Gene T22B11.3 (Nematode worm)

T22B11.3

Species: Nematode worm
Alias: CE17242, T22B11.3, aSWK413
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:0.83, WormBase Physical Map location: IV: 4682950-4685106

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
T22B11.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 277 Kinase domain by global Sugen HMM Fasta, JSON
T22B11.3.AA Protein Genbank 370 None Fasta, JSON

Protein domain

Protein domains of T22B11.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T22B11.3.AA TK-Unique 64-337 24 5.70000000001e-107 361.67 In-house 1-294 (294) Show / Hide 
Range on Protein: 64-337
Range on HMM: 1-294/294
Sequence Identity: 24% (71 aa)

VELGITVGMGKFGPIHRAMFSSFN-GSVHDVNVYLLKNIARLSDEELVKLTSLLKSNIAAGAHQNVVSLCGVSPSGS-DVMLMWEPLHQSVLRGVLRESR
.|.|...|.|.||...|....... .. ....|.. .. ....|..  .... .. . . |.|.|.|...|.. . . ..|...|..... |.. ||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

CARFGT-------------EPFNMASFLSSERLAAIAIGCCNGVEHLLK--KNVFPPHLSTSNVLLAERGIVKIGGFGLAE----HHALDMTTESAPTKL
.|....             ..... ...|...|. .|.....| |.| .  |.... .|...||||.|....||..||.|.    .....|.... .. .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGSLRQAQTFIDAMRDGSAQLDPISYCGEAVTQLLATCTSHVPEARGDIRTIIKRL
|||.||..|....|........|..||..||||.||..|........ .....|||. ...| ..| .....|. .|....|| |...|.|..||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase T22B11.3.AA TK 64-337 14 1.3e-45 150.46 In-house 1-486 (486) Show / Hide 
Range on Protein: 64-337
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

VELGITVGMGKFG---PIHRAMFSSFN----------------------GSVHDVNVYLLKNIARLSDEELVK---------------LTSLLKSNIAAG
..|| . | | ||    .....  . |                      | ...| |  ||  .  |.||                  .  . . . ..|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

AHQNVVSLCGVSPSGSD------------VMLMWEPLHQSV----LRGVLRESRCARFGTEPFN------------------------------------
 |.|.|.| ||.  |              .|.. |  .       ||  ||..|  ..  .. .                                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------MASFLSSERLAAIAIGCCNGVEHLLKK------NVFPPHLSTSNVLLAERGI-----------VKIGGFGLAE
                           . ..|. ..|  ..   ..| |.| .|      |.    | . |.|..|...           .||. |||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

H----HALDMTTE-------------------------------SAPTKLRWMPPEYFKRDQ------KMIYNEQTMIWPLGVTLWEIFSLGGTPFGSLR
.    .| |.  .                               ..   .|||.|| ..  .      . .. ... .| .||..||||..| .|..   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

QA---------QTFIDAMRDG-------------SAQLDPISYCG--------------EAVTQLLATCTSHVPEARGDIRTIIKRL
           | ...  |.|               .. .  .|               |.. .|.  | .. || | . ... ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase T22B11.3.AA UTK 64-337 20 2e-19 63.11 In-house 1-296 (296) Show / Hide 
Range on Protein: 64-337
Range on HMM: 1-296/296
Sequence Identity: 20% (63 aa)

VELGITVGMGKFGPIHRAMFSSFN--GSVHDVNVYLLK--NIARLSDE---ELVKLTS---LLKSNIAAGAHQNVVSLCGVSPSGSDVMLMWEPLHQSVL
|.|| . | | || .|.|.|   .  . . || |  ..    |. . |   .. ...    ..|       |.||. | ||  ...  |. .|   .. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGDL

RGVLRESRCARFGTEPFNMASFLSSERLAAIAIGCCNGVEHLLKKNVFPPHLSTSNVLLAERG-------IVKIGGFG---LAEHHA------------L
| .|| .| . .         .|.....   |    .|...|  ...    |   |.|... .       ..||..||   ..   .            .
RSYLRRHRPTPP-----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYY

DMTTESAPTKLRWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGSLRQAQTFIDAMRDGSAQLDPISYCGEAVTQLLATCTSHVPEARGDIR
 | ..  .  .||| || .       . ... .| .||..|||.. | .|.. .  .|..   .. | ... ..  |...| .|.  |    |. | |..
YMAQHQDRWPIRWMAPEALTHHT--RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

TIIKRL
.. ...
DLVQQM
Kinase T22B11.3.AA Tie 73-337 25 1.2e-17 49.7 In-house 2-267 (267) Show / Hide 
Range on Protein: 73-337
Range on HMM: 2-267/267
Sequence Identity: 25% (71 aa)

GKFGPIHRAMFSSFNGSVHDVNVYLLKNIARLSDEELVKLTSLLKSNIAAGAHQNVVSLCGVSPSGSDVMLMWEPLHQSVLRGVLRESRC----ARFGTE
| || . .||     | . .| .  .|. |  |...       |      | | |.. | |       . .  |      |   ||.||     . |  |
GNFGQVMKAMIKK-DGLKMEVAIKMMKEYA--SEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFARE

PFN-----MASFLSSERLAAIAIGCCNGVEHLLKKNVFPPHLSTSNVLLAERGIVKIGGFGLAEHHALDMTTESAPTKLRWMPPEYFKRDQKMIYNEQTM
.       .|| |||. .   |    .|...| .|..    |   |.| .|  . ||  |||.  .   . .       |||  |        .|  .  
HTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESL---NYSVYTTKSD

IWPLGVTLWEIFSLGGTPFGSLRQAQTFIDAMRDGSAQLDPISYCGEAVTQLLATCTSHVPEARGDIRTIIKRL
.|  || |||| ||||||.  .  |. . . .  |     |   | . | .|.  |  . |  |  .  |. .|
VWSYGVLLWEIVSLGGTPYCGMTCAELY-EKLPQGYRMEQPRN-CDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase T22B11.3.AA RTKB 176-291 33 1.4e-15 49.0 In-house 106-220 (264) Show / Hide 
Range on Protein: 176-291
Range on HMM: 106-220/264
Sequence Identity: 33% (40 aa)

LSSERLAAIAIGCCNGVEHLLKKNVFPPHLSTSNVLLAERGIVKIGGFGLAE---HHALDMTTESAPTKLRWMPPEYFKRDQKMIYNEQT-MIWPLGVTL
|... |.  .   ..|  .| ..||    |.  |||.      ||  ||.|    |     |.   |   .|| ||  ..    ||. .   .| .||| 
LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLP--IKWMAPESWAH---RIYTTKSGDVWSFGVTM

WEIFSLGGTPFGSLRQAQTF
||||||||||.  .| .. |
WEIFSLGGTPYQQYRNGDIF
Kinase T22B11.3.AA TyrKc 64-337 22 1.7e-15 27.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 64-337
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

VELGITVGMGKFGPIHRAMFSSFNGSVHDVNVYLLKNIARLSDEELVKLTSLLKSNIAAG-AHQNVVSLCGVSPSG-------SDVMLMWEPLHQSVLRG
..|| . | | || ..... .       .| |  ||. |    |.. .  .....    |  |.|.| | ||  ..         .|.  |      |. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLRESRCARFGTEPFNMASFLSSERLAAIAIGCCNGVEHLLKKNVFPPH--LSTSNVLLAERGIVKIGGFGLAEHHALD--------MTTESA--PTK--
 ||..|              |. . |  ...  ..| |.| .||.   |  | . |.|..|...|||. |||.  .  |        . . .    .|  
YLRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCI--HRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

--LRWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGSL----RQAQTFIDAMRDGSAQLDPISY-------CGEAVTQLLATCTSHVPEARG
  .|||.|| .   .. ...... .|  ||..||||..|..|          .|  |   ..|     | ..       | ... |.  .|  . || | 
LPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

DIRTIIKRL
  ..|....
TFSEIHECF
Kinase T22B11.3.AA Fer 209-338 21 8.6e-12 36.54 In-house 141-283 (283) Show / Hide 
Range on Protein: 209-338
Range on HMM: 141-283/283
Sequence Identity: 21% (31 aa)

NVLLAERGIVK---IGGFGLAEHHALDMTTESAP---TKL--RWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGS------LRQA-QTFID
|.|. . ...|   |  ||.. . . .... . .   .|.  ||..|| .   |..||.. | .|  ||..||||. | .|..       . .   . . 
NCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETW---QTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARK

AMRDGSAQLDPISYCGEAVTQLLA-TCTSHVPEARGDIRTIIKRLE
. ...   . . . . ... |... .|  . || |    .|...|.
WIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase T22B11.3.AA TKL 205-337 18 1e-11 38.45 In-house 166-364 (364) Show / Hide 
Range on Protein: 205-337
Range on HMM: 166-364/364
Sequence Identity: 18% (38 aa)

LSTSNVLLAERGI--------------VKIGGFGLAEHHALDM--------------------TTESAPTKLRWMPPEYFKRD-------------QKMI
| ..|.|. | .               .||. |||.  .  ..                    || .    .|||.|| .. .             ..  
LKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFE

YNEQTMIWPLGVTLWEIFS--LGGTPFGSLRQAQTF------IDAMRDGSAQLDPI--------------SYCGEAVTQLLATCTSHVPEARGDIRTIIK
|.|.. ..  |. ||||..  .   |.  .   .        ...| ... .| |               ..| . . .|.  | .| ||.|    .|.|
YSEKCDVYSFGIVLWEILTRCR---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK

RL
||
RL
Kinase T22B11.3.AA KIN16 209-281 40 2e-10 25.92 In-house 191-270 (332) Show / Hide 
Range on Protein: 209-281
Range on HMM: 191-270/332
Sequence Identity: 40% (32 aa)

NVLLAERGIVKIGGFGLAEHHALDM--TTES---APTKLRWMPPEYFKR--DQKMIYNEQTMIWPLGVTLWEIFSLGGTP
||..    |. |. |||| .|. .    . |   .|  .|||.|| |    ..||. .| . .|  || | ||||||.||
NVFIKRNKIIRIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETP
Kinase T22B11.3.AA Pkinase_Tyr 209-337 23 3.6e-10 35.06 Pfam 141-270 (270) Show / Hide 
Range on Protein: 209-337
Range on HMM: 141-270/270
Sequence Identity: 23% (32 aa)

NVLLAERGIVKIGGFGLAEHH---ALD-MTTESAPTKLRWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTP-FGSLRQAQTFIDAM-RDGSAQL
|.|..| ..|||. ||||  .        ......   .||.|| ..      ..... .|  ||..||||..|..| .  .   . ....  .|   ..
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYED-GYRM

DPISYCGEAVTQLLATCTSHVPEARGDIRTIIKRL
..  .| . . .|.  |  . || |   . |. .|
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase T22B11.3.AA EGFR 205-286 30 8.8e-09 25.1 In-house 127-208 (258) Show / Hide 
Range on Protein: 205-286
Range on HMM: 127-208/258
Sequence Identity: 30% (26 aa)

LSTSNVLLAERGIVKIGGFGLA---EHHALDMTTESAPTKLRWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGSLR
| . |||.     |||  ||||   || . ... ... .  .||  | .   .. .|  |  .|  |||.||.   |. |.  ..
LAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECI---HHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIP
Kinase T22B11.3.AA Trk 243-337 26 1.1e-08 25.51 In-house 185-275 (275) Show / Hide 
Range on Protein: 243-337
Range on HMM: 185-275/275
Sequence Identity: 26% (25 aa)

RWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGSLRQAQTFIDAMRDGSAQLDPISYCGEAVTQLLATCTSHVPEARGDIRTIIKRL
||||||     .   .     .| .||..||.|. |  |.  |      |.    |  .|.    | . | ...  |    |. |  |. | ...
RWMPPESI---MYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEV-IECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase T22B11.3.AA S_TKc 64-340 17 5.7e-08 -59.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 64-340
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

VELGITVGMGKFGPIHRAMFSSFNGSVHDVNVYLLKNIARLSDEELVKLTSLLKSNIAAGAHQNVVSLCGVSPSGSDVMLMWEPLHQ--SVLRGVLRESR
 |.. ..| | ||  ...   .      .  .. .| |     | . .  ..||.      | |.| | .|  . ... .  | . .    |. .... .
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK----EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

C--ARFGTEPFNMASFLSSERLAAIAIGCCNGVEHLLKKNVFPPH--LSTSNVLLAERGIVKIGGFGLAEHHALDMTTESAPTKLRWMPPEYFKRDQKMI
.   ||.         ..  . . ..   |...|.. ....   |  |  .|.|| |   .||. |||| .     ||      . .|.|| .       
RHGLRFP---------FPE-HARFYMYQICCALEYCHSHGII--HRDLKPENILLDE--HIKICDFGLARQL----TTFCGT--PWYMAPEVL------G

YNE-QTMIWPLGVTLWEIFSLGGTPFGSLRQAQTFIDAMRDGSAQLDPISYCGEAVTQLLATCTSHVPEARGDIRTIIK------RLECI
|.     .| .|..|.| .. | .||    | |. .. ..             . . ...  |    || |  .  . .        . .
YGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF