Gene BARK2 (Human)

BARK2

Species: Human
Alias: BARK2, ADRBK2, GRK3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 22q11.1-q12.1,

Classification

Group: AGC
Family: GRK
Subfamily: BARK

Sequence

Name Sequence Type Origin Length Description Download
BARK2.AA Protein Sugen Kinome 688 None Fasta, JSON
BARK2.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON
BARK2.NA RNA Sugen Kinome 9068 None Fasta, JSON

Protein domain

Protein domains of BARK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS BARK2.AA RGS 54-174 26 4e-34 114.55 Pfam 1-124 (124) Show / Hide 
Range on Protein: 54-174
Range on HMM: 1-124/124
Sequence Identity: 26% (33 aa)

TFDKIF-NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKL--DNEEDRLCR-SRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPY
.|.... .|.||..||..|. .|  |  . ..|........|   |..|.....  |.||..||. .  .  |  .....||.|..| ..|.| ..|...
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

IEEICESLRGDIFQKFMESDKFTRF
...|.. ...| ...|..||.. ||
QRHIYTLMEKDSYPRFLKSDYYQRF
RGS BARK2.AA RGS 54-175 22 5.3e-31 110.23 SMART 1-121 (121) Show / Hide 
Range on Protein: 54-175
Range on HMM: 1-121/121
Sequence Identity: 22% (28 aa)

TFDKIF-NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS-CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIE
.|.... |..|| ..|..|. .|  |... ..|.....|..|... |.|    |.||| ||... .. ... .... .|..|..| .  .. ..|... .
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED-EERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN--PHPDCFDEAQR

EICESLRGDIFQKFMESDKFTRFC
.... ...| ...|..||...|..
HVYQLMEKDSYPRFLRSDYYKRYL
Kinase BARK2.AA BARK 191-453 93 3.2e-230 771.13 In-house 1-264 (264) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-264/264
Sequence Identity: 93% (248 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVF
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVF

SEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHS
||.||||||.||||||||||||||||||||||||||||.||.||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
SEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLRGHS

PFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFF
|||||||||||||||||||.||||||.||.|...||||||||||||||||.|.|.||||||.||
PFRQHKTKDKHEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase BARK2.AA GRK 191-453 60 6.9e-219 697.04 In-house 1-272 (272) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-272/272
Sequence Identity: 60% (164 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV--
|...|..|.||||||..|....||||||.|||||||||...|||.||||...|..|...||||||||.||..|.|.||.....|||||||||....|.  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

--FSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKK--PHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKL
  |.|..||||| ||..||||||.|..|||||||.|||||.||| |||||||||......  .|..|||||||||||||...|||.|.||.|||||....
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

LRGHSPFRQHKTKDKH-EIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGG--GSQEVKEHSFF
..|||||||||.|.|. |.||......|..|| ||.|.|...|.|||.|...||||.||  |.||||||.||
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase BARK2.AA AGC 191-453 28 1.6e-153 400.21 In-house 1-395 (395) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-395/395
Sequence Identity: 28% (113 aa)

FSVHRIIGRGGFGEVYGCRKA------DTGKMYAMKCLDKKR-IKMKQ--GETLALNE------------RIMLSLVSTGD-------CPFIVC-MTYAF
| ....||.|.||.|| .||       ||||.||||.|.||. |..|.   .  ...|            | .|....          .||||  . |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HTPDK--LCFILDLMN---------GG-DLHYHLS---QHGVFSEKEMRFYATE-------IILGLEHMHN-RFVVYRD-LKPANILLDEHGHARISDLG
...|.  |.|....|.         || .|..||    . |.|.|.. |||| |       |.|.||..|. . ...|| ||| ||||||.|| ...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LACDFSK----------------------------------------------------KKPHASVG--THGYMAPEVLQKGTAYDSSADWFS--LGCML
|.. . .                                                    .. .  .|  |. |||||.|     |. ..|| |  |||..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

FKLLRGHSPFRQH-------------KTKDKHEIDRMTLTVNVELP----------DTFSPELKSLLEGLLQRDVSKRLGCHGG-----GSQEVKEHSFF
. .| |..||. .             .. .| ...|.... .|..|          . ||||.|.|...||..| .|||||.|.     | .|.|.| .|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase BARK2.AA GRK 191-453 46 3.3e-107 362.45 In-house 1-265 (265) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-265/265
Sequence Identity: 46% (126 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG---
|   |. | ||||||  |    |||||| | |.||||| ..||..||||   |  |.    .|.| . ||. | | || .. .|||||| .|.   |   
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVH---SRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENP

VFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKP-HASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLR
 |.|.  .||| ||..|||| | . .||||.|| |||||.||| ||||||||      ..    ||| |||||||..    |. | ||..||| ..    
GFDEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNER-YTFSPDWWGLGCLIYEMIE

GHSPFRQHKTK-DKHEIDRMTLTVNVELP-DTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFF
|.||||| | |  . |.|| ..   .. . . || | |.. . ||. | ..|||| ..|..||..|.||
GRSPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase BARK2.AA Pkinase 191-453 28 2.3e-97 334.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL--NERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGG----DLHYHLS
. ..|.||.|.||.|| |.. .|||..|.|...|...|... .|...    .||..| .   .|.|| . ..|...|..........||    ||. ..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--QHGVF--SEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHA----RISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQKGTAYDSSAD
  .||.|  ||.| .||...|. |||..|.. ...|||||.|||.|..||     .|.| |||.     ..  ..  .|| .||||||...|. |....|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

WFSLGCMLFKLLRGHSPFRQH----KTKDKHEIDRMTLTVNVELPDTFS---------------------PELKSLLEGLLQRDVSKRLGCHGGGSQEVK
..|.||.|. .| |. ||..|    .  |. .. ....   .. .   .                     .|.|......|..| .||..      ....
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQIL

EHSFF
.| .|
QHPWF
Kinase BARK2.AA S_TKc 191-453 31 5.1e-90 306.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNG--GDLHYHLSQHGV
. ..|.||.|.||.|| ||. .||. .|.|...            ...|. .|.     ..|.|| . ..|.. |.|........|  |||. .. ..| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDS-SADWFSLGCML
      |.| . |||. .|...||..|.. ...|||||.||||||  |  |.| |||. .     .  .||  |||||||     |.  ..|| |.||.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

FKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGS--QEVKEHSFF
. .| |  ||.     ..  ....            |||.|......||.| .||...       ...| | .|
YEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BARK2.AA RSK 194-453 35 1e-89 304.4 In-house 1-278 (278) Show / Hide 
Range on Protein: 194-453
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

HRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQG-ETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV-
..  |.||.|.|. |||    |||. |||| |.|. |. .|     .. ||  |...  . .||||   |||.|..||  |.....||.| .||....  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERC--QQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

--FSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDE---HGHARISDLGLACDF--S-KKKPHASVGTHGYMAPEVLQ---KGTAYDSSADWFSL
  |||.| .||. ||.| .||.| . ...||||| |||.|.   .|| ...| |... |  . ... .  ..|. |||||.|    .. ..| ..||.||
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTVN--VELP--DTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFF
|. .. .| |..||..   . ...|| .  .. .  ...|  .. |.| |.|. ..|.|| .|||||  .. .|.|.|..|
GVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase BARK2.AA Akt 191-453 39 3.8e-87 278.61 In-house 1-264 (264) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-264/264
Sequence Identity: 39% (107 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMY-AMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVF
| . ...|.| || |. ..| ||.|.| ||| | |..| .|     .. || .|  .    .|||| . |.| |.|||.|..| .|||.| |||.. ..|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

SEKEMRFYATEIILGLEHMHNRFVVYRD-LKPANILLDEHGHARISDLGLAC-D-FSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFS-LGCMLFKL
||.. |||. ||||..|| |.. ..||| ||| |||.|..|| .. | ||.  .  .   |     ||  |.|||.|.. . .. ..|| . ||| .. .
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG-NGHTKAVDWWGSLGCVMYEM

LRGHSPFRQHKTKDKHEIDRMTLTVNVELP--DTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFF
. |  ||  .. .|.|.     .. .|. |  |..||| |.|..|||..| .|||| . .. ||.|.| .|
MCGRPPF--YN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase BARK2.AA SGK 191-453 35 1.7e-82 254.53 In-house 1-283 (283) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

FSVHRIIGRGGFGEVYGCRKADT------------------GKMYAMKCLDKKRIK-------MKQGETLALNER-IMLSLVSTGDCPFIVCMTYAFHTP
|    .|| |.||.||  .. |.                  .|.|||| | |. |         |  . . . ||   |....    ||||   ||| |.
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK---HPFIVNLHYAFQTK

DKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLAC-DFSKKKPHASV-GTHGYMAPEVL
.|| | .| .|||.. |||   . |.| . |||| ||.. ||. |   ..|||||| |||||  ||... | ||.  .  ...   .  ||  |.|||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

QKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFF
.| . .| . ||..||| |. .. |  ||     ..| .     .     .|  .|.. ..|..||||.|..|||| .  .. |.|.| ||
RKQP-HDRTVDWWCLGCVLYEMMYGLPPFYS---RNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG-TKRDFMEIKNHPFF
Kinase BARK2.AA AktR 191-453 36 1.3e-79 270.85 In-house 1-268 (268) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-268/268
Sequence Identity: 36% (99 aa)

FSVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLALNERIMLS-LVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV
| |....|.|.||.|| ..|  |..|.|||| ..|| |. .. .  ...||  .  ..   . |||| . |.| | .|| ||.. . ||.| .||.. . 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCC---NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FSEKEMRFYATEIILGLEHMHNR-FVVYRDLKPANILLDEHGHARISDLGLAC-DFSK-K--KPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFK
|||.. |||. .|.|.||. |..  ..|||||| ||||||.|| .|.| ||.   | . .  | .  .||. |||||...|   .. |.|| ..|. .. 
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYE

LLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDT--FSPELKSLLE-GLLQRDVSKRLG--CHGGGSQEVKEHSFF
.. |. || ....... .  .     ... |..  ||...|.|.. .||...  ||||  | |   .|.|.| .|
MVTGCPPFYHKNQNQMFQKIKIKQ--QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGW--EEIKSHPWF
Kinase BARK2.AA RSK 191-453 36 3.9e-74 252.62 In-house 1-271 (271) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-271/271
Sequence Identity: 36% (104 aa)

FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH
. .|. ||.| |..|| |.|    ||.. |||| ..|. .. | .    . .|||.|. .   . ||||   |.| .  |.  |.|.| ||||  .|.  
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG---HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQ

GVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEH----GHARISDLGLACDFSKKKPHASVG-------THGYMAPEVLQKGTAYDSSADWF
..|||.| .||. || | .|. |   .|.|||||.|||.|..    ||..| |.|.|     |.  .  |       |  ||||||| .   .| ..||.
KMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA-----KQLRDENGMLMTFCYTANYMAPEVLKR-QGHDQACDWW

SLGCMLFKLLRGHSPFRQHKTKDKHE--IDRMTLTV---NVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFF
|.|  ..  | |. || |.|..|  .  | |  |     .   .|. |.| |.|| ..| ||  .|||.   | ...|.|..|
SFGVLMYEMLTGCTPF-QNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase BARK2.AA RSK-Unclassified 191-347 38 3.9e-51 158.59 In-house 1-157 (283) Show / Hide 
Range on Protein: 191-347
Range on HMM: 1-157/283
Sequence Identity: 38% (61 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLS--QHGV
| .|| ||.| ||.||  || || ..|||| | |...  ..    .. |.  ...    . |||| . ..| | |.|  ...   |||.  ||       
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATT---NHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKC

FSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDF-SKKKP
|.| . |||| |... ||..| | ..|||||| ||.|.  ||.. .| .|  .    |||
FCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKP
Kinase BARK2.AA RSK-Unclassified 351-453 31 4.4e-24 72.1 In-house 183-283 (283) Show / Hide 
Range on Protein: 351-453
Range on HMM: 183-283/283
Sequence Identity: 31% (33 aa)

VGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELP--DTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVK
.||  |.|||.. ..       ||. || ... .| |  |.   .   | |.    .. .| .|     | . ..|.  ||||  .|||||  |  ...|
CGTEEYLAPEMI-RRCGHTKAVDWWTLGIVMYEMLFGCPPY---YGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIK

EHSFF
 | ||
RHPFF
Kinase BARK2.AA TyrKc 191-453 21 1.6e-11 -36.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-453
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIMLSLVSTG-DCPFIVCMTYAFHTP-------DKLCFILDLMNGGDLHY
 .  ...|.| ||||| ..      . | |.| .        .   ..| ||| .|   | . | ||..  .  ..       . |. .. .| .|||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLSQHGV-FSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKK------KPHASV----GTHG-----YMAPEVLQKG
.|  |.  .. |..  ... |  | |. | . .. |||   |.|..| ....||| ||. |   .      |   ..    |...      ||||....|
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

TAYDSSADWFSLGCMLFKLL-RGHSPFRQ-----HKTKD----KHEIDRMTLTVNVELPDT----FSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHS
. . .  | .| | ... .. .| .|         . ..      . .||    |.. |       ..|. .. .   ..| ..|        .|.  |.
K-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HE

FF
.|
CF
Kinase BARK2.AA S_TK_X 454-533 23 2.9e-11 44.68 SMART 1-79 (79) Show / Hide 
Range on Protein: 454-533
Range on HMM: 1-79/79
Sequence Identity: 23% (21 aa)

KGVDWQHVYL--QKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISER-WQQEVTET-----VYEAVNADT
.|.||...|   ....|| .|.  ||.| ...|.. ||.| |..          ..... ..|.. ||.|  ||      ..  ... 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase BARK2.AA Pkinase_Tyr 266-339 26 0.002162 12.11 Pfam 81-158 (270) Show / Hide 
Range on Protein: 266-339
Range on HMM: 81-158/270
Sequence Identity: 26% (21 aa)

KLCFILDLMNGGDLHYHLSQH----GVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLA
... .. .| .|||. .| .|    . .. |..  ....|  |.|. ...  . |||   |.|..| ....|.| |||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase BARK2.AA Pkinase_Tyr 191-206 43 0.899233 3.24 Pfam 1-16 (270) Show / Hide 
Range on Protein: 191-206
Range on HMM: 1-16/270
Sequence Identity: 43% (7 aa)

FSVHRIIGRGGFGEVY
 .  . .|.| |||||
ITFGKKLGEGAFGEVY
PH BARK2.AA PH 559-652 20 6.2e-15 56.5 Pfam 1-92 (92) Show / Hide 
Range on Protein: 559-652
Range on HMM: 1-92/92
Sequence Identity: 20% (20 aa)

CIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEG-ESRQNLLTMEQILSVEETQIKDKKCILFRIKGGK--QFVLQCESDPEFVQWKKELNETFK
.|..|...|.|  .. .|..|.| ||.|.| .  .. .. .  . .. . .|...    |.   |.|.     ....|.||. |. .| . ...  .
VIKEGWLHKKG--KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDC-QVTKVPDN-KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH BARK2.AA PH 559-654 17 7.8e-14 53.21 SMART 1-82 (82) Show / Hide 
Range on Protein: 559-654
Range on HMM: 1-82/82
Sequence Identity: 17% (17 aa)

CIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGK-QFVLQCESDPEFVQWKKELNETFKEA
 |..|...|..   . .|..|.|.||...| .  .        .   ...... .... .   |.|.  .  ...||||. |. .| . ...  ...
VIKEGWLYKKS---K-RWKKRWFVLFNDCLYYYKDK-------KPKGSIPLSDCTVRE-P--CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN