Gene PBS2 (Bakers Yeast)

PBS2

Species: Bakers Yeast
Alias: PBS2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
PBS2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
PBS2.AA Protein Refseq_NP 668 `Involved in osmoregulation, member of the HOG1 mitogen-activated protein kinase (MAPK) cascade; Pbs2p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of PBS2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PBS2.AA STE7-Unclassified 360-623 45 1.5e-159 536.3 In-house 1-301 (301) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-301/301
Sequence Identity: 45% (138 aa)

LEFLDELGHGNYGNVSKVLHKP------TNVIMATKEVRLELD-EAKFRQILMELEVLHKCN-SPYIVDFYGAFFIEGA---VYMCMEYMDGGSLD---K
||.|..||||..|.|.|.|||.      ...|||.|....... .....|||.||..||||. .||||..|||...|.    ...||||||.||||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

IYDESSE----IGG-IDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASL--AKTNIGCQSYMAPERIKSLNPDR
||....|    .|| |.||.|..||..|||||..|.|.|.|||||.||.|||... .|.||.|||||.|.|...|  |||..|||.||.||||.. .|.|
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNS-KGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHR

ATYTVQSDIWSLGLSILEMALGRYPYP----PETYDNIFS-------QLSAIVDGPP-PRLPSDK----FSSDAQDFVSLCLQKIPERRPTYAALTE-HP
..|.|.||||||||.|.|.|.|.|||.    .|.|...|.       .|.......| ||||.|.    .|....||.| |..|.|..||....|.. ||
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

WL
|.
WI
Kinase PBS2.AA STE7 360-623 52 1.9e-159 536.02 In-house 1-288 (288) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-288/288
Sequence Identity: 52% (154 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDE-AKFRQILMELEVLHKCN-SPYIVDFYGAFFIEGA--VYMCMEYMDGGSLDKIYDESSEI--
||...||||||||.| |..|||...||| |..||.... .   ||||||.|||||| .|||| |||||. ||   ...||||||||.|||.|..  ..  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASL--AKTNIGCQSYMAPERIKSLNPDRATYTVQSDI
    | | |. |. || |||.||. |.|.|.|||||||| |||.   .| |||||||..|.|| |.  |.| .|||.|||||||     ..  |.|.||.
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNS-RGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG---NKQHYDVRSDV

WSLGLSI-LEMALGRYPYP-----P---ETYDNIFS-------QLSAIVDG-PPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTE-HPWL
||||... .|||.||||||     |   ..|.|.|.       ||. ||.. ||||||  ||| . ||||..|||| |  ||.|  |.. ||..
WSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase PBS2.AA STE 360-623 32 7.2e-109 367.99 In-house 1-359 (359) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-359/359
Sequence Identity: 32% (118 aa)

LEFLDELGHGNYGNVSKVLHK------PTNVI---------MATKEVRLELDE----------------AKFRQILMELEVLHKCN--SPYIVDFYGAFF
.|.....|.|..| | | ...      .|. .         || |...|| ..                 .. |||.|.....|||  .|.|| .||..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEG-------AVYMCMEYMDGGSLDKIYDESSEIGG-----------IDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVS
 ||        ...|||||||||||.|...  ..|.           ..|.|.|.|. ....|| .....|.|||||.|| |||       ||||||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

GNLVASLA----------------K--TNIGCQSYMAPERIKSLNPD-RATYTVQSDIWSLGLSILEMALGRYPY---PPETY-----DNI-----FSQL
|.|. |.|                |  | .|.. .||||.|.  . . .  |....||||||. |.||| |..|.   .|        .|.     | ||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

SAIVDGPPPRLPSD------------------KFSSDAQDFVSLCLQKIPERRPTYAALTE--HPWL
 .||.||||.||..                  |.|.. .||...|||| |. |||.  | .  ||..
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PBS2.AA MEK3 360-623 44 7.6e-96 324.73 In-house 1-264 (264) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-264/264
Sequence Identity: 44% (121 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNS-PYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSE-IG-GI
.. . ||| | || | |. |...  ||| | .|        ...||.. .       || | |||| | || |  ||| ||  .||| |    . .|  |
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHI

DEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKT-NIGCQSYMAPERIKSLNPDRAT--YTVQSDIWSLGLS
 |. |  ||  .. .|. ..|| ..||||||| |.|  .. | ||.||||.|| || | |||   ||  |||||||   .|.     | | ||.||||  
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHH-GQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERI---DPEMNQKGYDVKSDVWSLGIT

ILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDK-FSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
. ||| |||||  .     | ||  .| .|||.|| .| || | |||.. ||.| .. ||.|  | ||| .
MIEMAIGRYPY--DNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase PBS2.AA MEK4 360-623 41 2.2e-92 301.82 In-house 1-275 (275) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-275/275
Sequence Identity: 41% (115 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVR-LELD-----EAKFRQILMELEVLHKC-NSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSE
|. | |.| |..| | | .||....||| | .|    |     .   .. |||..|  |  | |||| |||| | ||   .||| ||  |.|| |    .
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

I--GGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKT-NIGCQSYMAPERIKSLNPDRATYTVQSDIWS
.    | |  .. |. ...  |  |||.|.|||||||| |||  . .| |||||||..| || | |||   ||. ||||||| .    .  | . ||.||
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDR-HGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQ-NMDGYDIRSDVWS

LGLSILEMALGRYPYPPETYD--NIFSQLSAIVDGPPPRLPSDKF----SSDAQDFVSLCLQKIPERRPTYAALTEHPWL
||  . | | |..||.   ..  ..| |.. .| | ||.| .|..    | .  .|. .|| |  . || |  | ..|  
LGITMYEVATGKFPYR--KWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase PBS2.AA MEK1 360-566 53 5.1e-86 292.08 In-house 1-198 (297) Show / Hide 
Range on Protein: 360-566
Range on HMM: 1-198/297
Sequence Identity: 53% (111 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEP
.| . |||||| | | |. |..| .||| | ..||.  |  .||. ||.|||.||||||| |||||. .| . .||||||||||| .  .    | | | 
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA---GRIPEK

QLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMAL
 |  .. ||..||  |...|.|.|||||| |||  .. | .||||||||| |. |.|   .|  |||.|||..      . |||||||||.|||. |||.
ILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-----THYTVQSDIWSMGLSLVEMAI

GRYPYPP
|||| ||
GRYPIPP
Kinase PBS2.AA MEK5 360-623 45 2.8e-83 282.99 In-house 1-254 (254) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-254/254
Sequence Identity: 45% (122 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEP
. . | ||||| | | |  | |.  |.| | . |..     .||. |||.|.|| ||||. ||||||.|  . .| |.||||||| .|        | | 
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLD-MYRC------IPEH

QLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMAL
 |  .. |.. ||  | .   |.|||||| |.|    || .||||||||  || |...| ||   |||||||         | . ||.||||....|||.
ILGRMTVAIVKGLNYLWNLK-IMHRDVKPSNMLVNT-QGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISG-----DQYGIHSDVWSLGIFFMEMAT

GRYPYPPETYDN----IFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
||.|||    |         |  |||  |||||.||||    .|.  |.|| |. ||    | .||..
GRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase PBS2.AA MEK7 360-623 40 2.2e-76 258.65 In-house 1-269 (269) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-269/269
Sequence Identity: 40% (110 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCN-SPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEI--GGI
|... ..|||  |.| |. || ..|||| |  |        . ||| | |  .|. .||||  .|.|  .  |  ||| | .  .||    . .     |
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

DEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKT-NIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSIL
 |  .  .  |.|  |. ||| | |.|||||| |||    .| .||||||.|| .| | |.|   ||  |||||||    |    | . .|.|||| .. 
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILL-DWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLV

EMALGRYPYPPETYDNIFSQLSAIVDG--PPPRLPSDK---FSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
|.| |.||||    .  |  .. | .   .||.||  .   || | ..|| .|||| .  || |  | .||  
ELATGQYPYPGCDME--FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase PBS2.AA S_TKc 360-623 30 4e-74 253.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDG--GSLDKIYDESSEIGG--
 |.|...|.| .| | |. || |. |.| |...        ..|. |...|.| . |.|| .|..|   . .||.|||.||  |.| .. ..    |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTV-QSDIWSLGLS
 ..| . .|..  .. .|. . .. .|||||.|| |||..    ..|.||||..  |     .| .|   ||||| .         |.   .|.||.|  
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCI

ILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTE-------HPWL
. ||. |. |.|  ... .| ..                |..| ||.. |||| ||.|||   . .       |||.
LYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PBS2.AA STE20 360-623 34 5.4e-67 228.87 In-house 1-288 (288) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-288/288
Sequence Identity: 34% (102 aa)

LEFLDELGHGNYGNVSKVLHKPTNVI----MATKEVRLELDE---AKFRQILMELEVLHKCNSPYIVDFYGAFFIE----GAVYMCMEYMDGGSLDKIYD
 |.|...|.|.|| | |. ||||. .     | | . || ..    ... |. |  .. .|..|.|| .||... .       ...|||..||||  |..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ESSEIGG------IDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVA----SLA---KTNIGCQSYMAPERIKSLN
.. ..|.      ..|.| |.|   |  ||. |  ...|||||.|  ||| . . | |||.||||.. |      . .   .| .|   .|||| |.   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYL-HSNHIIHRDIKADNILLTED-GEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

PDRATYTVQSDIWSLGLSILEMALGRYPYPPETYD-NIFSQLSAIV--DGPPPRLP---SDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
  .  |.  .||||||  ..||| |. ||    .| . .. .  |   . |||.|    ..|.|.. .|||..|||| || |||   | .||..
GPDKGYDYKCDIWSLGITAIEMAEGEPPY----FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PBS2.AA Pkinase 360-623 27 1.9e-59 208.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQIL---MELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGG----SLD----KIYD
....  .| |..| | |  || |. | | |..... .. ...|..   .|.......|.|.|| .|..|  .. .||.|||..||    .|         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

ESSEIGGI--DEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTV----KLCDFGVSG---NLVASLAKTNIGCQSYMAPERIKSLNPDRA
  .. |..  .| .. |..  .. ||. . . ..|||||.|| |||.. |.|..    |.||||..    .   | ..|  |   ||||| |.    .. 
--WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQ

TYTVQSDIWSLGLSILEMALGRYPYPPE----TYDNIFSQLSAIVDGPPPRLPSDKFS-------------------SDAQDFVSLCLQKIPERRPTYAA
 |.  .|.||.|. . ||..|| |.| .    . ..    .  | ..|...  . . |                   ....||.. ||.| |..||| . 
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LTEHPWL
. .|||.
ILQHPWF
Kinase PBS2.AA SLK 361-623 34 1e-51 172.67 In-house 2-259 (259) Show / Hide 
Range on Protein: 361-623
Range on HMM: 2-259/259
Sequence Identity: 34% (92 aa)

EFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQ
| . ||| | .| | |  || ..|. |.| . .. || .    ..|...| .|. |.||. |.|..... ..| .|. ||| .| |  |  .   . |.|
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIK-DEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHP--LTEDQ

LAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAK--TNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMA
.....  .. .|. | .. ..||||.|  |||  . .| |.| |||||  .   . |  | ||   .|||| .       . |  ..||||||. ..|||
IQYVCKHMCEALNWLHSN-KVIHRDLKAGNILM-TMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMA

LGRYPYPPETYDNIFSQLSAIVDGPPPRL--PSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
 .    ||.   |    |  |    ||.|  || ..|.. .||.  ||.| |. |.| | | .|.|.
QME---PPHHEMNPMRVLLKIQKSEPPTLEQPS-HWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PBS2.AA MEK1 572-623 44 6.9e-16 50.29 In-house 246-297 (297) Show / Hide 
Range on Protein: 572-623
Range on HMM: 246-297/297
Sequence Identity: 44% (23 aa)

IFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
||  |  ||..|||.||.  ||.. ||||. ||.| |. | .   |. |...
IFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase PBS2.AA TyrKc 360-623 22 1.7e-14 11.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 360-623
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKC--NSPYIVDFYGAFFIE-------GAVYMCMEYMDGGSLDKIYDES
......||.|..| | |   |   .  | | .. .      . .. |.....|   . | || .||.   .       . ... ||||..|.|..   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVAS-------LAKTN---IGCQS-----YMAPERIKSLN
 .   .  ..|  ..  .  |   | ...|.||||    |.| ..|. ||| .||| | ..            ..     |. .      |||| |    
RPK--LCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

PDRATYTVQSDIWSLGLSILEMA-LGRYPYPPETY--DNIFSQLSAIVDGPPPRLPSD-------KFSSDAQDFVSLCLQKIPERRPTYAALTEHPWL
 .  ..| .||.|| |  . |.  .|  ||| ..    . .  .  . .|  .. | .         ...  .  . | .  || ||| ...  |  .
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase PBS2.AA Pkinase_Tyr 360-445 25 1.6e-10 36.29 Pfam 1-96 (270) Show / Hide 
Range on Protein: 360-445
Range on HMM: 1-96/270
Sequence Identity: 25% (24 aa)

LEFLDELGHGNYGNVSKVLHK----PTNVIMATKEVRLELDEAK--FRQILMELEVLHKC-NSPYIVDFYGAFF-IEGA--VYMCMEYMDGGSLDK
..|. .||.|..|.| |   |     |..  | | ..   ..     .  . |......  . | || .||.    ..   .|. |||| .|.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase PBS2.AA Pkinase_Tyr 477-508 46 0.689798 3.63 Pfam 128-158 (270) Show / Hide 
Range on Protein: 477-508
Range on HMM: 128-158/270
Sequence Identity: 46% (15 aa)

EQHNIIHRDVKPTNILCSANQGTVKLCDFGVS
|..|.||||.   |.| . |  .|| |||| .
ESKNCIHRDLAARNCLVTENN-VVKICDFGLA
Kinase PBS2.AA Pkinase_Tyr 526-551 42 3.015847 1.46 Pfam 181-201 (270) Show / Hide 
Range on Protein: 526-551
Range on HMM: 181-201/270
Sequence Identity: 42% (11 aa)

MAPERIKSLNPDRATYTVQSDIWSLG
|||| |.        .|..||.|| |
MAPECINYGK-----FTTKSDVWSFG