Gene PKH1 (Bakers Yeast)

PKH1

Species: Bakers Yeast
Alias: PKH1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
PKH1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
PKH1.AA Protein Refseq_NP 766 Pkb-activating Kinase Homologue; Pkh1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of PKH1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKH1.AA PDK1 125-391 53 3.7e-208 644.46 In-house 1-307 (307) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-307/307
Sequence Identity: 53% (164 aa)

FKFGEQLGDGSYSSVVLATARDS----GKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGT----KGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIK
|.||...|.||||.|.||.....    .|.||.|...|.|.||.||||||..|| ....||..    .||.||.||||||..|||.|||.|.||.|...|
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

K--YGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTA---KILPEE-------------PSNTADGKPYFDLYAKSKSFV
|  .||....|.|.||..||||.. ||..||||||.|||||||||.|....||||||   |||||.             ..|....||..|.....||||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAA-----NEYLTFQKVMKIQYAFTAG--FPQIVKDLVKKLLVRDPNDRLT-------IKQ
|||||||||||.|......|||||.|||.|||.||.|||...     |||.||||.||.||.|...  ||...|||||||||||||||||       ..|
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQ

IKAHLFF
|||| ||
IKAHPFF
Kinase PKH1.AA AGC 125-391 27 1.1e-135 353.05 In-house 1-395 (395) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-395/395
Sequence Identity: 27% (111 aa)

FKFGEQLGDGSYSSVVLATAR------DSGKKYAVKVLSKEY---LIRQKKVKYVTVE------------KLALQKLNG---------TKGIFK-LFFTF
|.|   .| ||.. | |.  .      |.|| ||.|||.|..   ......|... .|            .  |.|.|.            | | |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEAS--LYFLLEYAP--------HGD-FLGLIK----KYGSLNETCARYYASQ-------IIDAVDSLHN-IGIIHRD-IKPENILLDKNMKVKLTDFG
||.    |||..||.|         |.  | |..    |.|...| .||.||..       |. |...||.  |||||| .||||||||..  .||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKILPEEPSN---------------------------------------TADGKPYFDLYAKSKSFVG--TAEYVSPELLNDNYTDSRCDIWA--FGCI
 .|... ....                                       . |     .  .. ..|.|  |.||..|| |     .  ||.|.  .||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQE-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

LYQMLAGKPPFKAAN----------EYLTFQKVMKIQYAFTAG----------------FPQIVKDLVKKLLVRDPNDRLT----------IKQIKAHLF
.|.||.|.||| . |          .. .|||.|. .|... .                | .  |||.||||..||..||.          ...||.| .
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase PKH1.AA S_TKc 125-391 30 2.8e-97 330.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-231/231
Sequence Identity: 30% (87 aa)

FKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPH--GDFLGLIKKYGS--
.......| |....| ... ...|...|.|...          . .  |   |.|  . . | ||. .|||  .||. .||...  || . .|||.|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLNDNYTDS
    ..|  ||.|. ||..|.. .|. ||||||.||||||||.   .|..||| |..|                    ..|.|| .|..||.|   |.  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL--GYGKC

RCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYAFTAGFPQIVKDLVKKLLVRDPNDRLTIKQIKA-------HLFF
.||.|..||||| ||.|.|||   .....|.|..          .. .||...|.|..||..|.|. .. .       | .|
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKH1.AA CAMK 130-391 24 1.2e-86 279.18 In-house 1-425 (425) Show / Hide 
Range on Protein: 130-391
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

QLGDGSYSSVVLATARDSG------------KKYAVKVLSKEYLI-------------------------RQKKVKYVTVEKLALQKLNG------TKGI
.|| ||.. | |.. . ..            .|.|.|...|. |                          |.|. | |  |   ..||.|       . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

FKLFFTFQD-------------------EASLYFLL---EYAPHG----DFLGLIKKYGS---------------LNETCARYYASQIIDAVDSLHNIGI
 ||. ...|                   .  .|. .   ||.. |    | .  |.. |.               ..|  ||.|  ||..||. .|. .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENILLDKNM-----------------KVKLTDFGTAKILPEEPSNT----ADGKPYFDL--------YAKSKSFVGTAEYVS-PELLND----
.|||.||||||||.|.                 ..|..||| |.....  .|.     .|.  .            | | |.|| ||.. ||.||     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------NYTDSRCDIWAFGCILYQMLAGKPPFKAA-------------NEYLTFQKVMKIQYAFTAGFPQI------------------------V
           | .  ||.|. |.||| || |.||| .              |.| .|.|.|| .| |   .  .                        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLVKKLLVRDPNDRLTIKQIKAHLFF
|||..|.|..||..|.||.|...| ..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PKH1.AA Pkinase 125-391 27 7.9e-78 269.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

FKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTV--EKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHG----DFLGLIK--
...|...| ||...| ... ...||..|||...|.  .. .| .. .   |   ...||    | .|. .|.|. ..|. .||...|    |   .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KYGSL--NETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKV----KLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLN
..|..   |  .. |. ||. ... .|. ||||||.||||||.|.|. .    |..||| || .                .   ..|.|| .|..||...
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-MTTFCGTPWYMAPEVIR

-DNYTDSRCDIWAFGCILYQMLAGKPPFKAA------NEYLTFQKVMKIQYAFTAGFP---------------------QIVKDLVKKLLVRDPNDRLTI
 ..| ....|.|..|||||.|| |.|||. .      ...  ....|. .. |    .                     .  ||..|..| .||..|.|.
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

KQIKAHLFF
.||. | .|
EQILQHPWF
Kinase PKH1.AA RSK 127-391 30 2.6e-77 263.14 In-house 1-278 (278) Show / Hide 
Range on Protein: 127-391
Range on HMM: 1-278/278
Sequence Identity: 30% (90 aa)

FGEQ--LGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKK-VKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGS---
  .   .| |... .   | .|.|. ||.|||.|  ... .| ....  |   |.  .. . | .|. .||.|  ||  .|| . |...  ..| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDK---NMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLN----DN-
. |. |..|...|. ||. ||  ||||||.||||||.|    .  .|||||| .|..              |   . ..|..|.||. ||.|.    .. 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGG

YTDSRCDIWAFGCILYQMLAGKPPFKA---ANEYLTFQKVMKIQYAFTAG----FPQIVKDLVKKLLVRDPNDRLT-----IKQIKAHLFF
.. . ||.| .|...| ||.|.|||..   .|   ......| .. .| .      |  |||..|.| |||..||.     ...||.| .|
HDKA-CDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKH1.AA Ciliate-E2 125-391 25 5.7e-72 245.41 In-house 1-365 (365) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

FKFGEQLGDGSYSSVVLATARDSGKK-----------------------YAVKVLSKEYLIRQKKVKYVT----------VEKLALQKLNGTKGIFKLFF
.|| ...| |...|| ... .  .|.                       ||.|...|  .. .|.....            ||  |..||  . | |.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

TFQ--DEASLYFLLEYAPHGDFLGLIK------------KYGSLNETCARYYASQIID---------------AVDSLHNIG-IIHRDIKPENILLDKNM
.||  |. ..|. .||. .|| . .||            . ....|  ..|.  ||..               |. .||. . ||||||||||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKS--------------------FVGTAEYVSPELLN---------DNYTDSRCDIWAFGCILYQMLA
 .|..|||..|.. ..  |. . |.   .|   |.                    ..||..|..|| ||          .. |  ||||..|.|||.|| 
-IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GKPPFKAANEYLTFQKVM--KIQYAFT----------------AGFPQIVKDLVKK----LLVRDPNDRLT-IKQIKAHLFF
|||||        .|. .  ||.. .                    .| .||| ||    .|..||. |.| ..||. | .|
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PKH1.AA Ciliate-E2-Unclassified 125-391 26 2.6e-67 229.93 In-house 1-352 (352) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

FKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKG----------------------IFKLFFTFQDEASLYFL
.|...|.| |....| ..  .. ...|| | ..|   . ||.....  |..  .|    |                       | |.|..|||.  .|. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYAPHGDFLGLIKKYGS-----------------LNETCAR-----YYASQIIDAVDSLHNIG-IIHRDIKPENILLDKNM---KVKLTDFGTAKILPE
.||...|| .  |||...                 . |  |.     .|. ||... ..||  . ||||||||||||.|.|.   ..|..||| .| . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

EPSNTADG---KPYFDLYAKSKSFVGTAEYV----SPELLND-NYTDSR---CDIWAFGCILYQMLAGKPPFKAANEYL----------------TFQKV
 . .. .    |  .  . ....|.|| .|     .||.|   || .|    ||||..|.|||.|| |..||.. |..                  .|. 
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

