Gene CDK19 (Human)

CDK19

Species: Human
Alias: bA346C16.3, CDC2L6, CDK19, CDK11, KIAA1028
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 6q21-q22,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
CDK19.AA Protein Sugen Kinome 502 None Fasta, JSON
CDK19.NA RNA Sugen Kinome 6139 None Fasta, JSON
CDK19.kin_dom Protein Kinase Domain None 316 None Fasta, JSON

Protein domain

Protein domains of CDK19.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK19.AA CDK8 26-335 73 3.1e-276 876.86 In-house 1-329 (329) Show / Hide 
Range on Protein: 26-335
Range on HMM: 1-329/329
Sequence Identity: 73% (243 aa)

K-VGRGTYGHVYKARRKDG--KDEKEYALKQI----------EGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHR
| .|||||||||||.||..  |..|||||||.          |||||||||||||||.|||.|||||.||.|||.|.|..||.|||||||||||||||||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

ASKANKK-PMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE--RGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGAR
..||..| |...||.||||...||||||||||.|||||||||||||.|||.|||  .|.||||||||||.|..|||||.|||||||||||||||||||||
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

HYTKAIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRR-TTYANSSLIKYMEKHKVKPDS
||||||||||||||||||.||||||||..|  ||||.||.|||||||||.|||||.||.|.||.||||. .|.||||| .||.|.||..||||||.|.||
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDS

KVFLLLQKLLTMDPTKRITSEQALQDPYF
... ||.|.||||||||||.|||...|||
HAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase CDK19.AA CDK 22-335 36 3.7e-152 490.21 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-284/284
Sequence Identity: 36% (125 aa)

YEGCK-VGRGTYGHVYKARRKDGK---DEKEYALKQI---------EGTGISMSACREIALLRELKHPNVIALQKVFLSHS---------DRKVWLLFDY
|| .. .|.||||.||||| |. .    .. .|||.|         |..|....|.|||.||.|| |||.. |  |.....         ..|... |.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE-RGRVKIADMGFARLFNSPLK---PLADLDPVVV
..|||.....                  .|....|.|.|.||.| ||..||||||.|||..  | . .||.||||.|.||.|..|..   |.  ....||
MDHDLKKYMD------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

TFWYRAPELLLGARHYT--KAIDIWAIGCIFAELLT---SEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYAN
| ||||||||||..||.   .||.|..||||||..|    .|.|....|         .|||..|| ..| | ...| .. |.|.|              
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTPTEDNWPGVTKLPDY--------------

SSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF
                    ||.|.|..||.|||..|||||.|||
-------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDK19.AA CMGC 22-335 25 2.8e-121 400.56 In-house 1-513 (513) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YEGCK-VGRGTYGHVYKARRKD------------GKDEKEYALKQIE-------------GTGISMSACREIALLRELK-----------------HPNV
||  | .|.|||| |||.| |.             ......|.| |              ..|....|.||| .|..|.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IALQKVFLSHS---------------DRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSM------------VKSLL------YQILDGIH--YLH
. |. .| ..                .... | |.| .|||...|| ..  . .|.|| |.               .|...      |||| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ANW--VLHRDLKPANILVMGEGPE----------------RGRVKIADMGFARLFNSPLKP------------------LADLDPVVVTFWYRAPELLLG
 .|  ..||||||.|||.  ..                  .||.||.| |.|| .... ..                  .  . . ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ARHYT---------KAIDIWAIGCIFAELLTS--------EPIFHCRQE----DIKTSNPFHHDQLDRIFSVMGFPA---------------DKDWEDIR
..|||         ..||.|..||||||..|         .|.|. . |    | | .   | |||..|| |.| |                ...| .. 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

KMPEYPT---------------------LQKDFRRTTYANSSLIKYMEK-------------------HKVKPD------------SKVFLLLQKLLTMD
|.|.|..                     .|. .|  ..   .. . . .                   .|.|..            .. . ||.|.|..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PTKRITSEQALQDPYF
|.|||| ||||| |||
PDKRITAEQALQHPYF
Kinase CDK19.AA CDC2 26-335 36 1.4e-94 291.05 In-house 6-301 (301) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-301/301
Sequence Identity: 36% (118 aa)

KVGRGTYGHVYKARRKDGKDEKEYALKQI------EGTGISMSACREIALLRELK-HPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANK
|.| ||||.|||.. .. ..    |||.|      || |.  .| ||| .| ||| |||.. |. |. .   .|. . |.| ..||    .    ..   
KIGEGTYGVVYKCKDMQTNQ--IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN---

KPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV--VVTFWYRAPELLLGARHYTKAID
   ..| . |||..||||.|.|..|.. ..|||||| |||.  .|     .||||.| || |. |....    .   ||| ||||||.|||...|. ..|
--KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFGLARAFGIPIRTYT---TEHEVVTLWYRAPEILLGCKRYSTPVD

IWAIGCIFAEL---LTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQ
.|.|||||||.    | .|.||   | |        ||| .|| ..| | ...|... ..|.| .    ....   .    .. .|.    | . . ||.
MWSIGCIFAEMFMDVTKKPLFHGDSE-I--------DQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLM

KLLTMDPTKRITSEQALQDPYF
..|  || |||....||| |||
QMLQYDPQKRISAKEALQHPYF
Kinase CDK19.AA CDK7 22-281 37 2.9e-87 232.39 In-house 1-241 (288) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-241/288
Sequence Identity: 37% (102 aa)

YEGCK-VGRGTYGHVYKARRKDGKDEKEYALKQIE--------GTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHR
||  | .| |... ||||. .     .  | | |           || ..| ||| .|.|..|.||| |  .|   |   . | ||. . || ..||   
YEKIKHIGEGQFATVYKACDHQTG--QIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIK---

ASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYT
      |   |  . .|.   ..| |. |.|.||.||||||| | |.     | |..|||| | || . || . .    . ||| |||||||| |||||.
-----DKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMN----ENGQLKIADFGLARFYGSPNRIYT---HQVVTRWYRAPELLFGARHYG

KAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQK
 ..|.|..|||||||.   |..   . ||        ||| |||. .| | ...| .. .|..| ....
TGVDMWSVGCIFAELMLRVPYLPG-DSDI--------DQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKD
S_TKc CDK19.AA S_TKc 21-335 24 6.2e-85 289.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-335
Range on HMM: 1-231/231
Sequence Identity: 24% (81 aa)

EYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEH---DLWHIIKFHRASKAN
   . |.|.|..| |||.| |.  . ...|.|.|       ...|||..|.. .|||.. |  || .    .... ..|...   || ..|| ..  . .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK-AID
    ..|  ......|||.... |.| ....||||||.|||.        ..||.| |.||..          . ...| ||.|||.|    .|.| ..|
---FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCD

IWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLL
.|..|||..|.|. .| |.               |....| ..|                                            .. .  ...|.|
WWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG--------------------------------------------SPEAKDFIRKCL

TMDPTKRITSEQALQ-------DPYF
..||.||.|  .|||       .|.|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK19.AA CDK5 22-335 36 3e-82 259.59 In-house 1-287 (287) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-287/287
Sequence Identity: 36% (117 aa)

YEGC-KVGRGTYGHVYKARRKDGKDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKA
||   |.| |||| ||||| |. .    .|||..    |  |.  .| |||.||.||||.|.. |  |   ||..|  | | .   ||   .        
YEKMEKIGEGTYGTVYKARNKETHE--IVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDLKKYMDSCNG---

NKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAID
     ..   ..||..|| | |. . |.. |||||||| | |.      .|  | || | || |  | .        ||| |||.|  |.|..||.  ||
-----EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN----KNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYSTSID

IWAIGCIFAELL-TSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKL
.| .||||||.  .  | |   ...         ||| ||| .|| |    |  | |.|.|  . ...         . . ....  | |.|   ||||.
MWSCGCIFAEMANAGRPLFPGNDVE---------DQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYP-----AHQSWQQIVPKLDEKGMDLLQKM

LTMDPTKRITSEQALQDPYF
| ..| .||. ..||. |||
LQCNPNQRISAKAALHHPYF
Kinase CDK19.AA PITSLRE 26-335 33 1.1e-73 251.09 In-house 6-295 (295) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-295/295
Sequence Identity: 33% (108 aa)

KVGRGTYGHVYKARRKDGKDEKEYALKQIEGT------GISMSACREIA-LLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANK
... |||| ||.|  || . .   ||| .         |.   . |||  .|..|.|||....  . .     |... ..| ||||  ..  ..     .
RIHEGTYGVVYRA--KDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMK---RRN

KPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
.| ...   .|.|. | | |....| ||..||||| .|.|        |  ||.| | || . ||.||.    |.||| ||||||||||.. |. ..|.|
QPFKPGE--IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYS----HKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKYSTPVDMW

AIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFR-RTTYANSSLIKYME-KHKVKPDSKVFLLLQKLL
 .||||||..| .|.|  . |          ||...||  || |  | | .. ..|    . | .   . |  . | |      ..      | ||...|
SVGCIFAEFITMKPLFQGKSE---------IDQINCIFKEMGTPTEKIWPGWTELP----HWKMMNNFPHYPYNNLRKRFPAENHIS--DTGFDLLNQML

TMDPTKRITSEQALQDPYF
| .|..||| ..||..|.|
TYNPKNRITASDALKHPWF
Kinase CDK19.AA CRK7 26-335 29 1.3e-73 250.92 In-house 6-343 (343) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-343/343
Sequence Identity: 29% (108 aa)

KVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGI-------SMSACREIALLRELKHPNVIALQKVFLSH-------SDR-KVWLLFDYAEHDLWHIIKF
 .| |||| ||||. |.   ..  ||| ..  .           | ||| .||.|.|.|.. |  . ..        ...  ... |.|. |||    . 
QIGEGTYGQVYKAKNKH--TGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLLE-

HRASKANKKPMQ-LPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGAR
   ||.    |.    . .|... |.|.|. |.| . .||||.| .|||.      .| ||||| | |||.||  |  ...   |.| |||.||||||. 
---SKE----MHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMN----NQGEVKIADFGLARLYNSEEK-RRPYTNRVITLWYRPPELLLGEE

HY--------------------------------------TKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIR
.|                                      ...||.|  |||..||.| .|||  ..|          .||. |. ..| |    | .. 
RYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSPNPNNWPEVM

KMPEYPTLQKDFRRTTYANSSLIKYMEKHK-VKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF
|.| . |.     . .|   ..    .. | | .... . || |.|..||.||.| |..|| ..|
KLPWWNTMKP---KRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK19.AA Pkinase 26-335 25 6.5e-73 253.33 Pfam 6-293 (293) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-293/293
Sequence Identity: 25% (85 aa)

KVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACR------EIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEH-----DLWHIIKFHRAS
|.|.|..| |||...|.  .  ..|.|.|.  ..... ..      ||.....|.|||.. |  .| .  ...... ..|.|.     ||...|.     
KIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST----

KANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKA
  ..... ..   .|. .|||| |. |.|.....||||||.|||.  .|    .|||.| |.|..|.  . .   .. ...| ||.|||...|...|...
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHD-------QLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSK
.|.|..|||..|.|. .              || ..       |. .|. .|| | . ||.  . .. .. ..    .         .  ..  .. .. 
VDMWSCGCILYEMLCGR-------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------F-HWTF-HNWSEE

VFLLLQKLLTMDPTKRITSEQALQDPYF
   .. ..|..||.||.| ||.||.|.|
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDK19.AA MAPK 65-335 31 8.8e-61 208.25 In-house 53-328 (328) Show / Hide 
Range on Protein: 65-335
Range on HMM: 53-328/328
Sequence Identity: 31% (99 aa)

REIALLREL-KHPNVIALQKVFLSH-----SD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDG--IHYLHANWVLHRDL
||| |||.. .|.|.| |. .|  .     ..    . . . ... |.|| .|||  .         .|    .....|||| |  . |.|   |.||||
REIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ---------PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDL

KPANILVMGEGPERGRVKIADMGFARLFNS-PLKPLA----------DLDPVVVTFWYRAPELLLG--ARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ
||.||||     | . .||.|.| || . .   ..            .. . |.| ||||||..|.  ..|||||.|.|..||||||.||   |.|    
KPSNILVN----ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP---

EDIKTSNPFHH-DQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKY--MEKHKVKPDSKVFL------------LLQKLLTMDPTKR
         .. ||. .|..|.| | . ... | .                | . .  .  . |.. || .|.|             ||.|.|..|| ||
-------GKDYIDQWNLIMEVLGTPSEEFIQCICM-------------SEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKR

ITSEQALQDPYF
|| |.||| |||
ITVEEALQHPYF
Kinase CDK19.AA CDK4 22-267 37 1.3e-55 189.25 In-house 1-233 (290) Show / Hide 
Range on Protein: 22-267
Range on HMM: 1-233/290
Sequence Identity: 37% (99 aa)

YEGCK-VGRGTYGHVYKARRKDGKDEKEYALKQI------EGTGISMSACREIALLRELK---HPNVIALQKVF-LSHSDR---KVWLLFDYAEHDLWHI
|.    .| | || ||.||  | .. . .||||.      || |. ||  |||...| |.   |||.. |  |.  .  ||   |. . |   . ||   
YQCVAEIGEGAYGTVYRAR--DLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTY

IKFHRASKANKKPM-QLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLL
.         | |   .|   .| .  |.| |. .||.. . |||||| ||||  .    |.||.|| | || . .  .    | ||||| |||||| ||
L--------DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSD----GHVKLADFGLARIYSFQMA----LTPVVVTLWYRAPEVLL

GARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDW
 .  |   .|.|..||||||.    | |    |          |||..|| ||| |  .||
-QSYYNTPVDMWSVGCIFAEMYCRRPLFCGQSE---------KDQLHKIFDVMGLPPEDDW
Kinase CDK19.AA CDK7 311-335 48 4.2e-14 33.53 In-house 264-288 (288) Show / Hide 
Range on Protein: 311-335
Range on HMM: 264-288/288
Sequence Identity: 48% (12 aa)

LLQKLLTMDPTKRITSEQALQDPYF
|.....||.| ||.|  |.|. |||
LMCGMWTMNPCKRWTCTQCLKMPYF
TyrKc CDK19.AA TyrKc 21-333 18 4.4e-11 -43.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-333
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

EYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLREL--KHPNVIALQKVFLSH-----SDRKVWLLFDYAEH-DLWHIIKFHR
   | | |.| .| |||.. |      . | | .      .  .||. ....|  .|||...|  | ...     ..  ..... |..| || . .. ||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

ASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSP--------LKPLA---DLDPVVVTFWYRA
          |. .   |  .|| .|  ||| . . ||||   |.||  ..    .|||.| | .|   .          .  .   . . ..   |. |
PK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-A

PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR-----QEDIKTSNPFHHDQLDRIFSV---MGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSL
|| .   . .| . |.|. |    |..|     .        ...   .   .    ..      |                                  
PECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------

IKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDP
        |   .... . ..    || .| | ..  .. 
------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Pkinase_Tyr CDK19.AA Pkinase_Tyr 20-173 26 1.9e-08 29.22 Pfam 1-154 (270) Show / Hide 
Range on Protein: 20-173
Range on HMM: 1-154/270
Sequence Identity: 26% (44 aa)

FEYEGCKVGRGTYGHVYKARRK--DGKDEKEYALKQI-EGTGIS----MSACREIALLREL-KHPNVIALQKVFLSHSDR-KVWLLFDYAEH-DLWHIIK
 .    | |.| .|.|||.. |  ..... . | | . ||.  .     .  ||......| .|||.. |  | .....  .... . |..| || .  .
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

FHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIAD
 ||       . .|. ..  .  .|| .|  ||...   ||||   |.||     | . |||.|
KHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICD
Kinase CDK19.AA CDK4 311-335 52 1.2e-07 22.09 In-house 266-290 (290) Show / Hide 
Range on Protein: 311-335
Range on HMM: 266-290/290
Sequence Identity: 52% (13 aa)

LLQKLLTMDPTKRITSEQALQDPYF
|||| |. .. ||.. .|.|| |||
LLQKMLCYNHHKRMSAYQCLQHPYF