Gene gcy-23 (Nematode worm)

gcy-23

Species: Nematode worm
Alias: CE26010, T26C12.4, aSWK292, gcy-23
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 3289796-3282887, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-23.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 281 Kinase domain by global Sugen HMM Fasta, JSON
gcy-23.AA Protein Genbank 1139 None Fasta, JSON

Protein domain

Protein domains of gcy-23.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-23.AA ANF_receptor 99-459 18 2.4e-52 185.01 Pfam 1-364 (364) Show / Hide 
Range on Protein: 99-459
Range on HMM: 1-364/364
Sequence Identity: 18% (71 aa)

NAEKILQLSKEQLTQEGV-LGNDFDIEILNQMGC--GESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVAKMATFWNIPVVGYMASSNSFAD--KTIFK
...  ...  |.. ...  |. ......  .  |   ..  .||.... .| .|| |.|||.| .. ..||..|. ||||.... ... .. |  |. ..
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TLARVSLRTTNSLAEAAAALIKH-YGWNKVAIATNTGAV--AFER---VQSFEEVFHQRGINVVRK--IMLEEYTNAKAIMNSGLLQE-LENSARVVVCA
...|.  . |. ...|....|.| .||..||.  . ..     .    .. |.......|.|.|..   .  .... ...  .  ... .. .|||.|. 
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMC

FSSTRD--MNKEFMQAVTLSGMNNANYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDNTLVTPFKERLEASGYSTDDLEMKNIYG
.....   .....||..   ||..  |.||. .. ... ||  | .. ... .    . ....... .  . .. .  | .|. .      . .  |.|.
CYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W-WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK------TDTEMNYYA

YIHLYDALRLYALAVRATMNETGNENSYL------NGKEVWNHMRR-ITFPGLVSNAGVTSGTVMMDDIAERAPVYAAFYVPPN
. ..|||  ||| |.... ....|    .      .|. . ..|.  ..|          .|.|..||   | | |   .. ..
A-YAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNF-------EGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase gcy-23.AA RGC 602-872 34 3.2e-124 418.99 In-house 1-300 (300) Show / Hide 
Range on Protein: 602-872
Range on HMM: 1-300/300
Sequence Identity: 34% (105 aa)

TNTHASFHLYPQR---RPIVFNRQDLQLLNQMKQAVHDNLNPFLGMSFNEKEE-----MVVLWKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLGLEY
..... .. ..||   |.. |.|.....|.||.|..|||||.|.||......|     |...|..||||..|| ..| ....|..|...|||||. |..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWV--KQSQARRQM
||.| |.|||.|..|.|..|..|..|.||.|..|||..|.| | |... .| .|||| . |...  |..... .. | .| .||...|   .|.| ..| 
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP-CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQK

GDIYAFGMVMHEILFRALPF---PNGTN----VSEVMDYIRD--------GTKTFRPTVHDRT-----QIHPDLVALLLDCWNENPEVRPS-IRRVRLNT
||.|.||..|.||..|  |.   |.. .     .. |..|..        |.|.|||..|. .     ...|.|..|. |||.|.||.||. ....|.. 
GDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQL

EN
..
KT
Kinase gcy-23.AA RGC 602-872 34 3.2e-124 418.99 In-house 1-300 (300) Show / Hide 
Range on Protein: 602-872
Range on HMM: 1-300/300
Sequence Identity: 34% (105 aa)

TNTHASFHLYPQR---RPIVFNRQDLQLLNQMKQAVHDNLNPFLGMSFNEKEE-----MVVLWKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLGLEY
..... .. ..||   |.. |.|.....|.||.|..|||||.|.||......|     |...|..||||..|| ..| ....|..|...|||||. |..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWV--KQSQARRQM
||.| |.|||.|..|.|..|..|..|.||.|..|||..|.| | |... .| .|||| . |...  |..... .. | .| .||...|   .|.| ..| 
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP-CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQK

GDIYAFGMVMHEILFRALPF---PNGTN----VSEVMDYIRD--------GTKTFRPTVHDRT-----QIHPDLVALLLDCWNENPEVRPS-IRRVRLNT
||.|.||..|.||..|  |.   |.. .     .. |..|..        |.|.|||..|. .     ...|.|..|. |||.|.||.||. ....|.. 
GDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQL

EN
..
KT
Kinase gcy-23.AA TKL 683-862 18 1.4e-18 63.57 In-house 137-356 (364) Show / Hide 
Range on Protein: 683-862
Range on HMM: 137-356/364
Sequence Identity: 18% (45 aa)

FIRDITLGLEYLHSSII-------GYHGSLTPWSCLIDRNWM--------------IKLTDYGIANPLERWEKLGLISTETL-----KEGDDKSGSAQKT
...|| .|..||||..          |  |..  .|.|.||               .|..|.|..  ... ..   ..| .      .   .|  . |  
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCG

SLLYQPPEMLKNKE------SNRTRRMDQSWVKQSQARRQMG----------DIYAFGMVMHEILFRALPFPNGTNVSEV------MDYIRDGTKTFRPT
.. . .||.|....      ..                 .            |.|.||.|. ||| | .|. .  . ...      .. . .. |  ||.
TPRWMAPEVLRGQMNYTEKVGI----------------DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPP

V----------HDRTQIHPDLVALLLDCWNENPEVRPS
.           . ... |..  |. |||...|| |||
IPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPS
Kinase gcy-23.AA TKL-Unique 658-870 20 1.7e-15 51.23 In-house 81-290 (290) Show / Hide 
Range on Protein: 658-870
Range on HMM: 81-290/290
Sequence Identity: 20% (48 aa)

FCSRGTIQDMIY---------NQEVSLDSKFHGAFIRDITLGLEYLHSSI--IGYHGSLTPWSCLIDRN-----WMIKLTDYGIANPLERWEKLGLISTE
.|..|.  | .          |..  |. .    ...|| .|..|||...  | .|. |.. . |.|.|     | ||. | |..  . .      |...
YCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSK------INKM

TLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRAL------PFPNGTNVSEVMDYIRDGTKTFRPTV
|..|     ..  ..|... .||.|.. .                 . .  |.|.||.|. ||. | .      |.  | .  ..   ...  . .||..
TNNEHKGTRNQTRCGSFRWMAPEVLRMNF---------------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY-QGMDQEQWCEMVHYMEENYRPPI

HDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNT
 ..  . ...  |. .||. .|. |||   ..   
PNH--CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase gcy-23.AA TK 793-870 20 1.4e-11 34.29 In-house 376-486 (486) Show / Hide 
Range on Protein: 793-870
Range on HMM: 376-486/486
Sequence Identity: 20% (23 aa)

DIYAFGMVMHEILFRA-LPFPNGTNV---------SEVMDYIRDGTKT-----------FRPT--VHDRT---------QIHPDLVAL-LLDCWNENPEV
|...|| .|.||. ..  |.. | .           |||.|.|.| ..           .|.   .|            . .|..... ...||...|| 
DVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPED

RPSIRRVRLNT
||. . ..   
RPTFSQLHEQL
Kinase gcy-23.AA LRRK 793-862 29 4.4e-10 31.86 In-house 264-341 (351) Show / Hide 
Range on Protein: 793-862
Range on HMM: 264-341/351
Sequence Identity: 29% (23 aa)

DIYAFGMVMHEILFRA-LPFPN--GTNVSEVMDYIRD-GTKTFRPTVH----DRTQIHPDLVALLLDCWNENPEVRPS
|.|.|||...|.| |  .|| .  .  ... |  |.|  ..  |||.      ..|  ... .|. .||...|. ||.
DCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPH
S_TKc gcy-23.AA S_TKc 572-874 14 2.1e-09 -39.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 572-874
Range on HMM: 1-231/231
Sequence Identity: 14% (48 aa)

NEMKSMLSIGSSKTKMSNMSMF------VKHHAVVGTNTHASFHLYPQRRPIVFNRQDLQLLNQMKQAVHDNLNPFLGMSFNEKEEMVVLWKFCSR--GT
 |.   .  |.  . .            .|                         |. .|.| .     |.|.  ....  .  ... .   .|.   |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD

IQDMIYNQEVS-----LDSKFHGAFIRDITLGLEYLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQKTSL
  |.| ..        ..      ... | ..|||.||  |  |  | |   |.|.   ||..| |.|  |                      . .  ..
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTP

LYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPE
 | .||.|                   .  .   |....| .. | | .  |||   .. .... |.                 |..  ..  |.. .||
WYMAPEVL-------------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPE

VRPSIRRVRLNT-----ENYL
 ||..  .  .        ..
KRPTA-EALQDEWDIKCHPWF
Kinase gcy-23.AA Axl 793-868 30 2.3e-09 29.07 In-house 197-267 (267) Show / Hide 
Range on Protein: 793-868
Range on HMM: 197-267/267
Sequence Identity: 30% (23 aa)

DIYAFGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRL
|..|||. | ||  |      | . .|. ||...| .   |      .   .| .|.  ||. .|. |||   .|.
DVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQP-----EDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase gcy-23.AA TAK1 793-862 30 2.4e-09 27.62 In-house 207-277 (284) Show / Hide 
Range on Protein: 793-862
Range on HMM: 207-277/284
Sequence Identity: 30% (22 aa)

DIYAFGMVMHEILFRALPFPNGTN---VSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPS
||| .| .| |.. | .|.    |   . . |  |  |..  .|    |  . . .  .   ||..||| |||
DIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNR--PPMETNRSDCPKRIEQFMKCCWDDNPEKRPS
Kinase gcy-23.AA RIPK 793-870 23 5.3e-09 26.78 In-house 210-290 (290) Show / Hide 
Range on Protein: 793-870
Range on HMM: 210-290/290
Sequence Identity: 23% (20 aa)

DIYAFGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPD------LVALLLDCWNENPEVRPSIRRVRLNT
|.| |..|| |.| .  |. . ..    |  .  |    || . . ..  |       .. |. .||  .|..||. . ..  |
DVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGH---RPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase gcy-23.AA RAF 793-870 26 1.3e-08 25.61 In-house 199-275 (275) Show / Hide 
Range on Protein: 793-870
Range on HMM: 199-275/275
Sequence Identity: 26% (21 aa)

DIYAFGMVMHEILFRALPFPNGTNVSEVMDYIRDG-TKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNT
| |||| |. |.. ...|. .  ..  .   .  |  . .|. .  | |.  ..  ||..||. .|| ||| ...    
DVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKA--RVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase gcy-23.AA Pkinase 793-864 14 2e-06 23.56 Pfam 194-285 (293) Show / Hide 
Range on Protein: 793-864
Range on HMM: 194-285/293
Sequence Identity: 14% (13 aa)

DIYAFGMVMHEILFRALPFPNG-----TNVSEVMDYIRDGTKTFRPTVHDRTQ---------------IHPDLVALLLDCWNENPEVRPSIR
|....| ...| |.. .|||.       .  .... |...   |     ..                 .....  .. .|.. .|. ||...
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE
Kinase gcy-23.AA TyrKc 624-874 14 4e-06 -124.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 624-874
Range on HMM: 1-280/280
Sequence Identity: 14% (46 aa)

LQLLNQ-------------------------------------MKQA--VHDNLNPFLGMSFNEK------EEMVVLWKFCSRGTIQDMI-YNQE-VSLD
..|. .                                     |..    |.|.  ..|    ..      | . ..  ... |  .| . .... ....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

SKFHGAFIRDITLGLEYLHSSIIGYHGSLTPWS----------CLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSA--QKTSLL---YQ
 . .  |  .|  | |||||                       ||...|  .| .| | .  ..   . |        ..| .. .   .. ..|     
DLLS--FCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGGKTMLPIRWM

PPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRALPFPNG-----TNVSEVMDYIRDGTKTFRPTV-----HDRTQIHPDLVALLLD
.|| .. .. .                    |...|| .| ||. .  . . |      . .||. |...|    .|             ....  . ..
APECINYGKFT-----------------TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQ

CWNENPEVRPSIRRVRLNTENYL
||.|.|| ||. . .      ..
CWHEDPEDRPTFSEI----HECF
Kinase gcy-23.AA TK 624-726 11 0.082044 0.99 In-house 86-298 (486) Show / Hide 
Range on Protein: 624-726
Range on HMM: 86-298/486
Sequence Identity: 11% (24 aa)

LQLLNQMKQAV-----HDNLNPFLGMSFNEK-----------EEMVVLWKFCSRGT----IQDMIY-NQEVSLDSKFHGA--------------------
|.... ||.       |.|.  ..| .. ..           | . ..  ... |      .|    . .   ..  ...                    
LEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDIT

-----------------------------------------------------FIRDITLGLEYLHSSII-----GYHGSLTPWSCLIDRNWM-------
                                                     . ..|  |.|||||  .       |. |    ||...|         
YSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDG

----IKLTDYGIA
    .|..|.| .
CGPVCKIADFGLS
CYCc gcy-23.AA CYCc 908-1111 42 1.4e-100 341.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 908-1111
Range on HMM: 1-231/231
Sequence Identity: 42% (98 aa)

EANVRADKLLGQLLPKYVANELKMGR-SVPAKTFDMATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHG-----SYKVETIGDAYMIVSGI
... ..|.|| |.||..|||.|| || .|.....|..|..|.||||||..|| .||..|| ||| .|..||..| .||      |||||||||||.|||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PEENG-------------------NEHIRNICNTALELMLLLKTYEIPHR----RNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSE
|..|.                    .|...|.. ||. .  .||....|.    .. .||.| |||||.|..||||...||||.||||||.|||||||..
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PEKIQMSQEARDFCVRYYSEFQITLRGTVEAKG
| .|..|.|. .       .|.   .|..| ..
PGQIHVSEETYWCL-CLD-QFERRRCGQFEFEP
Guanylate_cyc gcy-23.AA Guanylate_cyc 935-1122 39 1.7e-76 265.23 Pfam 1-214 (214) Show / Hide 
Range on Protein: 935-1122
Range on HMM: 1-214/214
Sequence Identity: 39% (85 aa)

VPAKTFDMATVMFSDIVGFTTICSSST----PLEVVSMLNSIYSKFDDAINKH--GSYKVETIGDAYMIVSGIPEE-----NGNEHIRNICNTALELMLL
|.|. .|  |.||.|||||| .|| ..    |...|.||| .|..||. ...|  | |||.||||.||.|||.|..     ..  |.. ... ||..| .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

LKTYEIPHRRNVK-----LRIRLGIHTGTVAAGVVG--LTAPRYCLFGDTVNVASRMESTSEPE--KIQMSQEARDFCVRYY-SEFQI--TLRGTVEAKG
...  ..|          ...| |||||.| |||.|  .  ||||..|||||||||||||..|   ||..|.|. .   ...  .|..  . || .. ||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGP---VTSYWLLG
||.   .. |.| |
KGKMGEMETYFLHG