Gene lin-2 (Nematode worm)

lin-2

Species: Nematode worm
Alias: F17E5.1a, aSWK049, lin-2, CE27131
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 12417754-12417755, WormBase Genetic Map location: X:7.002,

Classification

Group: CAMK
Family: CASK

Sequence

Name Sequence Type Origin Length Description Download
lin-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
lin-2.AA Protein Genbank 965 None Fasta, JSON

Protein domain

Protein domains of lin-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase lin-2.AA CASK 17-281 45 8.49999999999e-197 644.67 In-house 1-330 (330) Show / Hide 
Range on Protein: 17-281
Range on HMM: 1-330/330
Sequence Identity: 45% (151 aa)

LSIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTG-----LGFEEIDEEIRICQNLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQR
.....|.|.|||..|.|..|..||..........|.|.||.|     |..|.|..|.|||..|.||.||.|..|.||.|.|...||.|||||.|||||||
YYMCQVMEKGPFCHVRRCIHRESNQHCVVKIVDVNKFTQHPGGFGIALPTEDIKREARICHCLKHPHICELCRTYNSDHMRYMVFEFMEGNDVCFEIVQR

----ASNGFVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDT-------------------------------------SAPLKLCGFGV
    |..|||.||||..||.||.|.||.|||.....|||||||..|.||||.                                     |||.|||||||
GLGPAKAGFVYSEYVACHYMRQILEALMYCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGV

AKDLSEIG------------------GSMACGRVGVPQFMAPEIVRKDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQTDVDVDG-YMPNIS
|..||...                  ..|||||||.|.|||||.||.....|..|||..||.||.||.|.|||.|......|.||....|.|. |.|.||
AIQLSHKFTSFYSDPNTKHITDFADEDPMACGRVGCPHFMAPEVVRREPYGCPCDIWGCGVMLFILLSGCLPFFGTKDRLFEMIMKGRYDMDPRYWPHIS

ESARNLVRRMLNADPSKRISAKEALNHEWI
|||..||||||.|||..|||..|||||.||
ESAKDLVRRMLMADPHHRISIYEALNHPWI
Kinase lin-2.AA CAMK 22-281 18 8.4e-80 256.68 In-house 1-425 (425) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

VIEQGPFSNVYRILHGPSN------------RKFLLRSINLNLFRQH-----------------------TGLGFEEIDEEIRICQNLQ-------HPYI
.. .| |. |..  |  ..            .|.    |. .  . .                       ..   ...  ||.|...||       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CRLEKTINSVHY-------------------RHIIF---ENMEGNDICFEIVQRASNG---------------FVFSEYVVSHYTRQLLDALDYCHTRKI
..|  .. . ||                    ....   | ..| . .... ..                   . |.|  ...| ||...|..||| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDVRPHNLVLASKDTS--------------APLKLCGFGVAKDLSEIG----------------------GSMACGRVGVPQFMA-PEIVRK------
||||  | |. | .....              ...|.. || |. . .                        | .   ..| | .|| ||....      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------DRVSCSSDIWSSGVVLFLLLAGRLPFSGST--------------SDIYERIMQTDVD-VDGYMPN------------ISES--------ARN
        . .. ..|.|| ||.|. .| |..|| |..              ....|.||. . |  . |...            ||..        ...
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVRRMLNADPSKRISAKEALNHEWI
|.|.||. ||.||......|||.|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase lin-2.AA S_TKc 17-281 27 6.8e-74 252.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-281
Range on HMM: 1-231/231
Sequence Identity: 27% (77 aa)

LSIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLGFEEIDEEIRICQNLQHPYICRLEKTINSVHYRHIIFENMEG--NDICFEIVQRASN
  | ..| .| |. ||.  |  ..|.. .  |.            | |  ||.|... .||.|..|  .. . .. ....| ..|   |    |..| ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G--FVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIGGSMACGRVGVPQFMAPEIVRKDRVSC-SSDIWSS
|  |.|.| .. .|..|...||.||| ..|.|||. | |. | .      .|.| ||.|. |           .| | .||||..     .. ..|.|| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLFLLLAGRLPFSGSTSDIYERIMQTDVDVDGYMPNISESARNLVRRMLNADPSKRISAKEALN-------HEWI
|..|. .|.|. ||.     ....|.             |..|....|..|. ||.||..| |||.       |.|.
GCILYEMLCGYPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase lin-2.AA Pkinase 67-281 29 3.9e-52 184.3 Pfam 50-293 (293) Show / Hide 
Range on Protein: 67-281
Range on HMM: 50-293/293
Sequence Identity: 29% (72 aa)

EIRICQNLQHPYICRLEKTINSVHYRHIIFENMEGN----DICFEIVQ-RASNGFVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLA-SKDTS
||.| ..|.||.|.||  .  .  . ....| .||     | . .... .....| ||| .. .| .|.| .|.||| ..|.|||. | |. .    ...
EIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHID

APLKLCGFGVAKDLSEIGGSMACGRVGVPQFMAPEIVR-KDRVSCSSDIWSSGVVLFLLLAGRLPFSGS-------TSDIYERIMQTDVDVDGYMP----
|..|.| ||.|| ...  .| . ...| | .||||..|     . ..|.|| |..|. .| ||.||.|.          ...|||..... | . .    
ACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSIS

--------------NISESARNLVRRMLNADPSKRISAKEALNHEWI
              |.||... .....|. ||.||..|...|.|.|.
YFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase lin-2.AA Ciliate-E2 62-281 20 8.6e-52 176.05 In-house 61-365 (365) Show / Hide 
Range on Protein: 62-281
Range on HMM: 61-365/365
Sequence Identity: 20% (66 aa)

EEIDEEIRICQ----------------NLQHPYICRLEKTIN--SVHYRHIIFENMEGNDICFEIVQRASNGF-------VFSEYVVSHYTRQLLD----
|.|  ||.|..                .|.||.|...  .    . ..  ...|  .|.|    | ..  . .        |.|. ......|.|.    
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKT

-----------ALDYCHTRK-IVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEI----------GGSMACG---------------------RVGVP
           || |.| .. |.|||  | |...        .|.. || .|....           .  |  .                      .| |
KAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTP

QFMAPEIVR---------KDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQTDVDVDGY---------------MPNISESARNLVRR----M
 .|||||..         . . . ..|||| ||.|. .| |..||       .. |.| ..| . .                 ..|... .| ..    |
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM

LNADPSKRIS-AKEALNHEWI
|. ||.|||. ....|||.|.
LQKDPEKRITGWEQILNHPWF
Kinase lin-2.AA CAMK2 18-281 32 3.6e-47 158.06 In-house 2-259 (259) Show / Hide 
Range on Protein: 18-281
Range on HMM: 2-259/259
Sequence Identity: 32% (87 aa)

SIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLGFEEIDEEIRICQNLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFV
 . . . .| || | | ..  .   .  . ||    .. .   .  .. | |||  |.|| | ||   |.   . ...|. . | ..  .|| |      
QLFEELGKGAFSVVRRCVKKCTGQEYAAKIINT---KKLSARDHQKLEREARICRKLKHPNIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVARE----Y

FSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIGGSMACGRVGVPQFMAPEIVRKDRVSCSSDIWSSGVVLFL
.||   ||  .|.|.....|| ..|||||..| ||.||||   |  ||  ||.| .. . .     |  | | ...||..|||  . . |||  ||.|..
YSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEV-QGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYI

LLAGRLPF-SGSTSDIYERIMQTDVDVDG-YMPNISESARNLVRRMLNADPSKRISAKEALNHEWI
|| |  ||       .|..|     |        .   |.||. .||  .|.||| |.||| | ||
LLVGYPPFWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI
Kinase lin-2.AA CAMK-Unique 63-281 23 1e-46 152.14 In-house 62-363 (363) Show / Hide 
Range on Protein: 63-281
Range on HMM: 62-363/363
Sequence Identity: 23% (71 aa)

EIDEEIRICQNLQHPYICRLEKT----INSVH---------------YRHIIFENMEGNDICFEIVQR-----------------ASNGFVFSE--YVVS
. ..|..| . . || | .|. .                        | .|. |  .|.|   .|...                  ..| .|||  . ..
KLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQG-HFSERCWDTC

HYTRQLLDALDYCHTRKIVHRDVRPHNLVLASK--D-----------TSAPLKLCGFGVAKDLSEIGGS-MACGRVGVPQFMAP--------------EI
 . ..|| |. | |  .|||||  . |... .   |               .||| || ......   . |   ..| | .|||              |.
FIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEV

VRKDRVSCSS----DIWSSGVVLFLLLAGRLPFSGSTSD---------IYERIMQTDV-DVDGYMPNI----SESARNLVRRMLNADPSKRISAKEALNH
.  .. .. .    |||| ||.....| |..|| ....|         |.|.|.. |. ..|  | ..    |..| ..| . .. ||..|.||||.| |
INMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEH

EWI
.||
QWI
Kinase lin-2.AA CAMK1 117-281 30 2.4e-44 126.78 In-house 104-276 (276) Show / Hide 
Range on Protein: 117-281
Range on HMM: 104-276/276
Sequence Identity: 30% (54 aa)

VFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLK--LCGFGVAKDLS-EIGGSMACGRVGVPQFMAPEIVRK---DRVSCSSDIWS
...|   .|  .|.|.|. |.| . |||||  | || ...||  ...|  .. || .| .. ...  .   ..| | ..|||..     .  . . |.||
NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN--LMKTACGTPGYVAPEVLECKKDKPYDKACDMWS

SGVVLFLLLAGRLPFSGST--SDIYERIMQTDVDVDGYMP---NISES-ARNLVRRMLNADPSKRISAKEALNHEWI
 ||... || |  || ...  . ..| |.  ... .  .|   |||.. | .... ||. ||.||......||| ||
IGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFP--SPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase lin-2.AA CAMKL 67-281 27 7.7e-44 137.7 In-house 62-297 (297) Show / Hide 
Range on Protein: 67-281
Range on HMM: 62-297/297
Sequence Identity: 27% (67 aa)

EIRICQNLQ---HPYICRLEKTINSVHY------RHIIFENMEGND--ICFEIVQRASNGF-VFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVL
||.| . |.   || |..|  .|    .       ... |  .| .    |. ...  ..   ..|    .| ||...|..||| ..|||||  | |. |
EIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDL-FDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL

ASKDTSAPLKLCGFGVAKDLSE--IG-GSMACGRVGVPQFMAPEIVRK--D-RVSCSSDIWSSGVVLFLLLAGRLPFSGSTS-----DIYERIMQTDVDV
 ... .  .|.. || .    .  .| | .   . | | .|||||. .  .       |||| ||.|. .. |.||| . |      | . . .  .   
DENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG

DGYMP---NISESARNLVRRMLNADPSKRISAKEALNHEWI
 .|.|    .| ..|.| |.||. .|.||..... .||.| 
-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase lin-2.AA RSK 66-281 25 2.3e-42 147.09 In-house 49-278 (278) Show / Hide 
Range on Protein: 66-281
Range on HMM: 49-278/278
Sequence Identity: 25% (59 aa)

EEIRICQNLQ-HPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTS-APL
.|..| .  | || |..|  .     . ..| | ..| .    . .. . |  |||  .. | ...  |... |...|.|||  | | ...... . . .
TERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG-CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHI

KLCGFGVAKDLSEIGGSMACGRVGVPQFMAPEIVR---KDR-VSCSSDIWSSGVVLFLLLAGRLPFSG----STSDIYERIMQTDVDVDGY-MPNISESA
||. || .| ..   ....   ..  ..||||...   ...  . . |.|| ||... .|.|..|| |    . ..| .||.. . ....   ...|. |
KLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEA

RNLVRRMLNADPSKRIS-----AKEALNHEWI
..|.|.||  ||.||..     |.| ..|.|.
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase lin-2.AA Ciliate-E2-Unclassified 61-281 21 6.6e-42 143.15 In-house 51-352 (352) Show / Hide 
Range on Protein: 61-281
Range on HMM: 51-352/352
Sequence Identity: 21% (64 aa)

FEEIDEEIR--------------ICQNLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRAS-------------NGFVFSEYVVS-----HYTR
.|.. ....              | .|..||.| ... . ..  .  |. | .||.|  . | .| .             ..  |.|. ..     .|..
NEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFA

QLLDALDYCHTRK-IVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEI--------------GGSMACGRVGVPQFM----APEIVRKDRVS----CS
|.|..|.|.|  . |.|||  | |... ..     .|...|| .| . .                  |.. ..| |..|    |||. ..   .     .
QILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYK

SDIWSSGVVLFLLLAGRLPFSGSTSD-----------------IYERIMQTDVDVDGYMP-----NISESARNLVR----RMLNADPSKRISAKEALNHE
.|||| ||.|. .| |..||.. ...                 .|. |.| ..... . .     ..|..| ....    .||. .|.|||.....||| 
CDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHP

WI
|.
WF
Kinase lin-2.AA RSK 117-281 31 5.6e-36 125.85 In-house 97-271 (271) Show / Hide 
Range on Protein: 117-281
Range on HMM: 97-271/271
Sequence Identity: 31% (56 aa)

VFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASK-DTSAPLKLCGFGVAKDL-SEIGGSMA-CGRVGVPQFMAPEIVRKDRVSCSSDIWSSGV
.|||  |. | . .. |..| |. .|||||  | | .....  .   .|.| || || | .| |. |  |. .   ..||||....   . ..|.|| ||
MFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTA---NYMAPEVLKRQGHDQACDWWSFGV

VLFLLLAGRLPFSGSTSDIYERIMQTDVDVD-----GYMPNISESARNLVRRMLNADPSKRISA-----KEALNHEWI
...  |.|..|| . . |  . | |   ..      |.  .||. |  |.|.||  || .| .|     .....| |.
LMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase lin-2.AA TyrKc 17-281 18 2.6e-09 -72.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-281
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

LSIRDVIEQGPFSNVYR----------ILHGPSNRKFLLRSINLNLFRQHTGLGFEEIDEEIRICQNL--QHPYICRLEKTINSV-------HYRHIIFE
..  ...  | |  ||.           |.  .                      |.. .|.||  .|  .|| | ||   . .        .   |..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

NMEGNDICFEIVQRASNGFVFSEYVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEI------GGSMAC----GRVG
 |..   .     |.. .  ..     ..  |  .  .| | ....|||    |  ....      | . || ..|. .       .         |. .
YMPH--GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-VPQF-MAPEIVRKDRVSCSSDIWSSGVVLF-LLLAGRLPFSG------STSDIYERIMQTDVDVDGYMPNISE--------SARNLVRRML---NADPS
 .|   ||||  .. . .  ||.|| ||... ..  |  | .|      | ....|...|      ..||   .            . . |.   ..||.
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-----GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE

KRISAKEALNHEWI
.| . .|   || .
DRPTFSEI--HECF
L27 lin-2.AA L27 371-425 19 1.8e-11 45.65 Pfam 1-56 (56) Show / Hide 
Range on Protein: 371-425
Range on HMM: 1-56/56
Sequence Identity: 19% (11 aa)

KVLGSLDAINSLLDPNSYK-PGSTTFQKIHDDGSVRNLLRLYDKIKALPCEPVVTE
.| ..|.....| ...... .. ...|.|... ....||...||... ...|...|
AVQRVLELLEQLQSLSEHHPEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE
L27 lin-2.AA L27 371-425 12 3.6e-08 34.39 SMART 1-62 (62) Show / Hide 
Range on Protein: 371-425
Range on HMM: 1-62/62
Sequence Identity: 12% (8 aa)

KVLGSLDAINSLLDPNSYK----PGSTTFQKIHDD---GSVRNLLRLYDKIKALPCEPVVTE
.| . ..  ..|    ...    ........|. .    ....|| ..||.... ..|.. .
AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP
L27 lin-2.AA L27 428-482 32 2.8e-15 59.56 Pfam 1-56 (56) Show / Hide 
Range on Protein: 428-482
Range on HMM: 1-56/56
Sequence Identity: 32% (18 aa)

TSTLRKETLNQIDGLLGPS-PEALELRQLLNSPHLASCVQALDVVVCEIRDPKNEA
......|.|.|...|.... ... ||.|.|.|||. |..|. |.|.|...||....
AVQRVLELLEQLQSLSEHHPEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE
L27 lin-2.AA L27 428-482 24 1.2e-12 49.28 SMART 1-62 (62) Show / Hide 
Range on Protein: 428-482
Range on HMM: 1-62/62
Sequence Identity: 24% (15 aa)

TSTLRKETLNQIDGLLGPS----PEALELRQLLNS---PHLASCVQALDVVVCEIRDPKNEA
 ... .|.|.... .|...    ... ||||.|.|   ||. ..... |.| |....|  ..
AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP
PDZ lin-2.AA PDZ 550-628 23 2.9e-24 85.7 Pfam 1-86 (86) Show / Hide 
Range on Protein: 550-628
Range on HMM: 1-86/86
Sequence Identity: 23% (20 aa)

LVQFQKD-TQEPMGITLKVNEDG----RCFVARIMHG-GMIHRQATLHVGDEIREINGMSVANRSVESLQEMLRDARG-QVTFKII
.|...|. .....|...|...|.     ......|.| |...|.  .|.|| | .||| ...| ...  ........| .|. .|.
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ lin-2.AA PDZ 559-631 22 6.3e-15 56.83 SMART 1-80 (80) Show / Hide 
Range on Protein: 559-631
Range on HMM: 1-80/80
Sequence Identity: 22% (19 aa)

EPMGITLKVNEDGRCFVARIMHGGMIHRQAT-----LHVGDEIREING-MSVANRSVESLQEMLRDARG-----QVTFKIIPSY
...|....      .|......||  ..  .     |..||.| |.|| ..| | . |  ..||. ..|     .||.....  
GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
SH3_2 lin-2.AA SH3_2 641-719 22 5.1e-11 41.48 Pfam 1-68 (68) Show / Hide 
Range on Protein: 641-719
Range on HMM: 1-68/68
Sequence Identity: 22% (19 aa)

FVRAQFDYEP-SQDDLIPCPQAGIPFKTGDILQVI---SKDDHNWWQA-RFVSSFPSIGNSSNAQRSNQQQVA--GLIPSPELQEW
..|. .||.| .  . ..   ... || ||.. ||   .||..|||.. .  .                  ..  |..||  ..|.
YYRVHCDYVPATYCNENH--EPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG----------------GRRMRGWFPSQWVEEC
SH3 lin-2.AA SH3 640-720 25 9.9e-11 42.89 SMART 1-58 (58) Show / Hide 
Range on Protein: 640-720
Range on HMM: 1-58/58
Sequence Identity: 25% (21 aa)

IFVRAQFDYEPSQDDLIPCPQAGIPFKTGDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVAGLIPSPELQEWR
 .|||..||..       .    ..|| |||..|..||| .||..|  .                    |..||  ..| .
PYVRALYDYQA-------QNPDELSFKKGDIITVLEKDDDGWWKGRCNR----------------TGQEGWFPSNYVEEID
SH3_1 lin-2.AA SH3_1 663-692 41 8e-06 22.77 Pfam 14-49 (49) Show / Hide 
Range on Protein: 663-692
Range on HMM: 14-49/49
Sequence Identity: 41% (15 aa)

IPFKTGDILQVISKDDH-NWWQARFVSS-----FPS
..|| |||..||.|.|  .|| .|  ..     |||
LSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_1 lin-2.AA SH3_1 643-654 41 1.084626 5.58 Pfam 1-12 (49) Show / Hide 
Range on Protein: 643-654
Range on HMM: 1-12/49
Sequence Identity: 41% (5 aa)

RAQFDYEPSQDD
.| .||...|.|
VALYDYQAQQPD
Guanylate_kin lin-2.AA Guanylate_kin 777-952 39 6.9e-96 329.59 Pfam 1-198 (198) Show / Hide 
Range on Protein: 777-952
Range on HMM: 1-198/198
Sequence Identity: 39% (79 aa)

RRKTLVLLGAHGVG---RRHIKNTLIHRHPNRF-A-YPIPHTTRPPRKDEVDGKHYYFV-TNEQMMADIQNNEYLEYGT-HEESMYGTKLETIRNIHKSG
.....||.|..|||   ..|||..|...||..| . |..||||||||..|||||||.|| ..|.|...|||.|..|... ....||||..||||.||..|
QMRPIVLSGPSGVGYEVKSHIKKALWDEHPHKFDGRYCVPHTTRPPRPGEVDGKHYHFVSSREEMWNMIQNHEFIEWAQVFNGNMYGTSKETIRQIHEQG

KI---AILDVE-PQALKVLRTA-EYSPFVVFIAAPNLQGMQDP-----DGSLEKLLNESDVLRQAFGHL-----FDFIITNSDIDDTIAQLERLVEKL
||   .|||.. .|..|.||.. |..|..|||..|..|..|..     ....||. .......|...|.     ||.||.|.|.|.....|....|..
KIMQLCILDIDTWQGVKQLRKTYELHPIMVFIKPPSMQELQRRLRCRNTEQEEKINKRMEAAEQEMQHYDEPGMFDYIIVNDDFDKAYWHLKEILEAE
GuKc lin-2.AA GuKc 777-953 32 1.1e-69 238.78 SMART 1-203 (203) Show / Hide 
Range on Protein: 777-953
Range on HMM: 1-203/203
Sequence Identity: 32% (66 aa)

RRKTLVLLGAHGVGRRHIKNTLIHRHPN--RFAYPIPHTTRPPRKDEVDG--KHYYFVT-NEQMMADIQNNEYLEYGTHEES-MYGTKLETIRNIHKSGK
.|...||.|..|||....|..|. ..|.  .|....||||||||. ||.|  ..|.||.  |.|. .|..|..||.|..... .|||..||.|..|..||
HRRPIVLSGPSGVGKSTLKHMLMQEYPDYPKFEFSVPHTTRPPRPGEVNGCVVDYHFVSLKEEMEQMIKHNKFLEWGEYHGNLYYGTSKETVRQVHEQGK

IAILDVEPQALKVLRTA----EYSPFVVFIAAPNLQGMQDPD-G----------SLEKLLNE-SDVLRQAFG---HLFDFIITNSDIDDTI-AQLERLVE
..|||..||....||.|    . .|.|.||..| ..  .. . .          ...| | . .. . |. .   |.|| .| |.|..|..  .|  ..|
HCILDIDPQGVRQLRYARRYSYFYPIVIFIKPPSMEELEERLRQPCQRGTETEERIQKRLAHQAQKEMQHYPKCHHEFDYVIVNDDLEDACYKELKEIME

KLP
.. 
QEQ