Gene CDKL2 (Human)

CDKL2

Species: Human
Alias: KKIAMRE, P56, CDKL2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4q13-q21.1,

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL2.AA Protein Sugen Kinome 570 None Fasta, JSON
CDKL2.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON
CDKL2.NA RNA Sugen Kinome 4948 None Fasta, JSON

Protein domain

Protein domains of CDKL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL2.AA CDKL 4-287 68 7.79999999999e-224 749.89 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-286/286
Sequence Identity: 68% (195 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVV
||.||.|||||||.|||||||.||.|||||||.||.||.|||||||||||.||||.|||.|||.||...|....||||..|||.|..|| .|||.|..||
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

QKYLFQIINGIGFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLF
.||..||...| |||.||.|||||||||||.. ..|.||||||||||.||.|||.|||||||||||||||||||..|||.||.|||||.. ||..|.||.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLS-EVVIDLAKKCLHIDPDKRPFCAELLHHDFF
||.|||||||||..|||.|||||||.|.|||.|.|...|||...||||.|||..| ....|..|||||.|||.|..|..|.||..|
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL2.AA CMGC 4-287 23 5.1e-126 416.42 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-513/513
Sequence Identity: 23% (122 aa)

YENLGLVGEGSYGMVMKCRN--------------KDTGRIVAIKKFLESDDDKMVKK----------IAMREIKLLKQLR-----------------HEN
||... .|||.||.| |||.              ..|..||||||. .   ..  .|          .| ||||.||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLLEVCKKKK-----------------RWYLVFEFVDHTILDDLELFPN--------GLDYQV------------VQKYL------FQIINGIG--FC
.|.|..... |.                   |||||..||. .. ..  ..        .|.  .            .....      .||..|.   .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSHN--IIHRDIKPENILVSQS--------------------GVVKLCDFGFARTLAAP---------------------GEVYTDYVATRWYRAPELLV
|||.  |||||.||||||...                     |..|.||||.|| .  .                     .. ||.||.||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------VKYGKAVDVWAIGCLVTEMFMG--------EPLFPGDSD-----------IDQLYHIMMCLGNLI---------------PR-------
|.          .|....|.|..||   ||..|        .|||||.|.           ||||..|.  ||.                 ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HQELFNKNPVFAGVRLPEIKER--EPLERRYPK--------------------------------LSEVVIDLAKKCLHIDP
                  |.  | .|... . |.|... .  ..|. ..|.                                ...  ||| ||.|..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRPFCAELLHHDFF
|||. ... | |..|
DKRITAEQALQHPYF
Kinase CDKL2.AA CDK 4-287 34 1.6e-108 348.39 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-284/284
Sequence Identity: 34% (112 aa)

YENLGLVGEGSYGMVMKCRNKDTG-----RIVAIKKF-LESD----DDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKK-----------KRWYLVFEF
|| |  .|||.|| | |.|.|.||     .|||.||. .|..    ..  .   | |||.|||.| |.| |.|..||  |           .. |.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VDHT---ILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGV-----VKLCDFGFARTLAA------PGEVYTDYVATRWYR
.||    ..|             .. |..|...|. .|||..|.|||.|| |||..  |.     .|. |||.||          |  .||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELLVGDVKYG--KAVDVWAIGCLVTEMFM---GEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDL
||||| |. .|.   ..|.|..||   |||.   ..|||||||.|||| .|   .|   .     . | | .                          ||
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DL

AKKCLHIDPDKRPFCAELLHHDFF
  |.|  ||.||  . . |.|..|
LNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL2.AA Pkinase 4-287 31 2.5e-99 341.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMR--EIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELF-------
|. .. .|.||.| | ||..|.||.|||.|..  ..... ..... |  ||...| |.|.| | |....  |.. |.|.|.....    ..||       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

PNGL--DYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVV----KLCDFGFARTL-AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWA
 ...  .......|. ||. |. .|||..|||||.||||||... |..    |.||||.|. .   ... .|... |.||.|||.. |. .||..||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGCLVTEMFMGEPLFPGD----SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLH
.||.. ||. |.|.|||.    . .||.. | . .|  .... .  . .. |  .|  . .  . .... ...||  .|. |.||. || ||| ....|.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HDFF
|..|
HPWF
Kinase CDKL2.AA S_TKc 4-287 31 9.7e-99 335.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDH---TILDDLELFPNG---
|| | ..|.|..| |.|||.|.||||||||.           . ..|||..||. .|.|.|.|..|.   .. |.|.|..|.   . .| ..  . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGK-AVDVWAIGCLVTE
  ..  ....|. ||.... .||||.|||||.||||||...  ..|.||||.|| |       | .. |.||.|||.|    .||| ..|.|..||.. |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLH-------HDFF
|. |.|.||   ..........                                        |. ..|. .|||. ||.||| . |.|.       | .|
MLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL2.AA CDC2 4-214 43 6.7e-98 301.48 In-house 1-221 (301) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-221/301
Sequence Identity: 43% (97 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF-LESDDDK-MVKKIAMREIKLLKQLR-HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLE-LFP--NG
|. .  .|||.|| | ||....|..|||.||. ||..|.   |   |.||| .|| |. |.|.| | .| .. .. |.|||..|.     .. ..|    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYT--DYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEM
.. |.|..|..||..|. |||.. |.|||.|| |||.. .|..|. ||| ||.   |  .||    | |.||||||.| |. .|  .||.|.|||.  ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

FMG---EPLFPGDSDIDQLYHI
||    .|||.||| ||||. |
FMDVTKKPLFHGDSEIDQLFKI
Kinase CDKL2.AA CDK7 4-219 39 3.8e-89 237.5 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-220/288
Sequence Identity: 39% (88 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFL----ESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVD---HTILDDLELFPN
|| . ..||| .. | | . . ||.||||||       |. .  .   |.||||.|. ..|.| ..|. .  .|   .|||.| |     .  | ..   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSII--

GLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF
 |    .  |  ..  |. .|| . | |||.|| | |... |..|. ||| ||   .| ..||  | |||||||||| |   || .||.|..||   |  
-LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM

MGEPLFPGDSDIDQLYHIMMCLG
   | .|||||||||  |   ||
LRVPYLPGDSDIDQLTRIFQTLG
Kinase CDKL2.AA CDK5 4-287 36 1.1e-83 264.18 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 36% (106 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVV
|| .  .||| ||.| | |||.|. |||.|.    ..|  |   |.||| ||| |.|.| | |  |    |.  |||||.|  .   .. .  ..| ...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

QKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF-MGEPLF
. ...|   |..|||.|.. ||| || | |... |  || ||| ||    |   |.  | | |||.|  | |  .|   .|.| .||   ||   | |||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA--GVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF
|| .. |||  |   .|     .     | | .    . .|    .....   |||.|   || .| | ..|..|   .. ||| .|
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL2.AA RCK 4-287 34 4e-78 247.42 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-298/298
Sequence Identity: 34% (105 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLLEVCKKKK--RWYLVFEFVDHTILDDLELFPNGLDY
|  .  .|.|.|| ||| .||.|| ||||||       .    .  |||| |. |  |.|...|.|| . ..  . |.|||..|  .   .. |    . 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RRK

----QV--VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ---------SGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAPELLVGDVKYGKAVD
    ..  . ....||. |. ..|.|.. |||.|||||...          ....|..||| .|      .  ||||| ||||||||.|  . .| . .|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRS--KPPYTDYVSTRWYRAPECLLRCTYYNSPMD

VWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQEL--FNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELL
.||.||   |  |  ||||| | |||.. |   .|  .| ....  . |     . ..|  |   ||.   | .|   |.| .|.| .||.||.  ...|
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG--TPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQAL

HHDFF
 | .|
QHPYF
Kinase CDKL2.AA MAPK 4-220 35 2.7e-69 236.53 In-house 1-253 (328) Show / Hide 
Range on Protein: 4-220
Range on HMM: 1-253/328
Sequence Identity: 35% (89 aa)

YENLGLVGEGSYGMVMKCRNKD------TGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL-RHENLVNLLEVCKKK-----------KRWYLVFEFVDH
|..|  .|.|.||.| ... |       .|..|||||.    ....  | . ||||||. . .||| ..||.. . .           .  |.|.|. ..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TILDDLELFPNGLDYQVVQKYLFQIING--IGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAA-PGEVY-------------TDYVATRWYRA
  |  .   .. |. . .|  ..||..|  . . || |.||||.||.|||| . . .|.|||| ||...    . .             |.|||||||||
D-LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--VKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGN
||.. .    .| ||||.|..||   ||   . |||||.. |||. .||  ||.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGT
Kinase CDKL2.AA CDK-Unclassified 4-220 29 3.7e-69 226.61 In-house 1-257 (324) Show / Hide 
Range on Protein: 4-220
Range on HMM: 1-257/324
Sequence Identity: 29% (76 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDK----------MVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWY-------------LVF
|. .  .||| .|.| | .  .| ..|||||   .                | .. |||..|... |.|.  ....  .  |               .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSG-----VVKLCDFGFARTLA------------APGEVYTDYVA
| .. |    |.   . |  . ..... |.. || . |.  |.||||||.||...  .     ..|. ||| |.  .             |.  |.  |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN
|||||||||| |. .|. .||.|..|| . |.| | |.|.| ..|.|. ||   ||.
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGT
Kinase CDKL2.AA ERK7 4-287 35 1.7e-68 233.31 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-292/292
Sequence Identity: 35% (105 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLLEVCKKK--KRWYLVFEFVDHTILDDLELFPNGLDY
|| .  .| | ||.| |   | |. .||.||      ..       ||| .|.... |.|.. |..| . .  .  |||||| . | |       | |  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

QVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGE------VYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTE
  .|  ..|... | . || |.||||.|| |||.    .||.|||| ||..|   |      . |.||||||||||| |.|  .| |.|| | ||| . |
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEI--KEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF
|  | |.||| | ..|.  |.  ...  | ....   .. .| . | ..  ..|..|.  .|. ..  ||| |. |   |.||    . |.| . 
MLRGKPMFPGTSTMNQIEKILETIPK--PTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL2.AA TyrKc 4-287 23 2.1e-22 81.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL--RHENLVNLLEVCKKK-------KRWYLVFEFVDHTILDDLELF
 . .   ||| .| |.|.. |   . ||.|.  |.      ..  |||......|  .|.|.|.|. || ..       .  ..|.|...|  |.|    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

PNG-LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAP------GEVYT------DY--VATRWYRAPELLVGDVKY
. . |  .   .. .|| .|  . ||.|.||||.   |.||.  ..|| .||| .| .         ...|.          .  ||. ||| .  . |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GKAVDVWAIGCLVTEMF-MGEPLFPG-----DSDIDQLYHIMMCLGNLIPRH----QELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLH
  . |||. | .  |.|  |..  ||      |... . ...      .| .                               ..  .. . .. |.| |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCWH

IDPDKRPFCAELLHHDFF
 ||..||  .|.  |..|
EDPEDRPTFSEI--HECF
Kinase CDKL2.AA Pkinase_Tyr 4-85 29 1.8e-15 52.99 Pfam 1-91 (270) Show / Hide 
Range on Protein: 4-85
Range on HMM: 1-91/270
Sequence Identity: 29% (27 aa)

YENLGLVGEGSYGMVMKCRNK----DTGRIVAIKKFLESDDDKM--VKKIAMREIKLLKQL-RHENLVNLLEVCK-KKKR--WYLVFEFVDH
 . .   |||..|.|.|.. |    .|.  ||.|.  |. ...    ..    |.|..||| .|.|.|.|. ||  ...   .|.|.|.. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH
Kinase CDKL2.AA Pkinase_Tyr 118-196 35 1.1e-09 33.37 Pfam 128-208 (270) Show / Hide 
Range on Protein: 118-196
Range on HMM: 128-208/270
Sequence Identity: 35% (30 aa)

HSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVAT------RWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF
.|.|.||||.   |.||. ..||| |||| ||..  . . |  ....      .|. ||| .   . .  . |||. | |  |.|
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIF
Kinase CDKL2.AA MAPK 244-287 35 3e-06 17.63 In-house 281-328 (328) Show / Hide 
Range on Protein: 244-287
Range on HMM: 281-328/328
Sequence Identity: 35% (17 aa)

KEREPLERRYPK----LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF
. . |.|  .|.     .   ||| .| |..|||||   .| | | .|
YPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL2.AA CDK7 246-287 28 1.1e-05 10.62 In-house 247-288 (288) Show / Hide 
Range on Protein: 246-287
Range on HMM: 247-288/288
Sequence Identity: 28% (12 aa)

REPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF
| ||. ..   |.  .|| .. .  .| ||  |.. | ...|
RTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL2.AA CDK-Unclassified 256-287 21 0.000466 9.09 In-house 293-324 (324) Show / Hide 
Range on Protein: 256-287
Range on HMM: 293-324/324
Sequence Identity: 21% (7 aa)

LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF
.... ...    .. .|..|. | |.|.|  |
KHASENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDKL2.AA CDC2 261-287 44 0.001349 6.34 In-house 275-301 (301) Show / Hide 
Range on Protein: 261-287
Range on HMM: 275-301/301
Sequence Identity: 44% (12 aa)

IDLAKKCLHIDPDKRPFCAELLHHDFF
||| .. |..|| || .  | | | .|
IDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDKL2.AA Pkinase_Tyr 262-286 44 4.15111 0.99 Pfam 247-270 (270) Show / Hide 
Range on Protein: 262-286
Range on HMM: 247-270/270
Sequence Identity: 44% (11 aa)

DLAKKCLHIDPDKRPFCAELLHHDF
|| |.| | ||..||  .|. |...
DLMKQCWHYDPEDRPTFSEI-HEQL