MKIQYAFTA--------GFPQIVKDLVK----KLLVRDPNDRLTIKQIKAHLFF
.. .. |          . .. .||...    |.|. .|| |.|..||. | .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase PKH1.AA AktR 125-391 33 6.6e-67 228.59 In-house 1-268 (268) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-268/268
Sequence Identity: 33% (95 aa)

FKFGEQLGDGSYSSVVLATAR-DSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGSLNE
|.. . || | .. |.|.. . |..|.|| |...|. .|.... ...  |.  .....   .| ||...||..  |.|..|| | |. .  .|| . ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

TCARYYASQIIDAVDSLHNI-GIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDL-Y-AKSKSFVGTAEYVSPELLND----NYTDS
  || |..||. |.. ||.   || ||.||||||||..  ||.|||| .|               |.  |  | .||.|| ||..|| ..     |..  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKS--

RCDIWAFGCILYQMLAGKPPFKAAN-EYLTFQKVMKI--QYAFTAGFPQIVKDLVK-KLLVRDPNDRLT-----IKQIKAHLFF
 .|.||||. .| |..| ||| . | ... . .  |   .  ... | .  |||.. ||| ..|| ||.     ...|| | .|
-VDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKH1.AA CAMKL 125-391 29 4.1e-62 196.97 In-house 1-297 (297) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-297/297
Sequence Identity: 29% (92 aa)

FKFGEQLGDGSYSSVVLATA-RDSGKKYAVKVLSKEYLIR-------------QKKVKYVTVEKLALQKLNGTKG----IFKLFFTFQDEAS------LY
...|..|| ||.. | |||  |  |.|.|.|.. |. .               ....  .. |   ...||  .|    | ||. .....        .|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLN--IGKHPNIIKLYEVIETPEHDIETKKIY

FLLEYAPHGD--FLGLIKKY----GSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNM--KVKLTDFGTAKI---LPEEPSNTADGKPYFD
  .||.. |.   .  |.|     |.. |  || |  ||..||. .|. ||.||||||||||||.|.  ..|..||| . .                 | 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC------------IFG

LYAKSKSFVGTAEYVSPELLND--N-YTDSRCDIWAFGCILYQMLAGKPPFKAA--------NEYLTFQKVMKIQYAFT--AGFPQIVKDLVKKLLVRDP
   | | | |. .| .||....    |     |||. | ||| |. |. ||...        |  . . |.|.  | ..     .  ..|| .|.|...|
PGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNP

NDRLTIKQIKAHLFF
..| ||.||. | ..
EKRPTIHQIMNHPWM
Kinase PKH1.AA MSK 125-391 28 7.1e-62 207.94 In-house 1-277 (277) Show / Hide 
Range on Protein: 125-391
Range on HMM: 1-277/277
Sequence Identity: 28% (84 aa)

FKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYV-TVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGSLNE
 | . ..|.|... .   . .|.|| ||.|.|||  .. ..|..     |  .|. . ... | .|. .|||.. .|  .||.  |  .. |.| .   |
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

TCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKN---MKVKLTDFGTAKILPEE---PSNTADGKPYFDLYAKSKSFVGTAEYVSPELLND---NYT
. .|..  ... |||..|  ||||||.||||||.| .    .|||.||| |...|..   . ..               . .| .| .||.|..   . .
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS---------------PCFTLHYMAPEMLRRGYAQDG

--DSRCDIWAFGCILYQMLAGKPPFK--AANEY-------LTFQKVMKIQYAFT----AGFPQIVKDLVKKLLVRDPNDRLTIKQIKAHLFF
  |. ||.|  | ||| || |. ||.  .. .           ....| .  |.     .. .  |||...|| .||..||.   . ||   
GYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase PKH1.AA Aur 193-269 46 8.6e-36 91.51 In-house 68-147 (257) Show / Hide 
Range on Protein: 193-269
Range on HMM: 68-147/257
Sequence Identity: 46% (37 aa)

FQDEASLYFLLEYAPHGDFLGLIKKY--GSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLD-KNMKVKLTDFG
|.|.   |..|||||.|.   ...|   ....|  | .| .||..|.| .|  .|||||||||||||| .| ..|. |||
FHDDQRIYLILEYAPGGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFG
Kinase PKH1.AA Aur 299-391 32 3e-33 84.66 In-house 163-257 (257) Show / Hide 
Range on Protein: 299-391
Range on HMM: 163-257/257
Sequence Identity: 32% (31 aa)

GTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKA-ANEYLTFQKVM-KIQYAFTAGFPQIVKDLVKKLLVRDPNDRLTIKQIKAHLFF
|| .|..||  ...  | . |||..| ..| .. |.|||..  |   |....  | .. |   ... .|||..|.|..||. |.|..||..| ..
GTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase PKH1.AA TyrKc 125-389 20 1.2e-14 14.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 125-389
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKL-NGTKGIFKLF-FTFQDE------ASLYFLLEYAPHGDFLGLIK
 ..|..|| | .  |...|..    . |||.| ..       ..    |   . ||    . | .|.    |..        |. ..||.|||| .  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KYGS-LNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEE-------PSNTA----DGK---PYFDLYAKSKSFVGTA
|..  |.     ... || .  . ||  ..||||.   |.|...|  || .||| .. . ..          ..    .||   |.              
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-------------

EYVSPELLNDNYTDSRCDIWAFGCILY--QMLAGKPPFK-----AANEYLTFQKVMKIQYAFTAG--------FPQIVKDLVKKLLVRDPNDRLTIKQIK
   .|| .|..   .  |.|.||  ..    . ..|.         |. .  .          .          |. . .. |.   .||.|| | ..|.
-WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

AHL
  .
ECF
Kinase PKH1.AA Aur 125-165 31 7.3e-14 32.46 In-house 1-41 (257) Show / Hide 
Range on Protein: 125-165
Range on HMM: 1-41/257
Sequence Identity: 31% (13 aa)

FKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQK
|..| .|| |... | ||  . .....| ||..|| .. ..
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYC
Kinase PKH1.AA Pkinase_Tyr 240-269 43 0.000887 13.42 Pfam 127-156 (270) Show / Hide 
Range on Protein: 240-269
Range on HMM: 127-156/270
Sequence Identity: 43% (13 aa)

LHNIGIIHRDIKPENILLDKNMKVKLTDFG
|.....||||.   |.|...|..|| .|||
LESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase PKH1.AA Pkinase_Tyr 125-159 33 0.002237 12.06 Pfam 1-38 (270) Show / Hide 
Range on Protein: 125-159
Range on HMM: 1-38/270
Sequence Identity: 33% (13 aa)

FKFGEQLGDGSYSSVVLATAR----DSGKKYAVKVLSKE
 .||..|| |.. .|...|..    . . . |||.| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE
Kinase PKH1.AA Pkinase_Tyr 375-389 46 1.938676 2.11 Pfam 256-270 (270) Show / Hide 
Range on Protein: 375-389
Range on HMM: 256-270/270
Sequence Identity: 46% (7 aa)

DPNDRLTIKQIKAHL
||.|| | ..|  .|
DPEDRPTFSEIHEQL
Kinase PKH1.AA Pkinase_Tyr 305-328 29 7.19905 0.18 Pfam 182-205 (270) Show / Hide 
Range on Protein: 305-328
Range on HMM: 182-205/270
Sequence Identity: 29% (7 aa)

SPELLNDNYTDSRCDIWAFGCILY
.|| .|..   .  |.|.||  ..
APECINYGKFTTKSDVWSFGVLMW
PDK1_PH_fungi PKH1.AA PDK1_PH_fungi 588-673 23 1.3e-36 116.71 In-house 1-100 (100) Show / Hide 
Range on Protein: 588-673
Range on HMM: 1-100/100
Sequence Identity: 23% (24 aa)

KFYKKMFLITNLGRALVFVKRRSLSMWEEQEFELQFELELN--DVEKIRFISDQVLEIDGS-------------RTIFIGCKERAVLMKLWKLIHNGMTA
|.||.|..||..||.|.|.||.....|......|..|..||  .|......|.| ......             ......|....|....|.|.......
KYYKCMMVITTHGRCLIFTKRNKPNPWTNLNYDLCYEINLNQPFVKIKELVSPQ-TKFQKMMPSTGIFVIQTPYKSFVFECEKFDVNQWTWALKKSIKNN

K
.
H