Gene jkk-1 (Nematode worm)

jkk-1

Species: Nematode worm
Alias: CE24941, F35C8.3, aSWK317, jkk-1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 5337574-5341167, WormBase Genetic Map location: n/a,

Classification

Group: STE
Family: STE7
Subfamily: MEK7

Sequence

Name Sequence Type Origin Length Description Download
jkk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
jkk-1.AA Protein Genbank 435 None Fasta, JSON

Protein domain

Protein domains of jkk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase jkk-1.AA MEK7 122-385 57 1.3e-201 676.13 In-house 1-269 (269) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-269/269
Sequence Identity: 57% (154 aa)

IHIISLLGSGSCGVVESATVRS--KLMAVKTMYKNDNKENLKRILRDVRIMSMCN-SPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFP
.|.|...|.|||| |     .|    ||||.|....|||..||||.|...|.||. .|.||...||||.||.|.|||..||.||.|||.||.|.||||.|
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTI--ETNSKYDVRSDVWSLGITVYQL
|...|..|...|.||.||||||.|.|||.||||||.|..||.|||||||||.|.||.||..|||||.||||||...  ..|.|||.|.||||||||...|
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

VTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFY
.||.||.|..||||...|.|.|.||..|.|.|..|..|||.|..|.|.||.||.|.||.||.||.|.|.
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase jkk-1.AA STE7 122-385 42 1.2e-142 480.24 In-house 1-288 (288) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-288/288
Sequence Identity: 42% (124 aa)

IHIISLLGSGSCGVVESATVRS--KLMAVKTMYKNDNK-ENLKRILRDVRIMSMCN-SPFIVTSYGYFMFDSS--VKICMQIMS-ACCEKLLRRIYHS--
...|. ||.|..|||. .  .   |.||||... ..|. |  |.||... .. .|| .|.||. ||.|. . .  ..|||  |.  |..|...|...   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--KLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSM-AHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSL
  | ...||.. |.|... |..|.||.|||.|||||.|||||| . .|.||||||||.| ..||| |.....||.|||||||..  ....||||||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG-NKQHYDVRSDVWSL

GITV-YQLVTGLYPFPLNDM-----------------EFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMK-HDFY
|||  ....|| ||.| ...                 .|. ||.| | | |.| |      .||| |..| ..||.|| .||| |.|||| |.|.
GITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNEN-PPPRLP-----KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase jkk-1.AA STE 122-385 26 4.6e-92 312.16 In-house 1-359 (359) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-359/359
Sequence Identity: 26% (98 aa)

IHIISLLGSGSCGVVESATVR-----------------SKLMAVKTMY----------------KNDNKENLKRILRDVRIMSMCN--SPFIVTSYGYFM
  .|. .|.|..|.|  |  .                  ..||.| |                 .|.|.|....||....||. ||  .|.||. ||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

FD-------SSVKICMQIMSA-CCEKLLRRIYHSKL---------DFFPEFVAGHIVYSAISA-LDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGIS
 .       ... |||  |.. ........ |  .          ..||| . ..|... . . |.|| ..| ||||||||.|||.     |||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GFMTDSMA----------------HS-KSAGCPPYMAPERLTIET---NSKYDVRSDVWSLGITVYQLVTGLYPFPL-NDM--EFTTLTIIANLN-----
| .|||||                ..   .|.| .||||... ..   ...||...|.||||.|.  ..|| .|.   ..|   | ... ..  .     
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----LPSPSLREETK---------------RSFSPLFIEFLDLCLRKDVRERPEYRQLMK--HDFY
     |.|.| ....               ...|| |..|...||.|| ..|| . ||.|  | | 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase jkk-1.AA MEK4 122-385 39 6.8e-86 280.32 In-house 1-275 (275) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-275/275
Sequence Identity: 39% (109 aa)

IHIISLLGSGSCGVVESATVRS--KLMAVKTMY--KND-----NKENLKRILRDV-RIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYH
   ....| |. |.|   . .   |.||||      .|     .||  || |...  .|   | | ||  ||         |||  |.    |. ...| 
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKE-QKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYM

SKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNS-KYDVRSDVWSLG
 . .  || . ||| .  . ||.||||.| |||||.|||||| | .|.||||||||.|   ||.| .. ||| |||||||.. | |. .||.||||||||
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

ITVYQLVTGLYPFPLND--MEFTTLTIIANLNLPSPSLREETK-RSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFY
|| | . || .|..  .    |  .... .    .| | .. . ...|. ...|  .||.|| ..|| | .| |..||
ITMYEVATGKFPYRKWNDASVFDQICMVVKGD--PPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase jkk-1.AA MEK3 122-385 41 2.1e-70 238.63 In-house 1-264 (264) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-264/264
Sequence Identity: 41% (112 aa)

IHIISLLGSGSCGVVESATVR--SKLMAVKTMYKNDNKENLKRILRDVRI-MSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFP
.  |. || |  |.|.    |     |||| .    |    ||.| |  | |     |. |. ||       | ||| .|. |  |. |. |  .  . |
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNS-KYDVRSDVWSLGITVYQLV
| . | |  | .||| |..|. ..||||.||||.|    | ||.|||||||. .||||    ||| |||||||   |.|.  |||.|||||||||.  . 
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFY
.| ||.      |  |. .     |.| | .|.   ||| .  |   ||.|.  |||.| .||.| | 
IGRYPYDNWHTPFQQLKQV--VEEPPPQLPMEK--GFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase jkk-1.AA S_TKc 122-385 25 3.3e-70 240.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

IHIISLLGSGSCGVVESATVRS--KLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSA---CCEKLLRRIYHSKLDF
 .|. ..|.|. |.|  .. ..  ...|.| .         ..|.| ..|... . |.||. |..|   ... ..|  ..       .....  . .|.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDV-RSDVWSLGITVY
 ||| .| ...|  ..||.|. ..  |||||.||.|||.|.  ..|.||||.. ..      .   | | ||||| |      .|.  ..|.||.|...|
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILY

QLVTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMK-------HDFY
 ...|  |||    ..... .|                  || ...|.. ||.|| ..||   ....       | . 
EMLCGYPPFP---QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase jkk-1.AA STE7-Unclassified 122-385 32 1.1e-64 221.2 In-house 1-301 (301) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-301/301
Sequence Identity: 32% (99 aa)

IHIISLLGSGSCGVVESATVRS--------KLMAVKTMY-KNDNKENLKRILRDVRIMSMCN-SPFIVTSYGYFMFDSS---VKICMQIMSACCEKLLRR
..... ||.|. |.|. .            | || |.    ... |  | ||| . .   |. .|.||. ||..  . .   ..|||  |      ..  
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

IYHSKLD-------FFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSM--AHSKSAGCPPYMAPERLTIE--TN
||   .         .||.| | |.|. | .|.||.||| ||||||||.||| .  |.||.||||..|   ...  | .  .||  ||.|||.  .    
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

SKYDVRSDVWSLGITVYQLVTGLYPFP-------LNDM-------EFTTLTIIANLNLPSPSLRE--ETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMK
  | |.||.||||.|   ..|| ||..       .|.        ... |..|  .| |.| | .  |   ..|. |. | . |. |. |||| ..|| .
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCI--VNFPVPRLPDDPE-DIIWSKEFMDFISKCCKKHPRERPDIHQLLN

-HDFY
 |.. 
EHPWI
Kinase jkk-1.AA Pkinase 122-385 26 2.3e-49 175.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

IHIISLLGSGSCGVVESATVRSK--LMAVKTMYKNDNKENLKRILR---DVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSAC--CEKLLRRIY---H
.||.. .|||| |.|  .. ..   . |||.. | ..|.. ....|    ..|| ..|.|.||. |..|. .... ..|  .     .  | ..|    |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNV----KLCDFGISGF--MTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSD
 ..  |.| .. ...|  ...|.|. . ..|||||.||.|||.|. |..    |.||||.. .     .   .  .| |.|||||   | ....|. ..|
GCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVD

VWSLGITVYQLVTGLYPFPLND----MEFTTLTIIANLNLPSPSLREETKRSFS-----------------PLFIEFLDLCLRKDVRERPEYRQLMKHDF
.||.|...|....|  ||| ..       . . .|..   | ..  .....| |                 . ...|.. ||.||  .||  .|...|..
MWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

Y
 
F
Kinase jkk-1.AA MEK1 122-324 36 4.4e-48 162.18 In-house 1-197 (297) Show / Hide 
Range on Protein: 122-324
Range on HMM: 1-197/297
Sequence Identity: 36% (76 aa)

IHIISLLGSGSCGVVESATVR-SKLMAVKTMYKNDNKENLKR-ILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIM-SACCEKLLRRIYHSKLDFFP
.. |. ||.|  |||  .  | . ..  . . . . |  ... |.|.....  ||||.||  || |. |  . |||  |     . .|...        |
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRIP

EFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVT
| . |..    .  | ||..|| |.|||.||||||   .| .||||||.|| . |||| |   |   ||.||||   . . | |.||.||.|. .  .. 
EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL---QGTHYTVQSDIWSMGLSLVEMAI

GLYPFP
| || |
GRYPIP
Kinase jkk-1.AA STE20 122-385 29 2.4e-47 163.59 In-house 1-288 (288) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-288/288
Sequence Identity: 29% (85 aa)

IHIISLLGSGSCGVVESATVR--SKL----MAVKTMYKNDNK----ENLKRILRDVRIMSMCNSPFIVTSYGYFMFD----SSVKICMQIMSA-CCEKLL
  ..  .|.|| |.|  |. .   ..     |.| | . ...    . .. |.  ..||. |..| ||. || .. |    ..  |.|  ... ..  ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKM-NLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

RRIYHSKLD----FFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTD----SMA--HSKSAGCPPYMAPERLTIET
.. .  .       . |     | . .  .|||| ..| |||||||  ||| ...|.|||.||| .. .|.    .|.       | | .|||| .  ..
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH-IIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

N--SKYDVRSDVWSLGITVYQLVTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETK-RSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFY
.  ..|| ..|.||||||   ...|  |. ..   .  .  |.. . |.| |... | ...|| | .|.|.|| ||. .||   ||.|| | 
GPDKGYDYKCDIWSLGITAIEMAEGEPPY-FDMHPMRAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase jkk-1.AA Ciliate-E2 122-385 20 1.8e-46 157.5 In-house 1-365 (365) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

IHIISLLGSGSCGVVESATV-------------------------RSKLMAVKTMYKN--DNKENLKRILRDVR----------IMSMCNSPFIVTSYGY
. .| ..|.|. |.|  ..|                          .|. |.|.| ||   .... ..|.| ..          |..  |.|.|.  | .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FM--FDSSVKICMQIMSACCEKLLRRIYHSKLDF---------FPEFVAGHIVYSAIS---------------ALDYLKEKHSIIHRDIKPSNILFDDSG
|    |... . |   .     |. .|...|. .         | |. ...| .  ..               || ||..|..||||||||.||||    
FQEKDDNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NVKLCDFGISGFMTDS--------------------------------MAHSKSAGCPPYMAPERLTIETNSK------YDVRSDVWSLGITVYQLVTGL
 .|..|||.| . .|.                                . .   .| |.||||| |  . ...      ||  .|.||||.. |....| 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPFPLNDMEFTTLTIIA--NLNLPSPSLREETKR----------SFSPLFIEFLDL----CLRKDVRERPE-YRQLMKHDFY
.||         . .|   ....|.|  ... .           . |.  . ..      .| ||  .|.  . |...| . 
PPF---------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase jkk-1.AA MEK5 122-385 32 1.3e-44 154.49 In-house 1-254 (254) Show / Hide 
Range on Protein: 122-385
Range on HMM: 1-254/254
Sequence Identity: 32% (88 aa)

IHIISLLGSGSCGVVESA--TVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPE
|     || |  | |  |      |..||| .  .   |  |.|. .. |.  | ||.|.  || |  .  . ||   |      . |.|        ||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRCI--------PE

FVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTG
 . | .  . .  | || .   |.|||.||||.|    |..||||||.|  . .|...    |   ||||||.  .   .| . |||||||| .  . ||
HILGRMTVAIVKGLNYLWNLK-IMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGD---QYGIHSDVWSLGIFFMEMATG

LYPFPLNDMEFTTLTIIANL----NLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFY
 .|.|  . .   |  |. |    .  .| |  .    ||  |..|.  |..|  ..||. ..||.| | 
RFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDK---FSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase jkk-1.AA TyrKc 122-384 20 4e-13 -10.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 122-384
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

IHIISLLGSGSCGVVESATVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMC--NSPFIVTSYGYFMFD-------SSVKICMQIMSA-CCEKLLRRIYH
|. .  ||.|  |.|  .| .    |||.. ..     .. ..|  |||..   . | ||  ||. . .         . | |  |.  .. . ||.  .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDS--------MAHSKSAGCPP------YMAPERLTIETN
     ..     .. . . .  .|| .|  .||||.   |.| .. . || .||| | . .|         . ..|. ..         |||| .     
K----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NY

SKYDVRSDVWSLGITVYQLVTGLYPFPLNDME--FTTLTIIANLNLPSPSLREETKRS--------FSPLFIEFLDLCLRKDVRERPEYRQLMKHDF
.|.   ||||| |.. . . |   . . .. .   .   .|...       | .   .         ..   .    | . |  .||  ... ...|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG---YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase jkk-1.AA MEK1 351-385 45 2.4e-07 20.59 In-house 263-297 (297) Show / Hide 
Range on Protein: 351-385
Range on HMM: 263-297/297
Sequence Identity: 45% (16 aa)

KRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFY
.| ||  |..| | ||.|   || . .||| | | 
HRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase jkk-1.AA Pkinase_Tyr 231-314 30 2.3e-05 18.78 Pfam 122-205 (270) Show / Hide 
Range on Protein: 231-314
Range on HMM: 122-205/270
Sequence Identity: 30% (27 aa)

SALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFM--TDSM--AHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVY
....|| .|. .||||.   |.| .... || |||| .  .  .|    .....    . ||||   | ..  . . ||||| |.. .
KGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE--CINYGK-FTTKSDVWSFGVLMW
Kinase jkk-1.AA Pkinase_Tyr 122-183 26 0.000515 14.22 Pfam 1-71 (270) Show / Hide 
Range on Protein: 122-183
Range on HMM: 1-71/270
Sequence Identity: 26% (19 aa)

IHIISLLGSGSCGVVESATVR------SKLMAVKTMYKNDNKEN---LKRILRDVRIMSMC-NSPFIVTSYG
|...  ||.|. |.|  .| .          |||.. |..  .    ..  .| ..||.   . | ||  ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYG