Gene CDK8 (Human)

CDK8

Species: Human
Alias: CDK8, K35, MGC126074, MGC126075
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 13q12.3,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
CDK8.NA RNA Sugen Kinome 1772 None Fasta, JSON
CDK8.AA Protein Sugen Kinome 464 None Fasta, JSON
CDK8.kin_dom Protein Kinase Domain Sugen Kinome 316 None Fasta, JSON

Protein domain

Protein domains of CDK8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK8.AA CDK8 26-335 75 4.4e-280 889.13 In-house 1-329 (329) Show / Hide 
Range on Protein: 26-335
Range on HMM: 1-329/329
Sequence Identity: 75% (250 aa)

K-VGRGTYGHVYKAKRKDG--KDDKDYALKQI----------EGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHR
| .||||||||||||||..  |..|.|||||.          |||||||||||||||.|||.|||||.||.|||.|.|..||.|||||||||||||||||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

ASKANKK-PVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE--RGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGAR
..||..| |...||.||||...||||||||||.|||||||||||||.|||.|||  .|.||||||||||.|..|||||.|||||||||||||||||||||
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

HYTKAIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRR-NTYTNCSLIKYMEKHKVKPDS
||||||||||||||||||.||||||||..|  ||||.||||||||||||.|||||.||.|.||||||||..||||||| .||.||||..||||||.|.||
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDS

KAFHLLQKLLTMDPIKRITSEQAMQDPYF
.|.|||.|.|||||.||||.||||..|||
HAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase CDK8.AA CDK 22-335 35 5e-152 489.79 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-284/284
Sequence Identity: 35% (122 aa)

YEGCK-VGRGTYGHVYKAKRKDGK---DDKDYALKQI---------EGTGISMSACREIALLRELKHPNVISLQKVFLSHA---------DRKVWLLFDY
|| .. .|.||||.||||. |. .    .. .|||.|         |..|....|.|||.||.|| |||...|  |.....         ..|... |.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE-RGRVKIADMGFARLFNSPLK---PLADLDPVVV
..|||.....                  .|....|.|.|.||.| ||..||||||.|||..  | . .||.||||.|.||.|..|..   |.  ....||
MDHDLKKYMD------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

TFWYRAPELLLGARHYT--KAIDIWAIGCIFAELLT---SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTN
| ||||||||||..||.   .||.|..||||||..|    .|.|....|         .|||..||...| | ...| ...|.|..              
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTPTEDNWPGVTKLPDY--------------

CSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF
                   .||.|.|..|| |||..|||.|.|||
-------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDK8.AA CMGC 22-335 24 2.7e-122 403.94 In-house 1-513 (513) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-513/513
Sequence Identity: 24% (127 aa)

YEGCK-VGRGTYGHVYKAKRKD------------GKDDKDYALKQIE-------------GTGISMSACREIALLRELK-----------------HPNV
||  | .|.|||| |||.. |.             .... .|.| |              ..|....|.||| .|..|.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ISLQKVFLSHA---------------DRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGM------------VKSLL------YQILDGIH--YLH
..|. .| ..                .... | |.| .|||...|| ..  . .|.|. |.               .|...      |||| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ANW--VLHRDLKPANILVMGEGPE----------------RGRVKIADMGFARLFNSPLKP------------------LADLDPVVVTFWYRAPELLLG
 .|  ..||||||.|||.  ..                  .||.||.| |.|| .... ..                  .  . . ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ARHYT---------KAIDIWAIGCIFAELLTS--------EPIFHCRQE----DIKTSNPYHHDQLDRIFNVMGFPA---------------DKDWEDIK
..|||         ..||.|..||||||..|         .|.|. . |    | | .   | |||..||.|.| |                ...| ...
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

KMPEHST------------LMKDFRRN------TYTNCSLIKYMEKHKVKPD----------------------------------SKAFHLLQKLLTMD
|.|.. .             ...| ||      .. ..  ..  .... .|.                                  ..|..||.|.|..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PIKRITSEQAMQDPYF
| |||| |||.| |||
PDKRITAEQALQHPYF
Kinase CDK8.AA CDC2 26-335 36 5.7e-97 298.57 In-house 6-301 (301) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-301/301
Sequence Identity: 36% (117 aa)

KVGRGTYGHVYKAKRKDGKDDKDYALKQI------EGTGISMSACREIALLRELK-HPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANK
|.| ||||.|||.| .. ..    |||.|      || |.  .| ||| .| ||| |||...|. |. .   .|. . |.| ..||    .    ..   
KIGEGTYGVVYKCKDMQTNQ--IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN---

KPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV--VVTFWYRAPELLLGARHYTKAID
   ..|   |||..||||.|.|..|.. ..|||||| |||.  .|     .||||.| || |. |....    .   ||| ||||||.|||...|. ..|
--KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFGLARAFGIPIRTYT---TEHEVVTLWYRAPEILLGCKRYSTPVD

IWAIGCIFAEL---LTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQ
.|.|||||||.    | .|.||   | |        ||| .|| ..| | ...|......|.  .    ....  ..    .. .|.    | ... ||.
MWSIGCIFAEMFMDVTKKPLFHGDSE-I--------DQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLM

KLLTMDPIKRITSEQAMQDPYF
..|  ||.|||....|.| |||
QMLQYDPQKRISAKEALQHPYF
Kinase CDK8.AA CDK7 22-335 34 5.4e-95 253.4 In-house 1-288 (288) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-288/288
Sequence Identity: 34% (113 aa)

YEGCK-VGRGTYGHVYKAKRKDGKDDKDYALKQIE--------GTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHR
||  | .| |... ||||  .  . ..  | | |           || ..| ||| .|.|..|.||| |  .|       . | ||. . || ..||   
YEKIKHIGEGQFATVYKACDH--QTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIK---

ASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYT
      | . |    .|.   ..| |. |.|.||.||||||| | |.     | |..|||| | || . || . .    . ||| |||||||| |||||.
-----DKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMN----ENGQLKIADFGLARFYGSPNRIYT---HQVVTRWYRAPELLFGARHYG

KAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLL
 ..|.|..|||||||.   |..   . ||        ||| |||. .| | ...| .. .|..  .. .      ..  | .   .     .|  . .|.
TGVDMWSVGCIFAELMLRVPYLPG-DSDI--------DQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKD------FPGYSRTPLRHIFTAASD-DLLDLM

QKLLTMDPIKRITSEQAMQDPYF
....||.|.||.|  |. . |||
CGMWTMNPCKRWTCTQCLKMPYF
S_TKc CDK8.AA S_TKc 21-335 24 3.8e-85 290.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-335
Range on HMM: 1-231/231
Sequence Identity: 24% (80 aa)

EYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH---DLWHIIKFHRASKAN
   . |.|.|..| |||.. |.  ... .|.|.|       ...|||..|.. .|||.. |  || .    .... ..|...   || ..|| ..  . .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK-AID
   ...|  ......|||.... |.| ....||||||.|||.        ..||.| |.||..          . ...| ||.|||.|    .|.| ..|
---FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCD

IWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLL
.|..|||..|.|. .| |.               |....|...|                                            .. | ....|.|
WWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG--------------------------------------------SPEAKDFIRKCL

TMDPIKRITSEQAMQ-------DPYF
..|| ||.|  .|.|       .|.|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK8.AA CDK5 22-335 35 2.9e-80 253.25 In-house 1-287 (287) Show / Hide 
Range on Protein: 22-335
Range on HMM: 1-287/287
Sequence Identity: 35% (114 aa)

YEGC-KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKA
||   |.| |||| ||||. |. .    .|||..    |  |.  .| |||.||.||||.|.. |  |   |...|  | | .   ||   .        
YEKMEKIGEGTYGTVYKARNKETHE--IVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDLKKYMDSCNG---

NKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAID
     ..   ..||..|| | |. . |.. |||||||| | |.      .|  | || | || |  | .        ||| |||.|  |.|..||.  ||
-----EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN----KNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYSTSID

IWAIGCIFAELL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKL
.| .||||||.  .  | |   ...         ||| ||| .|| |    |  | |.|.   ....     |    . . ....  | |.|   ||||.
MWSCGCIFAEMANAGRPLFPGNDVE---------DQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQ-----YPMYPAHQSWQQIVPKLDEKGMDLLQKM

LTMDPIKRITSEQAMQDPYF
| ..| .||. ..|.. |||
LQCNPNQRISAKAALHHPYF
Kinase CDK8.AA PITSLRE 26-335 34 4.1e-76 259.17 In-house 6-295 (295) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-295/295
Sequence Identity: 34% (109 aa)

KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGT------GISMSACREIA-LLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANK
... |||| ||.|| |  . |   ||| .         |.   . |||  .|..|.|||....  . .     |... ..| ||||  ..  ..     .
RIHEGTYGVVYRAKDK--RTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMK---RRN

KPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
.| ..  | .|.|. | | |....| ||..||||| .|.|        |  ||.| | || . ||.||.    |.||| ||||||||||.. |. ..|.|
QPFKP--GEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYS----HKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKYSTPVDMW

AIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFR-RNTYTNCSLIKYME-KHKVKPDSKAFHLLQKLL
 .||||||..| .|.|  . |          ||...||. || |  | | .....|    ..| .     |  . | |      ..     .| ||...|
SVGCIFAEFITMKPLFQGKSE---------IDQINCIFKEMGTPTEKIWPGWTELP----HWKMMNNFPHYPYNNLRKRFPAENHIS--DTGFDLLNQML

TMDPIKRITSEQAMQDPYF
| .| .||| ..|...|.|
TYNPKNRITASDALKHPWF
Kinase CDK8.AA CRK7 26-335 29 2.9e-74 253.01 In-house 6-343 (343) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-343/343
Sequence Identity: 29% (106 aa)

KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGI-------SMSACREIALLRELKHPNVISLQKVFLSH-------ADR-KVWLLFDYAEHDLWHIIKF
 .| |||| ||||| |. ..    ||| ..  .           | ||| .||.|.|.|.. |  . ..         ..  ... |.|. |||    . 
QIGEGTYGQVYKAKNKHTGE--MVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLLE-

HRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH
      .|  ..   . .|... |.|.|. |.| . .||||.| .|||.      .| ||||| | |||.||  |  ...   |.| |||.||||||. .
------SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMN----NQGEVKIADFGLARLYNSEEK-RRPYTNRVITLWYRPPELLLGEER

Y--------------------------------------TKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKK
|                                      ...||.|  |||..||.| .|||  ..|          .||. |. ..| |    | .. |
YTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSPNPNNWPEVMK

MPEHSTLMKDFRRNTYTNCSLIKYMEKHK-VKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF
.|   |..    . .|.  ..    .. | | ...... || |.|..|| ||.| |.. | ..|
LPWWNTMKP---KRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK8.AA Pkinase 26-335 26 2.9e-71 247.87 Pfam 6-293 (293) Show / Hide 
Range on Protein: 26-335
Range on HMM: 6-293/293
Sequence Identity: 26% (87 aa)

KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACR------EIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-----DLWHIIKFHRAS
|.|.|..| |||...|.  .   .|.|.|.  ..... ..      ||.....|.|||.. |  .| .  ...... ..|.|.     ||...|.     
KIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST----

KANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKA
  ..... ..   .|. .|||| |. |.|.....||||||.|||.  .|    .|||.| |.|..|.  . .   .. ...| ||.|||...|...|...
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWAIGCIFAELLTSEPIFH--CRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLL
.|.|..|||..|.|. .|.|   | ..      .  |||. .|...|| | . ||.    ..  . ..    .         .  ..  .. .. . ...
VDMWSCGCILYEMLCGRPPFPGHC-WH------DN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------F-HWTF-HNWSEECKDFI

QKLLTMDPIKRITSEQAMQDPYF
 ..|..|| ||.| ||..|.|.|
KWCLCKDPKKRPTAEQILQHPWF
Kinase CDK8.AA MAPK 65-335 31 7.5e-61 208.47 In-house 53-328 (328) Show / Hide 
Range on Protein: 65-335
Range on HMM: 53-328/328
Sequence Identity: 31% (95 aa)

REIALLREL-KHPNVISLQKVFLSH-----AD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDG--IHYLHANWVLHRDL
||| |||.. .|.|.|.|. .|  .      .    . . . ... |.|| .|||  .         .|    .....|||| |  . |.|   |.||||
REIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ---------PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDL

KPANILVMGEGPERGRVKIADMGFARLFNS-PLKPLA----------DLDPVVVTFWYRAPELLLG--ARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ
||.||||     | . .||.|.| || . .   ..            .. . |.| ||||||..|.  ..|||||.|.|..||||||.||   |.|    
KPSNILVN----ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP---

EDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHS-TLMKDF----RRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDP
         . ||. .|..|.| | . ... |.. .||  .. . .    ... ..  ....   .   . ...| .||.|.|..|| |||| |.|.| |
------GKDYIDQWNLIMEVLGTPSEEFIQCICM-SEHARNYIQSLGNLPKYPKKPWEKMFPNANF---NANPQAIDLLEKMLVFDPDKRITVEEALQHP

YF
||
YF
Kinase CDK8.AA CDK4 22-267 37 1.3e-55 189.14 In-house 1-233 (290) Show / Hide 
Range on Protein: 22-267
Range on HMM: 1-233/290
Sequence Identity: 37% (98 aa)

YEGCK-VGRGTYGHVYKAKRKDGKDDKDYALKQI------EGTGISMSACREIALLRELK---HPNVISLQKVF-LSHADR---KVWLLFDYAEHDLWHI
|.    .| | || ||.|   | .. ...||||.      || |. ||  |||...| |.   |||...|  |.  .  ||   |. . |   . ||   
YQCVAEIGEGAYGTVYRA--RDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTY

IKFHRASKANKKPV-QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLL
.         | |   .|   .| .  |.| |. .||.. . |||||| ||||  .    |.||.|| | || . .  .    | ||||| |||||| ||
L--------DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSD----GHVKLADFGLARIYSFQMA----LTPVVVTLWYRAPEVLL

GARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDW
 .  |   .|.|..||||||.    | |    |          |||..|| ||| |  .||
-QSYYNTPVDMWSVGCIFAEMYCRRPLFCGQSE---------KDQLHKIFDVMGLPPEDDW
TyrKc CDK8.AA TyrKc 21-283 20 1.7e-10 -52.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-283
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

EYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLREL--KHPNVISLQKVFLSH-----ADRKVWLLFDYAEH-DLWHIIKFHR
   | | |.| .| |||.. |      . | | .      .  .||. ....|  .|||.. |  | ...      .  ..... |..| || . .. ||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

ASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSP--------LKPLA---DLDPVVVTFWYRA
          |.     |  .|| .|  ||| . . ||||   |.||  ..    .|||.| | .|   .          .  .   . . ..   |. |
PK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-A

PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR-----QEDIKTSNPYHHD-QLDRIFNVMGFP-----ADKDWEDI-----KKMPEH----STLMK
|| .   . .| . |.|. |    |..|     .        ...   .   .   ...  |.   |     . ..  .|     .  ||     |.. .
PECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

DF
.|
CF
Pkinase_Tyr CDK8.AA Pkinase_Tyr 20-173 26 3.1e-07 25.14 Pfam 1-154 (270) Show / Hide 
Range on Protein: 20-173
Range on HMM: 1-154/270
Sequence Identity: 26% (44 aa)

FEYEGCKVGRGTYGHVYKAKRK--DGKDDKDYALKQI-EGTGIS----MSACREIALLREL-KHPNVISLQKVFLSHADR-KVWLLFDYAEH-DLWHIIK
 .    | |.| .|.|||.. |  ..... . | | . ||.  .     .  ||......| .|||...|  | ... .  .... . |..| || .  .
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

FHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIAD
 ||       . .|.  .  .  .|| .|  ||...   ||||   |.||     | . |||.|
KHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICD
Kinase CDK8.AA CDK4 305-335 38 2e-06 17.92 In-house 260-290 (290) Show / Hide 
Range on Protein: 305-335
Range on HMM: 260-290/290
Sequence Identity: 38% (12 aa)

DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF
.  .  |||| |. .. ||.. .|. | |||
CKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF