Gene EphB1 (Human)

EphB1

Species: Human
Alias: ELK, EphB1, Hek6, HEK6, FLJ37986, EPHB1, EPHT2, NET
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3q22.2,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB1.NA RNA Sugen Kinome 4536 None Fasta, JSON
EphB1.AA Protein Sugen Kinome 984 None Fasta, JSON
EphB1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of EphB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB1.AA Ephrin_lbd 19-196 64 6.6e-142 442.39 Pfam 1-190 (190) Show / Hide 
Range on Protein: 19-196
Range on HMM: 1-190/190
Sequence Identity: 64% (122 aa)

EETLMDTRTATAELGWTANPASG---------WEEVSGYDENLNTIRTYQVC-NVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKE
|..||||.|||..||||. |..|         ||||||.||| ..||||||| ||.|||||||| |..|.||||.||| |..||.|||.|.|.|.|.|||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYYETDS-VIATKKSAFWSEAPYLKVDTIAADES-FSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKC
||||||||.|.   |.|....| | .| |.|||||||| |.|.|||.| ||.||||||.|||.. ||||||||.||||.|.||||..|||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphB1.AA EPH_lbd 19-196 69 7.50000000001e-132 445.25 SMART 1-184 (184) Show / Hide 
Range on Protein: 19-196
Range on HMM: 1-184/184
Sequence Identity: 69% (127 aa)

EETLMDTRTATAELGWTANPASG--WEEVSGYDENLNTIRTYQVCNVFE---PNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPG-SCKETFNL
|..||||.|.|.|||||..| .|  ||||||.||. |.|||||||||.|   |||||||.|..|.||||.||| |..||.|||.|.|.|.| ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKC
||||.|. .||....|| | ||.|.|||||||||.|.|||.| ||.||||||||||...||||||||.||||.|.|||||.|||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
NCD3G EphB1.AA NCD3G 267-293 25 0.000965 13.08 Pfam 28-54 (54) Show / Hide 
Range on Protein: 267-293
Range on HMM: 28-54/54
Sequence Identity: 25% (7 aa)

CKACPAGTFKASQEAEGCSHCPSNSRS
|  ||.|..  .  .  | .||   ..
CIPCPEGEYSNTTDSYTCTPCPEDQWP
FN3 EphB1.AA FN3 323-416 17 1.4e-07 32.46 SMART 1-69 (69) Show / Hide 
Range on Protein: 323-416
Range on HMM: 1-69/69
Sequence Identity: 17% (19 aa)

PSGPRN----VISIVNET------SIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAH----TPYTFDIQA
|. |.|    ... |..|      |. |.| ||        |.|                                  . .. | ..    | |.| ..|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

ING-VSSKS
.||     .
VNGNDAGEG
FN3 EphB1.AA FN3 434-515 21 1.2e-11 45.95 SMART 1-69 (69) Show / Hide 
Range on Protein: 434-515
Range on HMM: 1-69/69
Sequence Identity: 21% (21 aa)

PSTVPI---MHQVSATMR------SITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPG----MVYVVQVRARTV--AGYG
|. .|     . .. | .      |.||||  |          ...|                   ....||.||      |...|||..   ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB1.AA Eph 619-878 85 6.8e-225 753.42 In-house 1-264 (264) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-264/264
Sequence Identity: 85% (226 aa)

VKIEEVIGAGEFGEVYKGRLKLP-GKREI---YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDG
.|||.||||||||||..|||||| ||||.   .||||||||||.||||.||||||||||||||||||||||||||||||||.||.||||.|||||||.||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTS-DPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIV
|||||||||||||||.|||||..|||||||||||||||||||||||||||||| |.||.| ..|||.. |||||.|||||||||||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL
||||||.||||||||||||||.||||.||||||||||.|||||||||||||||.||.|..||..|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB1.AA Pkinase_Tyr 619-878 45 2.3e-156 530.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-270/270
Sequence Identity: 45% (123 aa)

