTQTAIE---KRDYLIKIATHDMIGDEYVHIMLSMRNIAFGAQTSLGKPTFSQSGLTPIWESFTEGTDDFEKMVKQAATRMFVLDVNSEVADKKYLDYLQ
|.. .     .| ...... . | ...||.|. .. . ... | .                      || ...  ..|  ... .    . .... ...|
CCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W-------------------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQ

KNIMKAVQSPPMNCSTVECMTANTTIMGGYARQLFDVVYLYGVALTNTNSTDPAVYDDV---------DVIVPQFV-TSFQGMTGKVVISPNLTRMPIFQ
.. .                  ..| | .|| ...| ||||. || |....||.....          ...      ..|.|.|| |..  |  |.| ..
RWKK------------------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYM

LYGLNSD
.. .| |
YWIMNWD
Kinase gcy-2.AA RGC 587-770 30 9.7e-92 311.09 In-house 1-239 (300) Show / Hide 
Range on Protein: 587-770
Range on HMM: 1-239/300
Sequence Identity: 30% (73 aa)

EKEMVLTAKYQYT----HLTK--ADKERFVKMRKLDHENINRFIGLSIDSA------HFIAVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEY
|...|.. |....    |..   ...  . .||.|.|.|.|.|||..||.       ... |...||||||||||......|| .|... |||..||..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMD----------------------NLV-EEQTPPKKRLLWVAPEVLRGSLSVSQME---------PSAD
||. ..| ||||.|..|.|...|.||.. .|.                       ..  ....| .|..|| |||.||.... .|..         ...|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIIASEILTKKEAWDIL-----------DRKEDCE
.|||.||..||.|.|..||.            ...|. |
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIE
Kinase gcy-2.AA RGC 587-770 30 9.7e-92 311.09 In-house 1-239 (300) Show / Hide 
Range on Protein: 587-770
Range on HMM: 1-239/300
Sequence Identity: 30% (73 aa)

EKEMVLTAKYQYT----HLTK--ADKERFVKMRKLDHENINRFIGLSIDSA------HFIAVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEY
|...|.. |....    |..   ...  . .||.|.|.|.|.|||..||.       ... |...||||||||||......|| .|... |||..||..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMD----------------------NLV-EEQTPPKKRLLWVAPEVLRGSLSVSQME---------PSAD
||. ..| ||||.|..|.|...|.||.. .|.                       ..  ....| .|..|| |||.||.... .|..         ...|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIIASEILTKKEAWDIL-----------DRKEDCE
.|||.||..||.|.|..||.            ...|. |
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIE
Kinase gcy-2.AA TKL 606-797 18 2.4e-29 102.81 In-house 72-364 (364) Show / Hide 
Range on Protein: 606-797
Range on HMM: 72-364/364
Sequence Identity: 18% (56 aa)

KERFV-KMRKLDHENINRFIGLSIDSAH-------------FIAVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFL-------RLHG
.|. .  |..|.|.|| .|.| .... .             .  |. .|..||| ..|           .. ...|.|.|..|||            .| 
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHR

NLRSATCLVNDSWQ--------------VKLAEYGMDNLVEEQTP-----------------------PKKRLLWVAPEVLRGSLSVSQME---------
.| |. .||.. |.              .|.. .|    ... .                        .   . | |||||||..  ..           
DLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGF

---PSADIYSFAIIASEILTKKEAWD-----------------ILDRK--------------------EDC-EALIALVKDCWAEVPEDRPTAENICSQM
   ...|.|||.|.  |||| .. ..                 ... .                    .|| . .. | .|||.. ||.||... | ...
EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase gcy-2.AA TKL-Unique 612-757 25 1.5e-20 69.28 In-house 49-225 (290) Show / Hide 
Range on Protein: 612-757
Range on HMM: 49-225/290
Sequence Identity: 25% (46 aa)

MRKLD-HENINRFIGLSI----DSAHFIAVTKLCSRGSLQDILS---------RGNFSMDYFFMFCIIRDVAKGLEYLHKTFL-RLHGNLRSATCLVNDS
| ||. |.|| ...| ..    . .... |.  |..||| | |.         . |  ...  .  ...|.|.|..||| .    .|..|.|   ||.  
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

-----WQVKLAEYGMDNLVE-EQTPPKKRL------------LWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKK
     |..|..  |   .   . . .....            .|.||||||..   .|   ..|.|||.|.  ||.| |
SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIATRK
Kinase gcy-2.AA RGC 771-799 46 1.1e-13 44.58 In-house 271-300 (300) Show / Hide 
Range on Protein: 771-799
Range on HMM: 271-300/300
Sequence Identity: 46% (14 aa)

ALIALVKDCWAEVPEDRPT-AENICSQMKG
.|..|..||||| ||.||. ...|..|.|.
CLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-2.AA RGC 771-799 46 1.4e-13 44.58 In-house 271-300 (300) Show / Hide 
Range on Protein: 771-799
Range on HMM: 271-300/300
Sequence Identity: 46% (14 aa)

ALIALVKDCWAEVPEDRPT-AENICSQMKG
.|..|..||||| ||.||. ...|..|.|.
CLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-2.AA DRK 612-755 33 2.3e-13 41.68 In-house 51-197 (258) Show / Hide 
Range on Protein: 612-755
Range on HMM: 51-197/258
Sequence Identity: 33% (51 aa)

MRKLDHENINRFIGLSIDSAHFIAVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLH-KTFLRLHGNLRSATCLVNDSWQVKLAEYGMDN--
| .| | ||  |.|    .     ..   .||||  ||     .||   |  .  |.|||. |||  .   .|  | |   || ..|||| | .|     
MCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRF

-LVEEQTPPKKRL---LWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILT
  .....  .       |.||||||   .    |  ||.|||||.  |..|
KKHKQHKFAMTMCGTPCWTAPEVLR---NQRYTE-KADVYSFAIVLWECVT
S_TKc gcy-2.AA S_TKc 558-798 16 3.7e-10 -28.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 558-798
Range on HMM: 1-231/231
Sequence Identity: 16% (42 aa)

LQSAPSISTGHSGVTTVSDFCENYTMMMYEKEMVLTAKYQYTHLTKADKERFVKMRKLDHENINRFIGLSIDSAHFIAVTKLCSR--GSLQDILSRGNFS
 .    |  |  |.       .           .   |       .. .|. . ..  .|.|| ....   |  |.  |. .|.   |.| |.. . .  
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----MDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQTPPKKRLLWVAPEVLRGSLSVSQMEP-SADIYSFAII
     ..     .... ....|||.|.    .|  |  .  |...  ..|..  |.  ..   |     . ..|||||       .  . ..|..|. .|
GLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

ASEILTKKEAWD----ILDRKEDCEALIALVKDCWAEVPEDRPTAENICS--------QMK
  | |. .  ..    ....    . .. ... |.   ||.||||  .          .  
LYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gcy-2.AA TK 611-706 13 9.3e-10 28.09 In-house 93-297 (486) Show / Hide 
Range on Protein: 611-706
Range on HMM: 93-297/486
Sequence Identity: 13% (28 aa)

KMRK---LDHENINRFIGLSIDS------------AHFIAVTKLCSRGS----LQDILS--RGNFS----------------------------------
|| .   ..|.|| |..| . ..             ... |. ... |.    |.| |   |..|.                                  
KMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNS

---------------------------------------MDYFFMFCIIRDVAKGLEYLHKTFLR-----LHGNLRSATCLVNDSWQ-----------VK
                                       ..   .  . ...|.|.||||.   .      |..|    |||... .           .|
PCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

LAEYGM
.| .|.
IADFGL
TyrKc gcy-2.AA TyrKc 583-797 18 2.4e-09 -71.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 583-797
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

MMMYE---------------------KEMVLTAKYQYTHLTKADKERFVK----MRKL--DHENINRFIGLSIDS-------AHFIAVTKLCSRGSLQDI
  . .                     | .   |           .| | .    |.||  .|.|| |..|  ...            |. ... |.|.| 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

L--SRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGM--DNLVE-------EQTPP----KKR----LLWVAPEVLR
|  .|....|. .  ||.  ..|.| ||||.  .  |  |    |||..  .|| .  |.  |   .       .   .     ..    . | |||...
LRKHRPKLCMKDLLSFCW--QIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GS------------------LSVSQMEPSADIYSFAIIASEILTKKEAWDILDRKED--------C-EALIALVKDCWAEVPEDRPTAENICSQM
 .                  ..  |. .. .|    . ..|.. . .. . ... ..        | ...  . |.||.| |||||| ..|....
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase gcy-2.AA TESK 612-693 31 1.1e-08 23.04 In-house 47-127 (292) Show / Hide 
Range on Protein: 612-693
Range on HMM: 47-127/292
Sequence Identity: 31% (26 aa)

MRKLDHENINRFIGLSIDSAHFIAVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLV
| || | || || |  .   .  |.|   . |.| ..|.  .  .          |.|.|. |||.     |  | |. |||
MNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLAYDIARGMSYLHSKGV-FHRDLTSKNCLV
Kinase gcy-2.AA TK 763-797 20 3.3e-08 22.82 In-house 437-486 (486) Show / Hide 
Range on Protein: 763-797
Range on HMM: 437-486/486
Sequence Identity: 20% (10 aa)

LDRKEDCE--------------ALIAL-VKDCWAEVPEDRPTAENICSQM
. . ..|               .....  ..||.. |||||| . . .|.
MPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase gcy-2.AA UTK 612-706 23 2.5e-07 21.15 In-house 63-174 (296) Show / Hide 
Range on Protein: 612-706
Range on HMM: 63-174/296
Sequence Identity: 23% (27 aa)

MRKLD-HENINRFIGLSIDSAHFIAVTKLCSRGSLQDILSRGNFSMD----YFF---MFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDS-------
| ... |.|. |..|.  ..  .. || ....|.|.. | |   . .    ..    . |  .|.| |..|||   .  |..|    |||...       
MKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCM

WQVKLAEYG---M
...|.| .|   |
MVCKIADFGRGGM
Kinase gcy-2.AA MLK 613-677 25 2.8e-07 21.47 In-house 60-142 (291) Show / Hide 
Range on Protein: 613-677
Range on HMM: 60-142/291
Sequence Identity: 25% (21 aa)

RKLDHEN----INRFIGLSIDS-AHFIAVTKLCSRGSLQDILSRGN-------------FSMDYFFMFCIIRDVAKGLEYLHK
|.|.|.|    | .| | ....  ||  |.  |. ||| ..|  ..             . .|  ... .  ..|.|..|||.
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS
Kinase gcy-2.AA Pkinase 612-677 28 4.7e-07 26.03 Pfam 54-126 (293) Show / Hide 
Range on Protein: 612-677
Range on HMM: 54-126/293
Sequence Identity: 28% (21 aa)

MRKLDHENINRFIGLSIDSAHFIAVTKLCSRG----SLQDILS---RGNFSMDYFFMFCIIRDVAKGLEYLHK
|..|.|.|| |...   |. |   |. .|  |    .| |..|   .|.|....    .... ...||||.|.
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS
Kinase gcy-2.AA Pkinase 722-797 17 9.1e-07 25.01 Pfam 177-293 (293) Show / Hide 
Range on Protein: 722-797
Range on HMM: 177-293/293
Sequence Identity: 17% (21 aa)

WVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDIL-----------DRKEDC-------------------------------EALIALVKDC
..||||.|   . .   |..|..|. .|  | |...  ..              ..  .                               |... ..|.|
YMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WAEVPEDRPTAENICSQ--M
..  |..||||| |.    .
LCKDPKKRPTAEQILQHPWF
Kinase gcy-2.AA UTK 775-797 39 5e-06 16.49 In-house 274-296 (296) Show / Hide 
Range on Protein: 775-797
Range on HMM: 274-296/296
Sequence Identity: 39% (9 aa)

LVKDCWAEVPEDRPTAENICSQM
|...||.  |..||..| . .||
LMHRCWHYDPQERPDFEDLVQQM
Kinase gcy-2.AA Pkinase_Tyr 612-676 25 6e-06 20.88 Pfam 57-128 (270) Show / Hide 
Range on Protein: 612-676
Range on HMM: 57-128/270
Sequence Identity: 25% (18 aa)

MRKL-DHENINRFIGLSI-DSAH--FIAVTKLCSRGSLQDILSRG---NFSMDYFFMFCIIRDVAKGLEYLH
|..| .|.|| |..|  . .. .   . |. ..  |.| | | .    . . .   . .. ...|||.|||.
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase gcy-2.AA Dicty5 616-705 26 1.1e-05 15.53 In-house 56-149 (260) Show / Hide 
Range on Protein: 616-705
Range on HMM: 56-149/260
Sequence Identity: 26% (25 aa)

DHENINRFIGLSIDSAHF-IAVTKLCSRGSLQDILSRGNF----SMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYG
|| |. |. |           || .|..||| . |          . ||    .  |.|.....||      |  | |   |..  |..|.  .|
DHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNI-IHRDLKSMNFLITENWKIKIIDFG
Kinase gcy-2.AA MLK 775-797 34 0.00011 12.32 In-house 269-291 (291) Show / Hide 
Range on Protein: 775-797
Range on HMM: 269-291/291
Sequence Identity: 34% (8 aa)

LVKDCWAEVPEDRPTAENICSQM
| |.|| . |..||.   | .. 
LMKQCWNQDPHKRPSFRQIVQHL
Kinase gcy-2.AA DRK 773-799 33 0.000121 11.69 In-house 232-258 (258) Show / Hide 
Range on Protein: 773-799
Range on HMM: 232-258/258
Sequence Identity: 33% (9 aa)

IALVKDCWAEVPEDRPTAENICSQMKG
|.| .||| | |  ||. . .   .  
IQLMNDCWNEDPQHRPSMQECLERLEA
Kinase gcy-2.AA Pkinase_Tyr 777-797 52 0.000165 15.89 Pfam 250-270 (270) Show / Hide 
Range on Protein: 777-797
Range on HMM: 250-270/270
Sequence Identity: 52% (11 aa)

KDCWAEVPEDRPTAENICSQM
|.||.. |||||| . | .|.
KQCWHYDPEDRPTFSEIHEQL
Kinase gcy-2.AA TESK 722-753 46 0.000206 9.35 In-house 202-229 (292) Show / Hide 
Range on Protein: 722-753
Range on HMM: 202-229/292
Sequence Identity: 46% (15 aa)

WVAPEVLRGSLSVSQMEPSADIYSFAIIASEI
|.||||||| .   .    ||..|| |.  ||
WMAPEVLRGEWYDEK----ADVFSFGIVLCEI
Kinase gcy-2.AA Dicty5 775-801 33 0.000248 10.81 In-house 234-260 (260) Show / Hide 
Range on Protein: 775-801
Range on HMM: 234-260/260
Sequence Identity: 33% (9 aa)

LVKDCWAEVPEDRPTAENICSQMKGLV
|.| || . |  ||.   ||  .. ..
LIKKCWQQKPHNRPSFKEICKYFESII
Kinase gcy-2.AA Dicty5 741-761 47 0.000798 9.04 In-house 184-204 (260) Show / Hide 
Range on Protein: 741-761
Range on HMM: 184-204/260
Sequence Identity: 47% (10 aa)

ADIYSFAIIASEILTKKEAWD
.|.|||.|.  |..|.||. |
CDVYSFGIVLWEMFTRKEPYD
Kinase gcy-2.AA TKL-Unique 775-797 30 0.00317 7.44 In-house 268-290 (290) Show / Hide 
Range on Protein: 775-797
Range on HMM: 268-290/290
Sequence Identity: 30% (7 aa)

LVKDCWAEVPEDRPTAENICSQM
| ..||.  |..||. ..| .  
LIQQCWHHDPSQRPSFDEIIHRL
Kinase gcy-2.AA MLK 722-758 26 0.003462 7.06 In-house 199-234 (291) Show / Hide 
Range on Protein: 722-758
Range on HMM: 199-234/291
Sequence Identity: 26% (10 aa)

WVAPEVL-RGSLSVSQMEPSADIYSFAIIASEILTKKE
| ||||. .  .  ..   ..|..|....  |.||...
WMAPEVIQQ--FRCEKYSEKCDVWSWGVVLWEMLTREV
CYCc gcy-2.AA CYCc 836-1032 41 6.4e-103 349.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 836-1032
Range on HMM: 1-231/231
Sequence Identity: 41% (96 aa)

LEKKKADILLSRMLPKQVAERLKAGQ-TVEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHG-----VYKVESIGDGYLCVSGL
 ||.|.| || .|||. ||..||.|. .|.|. .|.||. |.|.| || |.|.|.|.|.||.|||.|..||.||..||     .|||| |||.| .|||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PTRNG-------------------YAHIKQIVDMSLKFMEYCRSFKIPHL----PRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGK
||||.                   ..|...|.|..|. .| ...|...|     | ... .|||...||.|.||||. |||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PSLIHLTSDAHLLL-----LTHYPNHYDTSS
|  ||........|      .. ....... 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc gcy-2.AA Guanylate_cyc 863-1051 42 1.2e-98 338.85 Pfam 1-214 (214) Show / Hide 
Range on Protein: 863-1051
Range on HMM: 1-214/214
Sequence Identity: 42% (92 aa)

VEPEGFDSVTVFFSDVVKFTILASKCS----PFQTVNLLNDLYSNFDTIIEQH--GVYKVESIGDGYLCVSGLPTR-----NGYAHIKQIVDMSLKFMEY
|... .|.||..|.|.| || ..|.||    |.| |..|||.|..||....||  |.|||. ||| |.|||||| .     ....|. ...||.|..|||
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

CRSFKIPHLPREN-----VELRIGVNSGPCVAGVVG--LSMPRYCLFGDTVNTASRMESNGKPS--LIHLTSDAHLLLLTHYPNHYDT--SSRGEVIIKG
|... ..|..||.     ...|||...||.||||.|  ..|||||..|||||.||||||.|.|.   ||..  .. .| .|..  ...  ..|||. .||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGV---METFWVHG
||    |||...||
KGKMGEMETYFLHG
HNOBA gcy-2.AA HNOBA 823-857 51 5e-07 26.97 Pfam 200-234 (234) Show / Hide 
Range on Protein: 823-857
Range on HMM: 200-234/234
Sequence Identity: 51% (18 aa)

LEEEIEERTKELTLEKKKADILLSRMLPKQVAERL
| ...|. ..||  |||| | ||  |.||.||.||
LKDKLEQMHRELEEEKKKTDDLLYSMFPKSVANRL