Gene EGFR (Human)

EGFR

Species: Human
Alias: ERBB, ERBB1, EGFR, mENA, EGFRvIII
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7p11.1-p11.2 ,

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
EGFR.NA RNA Sugen Kinome 5616 None Fasta, JSON
EGFR.AA Protein Sugen Kinome 1210 None Fasta, JSON
EGFR.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of EGFR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain EGFR.AA Recep_L_domain 57-168 37 1.4e-44 151.59 Pfam 1-121 (121) Show / Hide 
Range on Protein: 57-168
Range on HMM: 1-121/121
Sequence Identity: 37% (47 aa)

NCEVVLGNLEITYVQRN----YDLSFLKTIQEVAGYVLIALN--TVERIPLENLQIIRGNMYYEN-SYALAVLSNYDANKTGLKELPMRNLQEILH--GA
||.|. ||||||..  .    .||||...|.|. ||.||. .   .  ....||.||||.  ... .|||....|..    ||.|| |.|| .|..  | 
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM---GLQELWMWNLKNITRKNGG

VRFSNNP--ALCNVES-IQWRDIV
|...|||   ||.... |.|..|.
VYIHNNPHPKLCYTHTEIMWWMIY
Furin-like EGFR.AA Furin-like 184-338 43 5e-82 269.58 Pfam 1-182 (182) Show / Hide 
Range on Protein: 184-338
Range on HMM: 1-182/182
Sequence Identity: 43% (79 aa)

LGSCQ--------KCDPSC------PNGS-CWGAGEENCQKLTKIICAQQCSG-RCRGKSPSDCCHNQCAAGCTGPR-ESDCLVCRKFRDEATCKDTCPP
 ..|.        .|.|.|       .|. |||.....||.||| .|..||.. ||.| .|..||| ||..|||||. ..||..||.|... ||.|.|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

LMLYNPTTYQMDVNPEGKYSF-GATCV--KKCP-------RNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCN
.|.|||||.||..||.|.|.| |..||  |.||        ||.|...|.|.| |  . .| ||.....|..||||| |||.
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU EGFR.AA FU 228-270 33 2.2e-07 31.78 SMART 1-48 (48) Show / Hide 
Range on Protein: 228-270
Range on HMM: 1-48/48
Sequence Identity: 33% (16 aa)

PSDC--CHNQCAAGCTGPRESDCLVCRKFRDE---ATCKDTCPPLMLY
 . |  || .|| ||.||.. .|. |.....     || ..|||   .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain EGFR.AA Recep_L_domain 361-481 31 1.1e-43 148.58 Pfam 1-121 (121) Show / Hide 
Range on Protein: 361-481
Range on HMM: 1-121/121
Sequence Identity: 31% (41 aa)

NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHG-QFSLAVVSLN---ITSLGLRSLKEI
||| | |.|.|... . ..        ....|  .....||||.|||. .  | ..|. |.||.|||||...|. ...|....     ...|....||.|
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

SD--GDVIISGNK--NLCYANT-INWKKLF
..  |.|.|. |.  .||| .| |.|....
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU EGFR.AA FU 496-547 30 2.7e-09 38.14 SMART 1-48 (48) Show / Hide 
Range on Protein: 496-547
Range on HMM: 1-48/48
Sequence Identity: 30% (17 aa)

ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRG---RECVDKCNLLEGEPR
.. |    . ||. |.  ||||| | .|.||..   .   ..||..|.  .|. .
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like EGFR.AA Furin-like 514-539 48 8e-06 19.69 Pfam 72-98 (182) Show / Hide 
Range on Protein: 514-539
Range on HMM: 72-98/182
Sequence Identity: 48% (13 aa)

GCWGPE-PRDCVSCRNVSRGRECVDKC
|| ||  ..|||.||...    |||.|
GCTGPNNDTDCVACRHFYHNGTCVDQC
FU EGFR.AA FU 552-601 37 2.5e-12 48.21 SMART 1-48 (48) Show / Hide 
Range on Protein: 552-601
Range on HMM: 1-48/48
Sequence Identity: 37% (20 aa)

NSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPH---CVKTCPAGVMG
...|  |||||.      .|.| |||.|. |.|. ...|   ||..||.|  .
DGVCKPCHPECAT-----GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Kinase EGFR.AA EGFR 712-969 80 8e-203 679.51 In-house 1-258 (258) Show / Hide 
Range on Protein: 712-969
Range on HMM: 1-258/258
Sequence Identity: 80% (208 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGS
.||.||||||||||||||.||||||.||||||||.|||.|.||||.|.|||||||||||.||..||||.|..|..||.||.||.||||||||.|||||||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFG
|.||||||||||||.|||..|.|||||||||||||.|.||||||||||||| ..||||||.|||.||||||||.|.||.|||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

SKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFS
.||||||||.||...|||||||||||||||||||.||||||||.|.||.|.||. ||.
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase EGFR.AA TyrKc 712-968 36 3.2e-131 443.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-280/280
Sequence Identity: 36% (106 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV--DNPHVCRLLGICLT--------STVQLITQLMPFGCLLDY
 ...|.||.||||.|||| |.       |.||.| |.| .     .....|| .| ..  ..|.. ||.|.|..          . ... .|| |.|.||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAE------EKEYHAE---GGK--VPIKWMALESILHRI
 |.|....  . ||..|.|||.||.||......||||||||.||. ...|||.||||.. .. .      .. |..    |||  .||.|||.|.| ...
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTHQSDVWSYGVTVWELMTFGSKPYDG-----IPASEISSILEKGERLPQPPI--------CTIDVYMIMVKCWMIDADSRPKFRELIIEF
.|..|||||.||. ||..|.| .|| |     ....|.   ...|.|.||||         |. ..|.|| .||. |...|| |.|.. .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EGFR.AA Pkinase_Tyr 712-968 40 3.7e-129 438.04 Pfam 1-270 (270) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-270/270
Sequence Identity: 40% (110 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA--NKEILDEAYVMASV-DNPHVCRLLGICL--TST--VQLITQLMPFGCLLDYVRE
 ...|.||.||||.|||| | ..... |||||.| |.| .....   .. . || .| .  ..|.. ||.|.|.       . ... .|| |.|||| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE-YHAEGGKVPIKWMALESILHRIYTHQSDVWSY
|   |...  . ||..|.||||||.|||.....||||||||.||. . .|||.|||||...  ..   . ..|||.||||||.|.| ....|..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTVWELMTFGSKP-YDGIPASEISSIL-EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEF
||. ||..|.| .| | |.. .|.   . |.|.|.|.|. |. ..|..| .||. |.. || |.|.. ..
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EGFR.AA TK 712-968 21 6.1e-104 349.42 In-house 1-486 (486) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-486/486
Sequence Identity: 21% (106 aa)

FKKIKVLGSGAFG---TVYKGLWIPE---------------------GEKVKIPVAIKELRE--ATSPKANKE--------------ILDEAYVMAS--V
 . .|.||.|.||   .||||.|...                     .|..|.|||.| |.|  |.|... ..               . |. .| .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNPHVCRLLGICLTST-------------VQLITQLMPFGC----LLDYVREHKDN--------------------------------------------
. |.. ||.|.|. .              . ... .|| |.    |.|| |.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IGSQYLLNWCVQIAKGMNYLEDR------RLVHRDLAARNVLVKTPQH-----------VKITDFG---
                               .  . || .|.|||.|| ||...      ..|||||||||.||    .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGAEEKEYHAE------------------------GGKVPIKWMALESILHRI---------YTHQSDVWSYGVTVWELMTFG-SKPYDGI
     ||. .. ..  | ..                        |||.||.||| |....|.         .|..|||||.||..||..|.|   .| |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA---------SEISSILEKG--------------ERLPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELIIEF
.           |.   |..|               |.|||| |.               ..| .| .||  |.. || |..|  ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EGFR.AA Syk 718-962 39 8.1e-88 298.06 In-house 7-257 (257) Show / Hide 
Range on Protein: 718-962
Range on HMM: 7-257/257
Sequence Identity: 39% (99 aa)

LGSGAFGTVYKGLWIPE---GEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQY
.|.| ||.| ||        |||. |.|||| |. ... |   .|.. || ||.  |.|.. |..|||.     ..  . . | ...|  .|.. |  . 
IGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRHEITANN

LLNWCV-QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFG
 |     |.| || ||| .  |||||||||||  .    || |||. | ||| ...| |. .|| |.|| | |.|  ..  |.|||||.||| ||    |
VLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYG

SKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR
 ||| ..  .|.   .|.|.|...|. |  ..| .| |||  ..  || | 
QKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EGFR.AA Ack 712-968 38 2.2e-85 287.97 In-house 1-266 (266) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-266/266
Sequence Identity: 38% (103 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA--TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTV-QLITQLMPFGCLLDYVREHKD-
 .  . ||.| || | .|.|        |.||.| ||    ..|..  . | |. .| | | ||. || |. |..   ...| | | | |||  |.|.  
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-NIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHAEGGK---VPIKWMALESILHRIYTHQSDVWSYGV
       |...|.|||.|| ||| .|..||||||||.|. .. . ||| ||||   || .|  |  |. .   ||. |.| |.. ||  .| ||||..||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TVWELMTFGSKPYDGIPASEISSILE-KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEF
| ||  ..| .|. | ....|   .. .|||||.|. |  |.| .|..||  ..  ||.| ..   .
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase EGFR.AA UTK 712-968 31 1.6e-81 277.11 In-house 1-296 (296) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-296/296
Sequence Identity: 31% (92 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKI-PVAIKELR-EATSPKANK---EILDEAY---VMASVD-NPHVCRLLGICLTST-VQLITQLMPFGCLLDY
 .  . ||.||||.|.|. . .. | ..   ||.|... .|.....     ... ||    .|. ..  |.| ||.|.|. .    ..| .|. | |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VREHKDNIG-------SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-------QHVKITDFG---LAKLLGA--------EEKEYHAEG-GK
.| |... .       .  .| ....|| ||.||. ...|||||||||.||          . .|| |||   .......        |  .| | . ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPIKWMALESILHR-IYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG--ERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEF
.||.||| |.. |.  .|..|||||.||..||..|.|..|| |. . ..   ...|   |.|.|. |  .||..|..||. | . || |..|  ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EGFR.AA Src 712-968 35 8e-80 270.87 In-house 1-255 (255) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-255/255
Sequence Identity: 35% (94 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTS-TVQLITQLMPFGCLLDYVR--EHKDN
.| .. ||.| || |..|.|     . ...||.| |...|   ...  | || .| ... ... .|. .| .   .  .| .|  |.|||| .  .   .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY-HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
.  . |.    |.|.||.||| ....||||||||||| .   .|. |||||.|.  .. ||   .| |.||||.| | |... .|  |||||.|.  .|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM-IMVKCWMIDADSRPKFRELIIEF
.|.|  || |    |    .|.| |.|.|. |   .|. || .||  |.. || |  |   .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EGFR.AA TK-Unique 712-968 31 1.4e-79 270.71 In-house 1-294 (294) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-294/294
Sequence Identity: 31% (93 aa)