VKIEEVIGAGEFGEVYKGRLK-LPGKREIYVAIKTLKAGYSEKQ--RRDFLSEASIMGQF-DHPNIIRLEGVVT-KSRP--VMIITEFMENGALDSFLRQ
... ...|.|.|||||||..| .|.. .| ||.|.|| |....|  |.||..||.|| |. .||||.|| ||.| ...|  ..|..|.|..| |...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTY-TSSLGGKIPVRWTAPEAIAYRKFTSASDV
.   ....|. .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.|..   ..| .| ... |||.|..|.|||.|.|.|||..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGIVMWEVMSFGERP-YWDMSNQDVINAI-EQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL
||.|..|||....|| | |..|||..|...| |. ||.|.|..||. ...||..||..| . ||.|.||.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB1.AA TyrKc 619-878 41 1.9e-143 483.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-280/280
Sequence Identity: 41% (121 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQF--DHPNIIRLEGVVTKS-------RPVMIITEFMENGALDSFL
.. ....| |.|||||||..|      | ||.|.||..     |.||..||.|| ..  .||||.|| ||.|..        |.||..|.|..|.|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDD----TSDPTYTSSL--GGK--IPVRWTAPEAIAYRKF
| . ..... .|. .   ||.|| ||...|..||||||||.||..|...|.|||||||.. ||     |. .|...   |||  .|.||.|||.| |.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSFGERPYWD-----MSNQDVINAIEQDYRLPPPMD--------CPAALHQLMLDCWQKDRNSRPRFAEIVNTL
|..|||||.|..|||....|. ||..     ||||.||. ..| ||.|.| .        ||....|.|..||. | ..||.|.||.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB1.AA TK 619-878 24 2.7e-129 435.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)

VKIEEVIGAGEFG---EVYKGRLKLPG----------------------KREIYVAIKTLKAGYSEKQRR-------------DFLSEASIMGQFD----
.......|.|.||   |||||... ..                      . .. ||.|.||.| .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTKS------------RPVMIITEFMENGA----LDSFLRQNDG---------------------------------------------
 ||||.|| ||.|..            .|.||..|.|..|     |...||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMKYLAEM------NYVHRDLAARNILVNSNLV-----------CKVSDFGLSR
                              |.|. ||. | . ||.|| ||...      |.|||||||||.||..|.|           ||..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----YLQDDTSDPTYTSSL------------------------GGKIPVRWTAPEAIA---------YRKFTSASDVWSYGIVMWEVMSFG-ERPYWDM
        |. ||  |...                         |||.|.||.|||...         |.|||..|||||.|..|||....| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVINAIEQD--------------YRLPPPMDCP--------------AALHQLMLDCWQKDRNSRPRFAEIVNTL
||         |.|.. ...               .|.|.|..||              .....||..||..| . ||.|..... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB1.AA UTK 619-878 37 4.2e-116 392.02 In-house 1-296 (296) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-296/296
Sequence Identity: 37% (111 aa)

VKIEEVIGAGEFGEVYKGRLKLPG--KREIYVAIKTLKAGYS-EKQRR---DFLSEAS---IMGQFD-HPNIIRLEGVVTKSRPVMIITEFMENGALDSF
|.. . .|.|.||||.|.|.. .     | .||.|..... . .....   ||. ||    .|.||. |||..|| ||.|.. | ||.||.|||| |.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRYLQD------DTSDPTYTSSLGGK
||       ... ..|  |...| . ||.|| ||.....|||||||||.||...       .|||..|||   .||....      . ... |...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPVRWTAPEAIAYR-KFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD--YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL
.|.||.||||.... .||..|||||.|.|.||....| .|| .|||..|. ...    ||.|.| |||... .||..||..|   ||.| ..| ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB1.AA Src 619-878 42 1.4e-110 373.65 In-house 1-255 (255) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-255/255
Sequence Identity: 42% (112 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR-QNDGQ-F
.| .. .|.| ||||..|      . .. ||.||||.|    .  .|| || || ...|.....|  |...  |. |.||.|..| |  .|. . .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWE
 . ||. |   .|.||.|| .|||.||||||||.||. |.|||| |||| | ...|  |  |... | |.|..||||||| |..||  |||||.|| ..|
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQ-LMLDCWQKDRNSRPRFAEIVNTL
....|  ||  |.|..|. ..|. ||.| |. ||. |.. .|| ||.||   || |. . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB1.AA SFK-Src 619-882 41 5.6e-104 309.09 In-house 1-259 (259) Show / Hide 
Range on Protein: 619-882
Range on HMM: 1-259/259
Sequence Identity: 41% (112 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQ-NDGQFT
.. |.  |.| ||.|.|||          ||.|||| |    .   ||.|| .| .  ||| |.|  | |   |. |||| | .| |  .|.. .    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEV
. ||| |   .|.|| || . |.|||||||||.||  | |||| |||.|| | .|  |  ||   | | |..||||||  . .|   |||||.|| | |.
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQD--DEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSFGERPYWDMSNQDVINAIEQ--DYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMI
  .|  ||  |.|. |.  ...   ||.| |  || .....|.||||.    || |      ..   
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB1.AA Fer 619-879 34 2.4e-100 339.65 In-house 1-283 (283) Show / Hide 
Range on Protein: 619-879
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

VKIEEVIGAGEFGEVYKGR--LKLPGK-----REIYVAIKTL-KAGYSEKQRRDFLSEASIMGQ-FDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL
|......| | ||||||||  ||.  .     . . |. |..  .. ...|...|. || || . .||||.... || .   |.||. ||. .|.|||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RQNDGQ-FTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRYLQDDTSDPTYTSSLG---GKIPVRWTAPEAIAYRKFT
. |...  .. ... |. ..|.||.|| ..| .|||.||||.|.   ....|  .||||.||    ..|| .|.....    |.|.||.|||.. .. ..
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSR----QCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYS

SASDVWSYGIVMWEVMSFGERPYWD----MSNQDV----INAIEQ-DYRLPPPMDCPAALHQLML-DCWQKDRNSRPRFAEIVNTLD
...||||.|...||... |. || .    | .  |    . .|.. .|..|.|  .| .. |.|. .||||| . || ..||...| 
PKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphB1.AA TK-Unique 619-878 33 1.3e-96 327.23 In-house 1-294 (294) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-294/294
Sequence Identity: 33% (100 aa)

VKIEEVIGAGEFGEVYKGRLKLPG---KREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFD-HPNIIRLEGVVTKSR-PVMIITEFMENGALDSFLRQND
.....||| |.||.|..| .. .     . . ||.|.||.. .. ...|||.|...| . . ||||....|. |||  |.||| |....| |...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIAAGMKYLAE--MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLG-GK
 .....                     |.   |.  . .|| ||.|||.  .. |||||.|||.|.....|||..|||..|....   .  | .. . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

IPVRWTAPEAIA--YRKF-TSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDC-PAALHQLMLDCWQKDRNSRPRFAEIVNTL
||.|| |||..   .. . |. |||||.|..|||....|..|| .|.. |....|.. ||.| |  | . ....||  |||... .|| |..|.. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB1.AA Tec 619-880 39 7e-91 308.23 In-house 1-254 (254) Show / Hide 
Range on Protein: 619-880
Range on HMM: 1-254/254
Sequence Identity: 39% (105 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG-YSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT
 .. . .| | || |  |...     .. ||||..| |  ||    ||. || .|    ||. ..| || .. ||. |.||.||.| | ..||.. ..| 
LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

VIQ--LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMW
  .  | .|   .  || || . ...|||||||| ||... | ||||||..||  ||     |||| | | ||.| .||   | .. | ||||..|. ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDD----QYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDK
|| | |  ||  ||| .|. .. | .||  |  |.  . | | .||.     || |..   .. .
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphB1.AA RTKC 619-878 42 3.8e-90 297.71 In-house 1-261 (261) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-261/261
Sequence Identity: 42% (111 aa)

VKIEEVIGAGEFGEVYKGRLKLPG-KREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFT
... .  | | || |||. |  ||   .. || | |..  ... |.  | || .| ||.|||...| ||||. .|. .. ||.|.|.| |.| .|  . |
LTLLDELGRGAFGIVYKALLEEPGGMPGYLVACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNP-DCT

VIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYL-QDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWE
  | |   . .|.||   .. . .|||.||||.|. | | |||.|||| |    .| |. .|  | .| .|||||||||   |||. .||||. || | |
EHQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMYE

VMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL
.   .| || . ||| |   .   ||||.| ||....  .|.|||. ..  || | |.|  |
IYTKAEMPYDGWSNQRVWVEVCAGYRLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase EphB1.AA Frk 619-882 42 4.3e-90 305.6 In-house 1-260 (260) Show / Hide 
Range on Protein: 619-882
Range on HMM: 1-260/260
Sequence Identity: 42% (113 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR---QNDGQ
...   .|.| ||||. |.       .. ||.||||.|  . .  ||| || || .  || .|.|  | |   |..|||| |..|.|  .|.   ..  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMW
  . ||| |   .|||| || ..||.||||||||.||. ...||. |||| | |  |  |  | |  | ..|..||||||. | |||  |||||.||.. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMI
|.. .|  ||  | |..|.. ....||.| | .||  | ..||.||..| . || |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB1.AA S_TKc 619-882 22 1.7e-51 178.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 619-882
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMEN--GALDSFLRQNDGQ-
 .| ..|| | ||.|||.| |       .|||| .|        .....| .|. . .||||..| .|      . ...|....  | | ...... .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTS-ASDVWSY
    |.  .   ... |. ...|. ... .||||   |||...  . |..||||.| |                    . ||| .   ...  ..|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVN-----TLDKMI
|....| .. |. |..    | ... |            .  . ...  |.||| . ||   |. .      ..  .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB1.AA Pkinase 619-878 24 1.8e-47 168.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 619-878
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK--QRRDFL-SEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENG----ALDSFLR-
 .|...||.| ||.|||.. |  ||    ||.|..|    ..  ...... ||..||  ..||||.|| .... .. . ...|..|.|     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

QNDGQF--TVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVC----KVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA-YRKFTS
...| |  .  ..  ... |. |..|. .|. .||||   |||...| ..    |..||||.. ..   ... .|.  |     .. ||| |  ... ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP---WYMAPEVIRGGQYYGP

ASDVWSYGIVMWEVMSFGERPYWDM----SNQDVINAIEQDYRLPPPMDCP-----------------------AALHQLMLDCWQKDRNSRPRFAEIVN
..|.||.|....|... |. |...     .  | .  |... . |.. |.|                        .. ... .|..|| ..|| ...|..
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

T--L
   .
HPWF
SAM_1 EphB1.AA SAM_1 909-973 43 1.6e-28 103.94 Pfam 1-66 (66) Show / Hide 
Range on Protein: 909-973
Range on HMM: 1-66/66
Sequence Identity: 43% (29 aa)

DFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLR-IGITLAGHQKKILNSIHSMR
| ..| .|..|| .|.| ||.|.|. ||........||| |||.. .|.||.||.|||..||. ..
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphB1.AA SAM 908-975 41 3e-24 87.81 SMART 1-67 (67) Show / Hide 
Range on Protein: 908-975
Range on HMM: 1-67/67
Sequence Identity: 41% (28 aa)

PDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSMRVQ
.|   . .| ||| .|.| ||.| |...|... .|. ... |||...|||..||.||||..|..|. |
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 EphB1.AA SAM_2 908-973 39 5.7e-24 85.1 Pfam 1-71 (71) Show / Hide 
Range on Protein: 908-973
Range on HMM: 1-71/71
Sequence Identity: 39% (28 aa)

PDFTAFTTVDDWLSAIKM-VQYRDSFLTAGFTSLQLV-TQMTSEDL--L-RIGITLAGHQKKILNSIHSMR
.....| .| .||..|.|  ||.|.|. .|.|.....  .||..||    |.|||..||.|||.|.| .|.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
Sam7 EphB1.AA sam7 911-973 41 9.9e-24 82.16 In-house 1-70 (70) Show / Hide 
Range on Protein: 911-973
Range on HMM: 1-70/70
Sequence Identity: 41% (29 aa)

TAFTTVDDWLSAIKM---VQYRDSFLTAGF----TSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSMR
. | .| .|| .|.|    ||.|.|. .|.    |..... .|| |||...|||. ||.|||.|.|. ||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR