Gene PRK1 (Bakers Yeast)
PRK1
Sequence
Protein domains of PRK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | PRK1.AA | NAK-Unclassified | 22-297 | 38 | 4.7e-190 | 637.69 | In-house | 1-405 (405) | Show / Hide |
Range on Protein: 22-297 Range on HMM: 1-405/405 Sequence Identity: 38% (157 aa) AKIIKYLTSGGFAQVYTA----EISPPD-----PYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNNKHVVSYIDSHAARSVNG-IAYEVFVLMEFC ..|..||..|||..||.. .|.||| |.||.|..||||.|......|||...|.|.||..||....|.|||.|..|.... ..||||.|||.| YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC ERGGLIDFMN------TRL--QNRLQESEILEIMSQTVQGITAMHALQP--------------------------------------------PLIHRDI .||.|.|||| .|| |.|..|.|.|.|||...|||..||..|| ||||||| SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI KIENVLIS----------------------------------------------------------HDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDIL ||||||.. |.|.||.|||||....|....|.||..|.|..|. KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQYLQDWIN TNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAG-------ILH--ARYQYPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVL ..||.|||.||||||||..|||||.||||||.||||.|.||||||..|... ||| ..|..||...||..|.|||..||.|.|.|||||.||| MHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQVL EEVSR ..... NHICQ |
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Kinase | PRK1.AA | NAK | 22-295 | 45 | 1.9e-156 | 525.85 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 22-295 Range on HMM: 1-299/299 Sequence Identity: 45% (136 aa) AKIIKYLTSGGFAQVYTAE---ISPPD-PYSNANIACLKRVIVP-HKQGLNTLRAEVDAMKLLRNNKHVVSYIDSHAARSV-NGIAYEVFVLMEFCERGG ...|||..|||..|| .. |..|| |.||.. ..|||.|.. ..|.||....|...||.|......|.|||||..... . .|||.|||.|..|. YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS LIDFMNTRL---QNRLQESEILEIMSQTVQGITAMHALQP--PLIHRDIKIENVLIS---HDGLYKVCDFGSVSGVIRPPRNTQEFNY---VQHDILTNT |.|.||.|| .....| ||| |.... .|. |||..|| |.|||||||||.|.| ||| || |||||... |..|.|..|..| ||..| ..| LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT TAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEK------SGEAGILHARYQ--YPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEV | .||.|||.|||...|||||.||||||..|||.|.||.|||. |. .|....|. .|. ..||. ...||| ||.. |.|||||.|||. . TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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Kinase | PRK1.AA | BIKE | 24-294 | 36 | 4.9e-75 | 255.61 | In-house | 3-267 (267) | Show / Hide |
Range on Protein: 24-294 Range on HMM: 3-267/267 Sequence Identity: 36% (101 aa) IIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTR . . | |||| |. . . | ||| | .. || . |. || . | .| |.|. ||. .|. .|||.| . ... || | VEEQLAEGGFAMVFLVRDHKG------NKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGV-WECMILMEYCRH-QVVNMMNQR LQNR--LQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDG--LYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNTTAQYRSPEMIDLYRG || . |.|.|.| . . .| | | |||| |.||.|.. | | ||||| . . |. .. |||. | .|| ||.||||||| | LQQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQ-KHGVNYVKDEIEKYTTMCYRAPEMIDLYSG LPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQYPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVLEE ..| |.||||||. ||| |... ||. | | | .. |. ..||. .. ||| || . .||.| || . KEITTKADIWALGCMLYKLCFFCLPFGESQLA-ICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV |
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Kinase | PRK1.AA | GAK | 106-295 | 37 | 1.9e-41 | 135.47 | In-house | 82-277 (277) | Show / Hide |
Range on Protein: 106-295 Range on HMM: 82-277/277 Sequence Identity: 37% (73 aa) VLMEFCERGGLIDFMN-TRLQNRLQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRN---TQEFNYVQHDIL .|||.| . | |.. . . .| |. |. . || || ||||||||| ||. .. | ||||| . | |. |. . LLMEYCKFSQLVDCLKRMECYKPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMF TNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQ--YPS-FPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEV ..|| ||||||.||| || .| ||||.| || .|| ||| .. | . | | .||. . ||| .| | |. | .|.| RHTTPMYRSPEMCDLYSNWPIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYM-CFHDLIRACLQVNPDERLDIAMVVEYM |
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Kinase | PRK1.AA | TKL-ciliate1 | 108-295 | 25 | 3.4e-40 | 135.29 | In-house | 78-279 (279) | Show / Hide |
Range on Protein: 108-295 Range on HMM: 78-279/279 Sequence Identity: 25% (53 aa) MEFCERGGLIDFMNTRLQ--NRLQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNTT ||.|. | . | . . . . . .. . ||. .| .|.||||||.|..| | . . || |.|..| . . | .| .. ||| MEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTT AQYRSPEMID--LYRGLPIDEKSDIWALGVFLYKICYYTTPF-EKSGEAGILHARYQYPSFP------------QYSDRLKNLIRLMLMEAPSQRPNICQ .. || .| .. . || || ||.|.|. .| | ||| .| . . . || ... . ||. .. . | .||| . FHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQK---MSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNE VLEEV ... . IIQIL |
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Kinase | PRK1.AA | S_TKc | 22-298 | 20 | 2.9e-33 | 117.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-298 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) AKIIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCER--GGLIDF .|.. . .|.|..|| . | .|.. ...| |.. .| . ...| ..|. .... ||.|. | | |. YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDY MNTRLQNR----LQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNTTAQYRSPEMID . | .. . | .. .| |..... .| . ||||.| ||.|... |.||||. . | |..||.. IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL- LYRGLPIDE-KSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQYPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVLE-E-----VSRL . . |.|.|..|. || .. .||. .. ... |. .|..|| .| |..|| . ..|. | . -----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | PRK1.AA | Ciliate-E2-Unclassified | 108-293 | 22 | 1.4e-28 | 96.27 | In-house | 100-348 (352) | Show / Hide |
Range on Protein: 108-293 Range on HMM: 100-348/352 Sequence Identity: 22% (56 aa) MEFCERGGLIDFMNTRLQ---------------NRLQESEIL-----EIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDG---LYKVCDFGSVSGVI ||.|| | |..... | . ....| ... .. | .||. .| . |||||| ||.|.. .| |..|||. . . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ RPPRNTQEFN-----YVQHDILTNT--TAQYR----SPEMIDLYRGLPID----EKSDIWALGVFLYKICYYTTPFEKSGEAG---------------IL .. .. ... . ...... . | .| .||.. .| | .|.|||.||| || ... . ||. . .| QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL---QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL HARYQ-----YPSFP------QYSDRLKNLIR----LMLMEAPSQRPNICQVLE . . .|.|| . |. |..|. || |..|... |.|. YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN |
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Kinase | PRK1.AA | Ciliate-E2 | 22-293 | 18 | 2e-28 | 94.69 | In-house | 1-361 (365) | Show / Hide |
Range on Protein: 22-293 Range on HMM: 1-361/365 Sequence Identity: 18% (73 aa) AKIIKYLTSGGFAQVYTA-EISPPD-----------------PYSNANIACLKRVIVPHKQGLNTLRAEVDAMK-------------LLRNNKH--VVSY |.|| . .|.|..|| . .. . .. ...| .|... |.... . | . |. .|....| .. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMK---KNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM IDSHAARSVNGIAYE------VFVLMEFCERGGLIDFMNTRLQNRLQE---------SEILEIMSQTVQ---------------GITAMHALQPPLIHRD .. ... .. ||.|. | | |... . ..|..| ||..|| | .| .. .| . |||| YE----------CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRD IKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNT------------------------TAQYRSPEMIDL--YR----GLPIDEKSDI || ||.|. |..||| . . |... . . .. |. | .||.. | . . |.|.|| IKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDI WALGVFLYKICYYTTPFEKSGEAGILHARYQYP----------------SFPQYSDRLKNLIRL----MLMEAPSQRPN-ICQVLE |.||| || .. .|| . |. ...| |. . |. |.||. || |..|.. . |.|. WSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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Kinase | PRK1.AA | Pkinase | 22-295 | 22 | 1e-26 | 95.53 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 22-295 Range on HMM: 1-293/293 Sequence Identity: 22% (73 aa) AKIIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQG--LNTLRA--EVDAMKLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCERG--- .|.. . ||.|..|| . . .. | ..|.. ..|. . |.| |. || | | ...| ..|. .. . ||.|| | YHIGRKIGSGSFGCVYKC-HHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYV -GLIDFMNTRLQNRL--QESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLY----KVCDFGSVSGVIRPPRNTQEFNYVQHDILTNTTAQ | |.. |. .... .| |. .| |...|. .|. ||||.| ||.||...| |.|||| .. ... . |.. . .. | MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFG-LAKQFD------Y-NNS-MTTFC-GTPW YRSPEMIDLYR-GLPIDEKSDIWALGVFLYKICYYTTPFEKSGE------------AGILHARYQYPSFPQYS-------------------DRLKNLIR |..|| | | ... |.|.|..|. || . .|| |. . |..... .... .| . .| .|. YMAPEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP--GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK LMLMEAPSQRPNICQVLEE--V .| |..||.. |.|. . WCLCKDPKKRPTAEQILQHPWF |
