Gene BMPR1B (Human)

BMPR1B

Species: Human
Alias: ALK6, CDw293, BMPR1B, ALK-6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4q22,

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
BMPR1B.NA RNA Sugen Kinome 5560 None Fasta, JSON
BMPR1B.AA Protein Sugen Kinome 502 None Fasta, JSON
BMPR1B.kin_dom Protein Kinase Domain Sugen Kinome 288 None Fasta, JSON

Protein domain

Protein domains of BMPR1B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp BMPR1B.AA Activin_recp 30-110 22 1.2e-29 100.11 Pfam 1-121 (121) Show / Hide 
Range on Protein: 30-110
Range on HMM: 1-121/121
Sequence Identity: 22% (27 aa)

LRCK-CHHH-------CPEDSVN-----NICST----------DGYCFTMIEEDDSG--LPVVTS----GCLGLEGSD-----FQCRD-----TPIPHQR
|.|  |...       |.|. .|     ..|.|          ||.|....|..| .   .....    ||. |....     |.|..      | ....
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

RSIEC-CTERNECNKDLHPTL
...|| |.|.. ||..|.|..
HNHECWCCETDYCNRNLTPPP
Kinase BMPR1B.AA Type1 204-491 72 2.4e-277 761.19 In-house 1-290 (290) Show / Hide 
Range on Protein: 204-491
Range on HMM: 1-290/290
Sequence Identity: 72% (209 aa)

IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLK
|||...||||||||||.||||||.||||.||...|.||||||||||||.|||||||||||||.|..||||||.|||||||.|||||||...|||...||.
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LAYSSVSGLCHLHTEIFSTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY
|||| ..||.|||.|||.||  |||||||||.|||||.|||||.||||||||||.. .||...||..|.||||||||.||||||..| |.|.||.|||.|
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL
||||..||.||||..|||||.|||||.|.||.|||.||||..||..||||..||||.|..|.|.|.|||.|||..||..|.||||.||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase BMPR1B.AA STKR 204-491 58 3e-220 718.13 In-house 1-312 (312) Show / Hide 
Range on Protein: 204-491
Range on HMM: 1-312/312
Sequence Identity: 58% (184 aa)

IQMVKQIGKGRYGEVWMGKWRG----EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT-GSWTQLYLITDYHENGSLYDYLKSTTLDA
||....||||||||||.|||||    |.||||.|....|.|||||||||||..|||||||.|||||.|.| |||||..|||.|||||||.||||..|.| 
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

KSMLKLAYSSVSGLCHLHTEIF--STQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP-------PNTRVGTKRYMPPEVLDESL
..|...|.|  .||.|||.||.  .||  .||||||||.||||||||..|||||||.|||... .|||..||.       .||.|||||||.|||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NRNHFQS-YIMADMYSFGLILWEVARRCVSGG------IVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWS-SDECLRQMGKLMTECWAHNPA
| ..|.| . ..|||..||..||.|||| .||      ||.|||.|..| ||..||.|||...||.|..||..||||. .....|.| |.|.||| |.|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

SRLTALRVKKTL
 |||||.||||.
ARLTALCVKKTM
Kinase BMPR1B.AA Type2 204-491 40 6.5e-111 367.48 In-house 1-315 (315) Show / Hide 
Range on Protein: 204-491
Range on HMM: 1-315/315
Sequence Identity: 40% (126 aa)

IQMVKQIGKGRYGEVWMGKWRGE-----KVAVKVFFTTEEASWFRETEIYQT-VLMRHENILGFIAADI---KGTGSWTQLYLITDYHENGSLYDYLKST
||.  .|||||.|.|| ..| ..      ||||.|   . .||  | .||.. ..|.||||| ||.|.     ... | .. |.|..|..|||.||||. 
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TLDAKSMLKLAYSSVSGLCHLHTEIF-STQ---GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNE----VDIPPNTR----VGTKRYMPPEV
|.| ......| |   || |||.||  ..|    ||.|||||.||||.||| ..||||||.|||..|  ....    .  |  |     |||.||| |||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDESLNRNH-FQSYIMADMYSFGLILWEVARRCVSGG---IVEEYQLPYHDLVPSD-PSYEDMREIVCIKKLRPSFPNRWSSDECLR-QMGKLMTECWAH
|.  .| .    .   .|||..||.|||.. ||   .    | |||.|.   | .  || |||.| |  |. || .|. |.  . .  .   ....|| |
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NPASRLTALRVKKTL
 .  ||||. |.  .
DAEARLTAQCVQERM
Kinase BMPR1B.AA TKL 210-491 30 2.1e-110 373.12 In-house 1-364 (364) Show / Hide 
Range on Protein: 210-491
Range on HMM: 1-364/364
Sequence Identity: 30% (114 aa)

IGKGRYGEVWMGKWRG----------EKVAVKVFFTTE-------------------------EASWFRETEIYQTVLMR---HENILGFIAADIKGT--
||.|..|||. |||||          . ||||.| ...                         ||||||..|......|.   |.||. |..... ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIF--STQGKPAIAHRDLKSKNILVKKNGT--------------C
       |.|.||.....|...|||..||         ....|..  .|...||....  .|  ||.|.|||||||||||..|.|              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVKFISDTNEVDIP---------------PNTRVGTKRYMPPEVLDESLNRNH----------FQSYIMADMYSFGLILWEVARRCVSGGIVE
.|.|.||.  .  ..|  |.                 .|..||.|.|.||||....| ..          |.    .|.||||..|||.. ||.      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

EYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSS-------DECLRQMGKLMTECWAHNPASRLTALRVKKTL
.|..|| . ...|| .|.| ..|| |.|||  |..|..       . |...| |||..||.|.| .|.......|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BMPR1B.AA Pkinase 204-491 21 6.1e-58 203.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 204-491
Range on HMM: 1-293/293
Sequence Identity: 21% (71 aa)

IQMVKQIGKGRYGEVWMGKWRGEK--VAVKVFFTTEEASWFRET-----EIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENG----SLYDYLK
.. ...||.| .|.|. ....|.   ||||..   .| ||...|     ||.    ..|.||. .. .        . .|....|.|.|    .|.||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---STTL--DAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTC----CIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVL
   ....  . .   . .|  ..|| ..| .         | |||||. |||...||..    .|.| ||| .|    .  .  ..|..|| .||.|||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECL-----------------RQM
       .      .||.|.|.||.|.. .           .|. . .  ...  |.....| .. .|   ... ...                   . .
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

GKLMTECWAHNPASRLTALRVKKT--L
 .... |.. .|..|.||  ...   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BMPR1B.AA TKL-Unique 206-481 29 9e-40 137.96 In-house 1-280 (290) Show / Hide 
Range on Protein: 206-481
Range on HMM: 1-280/290
Sequence Identity: 29% (89 aa)

MVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE-IYQTV----LMR-HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLK-------
 .. || | ||.|  |||||..||.|.|.  .| | .....  .  |      . |.||. .... .. . .  .......| . |||||.|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----STTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKN-----GTCCIADLGLAVKFISDTNEVDIPPN------TRVGTKRY
    ...|. . ..|.|   ..|...||...     .| |.||||||.|.||  |         |.| ||. || |  |.  .  .      ||.|. |.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS-KFNSKINKMTNNEHKGTRNQTRCGSFRW

MPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCI--KKLRPSFPNRWSSDECLRQMGKLMTECWA
|.||||  .   ....  . .| |||| .|||    .... |   |  ||...     . |  .|.|    ...||  ||     .|  .  .|...||.
MAPEVLRMNF--CQYS--EKSDVYSFGIVLWE----IATRKITKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPN-----HCPKEYRDLIQQCWH

HNPASR
|.|  |
HDPSQR
Kinase BMPR1B.AA MLK 204-410 26 1.4e-33 113.88 In-house 1-229 (291) Show / Hide 
Range on Protein: 204-410
Range on HMM: 1-229/291
Sequence Identity: 26% (65 aa)

IQMVKQIGKGRYGEVWMGKWRGEK-----VAVKVFF-------TTEEASWFRETEIYQTVLMRHEN----ILGFIAADIKGTGSWTQLYLITDYHENGSL
||  . ||.| .|.|| |.||..      |||| ..        |.. .|  |.|...   ..|.|    |  | .. .. .    ...... | |.|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

YDYLKSTT---------------LDAKSMLKLAYSSVSGLCHLHTEIFSTQGKP-AIAHRDLKSKNILVK------KNGTCCIADLGLAVKFISD-TNEV
|..|.. .                |  .... |.   .|.  || .      .| .| ||||||.|||.       ..||. |.| |.. .. .  ||  
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

DIPPNTRVGTKRYMPPEVL---DESLNRNHFQSYIMADMYSFGLILWEV
.     . || ..| |||.    .. .       . .|..|.|..|||.
S-----NAGTYAWMAPEVIQQFRCEKYS------EKCDVWSWGVVLWEM
Kinase BMPR1B.AA S_TKc 204-493 19 3.4e-31 110.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 204-493
Range on HMM: 1-231/231
Sequence Identity: 19% (62 aa)

IQMVKQIGKGRYGEVWMGKWRG--EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHEN--GSLYDYLKSTT----
 .....|||| .|.|. .....  ..||.|.       .  || .| .    .|.||  .. .        . ||....| ..  |.|.||.|.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHF
   ..     ...|  ...| ..|           | |||||  |||. .  .  |.| ||| ..           .| .||  ||.||||         
RFPFPE-HARFYMYQICCALEYCHSH-G-------IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

QSYIM--ADMYSFGLILWEVARRCV--SGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVK
 .|    .|..|.| ||.| . ..   .     ..|. .. ..                                ...  ..  |.  .|. |.||  . 
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

K-------TLAK
.           
QDEWDIKCHPWF
Kinase BMPR1B.AA TK 204-410 15 8.4e-27 86.24 In-house 1-387 (486) Show / Hide 
Range on Protein: 204-410
Range on HMM: 1-387/486
Sequence Identity: 15% (61 aa)

IQMVKQIGKGRYG---EVWMGKWRG---------------------------EKVAVKVFF---TTEEASWFR-----------------ETEIYQTVLM
|...|..|.| .|   ||..|.|||                           ..||||.     .....  |                  | .. .  | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIAADIKGTGSW--------TQLYLITDYHENGS----LYDYLKSTT----------------------------------------------
.|.||. ....  .| ..           ..... | ..|.    | |||..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGT-----------CCIADLGL
                               |. . .|  ..   .|. .||   ..  . . . ||||   |.|| .|..           | ||| ||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE--FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

AV-----KFISDTNEVDIPPNTRVGT-------------------------KRYMPPEVLDESLNRNH---FQSYIMADMYSFGLILWEV
.          . .. |    .  ||                          |.|.||.|..   . .       .  |..|||  .||.
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase BMPR1B.AA STE 204-411 19 6.9e-21 70.57 In-house 1-262 (359) Show / Hide 
Range on Protein: 204-411
Range on HMM: 1-262/359
Sequence Identity: 19% (55 aa)

IQMVKQIGKGRYGEVWMGKWR-----------------GEKVAVKVF--------------------FTTEEASWFRETEIYQTVL-MRHENILGFIAAD
 . ...|||| .|.|  .. .                 || .|.|.                     ...|. .  .| .| .    | |.||  .. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

IKG---TGSWTQLYLITDYHENGSLYDYLKST-----TLD----------AKSMLKLAYSSVSG-LCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTC
.|.   ... ..|...  | ..||| | .|..     .|.           .   . ... . | | .||           | |||.|. |||.     .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----V

CIADLGLAVKFISDTN------------EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSY-IMADMYSFGLILWEVA
 ..| |.. .....                .   || |||  .| |||..   .    . | . .|..|.|. ..| |
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA
Kinase BMPR1B.AA TyrKc 204-491 24 4.3e-17 53.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 204-491
Range on HMM: 1-280/280
Sequence Identity: 24% (77 aa)

IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFF-TTEEASWFRETEIYQTVLM--RHENILGFIAADIKGTGSW---TQLYLITDYHENGSLYDYLKSTT--
|.. |..| | .|||. |.|. ..||||.    . ..   || .|        .|.||. .... ... . .    .|.... | ..|.| |||...   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDT-----NEVDIPPNTRVGTK-----RYMPPEVLDE
|  | .|. ..   .|  .||           . ||||   |.||..|.|. |.| ||. ..| |      ..  . . .. |.|     | |.||..  
LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

SLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE-----CLRQMGKLMTECWAHNPAS
    |.    .  | .|||  .||.  ..         | || . .  . | ....| |   . .|  ||     .     |   | ..|..||...|..
----NYGKFTTKSDVWSFGVCMWEIFTYG---------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPED

RLTALRVKKTL
| |   ... .
RPTFSEIHECF
TGF_beta_GS BMPR1B.AA TGF_beta_GS 174-202 62 1.2e-16 57.75 Pfam 1-29 (29) Show / Hide 
Range on Protein: 174-202
Range on HMM: 1-29/29
Sequence Identity: 62% (18 aa)

ESLRDLIEQSQSSGSGSGLPLLVQRTIAK
....|..|....||||||||||||||||.
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase BMPR1B.AA Pkinase_Tyr 204-306 25 1.7e-15 53.12 Pfam 1-118 (270) Show / Hide 
Range on Protein: 204-306
Range on HMM: 1-118/270
Sequence Identity: 25% (31 aa)

IQMVKQIGKGRYGEVWMGKWR------GEKVAVKVF--FTTEE----ASWFRETEIYQTVLM-RHENILGFIAADIKGTG-SWTQLYLITDYHENGSLYD
|.. |..|.| .|||..|.|.      . .||||.    ...|    .. .|| .|  .  . .|.||. .... ..  . .  |.|... | ..|.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

YLKST-----TLDAKSMLKLAY
||..       |. | .|. ..
YLRKHREDKQPLTMKDLLQMCW
GS BMPR1B.AA GS 174-204 61 2.9e-15 57.94 SMART 1-31 (31) Show / Hide 
Range on Protein: 174-204
Range on HMM: 1-31/31
Sequence Identity: 61% (19 aa)

ESLRDLIEQSQSSGSGSGLPLLVQRTIAKQI
....|..|.. .||||||||||||||.|.||
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
Kinase BMPR1B.AA CAMK 328-383 27 3.6e-13 38.08 In-house 200-292 (425) Show / Hide 
Range on Protein: 328-383
Range on HMM: 200-292/425
Sequence Identity: 27% (26 aa)

IAHRDLKSKNILVKKN-----------------GTCCIADLGLAVKFISDTNEV-------------------DIPPNTRVGTKRYMP-PEVL
|.|||||  |||. .|                 ..  |.| |.| ||... |.                    . . .|..||  ||. ||||
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL
Kinase BMPR1B.AA CAMK 209-293 13 9.4e-12 33.42 In-house 1-157 (425) Show / Hide 
Range on Protein: 209-293
Range on HMM: 1-157/425
Sequence Identity: 13% (21 aa)

QIGKGRYGEVWMGKWR-G-------------EKVAVKVFFTT-------------------------------EEASWFRETEIYQTVL-----MRHENI
..|.|..|.|  .. .               .|||.|.  ..                                ... .|| || ...      ..|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LGFIAADIKGTG--------SWTQ--------LYLIT---DYHENG----SLYDYLKS
. .. .   ..         . ..        .|...   .| ..|     |.||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVE
Kinase BMPR1B.AA Dicty4 204-236 48 7.2e-11 32.66 In-house 1-33 (277) Show / Hide 
Range on Protein: 204-236
Range on HMM: 1-33/277
Sequence Identity: 48% (16 aa)

IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTT
|.  . |||| .|||  |.||| .||||... .
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNH
Kinase BMPR1B.AA Dicty4 285-383 30 3e-08 23.78 In-house 87-189 (277) Show / Hide 
Range on Protein: 285-383
Range on HMM: 87-189/277
Sequence Identity: 30% (35 aa)

GSLYDYLKS--------TTLDAKSMLK---LAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV--KFISDTNE-VDIPPNT
|.||  | .        ..||   ...   .| . . |. .||. .      | | |||||| |.|| || .  ..|.||.   | ..| .   .    |
GNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQM----T

RVGTKRYMPPEVL
 .||  .| |||.
ACGTPCWMAPEVM
Kinase BMPR1B.AA TK 469-491 34 1.6e-05 13.61 In-house 464-486 (486) Show / Hide 
Range on Protein: 469-491
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

LMTECWAHNPASRLTALRVKKTL
||..||...|. | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase BMPR1B.AA Pkinase_Tyr 330-354 52 3.1e-05 18.36 Pfam 134-158 (270) Show / Hide 
Range on Protein: 330-354
Range on HMM: 134-158/270
Sequence Identity: 52% (13 aa)

HRDLKSKNILVKKNGTCCIADLGLA
||||  .|.||..|... |.| |||
HRDLAARNCLVTENNVVKICDFGLA
Kinase BMPR1B.AA Dicty4 444-481 42 4.2e-05 13.16 In-house 231-263 (277) Show / Hide 
Range on Protein: 444-481
Range on HMM: 231-263/277
Sequence Identity: 42% (16 aa)

VCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASR
|| |||||. |     | |.    .|...|| |.| .|
VCNKKLRPPIP-----DWCPPSWKHLIQWCWDHDPQHR
Kinase BMPR1B.AA Pkinase_Tyr 468-491 33 0.000835 13.51 Pfam 247-270 (270) Show / Hide 
Range on Protein: 468-491
Range on HMM: 247-270/270
Sequence Identity: 33% (8 aa)

KLMTECWAHNPASRLTALRVKKTL
.||..||...|. | |   .   |
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase BMPR1B.AA Dicty4 398-411 64 0.001819 7.62 In-house 198-211 (277) Show / Hide 
Range on Protein: 398-411
Range on HMM: 198-211/277
Sequence Identity: 64% (9 aa)

ADMYSFGLILWEVA
|| ||||..||| .
ADVYSFGIVLWEIL
Kinase BMPR1B.AA MLK 447-481 34 0.034047 3.57 In-house 252-281 (291) Show / Hide 
Range on Protein: 447-481
Range on HMM: 252-281/291
Sequence Identity: 34% (12 aa)

KKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASR
..|||  |.      | . . |||..||  .|..|
NGLRPPIPST-----CPEHWKKLMKQCWNQDPHKR