Gene AXL (Human)

AXL

Species: Human
Alias: Ark, AXL, UFO
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13,

Classification

Group: TK
Family: Axl

Sequence

Name Sequence Type Origin Length Description Download
AXL.NA RNA Sugen Kinome 4743 None Fasta, JSON
AXL.AA Protein Sugen Kinome 894 None Fasta, JSON
AXL.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of AXL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG AXL.AA IG 41-136 18 2e-08 35.22 SMART 1-58 (58) Show / Hide 
Range on Protein: 41-136
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

PGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDT---GQYQCLVFLGHQTFVS-QPGYVGLE
|. .|. .| | ||.|  .      ...|.                               |.| ..|..|.   | |.| .   | .  | |. ..  .
PP-VTVKEGETVTLTC-VS------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set AXL.AA V-set 34-132 18 3.1e-07 26.76 Pfam 1-124 (128) Show / Hide 
Range on Protein: 34-132
Range on HMM: 1-124/128
Sequence Identity: 18% (23 aa)

ESPFVG-NPG----NITGARGLTGTLRCQLQ---VQGEPP-EVHWLRDGQIL-----ELA-----DSTQTQVPLGEDEQDDWIVVSQ--------LRITS
 |.  . .|.     .|...| . ||.|...    . |..  ..| |. | .     ...     ...... .  ...  . . .|.        |.|..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

LQLSDTGQYQCLVFLGHQTFVSQPGY
||.||.| | | |. .  ... ..|.
LQPSDSGTYYCAVWNC-NEDYFGHGT
IGc2 AXL.AA IGc2 47-124 20 0.000108 19.88 SMART 1-56 (56) Show / Hide 
Range on Protein: 47-124
Range on HMM: 1-56/56
Sequence Identity: 20% (16 aa)

ARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQ
  | . ||.|      . |..||.. || |.                      . |.|.. ...| | |.|..   . 
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP--------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set AXL.AA I-set 35-117 26 0.00654 12.39 Pfam 1-75 (92) Show / Hide 
Range on Protein: 35-117
Range on HMM: 1-75/92
Sequence Identity: 26% (24 aa)

SPFVGNPGNITGARGLTGTLRCQLQVQGEPP-EVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQ-----LRITSLQLSDTGQYQC
  |.  | ...   | | .. |  ||.|.|| .| |..||| |              |..   .. ..     |.|.  | .|.|.| |
PKFTQKPKDVEVQEGETARFEC--QVTGDPPPQVSWFKDGQPLRP------------DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
FN3 AXL.AA FN3 225-318 12 7.4e-10 39.99 SMART 1-69 (69) Show / Hide 
Range on Protein: 225-318
Range on HMM: 1-69/69
Sequence Identity: 12% (14 aa)

PQQPRN---LHLVSRQPT------ELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPH----TPYHIRVAC
|  |.|   |....  .|       ... |.|        ....                                   ..  |.|.    | |..||..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------------------YTVTGLKPGQYPWTEYEFRVRA

TSS--QGPS
 ..  .|..
VNGNDAGEG
IG AXL.AA IG 145-224 16 1.5e-05 25.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 145-224
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

PEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKT-----SSFSCEAHNAKGVTTS-RTATITVL
|.  || .  . .|.| ..       . |.                 |.. .. .        . |.|.  .|...|  ..|.||.
PP-VTVKEGETVTLTC-VS------QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set AXL.AA I-set 139-169 32 0.000625 15.85 Pfam 1-31 (92) Show / Hide 
Range on Protein: 139-169
Range on HMM: 1-31/92
Sequence Identity: 32% (10 aa)

PYFLEEPEDRTVAANTPFNLSCQAQGPPEPV
|.|.  | | .|      ...||..| |.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQ
IGc2 AXL.AA IGc2 151-212 23 0.010609 0.8 SMART 1-56 (56) Show / Hide 
Range on Protein: 151-212
Range on HMM: 1-56/56
Sequence Identity: 23% (15 aa)

AANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSS--FSCEAHNAKG
   ... | | | | |.| .  |.    ||.         .|..    .  |   .|.| |..|
HEGQSVTLTCPATGNPDP-NIHWYK-GQPLP------WNWTLTIKNVTPEDSGYYTCYARNPWG
FN3 AXL.AA FN3 334-415 16 0.007137 15.91 SMART 1-69 (69) Show / Hide 
Range on Protein: 334-415
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

LGPPEN---ISAT-RNGS------QAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSV----SNLTVCVAAYTA--AGDG
 |||.|   ...|  . .      .. ..|..|        .|||                        . |        .. .. |.|...  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase AXL.AA Axl 536-801 80 4.4e-211 707.54 In-house 1-267 (267) Show / Hide 
Range on Protein: 536-801
Range on HMM: 1-267/267
Sequence Identity: 80% (214 aa)

VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY
..|||.|||||||.||||||.|.| |..|||||.|||.|||.||.|.|||||.|||||||||||||||||.|.|||...|.|.||||||||||||.||||
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

SRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWS
|||||||.|||.|||||||.|||.||||||...|||||||||||||.|.|.|||||||||||||.|||||||.||||||||||||||||||||||||||.
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRE
||||||||.||||||||||||.|.||||..|.|||||.||.|.||.||..|||..|.|||||..|||
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AXL.AA TyrKc 536-803 40 1.7e-138 467.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-280/280
Sequence Identity: 40% (121 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF--DHPNVMRLIGVCFQGSERESF---PAPVVILPFMKHGDLHS
. |||.||||.|| |..|...     ..||||..|        .|||..||  |...  .|||. ||.||| |....  |   . . ... .|.||||..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKD

FLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNG-------DYYRQGR--IAK--MPVKWIAIE
.| ..|       |... |..|. .||.|||||. |..||||||||||...||  | ..|||||..||..       ||||.     .|  .|..| |.|
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

SLADRVYTSKSDVWSFGVTMWEIATRGQTPYPG-----VENSEIYDYLRQGNRLKQPAD--------CLDGLYALMSRCWELNPQDRPSFTELREDL
.. ....|.|||||||||.|||| |.||.||||     ..|.|.. |..||.|..||..        | | .| .|..||. .| |||.|.|..|..
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AXL.AA Pkinase_Tyr 536-803 44 1.6e-132 449.44 Pfam 1-270 (270) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-270/270
Sequence Identity: 44% (122 aa)

VALGKTLGEGEFGAVMEGQLN--QDDSILKVAVKTMKIAICTRSE--LEDFLSEAVCMKEF-DHPNVMRLIGVCF-QGSERESFPAPVVILPFMKHGDLH
. .||.||||.|| |..| ..  .|.  ..||||..|   .. ..  .|||..||  ||.. .|||. ||.|||  ||        . .....|.||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLL

SFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY-RQGRIAKMPVKWIAIESLADRVYTS
..|   |  ...  |....|... ..||.|||||. |..||||||||||...||. | ..||||.. ||| ||| |..  .|.|.|| | |.......|.
DYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KSDVWSFGVTMWEIATRGQTP-YPGVENSEIYDYL-RQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDL
|||||||||.|||| |.|..| |||. |.|.|.|. ..|.|...| .| | .| || .||. .|.|||.|.|..|.|
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AXL.AA TK 536-803 26 2.6e-113 381.36 In-house 1-486 (486) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

VALGKTLGEGEFG---AVMEGQLNQDD-----------------------SILKVAVKTMK--IAICTRSELE----------DFLSEAVCMKEFD----
. |||.||||.||    |..|......                          .||||..|   |   . ...          |||.||  || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVMRLIGVCFQGSERESF------PAPVVILPFMKHGD----LHSFLLYSRLGDQPVY---------------------------------------
 |||. ||.|||.|| .. .|      . . ... .|.|||    |...|  .| . |.                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPTQMLVKFMADIASGMEYLSTK------RFIHRDLAARNCMLNENMS-----------VCVADFG---
                               |... |. ....||.|||||. |      .|.|||||||||...||.            . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKKIYN------------------------GDYYRQGRIAKMPVKWIAIESLADRV---------YTSKSDVWSFGVTMWEIATRGQTPYPG-V
     |...||.                         |||||   .|.|..| | |.|.|||         .|.|||||||||.|||| |.||.||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EN---------SEIYDYLRQG--------------NRLKQPADCL--------------DGLYALMSRCWELNPQDRPSFTELREDL
 |          |...|||.|              .|..||..|               . .| || .||...|.|||.|..|.| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AXL.AA Met 537-797 40 1.7e-105 346.91 In-house 1-271 (271) Show / Hide 
Range on Protein: 537-797
Range on HMM: 1-271/271
Sequence Identity: 40% (114 aa)

ALGKTLGEGEFGAVMEGQLNQ-DDSILKVAVKTMK-IAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY
.... .| | || |  |.. . |    ..|.|. .   | .  . . || |.. ||.||||||  |||.| . .       | |.||.|||||| .|   
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGH----MPWVVLPYMKHGDLKTFIR-

SRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKI-YNGDYY--RQGRI-AKMPVKWIAIESLA--------
    .    .    |. |  ..| ||.|.  ..|.|||||.||||| | . | ||||||. .. |   ||  .. .  |. |||| | |.|         
----NPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCP

DRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVEN-SEIYDYLRQG--NRLKQPADCLDGLY-ALMSRCWELNPQDRPSFT
..  .|.||||||||| |||  ||| .||| | |   |  .| ||  .|| ||  | | ||  .| .||. || |||.| 
TYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AXL.AA UTK 536-803 36 2.7e-101 342.85 In-house 1-296 (296) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

VALGKTLGEGEFGAVMEGQLNQDD---SILKVAVKTMKIAICTRSELE---DFLSEAV---CMKEFD-HPNVMRLIGVCFQGSERESFPAPVVILPFMKH
|.||..||.|.|| | .. ..|..     ..||||. .    .. | |   ||. ||     || |. ||||.||.|||.|..       . ... .|. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP------WMIVTEYMEN

GDLHSFLLYSRL--GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN-------MSVCVADFG---LSKKIY---------NGDYYR
||| |.| ..|   ...|..|    ......|||.||.||....|.||||||||| ....       |.. .||||   .|. ..         . .||.
GDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

QGRIAKMPVKWIAIESLADR-VYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQG--NRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRE
.    ..|..| | |.|...  .|.|||||||||..||| |.|..||||  | ..   .. |   |...|.|| . .| || |||. .||.||.| .|..
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQ

DL
 .
QM
Kinase AXL.AA InsR 536-805 38 8.6e-92 308.6 In-house 1-278 (278) Show / Hide 
Range on Protein: 536-805
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

VALGKTLGEGEFGAVMEG---QLNQDDSIL--KVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHS
..|.. .|.| || | ||    . .|      ..|.|| . .   |  .| ||.||  ||||.. .| || ||| .|      |.  |.  .|..||| |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIE-FLNEASVMKEFNCHHVVRLLGVCSRGQ-----PM-YVVMEMMTYGDLKS

FLLYSRLGDQ---PVYL------PTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESL
.|.  |   .   |..       . . ..   |.|..|| ||  | |.|||||.|||| |.   | ..|||.   ||  |||| |.  ..|| | | |||
YLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESL

ADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYL-RQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN
 | |.|..|||||||| .||..| |  || |  | .. .|  . || |..|  | . ...|| .||  .|..||.|... . | .
KDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AXL.AA TK-Unique 536-803 33 1.2e-84 287.53 In-house 1-294 (294) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-294/294
Sequence Identity: 33% (99 aa)

VALGKTLGEGEFGAVMEGQLNQDD---SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSF
. .|...|||.|| |  |.. ...   .  |... .|  .  |  .  |||.|.  ||| . |||. ...|.|   .|.     .  |....  |.| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEP-----WMIIMEYCPCGNLQHY

LLYSRLG-------------------DQPVY-LPTQMLVKFMADIASGMEYLST--KRFIHRDLAARNCMLNENMSVCVADFGLSKKIYN-GDYYRQGRI
| ..| .                   ... . .  . |. |. .||.|||||.   |...||||.|||..|.|.  . ..|||.....|. |.| .... 
LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQ

AKMPVKWIAIESLA--DRVY-TSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC-LDGLYALMSRCWELNPQDRPSFTELREDL
 ..|..| | |||   ...| |.|||||||||.||||.| |..||||. ...| . .|.| |..||. |  . .| ||..|| ..|..||||....  |
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AXL.AA ALK 536-805 39 2.6e-82 279.78 In-house 1-273 (273) Show / Hide 
Range on Protein: 536-805
Range on HMM: 1-273/273
Sequence Identity: 39% (111 aa)

VALGKTLGEGEFGAVMEGQLNQ---DDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL
. |.. || | || | .||      | . ..||.|| .   | . . |||. || .|  |.|.|| |.||.|||   .       ..| .|  ||. |||
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPE-DCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY------MIVLEYMEGGDMKSFL

LYSRLGDQ---PVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS---VCVADFGLSKKI-YNGDYYRQGRIAKMPVKWIAIESLADRV
  .|   .   |  |  . | .   |.| |  || ...||||| ||||| |    .   . .|||| .. | |  |||| |  | |||||   | . | .
RECRPHPESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGI

YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN
.|||.||||||| .|||   |  |||| .| |. . . .|.|.  | .|    | .|. ||   | |||.|. . | .. 
FTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AXL.AA Src 536-803 39 1.1e-81 277.3 In-house 1-255 (255) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-255/255
Sequence Identity: 39% (106 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP-FMKHGDLHSFLLY
. | . ||.| || | .|  |.     ||||||.| .     . |.|| ||  ||...|... .|  ||   |. |    |. |   .|.|| |  .|  
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVC---SQEE----PIYIVTEYMSHGSLLDYLKK

SRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNG-DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVW
    ..  .|. . |. . | .|.||.||. ...|||||||||   .||  . |||||| . | .. | |     ||.|.|| | | .  ...| |||||
---DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

SFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA-LMSRCWELNPQDRPSFTELREDL
|||. ..|| |.|..|||| .| |  . . .| |. .|. | | ||  .| .||.  |..|| |  |.. |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AXL.AA Abl 536-803 44 8.8e-81 269.16 In-house 1-252 (252) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-252/252
Sequence Identity: 44% (118 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYS
. . . || | .| | ||   . | .  |||||.|       |...|| ||  |||  |||...|.|||     ||  |   .|  || .| |  .|   
IMMKHKLGGGQYGEVYEGVWKRHDCT--VAVKTLKEDTM---EVHEFLKEAAIMKEMKHPNLVQLLGVC----TRE--PPFYIITEFMCYGNLLDYL---

RLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSF
|  |.   ||  .|.   . |||||.||  . |||||||||||.. |.  | ||||||. .. ..| |     || |.|| | ||||   . |||||| |
RECDR-EELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA-RMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAF

GVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDL
|| .||||| | .||||.. |..|. | .| |. .|  | .  | || .||. .. |||||.|. . .
GVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AXL.AA FGFR 649-803 45 4.1e-69 234.7 In-house 138-293 (293) Show / Hide 
Range on Protein: 649-803
Range on HMM: 138-293/293
Sequence Identity: 45% (71 aa)

LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQT
||..   .| |||||  .. |||||||||    ..    ..||||.  | . ||||       |.|| | |.| |||||..|||||.|| .||| | |..
LVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQ

PYPGVE-NSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDL
|||..    |.|.||. | |.  |. |   .| .|  ||  .|..||.|..| |.|
PYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AXL.AA S_TKc 536-810 19 2.4e-42 147.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 536-810
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKH--GDLHSFLL
  .....|.| || |. .. .   .  .||.| .|         |....|  ..|. .|||. .|..|.             ... .. .  |||.... 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIK

YSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTS-KSDV
  . .  ....|  .  ..|. |....||.  ...|||||   | .|.|   . ..||||....         .       ..| | |    |.  |.|.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRE--DLENTLKAL
||.|....| .. |..|.|  .  .... ..            . .  ....|.. .|..||.  |. .   . .    .
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AXL.AA Pkinase 536-803 19 8.3e-38 134.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 536-803
Range on HMM: 1-293/293
Sequence Identity: 19% (60 aa)

VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELE---DFL-SEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHG----D
  .|...|.| || | ...   .    .||||..|    .... .   ... ||.  ||...|||. ||....         . . ...... .|    |
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMD

LHSFLLYSRLGDQPVYL--PTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSV----CVADFGLSKKIYNGDYYRQGRIAKMPV---KWIAI
|....      ..   .  . . . ..|  |..|.||.  ...|||||   |.....|. .    ...||||.|...    |  .. .. ..    ..| 
LFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAP

ESLA-DRVYTSKSDVWSFGVTMWEIATRGQTPYPGV------ENSEIYDYLRQ-GNRLKQPADCL-------------------DGLYALMSRCWELNPQ
| .  .. |..|.|.||.|....| .. |..|.||       .  ....  ..  ..   | .|                    . .  ....|....|.
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

DRPSFTELRED--L
.||..... ..  .
KRPTAEQILQHPWF
Kinase AXL.AA FGFR 536-607 37 3.9e-10 30.69 In-house 1-77 (293) Show / Hide 
Range on Protein: 536-607
Range on HMM: 1-77/293
Sequence Identity: 37% (29 aa)

VALGKTLGEGEFGAVMEGQLN---QD--DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF-DHPNVMRLIGVCFQG
  |||.|||| || |  .  .   .|  .   .|||| .| .  |  .| |  ||   ||    |.|...|.|.| |.
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLK-MNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQE