Gene ACK (Human)

ACK

Species: Human
Alias: TNK2, ACK, FLJ44758, ACK1, FLJ45547, p21cdc42Hs
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3q29,

Classification

Group: TK
Family: Ack

Sequence

Name Sequence Type Origin Length Description Download
ACK.AA Protein Sugen Kinome 1079 None Fasta, JSON
ACK.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON
ACK.NA RNA Sugen Kinome 4318 None Fasta, JSON

Protein domain

Protein domains of ACK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SAM_Ack ACK.AA SAM_Ack 29-93 60 6e-41 142.37 In-house 1-65 (65) Show / Hide 
Range on Protein: 29-93
Range on HMM: 1-65/65
Sequence Identity: 60% (39 aa)

EGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAL
|.. ||.|.|.|.||.||....||.|.||||.||.|||.||||.|||.||.|||||||.|.... 
EECQWLYEFLREAQLEQYYNQIRDHLKVTRLDHFDYVKDEDLECIGMSRPEQRRLWEAYKKMCPH
Sam7 ACK.AA sam7 29-91 25 4.1e-14 48.05 In-house 1-70 (70) Show / Hide 
Range on Protein: 29-91
Range on HMM: 1-70/70
Sequence Identity: 25% (18 aa)

EGTGWLLELLSEVQL---QQYFLRLRDDLN---VTRLSHFEYVKNEDLEKIGMGRPG-QRRLWEAVKRRK
  . .. | | ....   |||  ..|| .    || ..|. ... |||...|. ||| ....|..... .
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
Kinase ACK.AA Ack 150-409 68 1.2e-204 686.13 In-house 1-266 (266) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-266/266
Sequence Identity: 68% (181 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPM-KMVTELAPLGSLLDRLRKHQG--
..|.||||||.||||.||||..|.||...||||||..|...||..||||.|||..||||||..|.|||||||. || .|||||||.|||||.||||..  
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRD-LVKIGDFGLMRALPQNDDHYVMQEHR--KVPFAWCAPESLKTRTFSHASDTWMFGVT
.||..||.....|.|.|| |||.||.|||||||||.||...| .|||.||||||||.||.|.|.|..||  ||||||||||.|..|.||||||.||||||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL
|||||.||.|||.|.||.|||.||||||||||||..||.|||..|.|||.|.|.|||||.|.||.|
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ACK.AA Pkinase_Tyr 150-409 42 1e-134 456.86 Pfam 1-270 (270) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-270/270
Sequence Identity: 42% (117 aa)

LRLLEKLGDGSFGVVRRGEWD-APSGKTVSVAVKCLKPDVLSQPEA--MDDFIREVNAMHSL-DHRNLIRLYGVVL--TPP--MKMVTELAPLGSLLDRL
.....||| |.||.|..|.|.  |..... ||||.||.   . .|.  ..||.||.. |..| .| |..|||||..    |  . .|.|..|.|.||| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKH---QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY-VMQEHRKVPFAWCAPESLKTRTFSHASDT
|||   .... . .|  ...|.|.|| |||||..||||||||| |..    |||.||||.|.. .||| | ..... |.|  |.|||..... |...|| 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WMFGVTLWEMFTYGQEP-WIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL
|.|||..||.||||..| . |.  ......|...|.|.|.||.||..||..| |||...||||||| ... .|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ACK.AA TyrKc 150-409 38 6.00000000001e-132 445.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-280/280
Sequence Identity: 38% (112 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL--DHRNLIRLYGVVLT--------PPMKMVTELAPLGSLLD
..|..||| | ||.|..|.|.      . ||||.||.|       . ||.|| . |..|  .| |..|||||...        .|. .|.|..|.|.|.|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

RLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN------DDHYVMQE--HRK--VPFAWCAPESLKTR
.||||.... . .|  ...|.|.|| ||.||..||||||||| |.. .  |||.||||.|..         .| |...|  ..|  .|  |.|||.....
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

TFSHASDTWMFGVTLWEMFTYGQEPWIG-----LNGSQILHKIDKEGERLPRPED--------CPQDIYNVMVQCWAHKPEDRPTFVALRDFL
.|...|| |.|||..||.|||||.|. |     .. ....... |.|.|.|.|..        ||...|..| |||...||||||| ......
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ACK.AA TK 150-409 22 1.4e-109 368.62 In-house 1-486 (486) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-486/486
Sequence Identity: 22% (111 aa)

LRLLEKLGDGSFG---VVRRGEWDA----------------------PSGKTVSVAVKCLKPDVLSQPEAMDD--------------FIREVNAMHS--L
..|..||| | ||   .|..|||                        ..|... ||||.||..  ...|.. |              . .|   |..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHRNLIRLYGVVLT-------------PPMKMVTELAPLGS----LLDRLRKHQGH--------------------------------------------
.| |..|||||..              .|. .|.|..|.|.    |.| |||. ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FLLGTLSRYAVQVAEGMGYLESK------RFIHRDLAARNLLLATRDL-----------VKIGDFG---
                               . . .|  ...|.|.|| ||.||      .|.|||||||| |.. ..            .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LMRALPQNDDHYVMQEHR-----------------------KVPFAWCAPESLK---------TRTFSHASDTWMFGVTLWEMFTYGQEPWIG-L
     | |.....|| |......                       |.|. |.|||.|.         ...|...|| |.|||..||.|||||||. | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NG---------SQILHKIDKE-----------GERLPRP--EDCP--------------QDIYNVMVQCWAHKPEDRPTFVALRDFL
.           ... .. ..           |.|...|  ..||              ...| .| |||...||||||| .|...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ACK.AA Syk 150-403 41 1.8e-93 316.81 In-house 1-257 (257) Show / Hide 
Range on Protein: 150-403
Range on HMM: 1-257/257
Sequence Identity: 41% (107 aa)

LRLLEKLGDGSFGVVRRGEWDAP----SGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQ
| . . .| | || |. |   .      .. . ||.| || | . ||   . |.|| . |. |||   .|. |. . ..| || |.|.||.... | .|.
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHN-QPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHR

GHFLL-GTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTL
 .      |   . ||| || |||.| |.|||||||| || .|   || |||. .||  ... |. . | | |  | |||.   ..|||.|| | ||||.
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFV
|||| ||| |  .  |. ..  |.. |.|...|. |||..| .| .||  |..||||||
WEMFSYGQKPYGEMKGQEVMKFIEN-GHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ACK.AA UTK 150-409 31 2.9e-92 312.85 In-house 1-296 (296) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-296/296
Sequence Identity: 31% (95 aa)

LRLLEKLGDGSFGVVRRGEWDAPS--GKTVSVAVKCLKPDVLSQPEAMD---DFIREVN---AMHSLD-HRNLIRLYGVVL-TPPMKMVTELAPLGSLLD
..|...|| | ||.|...... .|  .... |||| ..    . . ...   ||..| .    |  .. |.|..||.||..   |. .|||... |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

RLRKHQG-------HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATR-------DLVKIGDFG---LMRALP-------QNDDHYVMQEH-R
 ||.|         .. | ..  .|...|.|| ||.|..|.|||||||| |..          ..||.|||   . |...       . .. |.|. | .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KVPFAWCAPESLKTR-TFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEG-ERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL
..|..|.|||.|  . .|...|| | |||..||..|.|. |. |..  |..| . . |  |.|.|.||| ..|..|..||.  |..||.|. |....
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ACK.AA Src 150-409 41 1.2e-91 310.76 In-house 1-255 (255) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-255/255
Sequence Identity: 41% (110 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLR-KHQGH
..|..|||.| || |  | |.    ... |||| |||. .|.    ..| .| ..| .|.| .|..|| |. .  |   |||.   ||||| |. . .|.
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGTMSP----EAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

-FLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWE
   | .|   | |||||| ||||...||||||||| |  .  ..|..|||| | . ..|| |....  |.|  | ||| .  ..|.  || | ||. |.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

MFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN-VMVQCWAHKPEDRPTFVALRDFL
..|||. |  | .  . | .... | |.|.|. ||. .|. .| |||  .||.||||  |..||
IVTYGRVPYPGMTNHEVLQQVER-GYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ACK.AA SFK-Src 150-409 43 6.8e-91 269.56 In-house 1-259 (259) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-259/259
Sequence Identity: 43% (116 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHF
 || .||| | || | .| |     .|  |||| |||   |. |    | .|   |  | | |||.|| |     |.  .|||   ||||| |.  .|. 
IRLEKKLGSGQFGDVWKGRWN----NTTEVAVKTLKPGAMSAEE----FLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRS

L-LGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEM
| . .|   | ||| || ||| . |.|||||||| |      .|.||||. | | |.|  |  .|  | |  | |||  .. .||  || | ||. . |.
LRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

FTYGQEPWIGLNGSQILHKIDK-EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF----VALRDFL
 |||  |. |.    .| ..|. ||.|.| |  ||   |..| .|| |.|.|||||    . . || 
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase ACK.AA EGFR 150-410 40 4e-87 289.3 In-house 1-258 (258) Show / Hide 
Range on Protein: 150-410
Range on HMM: 1-258/258
Sequence Identity: 40% (107 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGH
|... .|| | || | .| |  | |..|   ||.| |.    . |.| .....|  .| |.|| .|.|| || ... |..|| . |.|.||| .|.|...
LKKVKVLGSGAFGTVYKGIW-IPEGENVKIPVAIKVLREQ--TGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDN

FLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEM
     |  ..||.| || ||| .| .|||||||| |. .   ||| |||| . |..... | .|.  |.|  | | |... | . |.|| | .|||.||.
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGG-KMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLL
 |.||.|. |.  ..| . . ..||||| |. | .|.| |||.||   .. ||||  |   . 
MTFGQKPYDGIPAREI-PDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ACK.AA TK-Unique 150-409 32 1.4e-76 260.74 In-house 1-294 (294) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-294/294
Sequence Identity: 32% (98 aa)

LRLLEKLGDGSFGVVRRGEWD---APSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLD-HRNLIRLYGVVLTP--PMKMVTELAPLGSLLDRLRK
|......|.|.|| | |||     ....|...|||| || ..  ...  .|| .| . | .|. | |.....|.  ..  |. .. | .| |.|.. ||.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNA--TDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

HQGH-------------------------FLLGTLSRYAVQVAEGMGYLES--KRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKV
 ..                            ...| ..|.|.| || ||.|  |...||||.||| ||. .  .||.|||. | .  | ..  |..  ..
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

PFAWCAPESLK--TRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC-PQDIYNVMVQCWAHKPEDRPTFVALRDFL
| .|.||||||  .... .  || |.|||..||.||.|. |  |.  ..|. .| ..| |.|.|| | ....||.| .|| ..||.||.| .... |
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ACK.AA SRM 150-410 40 1.8e-76 255.28 In-house 1-253 (253) Show / Hide 
Range on Protein: 150-410
Range on HMM: 1-253/253
Sequence Identity: 40% (108 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV-LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVV-LTPPMKMVTELAPLGSLLDRLRKHQGH
  |  |||.| || |  | |       | ||.|  | |  . |     ..  |. || .| |. .|||. |. .  |   .||| . |.|.  ||   . 
FTLCRKLGEGYFGEVWEGLWKG----QVHVAIKVIKRDNLMHQ----HMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEK

FL-LGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWE
 | .  |  .| |||||| |||....||||||||| |     | |.||||| | .   || |      ..|. | ||| .  | .|  || | ||. |.|
ALPIPHLLDFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLI--KDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHE

MFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLL
|||||| |. |.     . .||. | |.|.|  || ...  |..||   ||.||.| .||  | 
MFTYGQCPYPGMTNHETFQQIDR-GYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase ACK.AA Tec 150-411 40 1.9e-74 253.66 In-house 1-254 (254) Show / Hide 
Range on Protein: 150-411
Range on HMM: 1-254/254
Sequence Identity: 40% (107 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHF
| ... || | ||||..|.| .       ||.| .|    |     .||| |   |  | | .|..|||| .   |. .|||    |.||. ||.|..||
LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSE----EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHF

LLGT--LSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMR-ALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLW
   .  |     .| ||| |||.. |||||||||| |      ||. |||. |  |   || |.     | |  ||.|| ..   .|  || | |||  |
QKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVL---DDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLE
| |. |  |.  .  |..  ..  .| || ||. |.. || .| .|| .|||.||||  | . ..|
EVFSCGKMPYENMSNSEVVEHV-SQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase ACK.AA S_TKc 150-409 24 2.2e-48 167.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPL--GSLLDRLRKHQGH
 ..|.|.| |.||.|... .         ||.|..|          ....||.. ... .| |...||.|  .  . ||.|...   |.|.|...|...|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH-ASDTWMFG
     |   .  .|. |..... |. |...|||||   |.|| .   .||.|||| | |           .  .   ..||| |    ... ..| | .|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD---------FL
..|.||.. |. |.   .  ....||             ...  . . .|.   ||.|||   .           ..
CILYEMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ACK.AA Pkinase 150-409 22 4.8e-39 139.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 150-409
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFI-REVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLG----SLLDRLR-
.....|.| ||||.|... .   .     ||||..| .  .  . . ..  .|.  |..|.| | .|||... ... . ||.|... |    .| |... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KHQGHF--LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLV----KIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK-TRTFSHAS
. .| |     .. .|. |...|. |. |...|||||   |.|.  .. .    ||.|||| . .     ...   .. .   ..||| ..  .  ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DTWMFGVTLWEMFTYGQEPWIGL----NGSQILHKIDKEGE---RLPRPEDCP-------------------QDIYNVMVQCWAHKPEDRPTFVALRDF-
| | .|..|.||.. |. |. |     |    ...|.. ..   . ..|..|.                   ..   ..  |.. .|..|||.  .    
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
GTPase_binding ACK.AA GTPase_binding 471-538 59 9.5e-45 156.21 Pfam 1-71 (71) Show / Hide 
Range on Protein: 471-538
Range on HMM: 1-71/71
Sequence Identity: 59% (42 aa)

AGLSAQDISQPLQNSFIHTGHGDSDPRHC-WGFPDRIDELYLGNPMDPPDLLSVELSTS--RPPQHLGGVK
||.|||||..||...|||.|||.|..||| |||||..|..||.|||||.|...|..|..  || |||| |.
AGVSAQDIRVPLKHGFIHNGHGMSNMRHCYWGFPDEFDNNYLNNPMDPIDMIYVDNSCALRRPTQHLGRVG
SH3 ACK.AA SH3 415-471 37 5.8e-10 40.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 415-471
Range on HMM: 1-58/58
Sequence Identity: 37% (22 aa)

TDMRALQDFEE--PDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVA
  .||| |..   || | .. .|.|||.|   .. ||.|.. ||  .| || | |. . 
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
Inhibitor_Mig-6 ACK.AA Inhibitor_Mig-6 813-880 50 8.3e-31 112.91 Pfam 1-79 (79) Show / Hide 
Range on Protein: 813-880
Range on HMM: 1-79/79
Sequence Identity: 50% (40 aa)

SPPRVPPREPLSPQGSRTPSPLVPPGSSP------LPPR-----LSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG
.||.||||||||..|||||||......||      ..||     |...|.|.|||||||||||||....|||.......
RPPKVPPREPLSQCGSRTPSPRSFQVGSPHQRVYSCSPRAISCYLPTYPNKVMPTTQSFASDPKYVSCKVIQRQHKEHS
UBA ACK.AA UBA 996-1034 25 1.8e-08 34.24 Pfam 1-38 (38) Show / Hide 
Range on Protein: 996-1034
Range on HMM: 1-38/38
Sequence Identity: 25% (10 aa)

RPADKIQMLQAMVHGVTTEECQAALQCHGWSVQRAAQYL
. ......|..| .|.. ..|. ||. ....|.||...|
IDEEMVKQLMEM-TGFSMMQCKKALRACNNNVERAVEWL
UBA ACK.AA UBA 997-1036 35 0.000592 19.52 SMART 1-38 (38) Show / Hide 
Range on Protein: 997-1036
Range on HMM: 1-38/38
Sequence Identity: 35% (14 aa)

PADKIQMLQAMVHGVTTEECQAALQCHGWSVQRAAQYLKV
.. ||..|  |  | . |||..||.  .| |..|...|  
YEEKIDQLMEM--GFDREECVQALRACNWNVEMAMNWLFS
UBA ACK.AA UBA 1035-1068 31 6.37851 3.77 Pfam 5-38 (38) Show / Hide 
Range on Protein: 1035-1068
Range on HMM: 5-38/38
Sequence Identity: 31% (11 aa)

KVEQLFGL-GLRPRGECHKVLEMFDWNLEQAGCHL
.|.||  . |     .| | |.  ..|.|.|  .|
MVKQLMEMTGFSMM-QCKKALRACNNNVERAVEWL