Gene plk-2 (Nematode worm)

plk-2

Species: Nematode worm
Alias: Y71F9B.7, aSWK240, Y71F9B_297.b, CE22877, plk-2
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 2758207-2755625, WormBase Genetic Map location: n/a,

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
plk-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
plk-2.AA Protein Genbank 632 None Fasta, JSON

Protein domain

Protein domains of plk-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase plk-2.AA PLK 36-287 59 3.7e-192 630.89 In-house 1-258 (258) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-258/258
Sequence Identity: 59% (154 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRR-KAVTEP
||.|.||||||||.|||... .|.. .|.|||||.|..|..||.||.||..|||.|.|.|.||..|||||..||||.||.|..||||..|||| |..|||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDND-ERKKTLCGTPNYIAPEVL--NKIGHSFEVDLWAIGCILYILLFGHP
|.||..||||.|..|||. .|.|||||||||||||...||||||||||....| |||||.||||||||||||  ||.|||.||| |..|||.|.||.|.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFESKSLEETYSRIKNNNYVIPTS--ASAAASQLIRVLLDPVPSRRPNARAVCRDHFF
|||.|...|||.|||.|.|..|..  .|..| .||. .|...|..||.. ......||
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase plk-2.AA PLK1 36-287 76 2.5e-179 594.43 In-house 1-253 (253) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-253/253
Sequence Identity: 76% (193 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAVTEPE
||||.||||||||||||.|.|.| |.||||||||.|||||.|||||.||.||||.|.||..||..||||||.||||.|||| |||||||||||||.||||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

ARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDND-ERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPFE
.||..||||||..||||.||.|||||||||||||.||||||||||||.|..| ||||||||||||||||||||.|||||||.|.||||.||||||.||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

SKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFF
.|.|.|||||||.|.|.||...|..|.||||..|||.|.|||....|..|.||
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase plk-2.AA PLK2 36-287 50 1.1e-133 433.05 In-house 1-257 (257) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-257/257
Sequence Identity: 50% (130 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPR----RSLMELHKRRKAV
| .|| ||||||| |||.   .|.  .|.|.||.    |  || || .|. .|| |.||..|. .|.|||. |.|| ||.| |    .|.    | |.  
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCD-NDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGH
|||| ||.  |||.|. |||  .|.||||||||.|.||   |||||||||       ....|.|||||||||||||..|||.| | || ||| | .| | 
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFF
||||  .| ||| .|. | | .||. |. | .||  .| | |  ||    . |. ||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase plk-2.AA PLK-Unclassified 36-287 51 1.1e-132 447.08 In-house 1-264 (264) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-264/264
Sequence Identity: 51% (135 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRR-------
|..|.|||||||| ||.  | .| . .| |..||. | |. .| |  .| .||  | |.|.|| .|.||| .|||| ||.||  .|||..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDN-DERKKTLCGTPNYIAPEVL-NKI-GHSFEVDLWAIGCILYI
|  ||.|....|||||... |||. .| ||||||||.||||  .|||.||||||   |  |.||| ||||||||||.| .|  |||.||| |..||||| 
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLFGHPPFESKSLEETYSRIKNNNYVIPTSA--SAAASQLIRVLLDPVPSRRPNARAVCRDHFF
|| |.|||| |. . || .||.|.|  |  .  | .|  ||.  |...|..||.      . |.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase plk-2.AA Aur 36-275 36 5.4e-93 245.57 In-house 1-245 (257) Show / Hide 
Range on Protein: 36-275
Range on HMM: 1-245/257
Sequence Identity: 36% (89 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLMELHKRR--KAVTE
 | || |||| | . |  |.|.|. .|| ||. |  ..|.   . . .|. |.  |.| |. |.|..|.|. ..|. ||  |. .| .. ..   |  .|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

PEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLND-ELQVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPP
..| ...||| ... |.|  .|.|||.|  |. | . .  .||.||| .. |.| .| .|.|||  |..||. .  .| ..||.|..| ..| |. |.||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FES-KSLEETYSRIK-NNNYVIPTSASAAASQLIRVLLDPVPSRR
||| ..  |||.||| ......| . |  | .||  .|.  |..|
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQR
Kinase plk-2.AA S_TKc 36-287 32 8.5e-93 315.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPR--RSLMELHKRRKA---
||... .|||.|. .|  |.|.||...| |...          ... .|.||... .| |.|||| .|.| ...|. .|.|.    .|... |.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSF-EVDLWAIGCILYIL
    .| .||...|||.... |.|...|.|||||  |..|..  ..||.|||||.        .|.||||.|.|||||   |... ..| |..|||||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LFGHPPFESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCR-------DHFF
| | |||.   ..... .|.          |  | ..|| .|.  |..|| |  . .       . .|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase plk-2.AA AGC 36-287 21 2.4e-91 235.73 In-house 1-395 (395) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

YEKGKFLGKGGFAHCYELRNK------STGELFAGKVVPKAL---LIK--QYQRDKMA------------QEVQIHRNLQ--------HRNVVK-LYHFF
.|  | .|||.|  .|  | |      .||...| ||. |.    ..|  . .. . .             ..  . |          | ..|| |.. |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDKSN--VYITLELCP----------R-RSLMELHK--RRKAVTEPEARYFTYQ-------IVEGVLYLHN-LKIVHRD-LKLGNLFLNDELQVKIGDFG
.||..  .|. .|..|             ... |..  ...  .|..||... .       || .. |||. ..|.||| ||. |. |...  .|. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATTCDNDE---------------------------------------------------RKKTLCG--TPNYIAPEVLNKIGHSFEVDLWA--IGCILY
|..   ||.                                                   | .|.||  ||.|.|||.|    .....| |.   ||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ILLFGHPPFESKSLE----------ETYSRIK------NNNYVIP----------TSASAAASQLIRVLLDPVPSRRPN----------ARAVCRDHFF
 .|.|.||| ... .          |.. .|.      |..  .|           . |  |  ||. || . |..|.           |  . .  .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase plk-2.AA CAMK 41-287 21 4.3e-90 290.44 In-house 1-425 (425) Show / Hide 
Range on Protein: 41-287
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

FLGKGGFAHCYELRNKSTG------------ELFAGKVVPKALLIK-------------------------QYQRDKMAQEVQIHRNLQ-------HRNV
 ||.|.|.  .. ..|.|.            . .| |...|  | .                         .. |... .|..|...||       |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYHFFED-------------------KSNVYITL---ELCPRR----SLMELHKRR---------------KAVTEPEARYFTYQIVEGVLYLHNLKI
.|||...||                   ....|. .   |.|.       | .  ...               . .|| |||..  ||...| |.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKLGNLFLNDE-----------------LQVKIGDFGLATTCDN------------------------DERKKTLCGTPNYIA-PEVLNKIG----
||||||. |. |.|                   ..|| |||.|. .|                         ..  || |||| |.| |||||. |    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------HSFEVDLWAIGCILYILLFGHPPFESK-------------SLEETYSRIKNNNYV-IPTS-----------------------ASAAASQ
          .....| |..|.||||.| |.|||...             ...|.. .|.. .|  .|                          |. . .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRVLLDPVPSRRPNARAVCRDHFF
||| .| . |..|...  . .. ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase plk-2.AA Pkinase 36-287 28 2.7e-85 294.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMA-QEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRR----SLMELHK--RR
|..|. .|.|.|. .|. ..|.||...| |...|    .. .. .   .|.||...|.| |.|.||..||||...|. .|.|.      .|... .  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KAV--TEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQV----KIGDFGLATT--CDNDERKKTLCGTPNYIAPEVLN-KIGHSFEVDLWAI
...  .| |.. . |||..|. |.|. .|.|||||. |...... ..    ||.|||||      |..  .|.||||.|.||||..   ... .|| |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYILLFGHPPFESK------SLEETYSRIKNNNYVIPTSAS---------------------AAASQLIRVLLDPVPSRRPNARAVCRDHFF
|||||..|.|.||| ..      .  . . ||.   .  . . .                      .. ..|. .|.. |..||.|. .. . .|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase plk-2.AA CAMKL 36-287 26 6.7e-78 248.16 In-house 1-297 (297) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-297/297
Sequence Identity: 26% (80 aa)

YEKGKFLGKGGFAHCYELRN-KSTGELFAGKVVPKALLIKQYQRDKM------------AQEVQIHRNLQ---HRNVVKLYHFFEDKSN------VYITL
|. || ||||.|.     .. . |||  | |.. |  . .  . .|.             .|.||.. |.   | |..|||. .|....      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCPRRS--LMELHKRR----KAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDEL--QVKIGDFGLATTCDN-----DERKKTLCGTPNYI
|.|.  .  |..  ...    .  .|.||| .  |||..| |.|...|||||.|. |. | .    ..|| |||... ...     ..  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLNK--IGHS-FEVDLWAIGCILYILLFGHPPFE----------SKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFF
|||....    .  ..|| |..| ||| ...|. ||.           . ...   ..   .. |. . |  . .||| .| . |..||..  . .. ..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase plk-2.AA SAK 36-287 38 2e-73 249.4 In-house 1-254 (254) Show / Hide 
Range on Protein: 36-287
Range on HMM: 1-254/254
Sequence Identity: 38% (98 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFEDKSNVYITLELCPRRSLME-LHKRRKAVTEP
|. .. |||||||  |  .  .|.   | |.. | |. |    ... .||.||  |.|  ...|| .|||   ||. ||.|    .   ...| .  || 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDN-DERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPF
||| |  ||| |.||||   |.|||| | |. |  ....|| ||||||     .|.  |.|||||||.||.  .  |  . |.|..||.|| || | |||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFF
.  . ..|  ..   .|..|.  |  |  ||  .|   |  |    .|    | 
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase plk-2.AA ULK 36-268 29 4.8e-69 235.69 In-house 1-305 (324) Show / Hide 
Range on Protein: 36-268
Range on HMM: 1-305/324
Sequence Identity: 29% (89 aa)

YEKGKFLGKGGFA-HCYELRNKST---GELFAGKVVPKALLIK-------QYQRDKMAQEVQIHR---NLQHRN--VVKLYHFFEDK--SNVYITLELCP
|.. . |||| |.   |. ||| |   ....| |...|  ..|       ||. ..  .|.|| .   .|.| |  .||||..||..   |.|| .|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

RRSLMELHKRRKA---------VTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDEL------------QVKIGDFGLATTCDNDERKKTLC--
   | .. |..|           .|.||. | .||..|  .||. .|.|||.|. |. ...              ..||.|||.| ..||..  ...|  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTPNYIAPEVLN----KIGHS-FEVDLWAIGCILYILLFGHPPFESKSLEETYSR--------------IKNNNYVIP-----TSASAAASQ
        ||| | ||..|.    .. .. ...|.| .|||.| .|.| .||.|   ...| .              |||..  .|        |    .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIRVLL
||| .|
LIRRML
Kinase plk-2.AA Pkinase_Tyr 77-181 31 1.3e-16 56.92 Pfam 44-158 (270) Show / Hide 
Range on Protein: 77-181
Range on HMM: 44-158/270
Sequence Identity: 31% (36 aa)

Q--RDKMAQEVQIHRNL-QHRNVVKLYHFFE-DKSN--VYITLELCPRRSLME-LHKR---RKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLF
|  |... .|..| ..| .| |.|.||     ..    .|| .|..|  .| . |.|.   ....| ..   . .|| .|  ||.. ...||||   |  
QNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL

LNDELQVKIGDFGLA
......|||.|||||
VTENNVVKICDFGLA
Kinase plk-2.AA TyrKc 36-286 23 1.6e-16 44.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-286
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNL--QHRNVVKLYHFFEDK-------SNVYITLELCPRRSLME-LH
 ..|| || | |   |. . |   .  | |.. .        |  . .| .| ..|  .| |.|.||    ..         ..| .|..|  .| . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRRKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDELQVKIGDFGLATTCDND----ERKKTLC-----GTP-----NYIAPEVLNKIGHS
|.|. .. ..  .| .|| .|  |||  ...||||   |  ......|||.||||.   ..|    |.|..       |.         |||..|.   .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FEVDLWAIGCILY-ILLFGHPPFES-----KSLEETYSRIKNNNYV-IPTS--------ASAAASQLIRVLLDPVPSRRPNARAVCRDHF
.. | |. |  .. |. .| .| .      .| .| . ..|. ..  .| .        ....  |...   .  |. ||. ... .. |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
POLO_box plk-2.AA POLO_box 412-476 35 3.1e-23 88.29 Pfam 1-74 (74) Show / Hide 
Range on Protein: 412-476
Range on HMM: 1-74/74
Sequence Identity: 35% (26 aa)

YSDKYGIGYQLCDNSVGVL-FNDNSRIMLDTAGT-QLTYIE--KTEKEHYFDMESAI-----PSGLQKKMTLLK
|..||||.|||....|.|. ||| ..|.|.. .   .|||.  .  ..... ....      |. ||||.|.||
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box plk-2.AA POLO_box 511-580 51 5.9e-32 117.29 Pfam 1-74 (74) Show / Hide 
Range on Protein: 511-580
Range on HMM: 1-74/74
Sequence Identity: 51% (38 aa)

FRTKSAIVLHLSNGTVQINFFNDHIKMVLCPLMQ-AVTFID--ENKRMFTYKFSHLAENGC-PEKFLHRIQYAK
.|||..|. .|||||||.|||||| |..||| |. |||.||  .|.. .||..|.. |.|| || . ....|.|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK