Gene ALK (Human)

ALK

Species: Human
Alias: CD246, ALK, TFG/ALK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2p23-p24.3,

Classification

Group: TK
Family: ALK

Sequence

Name Sequence Type Origin Length Description Download
ALK.AA Protein Sugen Kinome 1620 None Fasta, JSON
ALK.kin_dom Protein Kinase Domain Sugen Kinome 270 None Fasta, JSON
ALK.NA RNA Sugen Kinome 6222 None Fasta, JSON

Protein domain

Protein domains of ALK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LDLa ALK.AA LDLa 437-473 25 1.5e-05 23.81 SMART 1-47 (47) Show / Hide 
Range on Protein: 437-473
Range on HMM: 1-47/47
Sequence Identity: 25% (12 aa)

LQSS-----FTCWNGTVLQLGQACDFHQDCAQGEDES-----QMCRK
  ..     |.| ||. . . . || . ||. |.||.     . | .
TCPPDHPNQFQCGNGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ
MAM ALK.AA MAM 480-636 22 1.3e-30 112.8 Pfam 1-175 (175) Show / Hide 
Range on Protein: 480-636
Range on HMM: 1-175/175
Sequence Identity: 22% (41 aa)

CNF--EDG-FCGWTQGTLSPHTPQWQV------RTLKDARFQDH------QDHALLLSTTDV-PASESATVTSATF-PAPIKSSPCELRMSWLIRGVLR-
|.|  ||| .|||||.. . .  .|..      .|..    .||      . | ....|.   .. ..|  .| .| |..   . |.|.. . ..|    
CDFEDEDGNLCGWTQDWTDDF--DWTRQSGPTPHTHYTGPWMDHTHGGQCSGHYMYVETS-HQQEGQTARLLSPWFYPPRG--PHCCLQFWYHMYGSHVH

-GNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDV-SDRFWLQMVAWWGQGSRAIVAFDNISIS----LDCYL
 |  .... ||........ .| ..   | . ||.  ..|    ...|........| |.|  .|.|.||.|     .| .
PGTLNVYVRENDNQGGWQTPLWSRSGNQG-NSWQQAHVTLNQFWPQPFQVVFEGVRGRGWRGDIAIDDISLSEGIMEPCPE
MAM ALK.AA MAM 475-636 15 5.1e-05 -25.5 SMART 1-192 (192) Show / Hide 
Range on Protein: 475-636
Range on HMM: 1-192/192
Sequence Identity: 15% (31 aa)

PVGFYCNFEDG----FCGWTQGTLSP-HTPQWQVRTLKD---------ARFQDH---QD--HALLLSTTDVPA-SESATVTSATFPAP-IKSSPCELRMS
. .. |.||.|    .||| |.. .     .|.. . ..           ..||   ..  | . . |.....  . |.  | ..... ..   . |. .
TSCGNCDFEWGNDHTMCGWHQDWWDDTG-FHWEWVSSHTFNHYAMSHDGPHRDHTMGNGSGHYMYFETSMGKPGGQTARLISPPLYPNRDQ---HCLQFW

WLIR---GVLRGN-VSLVLV-ENKTGKEQG--RMVWHVAAYEGLSLWQWMVLPLLD--VSDRFWLQMVAWWG-QGSRAIVAFDNISISLD----CYL
       |   |.  .. .  ||.... ..    .|..    |   |.   . .     .  | .   .| | |... ..| |.|... .    | .
YHMYHRKGSHTGTKLCVYVRYENNHPQDMWNNCLIWNRHGHQGRQ-WHQAEVTIHTGFWQQPFQVVFEGWRGSQWHCGYIALDDINFWNHPHENCWK
Kinase ALK.AA ALK 1116-1385 76 1e-235 789.37 In-house 1-273 (273) Show / Hide 
Range on Protein: 1116-1385
Range on HMM: 1-273/273
Sequence Identity: 76% (209 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP
|||.|.||||||||||.||.|.||.|..|.|||.|||||.||.|||.||.|||||..||||||.|||||...|..|..|.||.|.|||.||||||.||.|
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

S--QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDT
.  |||.|.| |||....|.|.||.|||||||||||||||||||||.||||||||.|||||||| |||.||||||.||.|||||||||||.||||||||.
ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV

WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
||||||.||||||||||||...||||.||||.|||||||.|||.||||||||||||||||||.|..|||.|.|
WSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase ALK.AA Pkinase_Tyr 1116-1383 47 3.6e-144 488.91 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-270/270
Sequence Identity: 47% (132 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD--ELDFLMEALIISKF-NHQNIVRCIGVSL-QSLP--RFILLELMAGGDLKSFLR
||... ||.|||||||.|   |   |   ..||||.|.| .....    ||. || | ... .|.||||..|| . |. |   .| .|.|..|||...||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY-RKGGCAMLPVKWMPPEAFMEGIFTS
. |   ... .| | |||. ...||.|..|||....||||.||||||.|.   ..|.||.|||.|||||  .|| ||.| ..||.|||.||....|.||.
KHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KTDTWSFGVLLWEIFSLGYMP-YPSKSNQEVLEFV-TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
|.| ||||||.||||..| .| ||  ||.||.|..  .|.||..|.||| ..|..|.|||...||||| |. |.|..
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ALK.AA TyrKc 1116-1383 43 1.7e-143 483.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-280/280
Sequence Identity: 43% (132 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF--NHQNIVRCIGVSLQS-------LPRFILLELMAGGDLKS
|||.. ||.|||||||.|. .        .|||||.| | .    . ||. || | .|.  .|.||||..|| .|.        | .|..|.|..||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA-------SYYRKGG--CAM--LPVKW
.||..||.      | | |||. . .||||..||.....||||.||||||.. ..   ..||.|||..||||         .|||| .  ..   ||..|
YLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-----KSNQEVLEFVTSGGRMDPPKN--------CPGPVYRIMTQCWQHQPEDRPNFAIILER
|.||....|.||.|.| |||||..||||..| .|||      .|||||.|.| .|.||..|.|        ||  .|.||.|||...|||||.|. | |.
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase ALK.AA TK 1116-1383 25 1.2e-120 406.36 In-house 1-486 (486) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

ITLIRGLGHGAFG---EVYEGQVSGMP--------------------NDPSPLQVAVKTLPEVCSEQDEL-------------DFLMEALIISKFN----
|||.. ||.|.||   |||.|.. |..                     .  . .||||.| | .....|              |||.||.......    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQNIVRCIGVSLQS------------LPRFILLELMAGGD----LKSFLRETRPRPSQ-----------------------------------------
 |.||||..||..|.             |  |..|.|..||    |...||. ||. ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------PSSLAMLDLLHVARDIACGCQYLEEN------HFIHRDIAARNCLLTCPGP--------GRVAKIGDFG---
                            .. | | .||  ...||||..||...      .|.|||.||||||..  ..        |.|.||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MARDIYRASYYRKGG------------------------CAMLPVKWMPPEAFMEGI---------FTSKTDTWSFGVLLWEIFSLGYMPYPS-K
     .|||||. ..|.. .                         ..||..||.||......         ||.|.| ||||||.||||..| .||.   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QEVLEFVTSG--------------GRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILERI
||         |||.|....|               || .|..||                .|..|.|||...|||||.|. ..|..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK.AA Sev 1116-1383 46 1.5e-115 386.45 In-house 1-277 (277) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-277/277
Sequence Identity: 46% (128 aa)

ITLIRGLGHGAFGEVYEGQVSGMP-NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPR
 .| | || ||||||||||.         . .||.|||      |.   || || . |||.| |||  .|| |   | .| .|.| |||| ..||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

PSQPSS----LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC-PGPG---RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIF
  | ..    |  .||.    ||. || |||. ||.||| |.|||| .   .     || |||||| |||||   |||| |   ||| || ||  | |.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
|.  | |.||.| ||| .||  ||| .|| ||| .|  ||| ..| .||  .. .|.|||.  |..|| |  . . .
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase ALK.AA InsR 1116-1385 40 3.4e-102 344.06 In-house 1-278 (278) Show / Hide 
Range on Protein: 1116-1385
Range on HMM: 1-278/278
Sequence Identity: 40% (115 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPL--QVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP
|.||| .| |.|| ||||   |.. |      ..|.||. |  |  . ..||.|| .  .||. ..||  ||  .  |  .  |.|. |||||.||  ||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

RPS-QPSSLA-------MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGI
    .   .          ...  | .|. |  ||. . |.||| |.|||.    .     |||||||.||||   ||||||  |||| ||.||   .|.
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDF---TVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV-TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
||.. | |||||.|||. .||  ||   || .||...   |. ..|| |||  .. .| .|||.|| .|| |  |.. .  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ALK.AA UTK 1116-1383 38 1.6e-101 343.56 In-house 1-296 (296) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-296/296
Sequence Identity: 38% (114 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELD----FLMEAL---IISKFN-HQNIVRCIGVSLQSLPRFILLELMAGGDLKSF
. | | ||.||||||... .   ..    ..||||.. .  . |.| .    |..||    . ..|. |.|..| .|| .|. |  |..|.|..||| |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRETRPRPS-QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG----PGRVAKIGDFG---MARDIY---------RASYYRKGGCAM
||  || |  .| .| . ..|. |.|||.| |||.. .|.|||.||||||..  .     ..|.||.|||   |.|...          . ||.. .  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPVKWMPPEAFMEG-IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGG--RMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
.|..|| |||. ..  ||.|.| |||||..|||.. | .|||  ||..|...|. ||  || .|. || ||||.|..||.  |..||.|  .....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ALK.AA TK-Unique 1116-1383 36 2.5e-93 316.37 In-house 1-294 (294) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-294/294
Sequence Identity: 36% (109 aa)

ITLIRGLGHGAFGEVYEGQVSGMP-NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN-HQNIVRCIGVSLQSL-PRFILLELMAGGDLKSFLRETR
... . .| ||||.|. |.|.| . ..  . .||||.| .  ...|. ||| |. . ..   |.|||.|.|..  |  | .|..| ...|.| ..||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PRPSQP-------------------SSLAMLDLLHVARDIACGCQYLEE--NHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY-RASYYRKGGCAM
| ..|.                   ... . ||.| | .|||| .||..   ...|||..|||.|||    . |.||.|||||||.| .  | ....  .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQGR

LPVKWMPPEAFM--EGIF-TSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNC-PGPVYRIMTQCWQHQPEDRPNFAIILERI
.|..||.||..   .|.. |.|.| ||||||.||||.|| .|||. .. ...| .. | ||. |..| .  .| .| .|||. ||.||.|. |. |.
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ALK.AA Trk 1116-1383 39 1.8e-88 300.07 In-house 1-275 (275) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-275/275
Sequence Identity: 39% (111 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP
| |.. || |||| |. ..   ....  .. |||||| .    .   ||  || .  .  ||.||.  ||     | ..  | |  |||. .||   |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

S-----QP----SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR-ASYYRKGGCAMLPVKWMPPEAFMEGI
.     ||      | . ..|..|..|| |  |. . ||.|||.|.||||    | . . ||||||| ||.|    ||| |.  |||. |||||. |   
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLV---GQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRK

FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGR-MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
||   | ||||| .||.|. |  |.   ||.|| |... |   .. |. ||  || ||  ||| .|. | |   | ..|
FTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase ALK.AA Fer 1116-1384 34 1.5e-86 293.87 In-house 1-283 (283) Show / Hide 
Range on Protein: 1116-1384
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

ITLIRGLGHGAFGEVYEGQ-----VSGMPNDPSPLQVAVKTL-PEVCSEQDELDFLMEALIISK-FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL
.||.  || ||||||| |.       |.  .. .. |.||..  |. ..    .|. || |. . ..| |.|...||. .  |  |..|.. ||.|.|.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAK--IGDFGMARD--IYRASYYRKGGCAMLPVKWMPPEAFMEG
...  .     .. . ...  . ..||| .||.... |||||||||||..    . . |  | ||||.|.   |  .|. |    ..|..|..||..  |
KKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYH--KDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTG

IFTSKTDTWSFGVLLWEIFSLGYMPYPS----KSNQEV----LEF-VTSGGRMDPPKNCPGPVYRIMT-QCWQHQPEDRPNFAIILERIE
|...||| |||||..||||. |. |||       . .|     .  ...| .| .|...| ....||. ||||. |||||... | ....
IYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase ALK.AA Musk 1116-1383 38 3.9e-81 267.84 In-house 1-282 (282) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-282/282
Sequence Identity: 38% (109 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP--
|  .| .| |||| |.     |.  .   . |||| | .  |.|   ||  || .. .| |.|||.  ||     |   |.| || |||  ||.   |  
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

---RPSQPSS------------LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPP
   |..|  .            |  ...| .|..||||  || |  |.|||.| ||||    .   . || |||..| || . ||.  .    |. ||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLI---NEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPP

EAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI
|. .   ||   | |..||.|||||| .  ||   .  ||. ..  | ..  | |||  || .| .||| .| ||| |. | . |
ESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase ALK.AA Src 1116-1383 40 1.4e-79 270.07 In-house 1-255 (255) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-255/255
Sequence Identity: 40% (110 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP
|.|.| || | ||||..|   |        .|||||| .     .  .|| || |  |. |...|.   |  |  | .|  |.|. | |  .|..     
IKLCRKLGQGQFGEVWMGYWNGN------TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----D

SQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY--RASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTW
.. ..| . .|.  |  .| | .|||.. .|||| |||| |    | . |.|..||| || |      |  . | |..|.||. |||. .| || |.| |
GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLV---GENNVCKVADFGLARLIKEDDDEYCARHG-AKFPIKWTAPEAINYGRFTIKSDVW

SFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYR-IMTQCWQHQPEDRPNFAIILERI
|||.||.||.. | .|||  .|.|||. |  | ||  |.|||  .|  ||.|||. .||.|| |... .  
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ALK.AA S_TKc 1116-1386 22 8.4e-35 122.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 1116-1386
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAG--GDLKSFLRETRP
 ...| .|.||||.|| ..  .     .  .||.| ..         ... |  | .| .| |||....|       .. .|.. |  |||...... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS-KTDT
.. . . .   .  .... |.|. .|. ....||||.   | ||.      . ||.|||.|| .                 .|.|| .    ..  | | 
HGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE------RIEYC
||.|..|.| .. || |.|    |.... .            . ..  .. .|.|  ||.||    .|.        .. 
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ALK.AA Pkinase 1116-1383 20 2.5e-28 101.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1116-1383
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL---DFL-MEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGG----DLKSF
....| .| |.||.||...  | .      .||||... . .| ..    ... .|. |  ..|| ||||....   .    . .|.. ||    ||...
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRETRPRPSQPSSL--AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA---KIGDFGMARDI-YRASYYRKGGCAMLPVKWMPPEAF
..      ..  ..   . .. .... |..| .|. .. .||||.   |.|.     | ..   ||.||| |. . |  .   .. |  ..  .|.||  
IST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPEVI

M-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK----SNQEVLEFVTSGGRMDPPKNCP-----------------------GPVYRIMTQCWQHQPEDR
.     ..| | ||.|..|.| .. |. |.|..    .  . .. .   .. ... ..|                        .   ... |..  |..|
RGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PNFAIILER--I
|... ||.   .
PTAEQILQHPWF