Gene CDKL5 (Human)

CDKL5

Species: Human
Alias: CDKL5, STK9, ISSX
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: Xp22,

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL5.AA Protein Sugen Kinome 1030 None Fasta, JSON
CDKL5.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON
CDKL5.NA RNA Sugen Kinome 3434 None Fasta, JSON

Protein domain

Protein domains of CDKL5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL5.AA CDKL 13-297 55 2.1e-204 685.35 In-house 1-286 (286) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-286/286
Sequence Identity: 55% (158 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKV
.|.||.||||.||||.|||.| |..||||||||.||....|| ...||.|||..||.||||.|.|.|||..||.|||||.....|..|||.||||....|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS-HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APYGKSVDMWSVGCILGELSDGQPL
..|..|..|||..|||....||||||||.||. .|...||||||||| . ......||.||||||||.||||.| . |||.||.|..||...|..|||||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF
.||.|.||||..|||.|||| ......|..||.|||..||...|...||.||....|...||.||..|..||..|. .||...||.|
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL5.AA CMGC 13-297 25 2.6e-130 430.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-513/513
Sequence Identity: 25% (129 aa)

FEILGVVGEGAYGVVLKCRH--------------KATHEIVAIKKFKDSEENEEVKE----------TTLRELKMLRTLK----------------QEN-
.||....|||.|||| |||.              . | |||||||.|  . .|| .           ..|||.|.|. |.                ..| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVELKEAFRRRG-----------------KLYLVFEYVEKNMLELLEEMPN--------GVPPEK------------VKSYI------YQLIKAIH--WC
|| |.. |....                 .|||||||.... .........        . .. .            .|...      ||......   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKND--IVHRDIKPENLLISHN--------------------DVLKLCDFGFARNLSEG--------------------NNANYTEYVATRWYRSPELLL
|...  |.|||.||||.||.||                    ..||.||||.|| ...                     .|  ||.||.|||||.||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GAP----------YGKSVDMWSVGCILGELSDG--------QPLFPGESE-----------IDQLFTIQKVLGPLP---------------SE-------
|..          |....||||||||..|.  |        .|||||.||           ||||| | ||||. .               .|       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------QMKLFYSNPRFHGLRFPAVN--HPQSLERRYLG-------------------------------ILNSVLLDLMKNLLKLDP
                  ... |. |... ..||| ..  . ..|. ..                                  ... ..||.|..|..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

ADRYLTEQCLNHPTF
..|   ||.|.|| |
DKRITAEQALQHPYF
Kinase CDKL5.AA CDK 13-297 35 5.5e-109 349.85 In-house 1-284 (284) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-284/284
Sequence Identity: 35% (115 aa)

FEILGVVGEGAYGVVLKCRHKATH-----EIVAIKKFK-DSE----ENEEVKETTLRELKMLRTLKQENIVELKEAFRRR-----------GKLYLVFEY
.|.|  .|||.|||| |.|.| |.     .|||.||.. ..|    | | .  |..|| ..|. |  .||| |.. .               |||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDV-----LKLCDFGFARNLSE-----GNNANYTEYVATRWYRSPE
..    ....          .|.|..||....| ||.| |.|||.|| |.||..| .     ||. |||.||  .      ..|  ||  | |.|||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGAP-YG--KSVDMWSVGCILGELSD---GQPLFPGESEIDQLFTIQKVLGPLPSEQM-KLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLM
||||.  |.   ..||||||||..|.     ..|||||.||||||| | ...|  |.|..   . . | .                           ||.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG-TPTEDNWPGVTKLPDY---------------------------DLL

KNLLKLDPADRYLTEQCLNHPTF
 ..| .||. |   ||.|.|| |
NKMLCYDPKKRISAEQALQHPYF
Kinase CDKL5.AA Pkinase 13-297 32 5.4e-98 336.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKETTLR--ELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEK-----NMLELLE-EMP
..|....|.|..|.| ||.|| | .|||.|..| ..|......| .|  |..... |. .|||.|...|......|.|.||.|.        .... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NGV--PPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVL----KLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPYGKSVDMWSV
...  ... .|.|.||.....  ||.. |.|||.||||.||..|...    |.||||.|. ... ||  .| .. |.||..||... | .||..|||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILGELSDGQPLFPGE----SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLN
|||| |.  |.|.|||.    . .||.. |....|| ....    .|...|. .|.         ...    ... ..|..|..|..||..|.  ||.|.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPTF
|| |
HPWF
Kinase CDKL5.AA S_TKc 13-297 30 4.2e-96 326.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEK---NMLELLEEMPNG---
.||| ..|.||.|.| ||||| |..|||||. |         |...||...|.  . .||| |...|.  ..||.|.||..    .......... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGK-SVDMWSVGCILGE
   |.  ...|.||...|.  ||.. |.|||.||||.|...  ..|.||||.|| |        | .. |.||..||.|   .||| ..|.||.|||| |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLN-------HPT
.  |.|.||      |.... |..|                                       . ..|.....|. ||..|.   ..|.       || 
MLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase CDKL5.AA CDC2 13-228 42 2.1e-95 293.66 In-house 1-226 (301) Show / Hide 
Range on Protein: 13-228
Range on HMM: 1-226/301
Sequence Identity: 42% (98 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEE--VKETTLRELKMLRTLK-QENIVELKEAFRRRGKLYLVFEYVEKNMLELLE-EMP--NG
.. .  .||| |||| ||... |..|||.||..   |.|.  | .|..||.  |  ||  .||| |.. .    |||.||||.. .  .... . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYT--EYVATRWYRSPELLLGAP-YGKSVDMWSVGCILGE
.||..||||.||.....| || . |.|||.|| |.||. . ..|. ||| ||. .  .  .||    | |.|||.||.|||.  |  .|||||.|||. |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGI-PIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---SDGQPLFPGESEIDQLFTIQKVLG
.       |||.|.||||||| | ..||
MFMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL5.AA RCK 13-297 35 5.5e-92 292.14 In-house 1-298 (298) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-298/298
Sequence Identity: 35% (109 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKE-TTLRELKMLRTLK-QENIVELKEAFRRRG--KLYLVFEYVEKNMLELLEE---MPN
  |.  .|.|.||.|.| . | | ||||||| |   . .  .| . |||.| || |.  .||..||| .| .    ||.||||...|  .....      
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRK

GVPPEK--VKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISH---------NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVD
 .| ..  .|...||...... .||. . |||.||||....          .|..|..||| .|     .. .||.|| |||||.||.|| .  | . .|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIR--SKPPYTDYVSTRWYRAPECLLRCTYYNSPMD

MWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLN
.|.||||  ||   .||||| |||||.| | ||.|    .    .|   .  ...|| .  ...|.  ..  ... ...||. .|. ||  |   .|.|.
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLK-QLIPNCSQDCIELMEKMLQWDPQKRITAQQALQ

HPTF
|| |
HPYF
Kinase CDKL5.AA CDK5 13-297 37 1.4e-84 267.12 In-house 1-287 (287) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-287/287
Sequence Identity: 37% (107 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKV
.| .  .||| ||.| | | | ||||||.|. .  .| | |  | .||  .|. || .||| |        || ||||.. . .   ....  .. .. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVDMWSVGCILGELS-DGQPL
||..||| | .  ||.. . ||| || ||||. |  ||| ||| ||      . .|.  | | ||| |  |.|.  |  |.||||.|||. |..  |.||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVR-CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPL

FPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFH--GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF
||| .. |||. | |..|    ..       | .      .|  .  ||..    . |.. ..||....|...|. |   .. |.|| |
FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL5.AA CDK7 13-228 40 9e-84 222.89 In-house 1-220 (288) Show / Hide 
Range on Protein: 13-228
Range on HMM: 1-220/288
Sequence Identity: 40% (89 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFK----DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVP
.|..  .||| ...| | . ..| .|||||| |     ||    .  | .|| |.|. .. .|...|  .|  .  ..|||.. .  . .  .       
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVDMWSVGCILGELSDG
|  .|.|  .. . . .||.| | |||.|| |||.. | .||. ||| ||      | .||  | |||||.|||| ||  || .|||||||||. ||   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYG-SPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

QPLFPGESEIDQLFTIQKVLG
 | .||.|.||||  | . ||
VPYLPGDSDIDQLTRIFQTLG
Kinase CDKL5.AA MAPK 13-297 31 1.6e-80 273.79 In-house 1-328 (328) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-328/328
Sequence Identity: 31% (102 aa)

FEILGVVGEGAYGVVLKCRHKA------THEIVAIKKFKDSEENEEVKETTLRELKMLRTL-KQENIVELKEAFRR------RG-----KLYLVFEYVEK
..||  .|.|||||| ....|       . ..|||||. .  .|.     |.||.|.|| . . |||. |.. |.       .       .|.|.|. | 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NMLELLEEMPNGVPPEKVKSYIYQLIKA--IHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANY-------------TEYVATRWYRS
..  ... ..     . ... .||....  .   |  ...|||.||.|.|.  |. ||.|||| || .    . ..             ||||||||||.
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLLG---APYGKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSEQM-KLF-YSNPRFHGLRF--PAVNHPQSLERRYLG---ILNS
||..|.     | |.|||||||||..|.   ..|||||.. |||.. | .|||  . | . ..  ....|    ..  .    ....|  . .   . |.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

VLLDLMKNLLKLDPADRYLTEQCLNHPTF
  .||.. .| .|| .|.  |..|.|| |
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL5.AA ERK7 13-297 35 5.1e-72 245.54 In-house 1-292 (292) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-292/292
Sequence Identity: 35% (104 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK-QENIVELKEAFRRRGK--LYLVFEYVEKNMLELLE--EMPNGV
.||.  .| ||||.| |   | |...||.||  |   |.     | ||  .|. ..  .||. | . .|      .|||||. |  .       ..   .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

PPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGN-----NANYTEYVATRWYRSPELLLGA-PYGKSVDMWSVGCIL
    ... .|||..|| . |  ...|||.|| |.|.  . ..|.|||| || ... .     |   ||||||||||.|| |||.  | | |||||.||||
---HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

GELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF
||.  |.|.||| | ..|.  | ....    | ..   |. .   |    ......|.  .        .||.|.|| . |  |   ||.|.||  
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL5.AA PITSLRE 13-297 38 1.4e-71 244.12 In-house 1-295 (295) Show / Hide 
Range on Protein: 13-297
Range on HMM: 1-295/295
Sequence Identity: 38% (116 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDS--EENEEVKETTLRELK-MLRTLKQENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMP---
|..| ...||.|||| . . | | ||||.|..|     | |    | ||| .  |. |. .||| .||        | |.|.||||  .  |.| |    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

NGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNN-ANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILG
    |  .|. . || ..... |.| | ||| |  |||.||. .||.|||| ||    | .   ||  | | |||.||||||.. |   |||||||||..
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREY--GSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFA

ELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFHGLR-FPAVNHPQSLERRYL--GILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF
|.  ..|||.|.|||||.  | | .|  |.|.    ..  | .  .  || .  .  | .|      .. . .||.  .| ..|. |   .. | || |
EFITMKPLFQGKSEIDQINCIFKEMG-TPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDKL5.AA Pkinase_Tyr 13-174 27 1.3e-17 60.33 Pfam 1-171 (270) Show / Hide 
Range on Protein: 13-174
Range on HMM: 1-171/270
Sequence Identity: 27% (48 aa)

FEILGVVGEGAYGVVLKCRHK----ATHEIVAIKKFKDSEENEE-VKETTLRELKMLRTL-KQENIVELKEAFR-RRGK--LYLVFEYVEK-NMLELLEE
 ... . ||||.|.| |.. |     |.  ||.|. |..   |.  .|  .||.|....| . .||| |  .   ...   .|.|.||... ..|. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

M---PNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVAT
    .. ....   .. .|  |.  . . . ..|||.   | |...| | | |||| || .    |  |  |...
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYY-YRKR
Kinase CDKL5.AA TyrKc 13-302 20 1.5e-14 12.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-302
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEENEEVKETTLRELKMLRTL--KQENIVELKEAFRRR-------GKLYLVFEYVEK-NMLELLEE
 . . . ||||.|.| |.. |   . ||.|. |..      .|  .||..... |  . .||| |  . .         . |..|.||... . .. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEG-----NNANYT------EY--VATRWYRSPELLLGAPYG
  . .....  |. .|  .     |.. ..|||.   | |...| . | .||| .|.. ..     .   |.      .   .  ||. .|| .    . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

KSVDMWSVGCILGEL-SDGQPLFPGESE--IDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRY
   | || |  . |. ..||.  ||. .  ..    |..|      .|..  |  |                   .  .  . . ..||   . ||.|| 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS----------------F-VCCPDEMYQIMKQCWHEDPEDRP

LTEQCLNHPTFQTQRL
  ...        ...
TFSEI-------HECF
Kinase CDKL5.AA CDK7 270-297 42 9e-09 19.03 In-house 261-288 (288) Show / Hide 
Range on Protein: 270-297
Range on HMM: 261-288/288
Sequence Identity: 42% (12 aa)

LLDLMKNLLKLDPADRYLTEQCLNHPTF
|||||. .. ..|  |    |||..| |
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL5.AA CDC2 271-297 37 4e-06 14.1 In-house 275-301 (301) Show / Hide 
Range on Protein: 271-297
Range on HMM: 275-301/301
Sequence Identity: 37% (10 aa)

LDLMKNLLKLDPADRYLTEQCLNHPTF
.|| ...| .||..|   .. |.|| |
IDLLMQMLQYDPQKRISAKEALQHPYF