FKKIKVLGSGAFGTVYKGLWIP--EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD-NPHVCRLLGICLTST--VQLITQLMPFGCLLDYVREHK
..  .|.|.||||.|..|   .  ...  .. ||.| |..  ..   .. |.|. .| ...  |.. ..||.| .|.  ...|   .| |.|..| |. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DN-------------------------IGSQYLLNWCVQIAKGMNYLED--RRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG--GKVP
..                         | .. |.....|||.||.||.   .. |||||.|||||.     .||.|||.|. . . ...|  ..  |..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWMALESIL--HRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC-TIDVYMIMVKCWMIDADSRPKFRELIIEF
|.|||.||..  |..| | .|||||.||. ||..|.|. || |.|...|   ...| |.|||. | . ..| .|  ||  ....|| ||... ..
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EGFR.AA FAK 713-973 34 7.5e-77 257.02 In-house 2-285 (285) Show / Hide 
Range on Protein: 713-973
Range on HMM: 2-285/285
Sequence Identity: 34% (99 aa)

KKIKVLGSGAFGTVYKGLWI-PEG----------------------EKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLI
.  ...| | || ||.| .. ...                         || ||||  .. ...    . . |||.|   | ||. .|.|||    . .|
TLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWII

TQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILH
  |...| |  | . .|.      |. .| |... | ||| .. |||| |||||||  |. ||  ||||  ..   .  |.|   || |||||. |||  
MELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESINF

RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMAR
| .|  |||| .|| .|| . .| ||. ..  ...   .|.||||| || |    | .| .||  |   ||.|.||  . ...  
RRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EGFR.AA Abl 712-968 40 1.6e-69 231.0 In-house 1-252 (252) Show / Hide 
Range on Protein: 712-968
Range on HMM: 1-252/252
Sequence Identity: 40% (104 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC-LTSTVQLITQLMPFGCLLDYVRE-HKDNI
    . || | .| ||.|.|     . .  ||.| |.| |   . .| | || .|  .  | . .|||.|   .   .||  |..| ||||.||  ....
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDT--MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMT
 .  ||    ||| ||.||| |  .|||||||| ||   . ||. |||||...  .    || | | |||| | ||. .  .  .|||| .|| .||. |
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA-GAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

FGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEF
.|  || ||  |..   |||| |. .|. |  .|| .| .||  ..  ||.|.|.  ..
YGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase EGFR.AA RTKB 716-968 37 6.8e-68 227.97 In-house 5-264 (264) Show / Hide 
Range on Protein: 716-968
Range on HMM: 5-264/264
Sequence Identity: 37% (97 aa)

KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN-PHVCRLLGICLTSTVQLI-TQLMPFGCLLDYVREHKDN-IGSQ
. ||.|||| |....    .   .  .| | |. . |  .  ....|  ||  .   |.|  ..| ||  . ...   |  .| | || |.      ..|
EKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQHNPQ

-----YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS-DVWSYGVTVWE
      |.  | |||.|| .|. .  .||||.|||||| .  | || |||.|  .  .. .|     . |||||| ||. ||||| .| ||||.||| ||
SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWE

LMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEF
  ..|. ||   .  .| . ||.| |||.|      .. || .||...|. || | ||. .|
IFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase EGFR.AA S_TKc 712-969 20 2.8e-45 157.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 712-969
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPF--GCLLDYVREHKDN-
.......|.||||.|||. ..      .  ||||...        . |. |  .. . . |....|.... .. . ... ...   | |.|| .... . 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTH-QSDVWSYGVT
    .       .. ||.....|. ... .||||   |.|. .  |.||.|||||..|             .   .|| | .    |..  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELII--------EFS
..|... |  |..     ..  ...|          . ..  .. ||.  | . ||   |.          .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EGFR.AA Pkinase 712-909 24 4.8e-35 124.99 Pfam 1-207 (293) Show / Hide 
Range on Protein: 712-909
Range on HMM: 1-207/293
Sequence Identity: 24% (52 aa)

FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILD----EAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFG----CLLDYV
.......|||.||.|||. .. .|.     ||.|...   . | .|.. .    |...|.... |...||....   . . ... ... |     | ||.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-EHKDNI--GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV----KITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQ
. . . ..    . . ... ||..|..|. ... .||||   |.|..   |.    ||.||||||..  . .   . .  . . .|| | |. .. |.. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTVWELMT
.|.||.|....|...
VDMWSCGCILYEMLC