Gene CDC15 (Bakers Yeast)

CDC15

Species: Bakers Yeast
Alias: CDC15
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: CDC15

Sequence

Name Sequence Type Origin Length Description Download
CDC15.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 248 Kinase domain by global Sugen HMM Fasta, JSON
CDC15.AA Protein Refseq_NP 974 `Required for mitosis and sporulation, cell division cycle blocked at 36 degrees; Cdc15p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of CDC15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC15.AA STE11 25-272 34 2.1e-135 456.16 In-house 1-303 (303) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-303/303
Sequence Identity: 34% (104 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDE--------ELND------IMAEISLLKNLNHNNIVKYHGFIR---KSYELYILLEYCANGSL
......||.|..|.|||..|..|....|.|.. ..|..        |...      |. ||.|.|.|||.|||.|.|. .   . ....| .|||..|||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

RRLIS-RSSTG-LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNT-VKLADFGVSTIVNSSALT-------------LAGTLN--------
..... .  .. ..|.. . |..| | ||.|||  |.||||||.||||| .|.. .|||||| .. .......             . ||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEILGNRG---ASTLSDIWSLGATVVEMLTKNPPYHNLT---DANIYYAVEN-DTYYP-PSSFS------EPLKDFLSKCFVKNMYKRPTADQLLKH
|||||.. . |    .. .||||||.||.||.| .||.||..    |........ ....| |...|      |...|||..||.....|||||.|||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

VWI
 .|
PFI
Kinase CDC15.AA STE 25-272 30 3.6e-106 359.04 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

YHLKQVIGRGSYGVVYKAINK------HTDQV---------VAIKEVVYEND-----------------EELNDIMAEISLLKNLN--HNNIVKYHGFIR
. . ..||.|..|.||||.|.      .|..|         .|||.. .||.                 ||...|. ||...|..|  | |||||.|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KSY-------ELYILLEYCANGSLRRLIS-RSSTGLS------------ENESKTYVTQTLLG-LKYLHGEGVIHRDIKAANILLSADNTVKLADFGVST
|         ||.| .||...|||. .|  . ..| .            |.. .... |.| | |.|||  ..||||||.|||||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IVNS-------------------SALTLAGTLNWMAPEILGN------RGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVEND-----------
....                      |..||  |||||.. .       | .| .|||||| |..||.| .||.|....   ...  .            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---TYYP--PS-------------------SFSEPLKDFLSKCFVKNMYKRPTADQLLK--HVWI
      |  |.                   ..|...|||..||..|.  |||||.||||  | .|
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CDC15.AA Pkinase 25-272 30 3.1e-104 357.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMA----EISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANG----SLRRLIS-RSS
||....||.||.|.|||...| | ..||.|.. ......  |. .    ||...|.||| |||..... . . ..|. .||| .|    .| ..|| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TGL--SENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTV----KLADFGVS----TIVNSSALTLAGTLNWMAPEILG-NRGASTLSDIWSL
...  ||.| | |..|.| ||.|.| .|.||||.| .|||.. ....    |..|||..    .  || . |..||...||||..  ... .. .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GATVVEMLTKNPPYHNL----TDANIYYAVENDTYYPPSSFS------------------------EPLKDFLSKCFVKNMYKRPTADQLLKHVWI
| .. |||...||. .     . .. .. .... . |... .                        |..|||...|. |...|||||.|.|.| |.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC15.AA S_TKc 25-272 32 2e-100 340.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-231/231
Sequence Identity: 32% (85 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCAN--GSLRRLISRSSTG-----
|.. ..||.|..|.|||...|.|...||||..        ..|. ||..||. .| ||||......   .||. .||| .  |.|...| .  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGAST-LSDIWSLGATVVEMLTKNP
..| . . |. |....|.|.|  |.||||.| .||||.   ..|..|||.....     |. ||...||||.|   | ..  .|.||.| .. |||.  |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLK-------HVWI
|..  ... ..  .           |...|||..||..|.  ||||| ..|.       | |.
PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC15.AA STE20 25-272 38 5.5e-91 308.57 In-house 1-288 (288) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-288/288
Sequence Identity: 38% (111 aa)

YHLKQVIGRGSYGVVYKAINKHTDQV----VAIKEVVYEND----EELNDIMAEISLLKNLNHNNIVKYHGFIRKS----YELYILLEYCANGSLRRLIS
| | ..||.||||.||||..|.|...    |||| . .|..    .|..||. ||| .|...| |||||.|   |.     ||.|. |||. |||. ...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

RS-STG-------LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNS----SAL----TLAGTLNWMAPEILGN----
.. ..|       ..| .  .   ..| ||.||| ...|||||||.||||. |  ||||||||.  ...    .      |. ||  |||||..      
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-RGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYP-------PSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI
  |  . .|||||| |  ||.. .|||...      . . . .  |       |...|  ..||..|| .|.  |||||.||||| .|
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase CDC15.AA Dicty2 25-272 44 8.7e-87 294.63 In-house 1-264 (264) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-264/264
Sequence Identity: 44% (117 aa)

YHLK-QVIGRGSYGVVYKAINKHTDQVVAIKEV------VYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTG
| .   .||.|  |.|||. .. | ..|||| .      .    | .  ||.|| |||.|||.||||| ..|  .  ||| |||  ||||.  | .  . 
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGC-

LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNT---VKLADFGVSTIVN----SSALTLAGTLNWMAPEILGNRG--ASTLSDIWSLGATV
..|     |. | | || ||| .||||||||||||| . ..    .||||||| | .      |..| .||  |||||.    |  ..| .|||||| |.
FPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTI

VEMLTKNPPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI
 |.|| ||||  |  .   ..  .|   | |   | ..||||  ||.|   .|.|| |||.| ||
IELLTGNPPYWDLNPMHAMFRMVQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase CDC15.AA STE11-Unclassified 25-272 32 8.5e-82 278.05 In-house 1-308 (308) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-308/308
Sequence Identity: 32% (101 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVY--EN--DEELNDI-----MAEISLLKNLNHNNIVKYHGFI--RKSYELYILLEYCANGSLRRLISR
.   ..||.||.| |||..|..| ...|.|..     |  .|.. ..       |...||.||| |||.| |.   ..   ..| .||...||..... .
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

SSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVST-------------------IVNSS-AL--------TLAGTLN--
    ..|.  | |..| | ||.|||  |.||||||.||||. .| ..||.||| .                     .... ..        .. ||..  
-YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-WMAPEILG---NRGASTLSDIWSLGATVVEMLTKNPPYHNLTD----ANIYYAV-ENDTYYPPSSFS-----------EPLKDFLSKCFVKNMYKRPTA
 |||||..    . | .. ||||||| ||.|| |  .|. |...    . |...| .| .   |.  |           . .||||.|||  .  |||||
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

DQLLKHVWI
.|||.| .|
NQLLQHPFI
Kinase CDC15.AA CAMK 30-272 18 6.9e-76 243.84 In-house 1-425 (425) Show / Hide 
Range on Protein: 30-272
Range on HMM: 1-425/425
Sequence Identity: 18% (79 aa)

VIGRGSYGVVYKAINKHTD------------QVVAIKEVVYE----------------------------NDEELNDIMAEISLLKN-------LNHNNI
..||||.|.|...|.|.|             | |||| .  .                            ... .  .. ||...|.       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYHGFIRK-------------------SYELYILL---EYCANG----S-LRRLISRSS-------------TGLSENESKTYVTQTLLGLKYLHGEGV
.| . ..                       ..|. .   ||| .|      . .......               ..| | ..|. | . ...|.|  ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKAANILLSAD-----------------NTVKLADFGVSTIVNS--------------------------SALTLAGTLNWMA-PEILGN------
.|||.|  ||||. .                 |..|..||| ......                             |  ||.  || ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYY-------------AVENDTYY-PPSSFSE-----------------------PLKD
        .. .  .|.||.|     ||.  ||.   .| .|.               . .  |. ||. ||.                         ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLSKCFVKNMYKRPTADQLLKHVWI
...|. ...  ||.|..| |.| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC15.AA Ciliate-E2 25-272 21 6.7e-69 235.21 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVA--------------------IKEVVYENDEELNDIMAEISLLK----------------NLNHNNIVKYHGF
| . ..||.|..|.|||. .. ... .|                    |... . .  ... |. ||....                .|||.||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IR--KSYELYILLEYCANGSLRRLISRSST----------GLSENESKTYVTQTLL---------------GLKYLHGEG-VIHRDIKAANILLSADNTV
    .   .|. .|||  |.|. .|  ...           ..|.| |.. .| |                .|.||| .. .||||||  |||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGVSTIVNSS----------------------------------ALTLAGTLNWMAPEILGNRG---------ASTLSDIWSLGATVVEMLTKNPP
|..||| |.... .                                  . |..||.. ||||||.. .          .. .|||||| .  |||...||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

YHNLTDANIYYAVEN-DTYYP-----------------PSSFSEPLKDFLSK----CFVKNMYKRPT-ADQLLKHVWI
.        .   .. .  .|                 . . |.  ||...|    ...|.  ||.| ..|.|.| |.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CDC15.AA ULK 25-272 26 3.5e-67 229.5 In-house 1-329 (329) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-329/329
Sequence Identity: 26% (88 aa)

YHLKQVIGRGSYGVVYKAINKHT----DQVVAIKEVV---YENDEELND-------IMAEISLLKNLN----HNN----IVKYHGFIRKSYE--LYILLE
|.|....| ||.|.|||..|| |    ...||.| .      ... ...       .. || ..| |.    |.|    |||.. . . | .  .|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCANGSLRRLISRSST---------GLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADN------------TVKLADFGVSTIVNSS-----
||  | |. .|..  .          |||.| . .  | | |.|.|| ...|||||| .|||.. ..            ..|.|||| .  |...     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-ALTLA------GTLNWMAPEILGNRG----ASTL-SDIWSLGATVVEMLTKNPPY--HNLTDANIYYAVENDTYYPPSS------------------FS
 ..|        ||   |||.|| ..|     ..  .||||||    |||.  ||.     .| ....  ..  ..||.                   .|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

EPLKDFLSKCFVKNMYKRPTADQLLKHVWI
. .||.........  .| . ..|..| |.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CDC15.AA YSK 25-218 41 8.1e-67 200.08 In-house 1-201 (257) Show / Hide 
Range on Protein: 25-218
Range on HMM: 1-201/257
Sequence Identity: 41% (84 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDE-ELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRS-STGLSENE
.    .|||||.|.|||.|...| .||||| .  | .| |  ||  ||  |  .   .| || |   |.  | |  |||. ||.. |. ..   .. |  
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

SKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSAL---TLAGTLNWMAPEILGN--RGASTLSDIWSLGATVVEMLTKNPP
  .     |.||.||| | .|||||||||.|||..  |||.||||.  .. . .   | .||  |||||.      .  .  |||||| |  ||.. .||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

Y
|
Y
Kinase CDC15.AA MST 25-221 41 3.1e-62 196.6 In-house 1-200 (254) Show / Hide 
Range on Protein: 25-221
Range on HMM: 1-200/254
Sequence Identity: 41% (83 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIR--KSYELYILLEYCANGSLRRLISRSSTGLSENE
. .   .|.||||.|||||.| |...|||| |  ..|  |..|  ||| ... .  .|||| |  .  | ... |  |||. ||.  ..      |.| .
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNED--LQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

SKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNS---SALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYH
  .   .||.||.|||    |||||||.||||. .   ||||||||         . |. ||  ||||| ... .  .  |||||| | .||   .|||.
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NL
..
DI
Kinase CDC15.AA Pkinase_Tyr 25-270 25 2.1e-42 144.25 Pfam 1-270 (270) Show / Hide 
Range on Protein: 25-270
Range on HMM: 1-270/270
Sequence Identity: 25% (70 aa)

YHLKQVIGRGSYGVVYKAINK----HTDQVVAIKEVVYENDEE---LNDIMAEISLLKNL-NHNNIVKYHGFIR-KSYE--LYILLEYCANGSLRRLISR
 .. ...|.|..|.|||.. |     |.. ||.| .    ..|   . | |.|....|.| .| |||...| .  ..    .|| .||...|.|.    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---STGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALT-LAGT-----LNWMAPEILGNRGASTLSDIWSL
       |.  .   . .|   |. ||.  . ||||. | |.|.. .|.|| .||| .  . .      ...       ||||| . ..  .| ||.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GATVVEMLT--KNPP-YHNLTDANIYYAVENDTYYPPSSF--SEPLKDFLSKCFVKNMYKRPTADQLLKHV
| .  |..|  .  | | ..... .| ..  | |  |     .... | . .|  ..  .|||  ... . 
GVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CDC15.AA TyrKc 25-270 24 3.6e-41 144.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-270
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNL--NHNNIVKYHGFIRKS-------YELYILLEYCANGSLRRLISRSS
 .|....|.| .|.|||.. |   . ||.| .  .    . |.| |......|  .| |||. .| ....         |.|..||...|.|.  . .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

TGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSS-------ALTLA-----GT----LNWMAPEILGNRG-ASTL
  |.  .   . .|   |  |||  ..||||. | |.|.....||| .||| |  . .            .     |     . ||||| . | |  .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK

SDIWSLGATVVEMLTK-NPPYHN-----LTDANIYYAVEND-TYYPPSS--------FSEPLKDFLSKCFVKNMYKRPTADQLLKHV
||.|| | .  |..|   .|| .     .... ..  |..     .| .         .. . .  ..|   .  .|||  .. .  
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CDC15.AA YSK 239-272 41 1.1e-11 31.14 In-house 224-257 (257) Show / Hide 
Range on Protein: 239-272
Range on HMM: 224-257/257
Sequence Identity: 41% (14 aa)

SSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI
.|.| ..|.|   | .|.  .||.|..||||  |
RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase CDC15.AA MST 238-272 45 2.7e-11 32.08 In-house 220-254 (254) Show / Hide 
Range on Protein: 238-272
Range on HMM: 220-254/254
Sequence Identity: 45% (16 aa)

PSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI
|. .|  . ||..|| .||  .|.|| |||.|  |
PEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI