Gene BUBR1 (Human)

BUBR1

Species: Human
Alias: Bub1A, BUB1B, SSK1, hBUBR1, MAD3L, BUBR1, BUB1beta
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q13-q15.1,

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
BUBR1.NA RNA Sugen Kinome 3749 None Fasta, JSON
BUBR1.AA Protein Sugen Kinome 1050 None Fasta, JSON
BUBR1.kin_dom Protein Kinase Domain Sugen Kinome 265 None Fasta, JSON

Protein domain

Protein domains of BUBR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Mad3_BUB1_I BUBR1.AA Mad3_BUB1_I 55-179 47 6.2e-72 250.09 Pfam 1-134 (134) Show / Hide 
Range on Protein: 55-179
Range on HMM: 1-134/134
Sequence Identity: 47% (63 aa)

LQQQKRAFEYEIRFYT---GNDPLDVWDRYISWTEQNYPQ--GGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCN----EPLDMYSYLHNQ
||||...|| ||..|.   |.|||..|.|||.|.|..|||  |.|.|.. |||||.|.......||. |||.|..||.. ..||    ||.|...|..||
LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ

GIGVSLAQFYISWAEEYEARENFRKADAIFQEGI
|||...|.||..||. .|......|||..||.||
GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI
Mad3_BUB1_I BUBR1.AA Mad3_BUB1_I 55-179 47 8.5e-70 239.1 SMART 1-133 (133) Show / Hide 
Range on Protein: 55-179
Range on HMM: 1-133/133
Sequence Identity: 47% (63 aa)

LQQQKRAFEYEI--RFYTGNDPLDVWDRYISWTEQNYPQG--GKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLC----NEPLDMYSYLHNQG
|.||...|| ||  ..| |.||||||.|||.|||||||||  .|.|.. |||||....... .||. |||.|..|... ..|    .||.....|....|
LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG

IGVSLAQFYISWAEEYEARENFRKADAIFQEGI
||...|.||..||..||...|..|||.|.| ||
IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI
Kinase BUBR1.AA BUB 753-1019 35 1.4e-152 513.18 In-house 1-311 (311) Show / Hide 
Range on Protein: 753-1019
Range on HMM: 1-311/311
Sequence Identity: 35% (109 aa)

LEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNED--------FDHFCSCYQYQDGCIVWHQYI-NCFT
..|.|||..|...|..|.|...|.||.|||||||.||.....||...|.||.|||.....|||.|.        |.|.|||..|||....|..|. ...|
FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT

LQDLLQHSE--------YITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYD-CNKNNQA-------LKIVDFSYSVDLRVQLDVFTL
|.|...|..        ..............|..||.||..||.|||..|....|.|||||..| ..|....       ||..||..|.|.....|....
LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF

SGFRTVQI--LEGQKIL----ANCSSPYQVDLFGIADLAHLLLFKEHLQVF--WDGSFWKLSQNISELKDGE-------LWNKFFVRILN----ANDEAT
......|.  .|.....    .||...||||.||||...|..||....||.  |||..|||.||........       .|||||.|.||    ..|..|
KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT

VSVLGELAAEM
.....||.. .
LPMWHELRQQF
Kinase BUBR1.AA SgK495 844-895 34 9.2e-07 17.22 In-house 2-53 (171) Show / Hide 
Range on Protein: 844-895
Range on HMM: 2-53/171
Sequence Identity: 34% (18 aa)

LQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIH
||    |   .    || | .    ||| ||.  ||| ||    ..|  . |
LQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTH
Kinase BUBR1.AA Ciliate-E2 843-915 18 0.000135 11.68 In-house 120-203 (365) Show / Hide 
Range on Protein: 843-915
Range on HMM: 120-203/365
Sequence Identity: 18% (18 aa)

TLQDLLQHS-----------EYITHEITVLIIYNLLT---------------IVEMLHKAE-IVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYS
.|.|.....           .|.|..    |.. .|                 .| ||.   |.| |. |  ...                .||.|| .|
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------IKIIDFGLS
Kinase BUBR1.AA S_TKc 755-1023 12 0.000858 -121.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 755-1023
Range on HMM: 1-231/231
Sequence Identity: 12% (37 aa)

IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKER--LNEDFDH-----FCSCYQYQDGCIVWHQYINC--FTLQ
 |.  ..|   .   .     .           . ..  ||. .         .  ..|.  | .  .|     .  ..|  |   .   |..    .| 
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF

DLLQHSEY------ITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQ
|....  .      ..   .  ..| ..  .| .|.  |.| || |  . | .              .|| ||  .  |                     
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL---------------------

KILANCSSPY------------QVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDE--ATVSVLGE--LAAEMNGVF
     | .|.             .|   .  .   .|  . .         .. ..|    . |... |  ..|. . |   |.  . .  ... .   |
--TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF