Gene ErbB4 (Human)

ErbB4

Species: Human
Alias: p180erbB4, MGC138404, ERBB4, ErbB4, HER4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2q34-q35,

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
ErbB4.NA RNA Sugen Kinome 11941 None Fasta, JSON
ErbB4.AA Protein Sugen Kinome 1308 None Fasta, JSON
ErbB4.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of ErbB4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain ErbB4.AA Recep_L_domain 55-167 42 3.1e-48 163.89 Pfam 1-121 (121) Show / Hide 
Range on Protein: 55-167
Range on HMM: 1-121/121
Sequence Identity: 42% (53 aa)

NCEVVMGNLEITSIEHN----RDLSFLRSVREVTGYVLVALN--QFRYLPLENLRIIRGTKLYED-RYALAIFLNYRKDGNFGLQELGLKNLTEILN--G
||.|..||||||.....    .||||....||.|||.|.. .   .   ...|||||||..|..| .|||.|. |. .    |||||...||..|..  |
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM----GLQELWMWNLKNITRKNG

GVYVDQNK--FLCYADT-IHWQDIV
|||. .|.   ||| .| |.|..|.
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like ErbB4.AA Furin-like 183-335 44 8.5e-82 268.83 Pfam 1-182 (182) Show / Hide 
Range on Protein: 183-335
Range on HMM: 1-182/182
Sequence Identity: 44% (81 aa)

SSGCG--------RCHKSC--------TGRCWGPTENHCQTLTRTVCAEQCDG-RCYGPYVSDCCHRECAGGCSGPK-DTDCFACMNFNDSGACVTQCPQ
.  |.         ||..|          |||||...||||||..||.||| . ||.||  ..||| .|.|||.||. ||||.|| .|...|.||.|||.
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

TFVYNPTTFQLEHNFNAKYTY-GAFCV--KKCP-------HNFVV-DSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACD
...|||||||.|.| ...|.. |. ||  |.||       .|..| . ..|.| ||| ..|.|||. .||.||.  ||| | 
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU ErbB4.AA FU 226-268 37 2.3e-12 48.33 SMART 1-48 (48) Show / Hide 
Range on Protein: 226-268
Range on HMM: 1-48/48
Sequence Identity: 37% (18 aa)

VSDC--CHRECAGGCSGPKDTDCFACMNFNDS---GACVTQCPQTFVY
 . |  || |||.||.||....| .|.....    |.||.|||. . .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU ErbB4.AA FU 183-223 29 0.083682 3.79 SMART 1-48 (48) Show / Hide 
Range on Protein: 183-223
Range on HMM: 1-48/48
Sequence Identity: 29% (14 aa)

SSGCGRCHKSCTGRCWGPTENHCQT------LTR-TVCAEQCDGRCYG
.. | .|| .| . ||||....|..      |    .| .||    |.
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain ErbB4.AA Recep_L_domain 358-478 33 3.7e-39 133.36 Pfam 1-121 (121) Show / Hide 
Range on Protein: 358-478
Range on HMM: 1-121/121
Sequence Identity: 33% (44 aa)

NCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYS--GLSLLILKQQG--ITSLQFQSLKEI
|||.|.|||... ...|..        ..|.|..|...|||||.|.|. . .|....|.|.|| .| ||.|.     .| |.. .   ...|.. .||.|
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

SA--GNIYITDNS--NLCYYHT-INWTTLF
.   | .||..|   .||| || |.|  ..
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU ErbB4.AA FU 493-544 32 1.8e-11 45.35 SMART 1-48 (48) Show / Hide 
Range on Protein: 493-544
Range on HMM: 1-48/48
Sequence Identity: 32% (18 aa)

AENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG---RICIESCNLYDGEFR
.  |    . |.. |.. ||||||||||.||...  .   ..|...|.  .|...
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like ErbB4.AA Furin-like 511-536 37 0.000199 15.13 Pfam 72-98 (182) Show / Hide 
Range on Protein: 511-536
Range on HMM: 72-98/182
Sequence Identity: 37% (10 aa)

GCWGPG-PDQCLSCRRFSRGRICIESC
|| ||. .  |..|| |.   .| ..|
GCTGPNNDTDCVACRHFYHNGTCVDQC
FU ErbB4.AA FU 549-599 35 6.9e-12 46.74 SMART 1-48 (48) Show / Hide 
Range on Protein: 549-599
Range on HMM: 1-48/48
Sequence Identity: 35% (19 aa)

GSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPN---CVEKCPDGLQG
.. |..|.|.|.       .| |||||.||.|.|......   ||..||.|  .
DGVCKPCHPECAT------GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like ErbB4.AA Furin-like 569-594 40 0.848871 3.23 Pfam 73-99 (182) Show / Hide 
Range on Protein: 569-594
Range on HMM: 73-99/182
Sequence Identity: 40% (11 aa)

CHGPG-PDNCTKCSHFKDGPNCVEKCP
| ||. . .|  | || .   ||..||
CTGPNNDTDCVACRHFYHNGTCVDQCP
FU ErbB4.AA FU 611-659 28 0.009346 15.21 SMART 1-48 (48) Show / Hide 
Range on Protein: 611-659
Range on HMM: 1-48/48
Sequence Identity: 28% (15 aa)

DRECHPCHPNCTQGCNGPTSHDCI--YYPWTGHSTLPQHARTPLI--AAGVIG
|..|.||||.|  ||.||.  .|.     . .|..     .| .    .|  .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-----GTCVSQCPPGYYP
Kinase ErbB4.AA EGFR 718-975 83 5.8e-206 690.1 In-house 1-258 (258) Show / Hide 
Range on Protein: 718-975
Range on HMM: 1-258/258
Sequence Identity: 83% (216 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGS
||.|||||||||||||||||.||||.||||||||.|.|.|||||| |..|||..|||.||||||||||||.....|||||.||.||||.||..|||||||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFG
|.||||||||||||.||||.|.||||||||||||||||||||||||||.||| |||||.|.|||||||||||||||.|..||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

GKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFS
.|||||||.||||||||||||||||||||||||||||||||||.|.||.||||..||.
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ErbB4.AA Pkinase_Tyr 718-974 45 2.3e-142 482.76 Pfam 1-270 (270) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-270/270
Sequence Identity: 45% (124 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA--NVEFMDEALIMASM-DHPHLVRLLGVCL--SPT--IQLVTQLMPHGCLLEYVHE
..  |.||.||||.||||.| ....  |||||.|.|.|.. ...    .|| || || .. .||..|||.|||.  .    | .|. .||||.||.| ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE-YNADGGKMPIKWMALECIHYRKFTHQSDVWSY
|   |...  . ||..|.|||||| |||.....||||||||.||...|.|||.||||||... |.   . ..|||.||||||.|||.|.|||..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTIWELMTFGGKP-YDGIPTREIPDLL-EKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF
||..||..|.|..| | |..  |. ... |.|.|.|.|. |. ..|..| .||. |.. || |.|.  ..
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ErbB4.AA TyrKc 718-974 40 5.8e-135 455.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM--DHPHLVRLLGVCLS--------PTIQLVTQLMPHGCLLEY
..  |.||.||||.||||.|        |.||.| |.| .      .||.|| || .   .||..|||.|||..        . . .|. .||||.|..|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD------EKEYNAD---GGK--MPIKWMALECIHYRK
 ..|....  . ||..|.|||.|| ||......||||||||.||.....|||.||||.| .. |      .. | .    |||  .||.|||.||| |.|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FTHQSDVWSYGVTIWELMTFGGKPYDG-----IPTREIPDLLEKGERLPQPPI--------CTIDVYMVMVKCWMIDADSRPKFKELAAEF
||..|||||.||..||..|.|..|| |     .. .|.  ....|.|.||||         |. ..|..| .||. |...|| |.|.  .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ErbB4.AA TK 718-974 23 8.60000000001e-115 386.43 In-house 1-486 (486) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

LKRVKVLGSGAFG---TVYKGIWVPE---------------------GETVKIPVAIKILNETTGPKANVEFM-------------DEALIMASMD----
.. .|.||.|.||   .||||.| ..                     .| .|.|||.|.| |...  .. .|.              ||..|. |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHLVRLLGVCLSPT-------------IQLVTQLMPHGC----LLEYVHEHKDN--------------------------------------------
 ||..|||.|||. .              . .|. .||||.    |..| ......                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IGSQLLLNWCVQIAKGMMYLEER------RLVHRDLAARNVLVKSPNH-----------VKITDFG---
                               .  . || .|.|||.|| ||...      ..|||||||||.|| . |.           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLLEGDEKEYNAD------------------------GGKMPIKWMALECIH---------YRKFTHQSDVWSYGVTIWELMTFG-GKPYDGI
     ||| .. |.  | ..                        |||.||.||| ||.          |.|||..|||||.||..||..|.| . .| |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PT---------REIPDLLEKG--------------ERLPQPPICT--------------IDVYMVMVKCWMIDADSRPKFKELAAEF
.          .|. ..|..|               |.|||| |.               ..| .| .||  |.. || |..|  ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ErbB4.AA Ack 718-974 40 7.2e-99 334.14 In-house 1-266 (266) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-266/266
Sequence Identity: 40% (107 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNET--TGPKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKD-
... . ||.| || | .| |        |.||.|.|     . |..  .|. |. || |.|||||||| || | .| ...|| | | | ||.  ..|.  
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-NIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSP-NHVKITDFGLARLLEGDEKEYNADGGK---MPIKWMALECIHYRKFTHQSDVWSYGV
      .|...|.|||.|| ||| .|..||||||||.|. |. . ||| |||| | | . |  |   . .    |. |.| ||. .|.|.| ||||..||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TIWELMTFGGKPYDGIPTREIPDLLE-KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF
|.||  ..| .|. | .  .|  ... .|||||.|. |  |.| .|..||  ..  ||.| .. . .
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ErbB4.AA Syk 718-968 40 1.2e-94 320.76 In-house 1-257 (257) Show / Hide 
Range on Protein: 718-968
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

LKRVKVLGSGAFGTVYKGIWVPE---GETVKIPVAIKILN-ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKD
| . . .|.| ||.| ||        || . |.||||.|  . . |    ||| || .|.  |||. ||..|.|. .   .|  . . | .. |  .|..
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

NIGSQLLLNWCV-QIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD-GGKMPIKWMALECIHYRKFTHQSDVWSYGVTIW
 |  .  |     |.| ||.||||.  |||||||||||       || |||. . |  |...| |  .|| |.|| | ||| |.|| |.|||||.|||.|
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

ELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFK
|    | ||| ..   |. ...|.|.|...|. |  ..| .| |||  ..  || | 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ErbB4.AA Src 718-974 40 7.6e-93 314.76 In-house 1-255 (255) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-255/255
Sequence Identity: 40% (105 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSP-TIQLVTQLMPHGCLLEYVH--EHKDN
.|... ||.| || |..|.|       ...||.| | . |   ..  |  || || ...|..||.|. ||     |  || .| ||.||.| .  .   .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEY-NADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWEL
.  . |.    |.|.||.|||.....|||||||||||   | .|. |||||||.. |. ||    | |.||||.| |.|.|..||  |||||.|. ..|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYM-VMVKCWMIDADSRPKFKELAAEF
.|.|  || |   .|  . .|.| |.|.|. |   .|. .| .||  |.. || |. |   .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ErbB4.AA UTK 718-974 30 7.5e-92 311.46 In-house 1-296 (296) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-296/296
Sequence Identity: 30% (92 aa)

LKRVKVLGSGAFGTVYKGIWVPEG-----ETVKIPVAIKILNETTGPKANV---EFMDEAL---IMASMD-HPHLVRLLGVCLSPT-IQLVTQLMPHGCL
... . ||.||||.|.|. ....        |...|.    .. .....     .|| ||    .|.  . ||...||.|||..   . .|| .|. | |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDL

LEYVHEHKDNIG-------SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSP-------NHVKITDFG---LARLLEG--------DEKEYNADG
. |.  |... .       .  .| ....|| || ||.....|||||||||.|| .        . .|| |||   ..|.. .        .  .|.|..
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

-GKMPIKWMALECIHYR-KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKG--ERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF
 ...||.||| |.. .. .||..|||||.||. ||..|.| .|| |. ....   ...|   |.|.|. |  .||..|..||. | . || |..| ...
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ErbB4.AA FAK 718-979 37 3.9e-85 285.2 In-house 1-285 (285) Show / Hide 
Range on Protein: 718-979
Range on HMM: 1-285/285
Sequence Identity: 37% (106 aa)

LKRVKVLGSGAFGTVYKGIWV-PEG----------------------ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL
 .  ...| | || ||.|... ...                         || ||||   . . .    .|| ||.||  .||||.|.|.|.|    | .
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD-GGKMPIKWMALECIH
.  |.. | |  |   .|.      |. .| |... | ||| .. |||| ||||||| ||. ||  |||| |... |.  | |   ||.|||||. | | 
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESIN

YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMAR
.| ||  |||| .|| .|| . .| ||. ..   ..   .|.||||| || |    | .| .||  |   ||.|||| .. . .  
FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase ErbB4.AA TK-Unique 718-974 30 5.5e-84 285.32 In-house 1-294 (294) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-294/294
Sequence Identity: 30% (90 aa)

LKRVKVLGSGAFGTVYKGIWVP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMD-HPHLVRLLGVCLSPT--IQLVTQLMPHGCLLEYVHEHK
|.  .|.|.||||.|..|  ..  ...  .. ||.| |..   .    .|..|. .| . . ||..|..||.| ...   ...   .| |.|. | .. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DN-------------------------IGSQLLLNWCVQIAKGMMYLEE--RRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG--GKMP
..                         | ...|.....|||.||.||..  .. |||||.|||||. . . .||.|||.|| ..  ...|.  .  |..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWMALECIH--YRKF-THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPIC-TIDVYMVMVKCWMIDADSRPKFKELAAEF
|.|||.| .   .. . | .|||||.||..||..|.|. || |.| ..| .....| |.|||. | . ..| .|  ||  ....|| | ... ..
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ErbB4.AA Abl 718-974 43 2.8e-77 257.27 In-house 1-252 (252) Show / Hide 
Range on Protein: 718-974
Range on HMM: 1-252/252
Sequence Identity: 43% (112 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNI
.   . || | .| ||.|.|   . |    ||.| | | |   .  ||. || ||  | || ||.|||||   |   ..|  |..| ||.|. |  ....
IMMKHKLGGGQYGEVYEGVWKRHDCT----VAVKTLKEDT--MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMT
 .  ||    ||| || |||.|  .|||||||| ||   . ||. ||||||....|     | | | |||| | | . | ||  .|||| .|| .||. |
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA-GAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

FGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF
.|  || ||   .. ..|||| |. .|. |  .|| .| .||  ..  ||.|||.  ..
YGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ErbB4.AA Frk 718-978 40 3.5e-76 259.41 In-house 1-260 (260) Show / Hide 
Range on Protein: 718-978
Range on HMM: 1-260/260
Sequence Identity: 40% (107 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVH---EHKD
.. .. |||| || |. | |      ...|||.| |   .|     .|. || || .. || |..|  || .   | ..| || || |.||.    ..  
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLK--PGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

NIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEK-EYNADGG-KMPIKWMALECIHYRKFTHQSDVWSYGVTIW
..  | |..   |.| || |||..  .|||||||||||   | .|| ||||||.|  |..  | .  | ..|||| | | ..| ||| .|||||.|. . 
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

ELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMA
|..|.|  || |.  .|. . ...| |.|||| |   .| .| .||  |.. || |  |   .    
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ErbB4.AA S_TKc 718-975 21 1.9e-48 168.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 718-975
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPH--GCLLEYVHEHKDN-
 . ....|.||||.|||....      .  |||||..          .. |  |. . .||..|.|..|. .  . .|. ....  | |..| .... . 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTH-QSDVWSYGVT
    .       .. ||.... |. ... .||||   |.|. .  |.||.||||||.|         .       .|| | .   ....  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA--------EFS
..|... |  |..     ..  ...|          . ..   . ||.  | . ||   |. .        .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ErbB4.AA Pkinase 718-915 25 2e-37 133.45 Pfam 1-207 (293) Show / Hide 
Range on Protein: 718-915
Range on HMM: 1-207/293
Sequence Identity: 25% (54 aa)

LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMD----EALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHG----CLLEYV
.......|||.||.|||.... .|.     ||.||..   . | ...  .    |. ||....||. |||....  .. | .|. ....|     | .|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

H-EHKDNI--GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHV----KITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH-YRKFTHQ
. . . ..    . . ... ||..|. |. ... .||||   |.|... .|.    ||.|||||....   .   ...    . .|| | |  ... .. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTIWELMT
.|.||.|....|...
VDMWSCGCILYEMLC