Gene let-23 (Nematode worm)

let-23

Species: Nematode worm
Alias: ZK1067.1, let-23, CE25678, aSWK334, kin-7
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 9197422-9207112, WormBase Genetic Map location: II:1.05393,

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
let-23.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
let-23.AA Protein Genbank 1367 None Fasta, JSON

Protein domain

Protein domains of let-23.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain let-23.AA Recep_L_domain 109-237 33 2.4e-41 140.75 Pfam 1-121 (121) Show / Hide 
Range on Protein: 109-237
Range on HMM: 1-121/121
Sequence Identity: 33% (47 aa)

GCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKS-INFFDNLEEIRGSLIIYRA--NIQKISFPRLRVIYGDEVFH--DNALYIHKNDK--VH
.|...||||||||.. ...                   |..  .|| |..||.|.|.|||     . . ||.||.|.|...||    ||||..|..    
NCTVIYGNLEITWRDEHNE-------------------LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQ

EVVMRELRVIRN--GSVTIQDNP--KMCYIGDKIDWKELL
|  |..|..|..  |.| |..||  |.||   .|.|....
ELWMWNLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like let-23.AA Furin-like 258-413 31 9.9e-69 225.98 Pfam 1-182 (182) Show / Hide 
Range on Protein: 258-413
Range on HMM: 1-182/182
Sequence Identity: 31% (59 aa)

GKSMA--------KCHESC-------NDK-CWGSGDNDCQRVYRSVCPKSCS--QCFYSNSTSSYECCDSACLGGCTGHG-PKNCIACSKYELDGICIET
.....        .||..|       ... |||.....||.....|||..|.  .|..   ..  |||.. |||||||.. ...|.|| ..  .|.| ..
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTG---PKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQ

CPSRKIFNHKTGRLVFNPDGRYQN-GNHCV--KECP--------PELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICT
|| ..|.|..|.....||||.||  | .||  ||||        ....|.|. |.|.|. |.. . ......||.|.   |||.|.
CPPMMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCE-GPCPKVCY
FU let-23.AA FU 303-345 29 3.2e-10 41.19 SMART 1-48 (48) Show / Hide 
Range on Protein: 303-345
Range on HMM: 1-48/48
Sequence Identity: 29% (14 aa)

SYEC--CDSACLGGCTGHGPKNCIACSKYELD---GICIETCPSRKIF
. .|  |.. |..||.|.|| .|..|... .    |.|...||.   .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU let-23.AA FU 251-298 21 0.144614 0.94 SMART 1-48 (48) Show / Hide 
Range on Protein: 251-298
Range on HMM: 1-48/48
Sequence Identity: 21% (12 aa)

HQHCYQNGKSMAKCHESCNDKCWGSGDNDCQR--VYRSV-----CPKSCSQCFYS
 ..|       ..||..| . |||.|...|.    ...      | ..|.. .| 
DGVC-------KPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain let-23.AA Recep_L_domain 428-535 32 2.3e-40 137.43 Pfam 1-121 (121) Show / Hide 
Range on Protein: 428-535
Range on HMM: 1-121/121
Sequence Identity: 32% (39 aa)

GCEQIDGHLIIEHAFTY----EQLKVLETVKIVSEYITIVQQ-NFYDLKFLKNLQIIEGRKLHNV-RWALAIYQCDD--LEELSLNSLKLIKT--GAVLI
.|..|.|.|.|.  ...    | | ...... ...|..| .  |. .|.|..||.||.||.|..  ..||.|| ...  |.|| . .|| | .  | | |
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGVYI

MKNH--RLCYVSK-IDWSSII
 .|.  .|||.   |.|..|.
HNNPHPKLCYTHTEIMWWMIY
FU let-23.AA FU 554-603 28 1.7e-09 38.76 SMART 1-48 (48) Show / Hide 
Range on Protein: 554-603
Range on HMM: 1-48/48
Sequence Identity: 28% (15 aa)

SKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSV---GTCVEKCDTKGFL
.. |    . |. .|   ||||  |..|..|.....    ||||..|  . . 
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like let-23.AA Furin-like 561-581 36 0.347966 4.5 Pfam 40-64 (182) Show / Hide 
Range on Protein: 561-581
Range on HMM: 40-64/182
Sequence Identity: 36% (9 aa)

Q----RVCDKNCNKRGCWGKEPEDC
|    .|| ..|..|.| |  | .|
QTLTKKVCPEQCKHRRCTGPKPGEC
FU let-23.AA FU 608-658 32 4.1e-12 47.48 SMART 1-48 (48) Show / Hide 
Range on Protein: 608-658
Range on HMM: 1-48/48
Sequence Identity: 32% (17 aa)

SMKCERCSPECET-CNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFP
. .|..|.|||.| |.| |. .|..|.|  . ...     .||..|| ...|
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN----GTCVSQCPPGYYP
FU let-23.AA FU 661-725 25 3e-06 28.21 SMART 1-48 (48) Show / Hide 
Range on Protein: 661-725
Range on HMM: 1-48/48
Sequence Identity: 25% (17 aa)

KNVCEKCHPTCYDNGCTGPDSNLGYGGCKQC-KYAVKYENDTIFCLQSSGMNNVCVENDLPNYYIS
..||..|||.| . ||.||.     . |. | .. .. .|            ..||. . |  |  
DGVCKPCHPECAT-GCWGPG----PDQCTSCPHGYYLHHN------------GTCVS-QCPPGYYP
FU let-23.AA FU 734-785 25 6.7e-10 40.13 SMART 1-48 (48) Show / Hide 
Range on Protein: 734-785
Range on HMM: 1-48/48
Sequence Identity: 25% (14 aa)

ETHCEKCSISCKT-CSSAGRNVVQNKCV-CKHVEYQPNPSERICMDQCPVNSFM
...|..|. .|.| |...|    ...|. |.|  |....  ..|..||| ... 
DGVCKPCHPECATGCWGPG----PDQCTSCPHGYYLHHN--GTCVSQCPPGYYP
Furin-like let-23.AA Furin-like 760-780 33 0.497817 3.99 Pfam 84-99 (182) Show / Hide 
Range on Protein: 760-780
Range on HMM: 84-99/182
Sequence Identity: 33% (7 aa)

VCKHVEYQPNPSERICMDQCP
.|.|. .     . .|.||||
ACRHFYH-----NGTCVDQCP
FU let-23.AA FU 791-841 29 1.8e-10 42.02 SMART 1-48 (48) Show / Hide 
Range on Protein: 791-841
Range on HMM: 1-48/48
Sequence Identity: 29% (15 aa)

NTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSECPKNLPF
..|||.||.||.   .|     . |..|... .....  .|||.|| .  .
DGVCKPCHPECAT--GCWGPGPDQCTSCPHGYYLHHN-GTCVSQCPPGYYP
Kinase let-23.AA EGFR 929-1186 51 7e-177 592.02 In-house 1-258 (258) Show / Hide 
Range on Protein: 929-1186
Range on HMM: 1-258/258
Sequence Identity: 51% (134 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF--QTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENL
.|..|.||.||||||..||..|. ..||||||||||.  ||......|||.||..|....|..|....|.|||.. ...||.|.|.|.|..... ||.|.
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNI

GAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIIT
|.......|.|||.||||||..|.||||||.||||||..|||.||||||.|.|.||........||..|||.|.|.....||||.||||..||||||..|
GSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMT

FGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFK
|||.||.|.....|...|..|.||.|||.|..|.|.....|||.|...||.|..|||.||
FGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase let-23.AA TyrKc 929-1185 36 1.4e-120 407.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-280/280
Sequence Identity: 36% (105 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRL--RHDNLLKIIGFCMHD-------DGLKIVTIYRPLGNLQNFL
 .|.|||| ||||.|. |...        |.||.|. . |     ....||  | .|  .|.|.....| |...       . | ||. | |.|.|...|
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHD------ADSITIK---SGK--VAIKWLAIEIFSKHCY
. |...|  .. . .|.|||.||.||......|||||.||.||.. ..| |.|||||. ...|       | .. |   .||  . |.|.|.| . ....
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

THASDVWAFGVTCWEIITFGQSPYQG-----MSTDSIHNFLKDGNRLSQPPN--------CSQDLYQELLRCWMADPKSRPGFEILYERF
|..||||.|||..||| |.||.|| |     || . .....|.|.|. ||||        |....||  ..||..||..|| |. ..|.|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase let-23.AA Pkinase_Tyr 929-1185 37 2.1e-118 401.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-270/270
Sequence Identity: 37% (102 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF--QTDQSQ--TDEMLEEATNMFRL-RHDNLLKIIGFCM-HDDG--LKIVTIYRPLGNLQNFLK
 ...||||.||||.|. |....   .| |||||.|.   .....|   .....||  |  | .|.|... .| |. ...   . ||. | |.|.| ..|.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

LH---KENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS-ITIKSGKVAIKWLAIEIFSKHCYTHASDVWA
 |   |..|   . . .|.|||.||.||| .. .|||||.||.||.. |.| |.||||.. . .|     . ..||. |||.| | ..   .|..||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVTCWEIITFGQSP-YQGMSTDSIHNFL-KDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERF
|||..|||.|.|..| |.|||   . ... .||.|. .|.||....|. ...||..||. || |. ..|..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase let-23.AA TK 929-1185 20 4.6e-97 325.94 In-house 1-486 (486) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-486/486
Sequence Identity: 20% (99 aa)

TKLDKKLGAGAFG---TVFAGIYYPKR--------------------AKNVKIPVAIKVFQ--TDQSQTDEML---------------EEATNMFR---L
 .| ||||.|.||   .|. |......                     ...|.|||.|.    ...||.....                |.  |..   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHDNLLKIIGFCMHDDG------------LKIVTIYRPLGN----LQNFLKLHKEN--------------------------------------------
.|.|.....| |.....            . ||. | |.|.    |...|. ....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGAREQVLYCYQIASGMQYLEKQ------RVVHRDLATRNVLVKKFNH-----------VEITDFG---
                               |  .... .|.|||.||.||...      ..||||||.||.|| . |.           . |.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKILKHDADSITIK------------------------SGKVAIKWLAIEIFS---------KHCYTHASDVWAFGVTCWEIITFGQSPYQG-M
     |.. . .| |  . .                        .||. |.|.| | .          .. .|..||||.|||..||| |.|| || | |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

ST---------DSIHNFLKDG--------------NRLSQPPNCSQ-------------DLYQE-LLRCWMADPKSRPGFEILYERF
|          . . ..|..|              .|. |||.|.              ..|.. ...|| .||. || |. |.|..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase let-23.AA UTK 929-1185 31 5.4e-82 278.72 In-house 1-296 (296) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-296/296
Sequence Identity: 31% (92 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ---TDQSQTD---EMLEEAT---NMFRLR-HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNF
..| ..||.||||.|. . . . .    .  ||.|| |   ..| . .   . .|||.    | ... | |.|. .| |. . .. ||| | . |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LKLHKENLG-------AREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKK-------FNHVEITDFG---LSKILK---------HDADSITIKSGK
|  |.....        .... ....||.|||||. ...|||||| ||.|| .       .. . | |||   .|. ..          .  .     ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VAIKWLAIEIFSKH-CYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDG--NRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERF
..|.| | |.. .|  .|..||||.|||.|||| |.|. || |||.. .  .. .|   |. .|. |. ..|. ..|||..||  || || |....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase let-23.AA Src 929-1185 36 1.2e-75 256.42 In-house 1-255 (255) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-255/255
Sequence Identity: 36% (96 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLK--LHKENL
 || .|||.| || |. |..      | ...||.|.   .. ...  |.||  |  |||..|...   |  ..   ||| |   |.|. .||      .|
IKLCRKLGQGQFGEVWMGYW------NGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

GAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSG-KVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEII
  ....    |.|.||.|||.....||||| ||||| . | . . |||| ...|.| |  . ..| |. ||| | | .. ...|  |||| ||.  .||.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

TFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQE-LLRCWMADPKSRPGFEILYERF
|.|. || ||.       .. | |. .|.|| . ||.. .|.|| .||. || ||.|.. .
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase let-23.AA Fer 929-1186 31 5.6e-71 240.93 In-house 1-283 (283) Show / Hide 
Range on Protein: 929-1186
Range on HMM: 1-283/283
Sequence Identity: 31% (89 aa)

TKLDKKLGAGAFGTVFAG-----IYYPKRAKNVKIPVAIKVFQTDQSQTD---EMLEEATNMFR-LRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL
 .|.|||| ||||.|. |     .. .|.. ..|..|. |   .. ....   |.. ||  |   . |.|  |..|.| ..  . ||  . . |.|...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KLHKE-NLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVE---ITDFGLSKILKHDADSITIK--SGKVAIKWLAIEIFSKHCYTHASD
|  |. ..  .| . .|||.|.||.||... ..|||.| ||.|. | ...    |.|||.|. .. .  . . |  . || |.||| | ... .|....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWAFGVTCWEIITFGQSPYQG----MSTDSI-----HNFLKDGNRLSQPPNCSQDLYQELL-RCWMADPKSRPGFEILYERFK
||.|||.|||| | |. || |    |    .      .  |.|...  |...  ...| .. .|| .||. || .  .....|
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase let-23.AA Frk 930-1189 36 3.2e-68 232.97 In-house 2-260 (260) Show / Hide 
Range on Protein: 930-1189
Range on HMM: 2-260/260
Sequence Identity: 36% (96 aa)

KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLK---LHKENL
.| ..||.| || |. | .      |...|||.|  ..     ...| ||  | .|||  |...   |  .. . |.|     | ||..|.    . ...
QLIRRLGSGQFGEVWEGLW------NNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQC

GAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDAD--SITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEI
  ...|    |.|.|| |||.|  .||||| ||||| . | . | |||| ..|. |      .    .. ||| | |    . .|  ||||.||.   ||
QMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEI

ITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFC
||.|. || ||    . . .. | |. ||||| | ||. .| || .||. || || |  ..... 
ITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase let-23.AA TK-Unique 929-1185 29 2.8e-66 226.49 In-house 1-294 (294) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-294/294
Sequence Identity: 29% (88 aa)

TKLDKKLGAGAFGTVFAGIYYPKR-AKNVKIPVAIKVFQTDQSQTD--EMLEEATNMFRLR-HDNLLKIIGFCMHDD-GLKIVTIYRPLGNLQNFLK---
 ......| ||||.|. | . ..    . .. ||.|  . . ..||  ..| |.  |  |  | |.....| |. .|    |.  | | ||||..|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-LHKEN---------------------LGAREQVLYCYQIASGMQYLEK--QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITI-KSGKVAI
  ....                     .  .  . ...|||.||.||..  ...|||||..||||.   . . |.|||... . .. . ... ..|.. |
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWLAIEIFS--KHCY-THASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNC-SQDLYQELLRCWMADPKSRPGFEILYERF
.|.| |...  .. | |  ||||.|||. ||| |.|. || ||. ..| . ..|| |. ||..| |...|. . .||  .|..|| |. .  |.
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase let-23.AA Abl 930-1185 36 7.9e-65 215.03 In-house 2-252 (252) Show / Hide 
Range on Protein: 930-1185
Range on HMM: 2-252/252
Sequence Identity: 36% (93 aa)

KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLK-LHKENLGA
 . .||| | .| |. |..     |  .  ||.|  . |. . .| |.||  |  ..| || ...| | ..    |.| . . ||| ..|.   .|.| |
MMKHKLGGGQYGEVYEGVW-----KRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPA

REQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSG-KVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITF
   .    ||||||.||||.  .||||| || ||   . | . ||||....| |    | . | |  ||| | |    . .   ||||||||  ||| |.
VVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDT--YTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATY

GQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERF
| ||| |.    . . | .| |. .|. | .. |. ...||  ..  || |. . ...
GMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase let-23.AA Syk 929-1179 35 5.1e-63 215.69 In-house 1-257 (257) Show / Hide 
Range on Protein: 929-1179
Range on HMM: 1-257/257
Sequence Identity: 35% (92 aa)

TKLDKKLGAGAFGTVFAGIYYPK--RAKNVKIPVAIKVFQTDQSQ---TDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK
. .|. .| | ||.|  | |  |      . |.||||.   | .|   ..|.. ||  | .| |    . || | |   .  |    .|| .  .|. |.
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGIC-HAEMMMMVMEMAELGPMHKYLQQHR

ENLGAREQVLYCY-QIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKS-GKVAIKWLAIEIFSKHCYTHASDVWAFGVTC
.   |.  .   . |.|.|| ||| .  |||||| ||||        | |||.|| |  | .  . .. ||  .|| | | . .    |.|||| |||| 
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFE
||    || || .|.   .  |.. | |...|. | |..||   .||  ... ||.| 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase let-23.AA Src-Echino1 929-1185 36 7.2e-61 208.54 In-house 1-252 (252) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-252/252
Sequence Identity: 36% (94 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKEN-LG
 ..|||.| | .| |. |..      |   |||.|  .       ..| ||  | ..||.....|   |   . . |||     ||||..||  |   . 
LRMDKKIGKGHCGEVWKGVW------NGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVK

AREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITF
  . .    .|||||.||... ||||||| ||||| | | . | |||| .....|     .   |. ||| | |      .|  ||||.||.   |..||
MTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQ-GAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTF

GQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQE-LLRCWMADPKSRPGFEILYERF
|. ||.|| .  . . .. | |. .. .|.  ||.  ...||  ||. || || |.. |
GRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase let-23.AA S_TKc 929-1186 20 2.7e-38 134.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 929-1186
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPL--GNLQNFLKLHKEN-
 .. .|.| ||||.|. ..         .  ||||.        . .. |   . . .|.|. |..... . | | .|. | .   |.|  ..| .. . 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTH-ASDVWAFGVT
    .   .   |.|||.....|. .....||||   |.|. .  |. |.||||...|         ..  .   ..| |..    |.. ..|.|..|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

CWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILY-------ERFK
 .| .. |. |..    . . . ..           |... . . .|.  ||. ||. |.|          . 
LYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase let-23.AA Pkinase 929-1185 20 4e-28 100.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 929-1185
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)

TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIP--VAIKVFQTDQSQTDEMLE------EATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLG----NLQ
 .. .|.|.|.||.|       ....... .  ||.|..  . .. .....      |.  | ||.|.| ........ .| . .|. | . |     | 
YHIGRKIGSGSFGCV-------YKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

NFLK--LHKEN-LGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHV----EITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS-KHCY
 ...   |.   .  .|   |.|||..|..|. .....||||   |.|... .|.     |.||||.| ..    .   ..  . . ..| |.      |
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

THASDVWAFGVTCWEIITFGQSPYQGM----STDSIHNFLKDGN---RLSQPPNCS-------------------QDLYQELLRCWMADPKSRPGFEILY
....|.|..|....| .. |. |..|     . | .. . ...    . . |  ||                   ... . . .|.  |||.||..| . 
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

ER--F
.   |
QHPWF