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Kinase | PRK1.AA | CAMK | 101-293 | 16 | 2.9e-26 | 81.04 | In-house | 106-421 (425) | Show / Hide |
Range on Protein: 101-293 Range on HMM: 106-421/425 Sequence Identity: 16% (53 aa) AYE-----------------------VFVLM---EFCERGGLIDFMNTRLQNR-----------------LQESEILEIMSQTVQGITAMHALQPPLIHR .|| .. | |.|. | | | . ... . ..|.| .. | .... .| . .|| VYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN--IVHR DIKIENVLISHD-----------------GLYKVCDFGSVSGVIRPPRNTQEFNYVQHDILTNT----------------TAQYRS-PEMIDLYR----- |.| ||.|.... . |..||| ... |... | . . .. | | . ||.. . DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ ------GLPIDEKSDIWALGVFLYKICYYTTPFEKSGEA-----------------GILHARYQYPSFP----------------------QYSDRLKNL ....|.|.|..|| || . ||. . . |. ..|..|... . |. |.| NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDL IRLMLMEAPSQRPNICQVLE || || |..|..| |.|. IRKMLQVDPEKRMTIEQCLN |
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Kinase | PRK1.AA | TKL | 28-295 | 14 | 1.1e-21 | 74.87 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 28-295 Range on HMM: 1-364/364 Sequence Identity: 14% (53 aa) LTSGGFAQVYTAEISPPD----PYSNANIACLKRVIVPHKQGLNT-------------------------LRAEVDAMKLLR-NNKHVVSYIDSHAARSV . ||||..|| .. . .. |. . . . . . |. .| ..| . ..|... . . . IGSGGFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC NGIAYE-------VFVLMEFCERGGLIDFMNTRLQNRLQESEILEIMSQTVQGITAMHALQ------PPLIHRDIKIENVLISHDGL------------- ... .. . ||.|..| | .... . .. .. .. .|. .|. . ||.||||.| .|.|. .. GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW -YKVCDFGSVS------GVIRPPRNTQ-----EFNYVQHDILTNTTAQYRSPEMID---LYR----------GLPIDEKSDIWALGVFLYKICYYTTPFE |.|||| . . ... |. .. . | .. .||... |. |.. .||.|... |. |. |. .|.. CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY KSGE-------------AGILHARYQYPSF------------PQYSDRLKNLIRLMLMEAPSQRPNICQVLEEV . .. ... . ... | |. ...|.|. . |..||. ..|.. DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | PRK1.AA | NEK | 223-297 | 37 | 9.2e-13 | 41.65 | In-house | 202-286 (286) | Show / Hide |
Range on Protein: 223-297 Range on HMM: 202-286/286 Sequence Identity: 37% (32 aa) DEKSDIWALGVFLYKICYYTT--PFEKS--GEAGIL----HARYQYPSFP-Q--YSDRLKNLIRLMLMEAPSQRPNICQVLEEVSR ..|||||.||. || .| ||| . . ||| | . ||. |.|||..|| |.|||.. |.|| NNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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Kinase | PRK1.AA | TyrKc | 22-295 | 18 | 6.2e-10 | -62.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 22-295 Range on HMM: 1-280/280 Sequence Identity: 18% (58 aa) AKIIKYLTSGGFAQVYTAEISPPDPYSNANIA--CLKRVIVPHKQGLNTLRAEVDAMKLL-RNNKHVVSYIDSHAARSVNGIAYE----------VFVLM . .| | .| | .|| .. . . | .|| . .. | |. | .....| . |.. . ....| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLY---------GVCTQQGRNFMYIEPLMIVM EFCERGGLIDFM-NTRLQNRLQESEILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFG-SVSGVIR---PPRNTQEFNYVQHDILT- |... | | |. ..| . |. .. |... | .| | ..||||. |.|..... |..||| | . . .| . EYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------ESKDYYRK ----NTT--AQYR--SPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFE-------KSGEAGILHARYQ-YPSFPQY---------SDRLKNLIRLM .. .| .|| |. .. .|||.|. || .. |. | . .| . | . . .. |.. .| . .... KEHKGGKTMLPIRWMAPECINYGK---FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC LMEAPSQRPNICQVLEEV .| |..||. .. |. WHEDPEDRPTFSEIHECF |
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Kinase | PRK1.AA | NEK | 108-178 | 27 | 3.7e-09 | 28.81 | In-house | 85-168 (286) | Show / Hide |
Range on Protein: 108-178 Range on HMM: 85-168/286 Sequence Identity: 27% (23 aa) MEFCE-RGGLIDFMNT-RLQN----RLQESEILEIMSQTVQGITAMHAL---QPPLIHRDIKIENVLISHDGL----YKVCDFG ||.|| | | .. .. | ..|..|.... | . .. || | .||||| |. .. .. |. ||| MEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFG |