Gene BCR (Human)
BCR
Sequence
Protein domains of BCR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Bcr-Abl_Oligo | BCR.AA | Bcr-Abl_Oligo | 1-79 | 78 | 4.5e-62 | 217.34 | Pfam | 1-89 (89) | Show / Hide |
Range on Protein: 1-79 Range on HMM: 1-89/89 Sequence Identity: 78% (70 aa) MVDPVGFAEAWKAQFPD--SEPPRMELRSVGD--------IEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRR |||||||||.|.||||| .|||.||.||.|| .|||||||||||||||||||.|||||||||||||||.|||||||||||| MVDPVGFAEWWRAQFPDWFQEPPYMECRSMGDRWVSLRSPMEQELERCKASIRRLEQEVNKERFRMIYLQTLLAKERKSYDRQRWGFRR |
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| RhoGEF | BCR.AA | RhoGEF | 502-690 | 32 | 3.6e-54 | 187.81 | Pfam | 1-196 (196) | Show / Hide |
Range on Protein: 502-690 Range on HMM: 1-196/196 Sequence Identity: 32% (65 aa) VLSGILASEETYLSHLEALLLPM-KPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFP--RVQQW--SHQQR--VGDLF--QK-LASQLGVY |. |. .|..|. .|. .. |||. .| ..|.|....|.||| ..|.||.|..|.. | |...| ...|. .||.| | ... . .| VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMY RAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPT-TKNS-LETLLYKPVDRVTRSTLVLHDLLKHTPA-SHP-DHPLLQDALRISQNFLSS .. || ||.. .||.. | .|... ...... .|| . . |. .| ||| |..| | | .|||||| .|| |.. || || ....|. SEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE-----NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASH INE ||| INE |
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| RhoGEF | BCR.AA | RhoGEF | 502-690 | 26 | 2.7e-52 | 180.99 | SMART | 1-211 (211) | Show / Hide |
Range on Protein: 502-690 Range on HMM: 1-211/211 Sequence Identity: 26% (57 aa) VLSGILASEETYLSHLEALLL-PMKPLKAAATTSQ-PVLTSQQIETIFF-KVPELYEIHKEFYDGLFPRVQQWS---------------HQQRVGDLFQK |. ....|..|. .|. .. |||.. ..... |.|. .....||. ..|.||.|..|.| | |...| ...|.||.|.| VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK L---ASQLGVYRAFVDNYGVAMEMAEK--CCQANAQFAEISENLRARSNKDAKDP-TTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDA . .... .| ....|. |... .| ||. | .|.. . . ...| . . . .||..| ||. |.|. | |...|||||..|||. ||.| WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSN-SEH-RLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKA LRISQNFLSSINE |..........|| LDCMKDVAQHCNE |
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| PH | BCR.AA | PH | 709-868 | 14 | 8.3e-11 | 43.15 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 709-868
Range on HMM: 1-82/82
Sequence Identity: 14% (23 aa)
LLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGS
..| .. . .| |...||.| |...| | ..| |||.|..... .
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK----------KPKGSIPLSDCTVRE-P----------------------------------------
KATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKC
.|..|. .. .|.| .|. |. || . |.. ....
------------------------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
|
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| PH | BCR.AA | PH | 834-866 | 21 | 0.011822 | 12.22 | Pfam | 61-92 (92) | Show / Hide |
Range on Protein: 834-866 Range on HMM: 61-92/92 Sequence Identity: 21% (7 aa) FRVHSRNGKSYTFLISSDYERAEWRENIREQQK |.... ....|.| .|. |. .| . |.. .. FQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR |
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| PH | BCR.AA | PH | 709-764 | 24 | 0.116308 | 8.64 | Pfam | 1-49 (92) | Show / Hide |
Range on Protein: 709-764 Range on HMM: 1-49/92 Sequence Identity: 24% (14 aa) LLKDSFMVELV-EGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSF . | .. .. . .| |...||.. |.. | .| |..| .||| |... VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK--------YRPKGSIPLSDCQV |
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| C2 | BCR.AA | C2 | 912-1017 | 15 | 2.3e-14 | 54.97 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 912-1017
Range on HMM: 1-92/92
Sequence Identity: 15% (19 aa)
FLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTA---EPNWNE---EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQ-
|.| ...| . . . |.... ||.| ..| | ||| .|.... | ||. .... ...|. ..
TLTVHIIEARNLP---DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH----------------DFIGHCCIPP
-------------LDPQALQDRDWQR
|. ..|. .
NNPHWHQWDGCIHLSDIL-GYRH-WW
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| C2 | BCR.AA | C2 | 913-1002 | 21 | 3.8e-13 | 47.29 | Pfam | 1-90 (90) | Show / Hide |
Range on Protein: 913-1002 Range on HMM: 1-90/90 Sequence Identity: 21% (21 aa) LNVIVHSATGFKQ-------SSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIE--LEGSQT-LRILCYEKCYNKTKIPKEDGESTDRLMGKGQ |.| |..| . . .|. |...... . ..| ||.| ..| | |||.|... .. | ||. .. .. . | ..|. . LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGR----------DDFIGQCC |
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| RhoGAP | BCR.AA | RhoGAP | 1065-1249 | 34 | 1.4e-72 | 248.34 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 1065-1249 Range on HMM: 1-193/193 Sequence Identity: 34% (72 aa) SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDV-----------SVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIA | .| |||.|.|.||..||...||||..|... ||.|..||| ... . ... .| ||...|| ||.|||||||||.|.| |..| | . SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK L--------------SDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEV . .|.... ....|. .||.... |. .|. ||.||||...||||..||||..|||||..|. |.|. . CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP---------------MMDMRHQNK MSQVQVLLYF . .... |. CVEFLIEHYD |
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| RhoGAP | BCR.AA | RhoGAP | 1068-1221 | 43 | 1.5e-72 | 248.14 | Pfam | 1-156 (156) | Show / Hide |
Range on Protein: 1068-1221 Range on HMM: 1-156/156 Sequence Identity: 43% (68 aa) PYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE--GIALSDPVAKESCML | |||.|.|.||..|....||||||| .. |..|..||| . .... .. ||...|. ||.|||||||||||.|.|..| | . |. . ..| PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMR NLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKL |. .||..|. |. .|..||.|||. ..||||. ||||..|||.|..|....|.. ELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDDDSMD |
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