Gene Erk4 (Human)

Erk4

Species: Human
Alias: ERK3, Erk4, ERK3-RELATED, PRKM4, MAPK4, p63mapk, p63MAPK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 18q21.1,

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK3

Sequence

Name Sequence Type Origin Length Description Download
Erk4.NA RNA Sugen Kinome 4736 None Fasta, JSON
Erk4.AA Protein Sugen Kinome 587 None Fasta, JSON
Erk4.kin_dom Protein Kinase Domain Sugen Kinome 293 None Fasta, JSON

Protein domain

Protein domains of Erk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk4.AA ERK3 20-312 75 2.7e-261 850.33 In-house 1-300 (300) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-300/300
Sequence Identity: 75% (226 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQ-----GELFKFSVAYIVQEYMETDLAR
|.|..|||.|.||||.|||||..|.|||.|||.|.|..|.|||||||||||||||||||||||||.|||.|.|     |.||......|||||||||||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKSCKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLAC

LLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
..||..|.||||.||||||||||||||||||||||||||||||.||||||||||||.|||||.||||||||||||||||||||||||.||||||||||||
VMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMWA

AGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMP-SFVS-STWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
|||||||||||.||||||||||||.|||..|||..||||.|||.||| .... ..|....||..||......|.||||..|||.|||||||||.||||||
AGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase Erk4.AA MAPK 20-312 39 3.3e-142 478.75 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-328/328
Sequence Identity: 39% (130 aa)

FVDFQPLGFGVNGLVLSAVDSR------ACRKVAVKKIA--LSDARSMKHALREIKIIRRL-DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMET
... .|.|.|  |.| ||.| |       ..|||.|||    ... ..|...||||. |.. .|.||.|..... |...| |..| .|   |||.|.|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLARLLEQGT-LAEEHAKLFMYQLLRG--LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKG-----------YLSEGLVTKWYRS
|| ......  | ..| . ||||.|||  |||||||||.||||||.|| . ..... ||.||||||..|..|.|..           ...|  .| |||.
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PRLLLSP--NNYTKAIDMWAAGCILAEMLT-GRMLFAGAHELEQMQLILETIPVIREEDKDELL-RVMP-SFVSS----TWEVKRPLRKLLPE----VNS
| ..|..  ..||||.|||..|||.||||| .. || | . ..|..||.|...   ||.   .    .. ....|    ..  |.|..|..|     .|.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

EAIDFLEKILTFNPMDRLTAEMGLQHPYM
.|||.||| |.|.|..|.|.|. |||||.
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk4.AA CMGC 20-312 24 7.50000000001e-109 358.96 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

FVDFQPLGFGVNGLVLSAVDSRACRK--------------VAVKKIALS-DARSMK----------HALREIKIIRRL-----------------DHDNI
.   ...| |  | | ...| |  .|              ||.||| .  . . .|           ||||||| ..|                 .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKVYEVLGPKGTDLQGELFK------FSVAYIVQEYMETDLARLLEQGT----------LAEEH------------AKLFM------YQLLRGLK--YIH
|| |... .|..| ... .|      |   |.| |||..||......            | | |             | ||      ||.|||||  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAN--VLHRDLKPANIFISTEDLV-------------------LKIGDFGLARIVDQHYSHKGY------------------LSEGLVTKWYRSPRLLLS
|..  ..||||||.|| |. .  .                   |||.||||||....| .|...                  ...  || |||.| .||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

P---------NNYTKAIDMWAAGCILAEMLTG--------RMLFA-----------GAHELEQMQLILETIPVIR---------------EEDKDELLR-
          ..||..||||..|||.|||.||        . ||            |.....|...| ...  .                ||.  . .  
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------VMPSF--------VSSTWEVKRPLRKLLPE-----------------------------------VNSEAIDFLEKILTFNPM
                  ...|         .  |  ..|...| |                                     ...|||.|.|.|...| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

DRLTAEMGLQHPYM
.|.|||  ||||| 
KRITAEQALQHPYF
Kinase Erk4.AA Pkinase 20-312 31 2.9e-102 350.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKH--ALR--EIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMET-----
..  ...| |  | |  ...   ...||||.| .....| |.  ..|  ||.| .||.|.|||. |..               .  |.|.||.|      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----------KDHIYMVMEYCEGGLYVM

DLARLLE---QGTL--AEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVL----KIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLL
||.....   .|..   |...| .|||.||||.|.|| ...||||||.||.|. .. ..    ||.|||||. .|  | ... ..   .| ||..| ...
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR

SPNNYTKAIDMWAAGCILAEMLTGRMLFAGA----HELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNP
. . |....|||..||||.|||.|| .| |.    . ..|||.| .. . . ..| ... .....|  .. . .. .... .....|..||....|...|
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDP

MDRLTAEMGLQHPYM
 .|.|||  ||||..
KKRPTAEQILQHPWF
Kinase Erk4.AA ERK1 20-312 42 3.8e-88 299.15 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-289/289
Sequence Identity: 42% (126 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQ
... | .| |  |.| ||.| .  ..||.|||.  .     .  ||||||. |  |.||... ...  .  .      ..   ||||. ||||| .||  
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIE------QMRDVYIVQCLMETDLYKLLKT

GTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI
  |. .|   |.||.|||||||||||||||||||.|. . |    ||| ||||||| | .  | |.| |   |.||| | ..|    |||.||.|. |||
QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI

LAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELL--RVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
|||||  | .| | | |.|. .||  .    ..| . ..  .      |     | |...| |.  | |.|.|.|.|||||  |.| |  | |||.
LAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk4.AA S_TKc 20-312 27 2.5e-82 280.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMET---DLARLL
.   ...| |  | |  ... .  |.||.|.|        .|..|||.| .. .|.|||| |.|               .  |.| ||...   || ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDLFDYI

EQGT-------LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTK-
..         . | ||. .|||....|.|.|| ...||||||.||....   ..||.||||||..          .   .| ||..| .|     |.| 
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKC

AIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQ
..|.|. ||||.|||.|. .|   .. . ...|.                                        .||.||..|.|...| .|.||   ||
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------HPYM
       ||..
DEWDIKCHPWF
Kinase Erk4.AA ERK7 20-312 38 8.4e-78 264.79 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-292/292
Sequence Identity: 38% (116 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRRLD-HDNIVKVYEVLGPK-GTDLQGELFKFSVAYIVQEYMETDLARL
.   . || |  |.|  |.| |.   ||.|||  |  ..       ||| ... .. |.||.....|.  .   |.          |.| |.|||||   
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDI----------YLVFEFMETDLHAV

LEQGTLAEE-HAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHY---SHKGYLSEGLVTKWYRSPRLLLSPNNYTKAID
  .| . .. | .  |||||| .||.||.||.||||||.|| . .| .| |. |||||| . |      ... | |   | |||.|  ||.  .|||..|
IRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMV-KVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVD

MWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFV--SSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQH
||  ||||.|||.|. .|.|   ..|. .||||||   .||   .   . . .  .   . ...| ...|.   .||| | ..| |||  |||||  |||
MWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQH

PYM
|| 
PYV
Kinase Erk4.AA ERK 20-245 40 1.1e-77 264.34 In-house 1-233 (307) Show / Hide 
Range on Protein: 20-245
Range on HMM: 1-233/307
Sequence Identity: 40% (96 aa)

FVDFQPLGFGVNGLVLSAVDSR-----ACRKVAVKKI--ALSDARSMKHALREIKIIRRLD-HDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETD
. . ...|.|  |.| ||.|          |||.|||  | .... .| .|||||. | .. |.||.. . .. |.  .   ..      |.|.|.||||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDI------YCVEELMETD

LARLLEQG-TLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSH-----KGYLSEGLVTKWYRSPRLLLSPNN
|..      .| ..| . ||||.|.||||||||||.|||||| || . ... .||| ||||||..| .|.      .....|  .| |||.| ..|| ..
LHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILV-NSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQK

YTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI
||||.|.|..|||.|||| .. || |.  ..|...|...|
YTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQII
Kinase Erk4.AA CDK 20-245 35 3.5e-70 223.69 In-house 1-241 (284) Show / Hide 
Range on Protein: 20-245
Range on HMM: 1-241/284
Sequence Identity: 35% (90 aa)

FVDFQPLGFGVNGLVLSAVDSRAC-----RKVAVKKIALSD-----A--RSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKF-SVAYIVQE
.   . .| |  | |  | | .       . || ||| .       .       |.|||.. . | |.||||...|   | .| ..  .|. .  |.| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDL----VLKIGDFGLARIV---------DQHYSHKGYLSEGLVTKW
||..||. ...         | .|.|||||| |.|| ...||||||.|| |.        .|||.||||||.           . |.|.       || |
YMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHE------VVTLW

YRSPRLLLSPNNYT--KAIDMWAAGCILAEMLT---GRMLFAGAHELEQMQLILETI
||.| |||   .|.   .||||..|||.|||.|   .. || |  |..|. .| ...
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRIC
Kinase Erk4.AA ERK5 20-312 35 2.5e-69 236.64 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-295/295
Sequence Identity: 35% (107 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLE
.     .| |  | | ||.  .  ..||.|||  |       |  .||.||.|   ||||. . ..| ||       .  .   |.| . || ||  .. 
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVP-----YSEMKDVYVVFDLMESDLHQIIH

QGT-LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQ--HYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
    .. || . |.||.||||||.|||.|.||||||.|. .  |   |||||||.|| .       |. .. |   |.||| | |..| ..||.|||.|.
SNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLV-NENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWS

AGCILAEMLTGRMLFAGAHELEQMQLILETI-----PVIREEDKDELLRVMPS-FVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQ
 |||. ||.. | .| |   ..|.|||.. .      .|.    | .   . . |   .    ... |. |.    |.| | ..| | | .|.|.   ||
VGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQ---PKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQ

HPYM
||..
HPFL
Kinase Erk4.AA p38 20-243 37 3.4e-65 221.73 In-house 1-218 (289) Show / Hide 
Range on Protein: 20-243
Range on HMM: 1-218/289
Sequence Identity: 37% (86 aa)

FVDFQPLGFGVNGLVLSAVDSRACRK---VAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLAR
... ||.| |  | | .|.|.|   |   ||.||..    ..   | . ||..  . ..|.|...  .|  |       ..  |.  |.| . |..|| .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP----PAHSMNDFQDVYMVTHFMGADLNN

LLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
.. . .| ..| ..  ||.||||||||||.. |||||| || . .||  |.| ||||||  |.     ||     .|.|||.|  .|.   ||...|.| 
IMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAV-NEDCELRILDFGLARHCDDEMT--GY----VATRWYRAPEIMLNWMHYTQTVDIWS

AGCILAEMLTGRMLFAGAHELEQMQLILE
 |||.||..||| || |   ..|.| |..
VGCIMAELITGRTLFPGDDHIDQLQRIMK
Kinase Erk4.AA MAPK-Unclassified 24-173 37 3.3e-46 159.85 In-house 5-157 (575) Show / Hide 
Range on Protein: 24-173
Range on HMM: 5-157/575
Sequence Identity: 37% (60 aa)

QPLGFGVNGLVLSAVDSRA-CRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQG-ELFKFSVAYIVQEYMET---DLARLL
. .| |  | |  |.|..   ..|| ||..    .    | .|||| | | | | ||... ... .|  .|.. |   |   ||| .||.|   ||  ..
KNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNK--ELHNQE---FDDIYIVMDYMQTSLFDLHQII

EQGT--LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLAR
 .    . ..| . |.||.||||||.|||...||||||.|. | ..|. ..| |||..|
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLI-NQDCSVRICDFGMSR
Kinase Erk4.AA MAPK-Unclassified 180-243 25 2.2e-18 62.7 In-house 400-494 (575) Show / Hide 
Range on Protein: 180-243
Range on HMM: 400-494/575
Sequence Identity: 25% (24 aa)

SHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTG-----------RMLFAGAH--------------------ELEQMQLILE
.|......  || ||| | ..||  .|....|.|..|||.|||.             | || |                         | ..|..
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFD
Kinase Erk4.AA ERK 271-312 43 3.3e-13 45.69 In-house 264-307 (307) Show / Hide 
Range on Protein: 271-312
Range on HMM: 264-307/307
Sequence Identity: 43% (19 aa)

KRPLRKLLPE--VNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
..|. .. |   .|..||| ||| |.|.| .|.|.|  |.||| 
PKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase Erk4.AA TyrKc 20-270 22 1e-11 -33.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-270
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRL--DHDNIVKVYEVLGPKGTDLQGELFKF---SVAYIVQEYMET-DLA
 .  . || |  | |  .. .   ..||||..  .    ..  .||..| ..|  .|.|||. | |   .|         |      .|| |||.  || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPHGDLK

RLLEQGT--LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQH--------YSHKGY--LSEG-LVTKWYRSPRLL
  |      |  ..   |..|  .|  |.|| |. ||||   |. .. .  . ||.||||.| .. .        | .|     . . |  .|. .|  .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI

LSPNNYTKAIDMWAAGCILAEMLT-GRMLFAGA----HELEQMQLILETI--PVIREE--------DKDELLRVM-----------PSFVSSTWEV
   . .| . | |. |  . |..| | .   |      . ...   ...   . . ..          ||. ..|           |.|     . 
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Erk4.AA p38 271-312 42 2e-10 31.54 In-house 248-289 (289) Show / Hide 
Range on Protein: 271-312
Range on HMM: 248-289/289
Sequence Identity: 42% (18 aa)

KRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
.| ....... |  ||| |||.|   |  |.|||  .||||.
RRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk4.AA CDK 278-312 42 7e-10 27.62 In-house 255-284 (284) Show / Hide 
Range on Protein: 278-312
Range on HMM: 255-284/284
Sequence Identity: 42% (15 aa)

LPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
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LPDY-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Erk4.AA MAPK-Unclassified 282-312 54 3.6e-09 28.78 In-house 545-575 (575) Show / Hide 
Range on Protein: 282-312
Range on HMM: 545-575/575
Sequence Identity: 54% (17 aa)

NSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
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NCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk4.AA Pkinase_Tyr 102-183 35 3.4e-07 24.97 Pfam 83-172 (270) Show / Hide 
Range on Protein: 102-183
Range on HMM: 83-172/270
Sequence Identity: 35% (32 aa)

YIVQEYMET-DLARLLEQG-----TLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIV--DQHY-SHKG
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YIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYYYRKRG
Kinase Erk4.AA Pkinase_Tyr 39-81 29 0.015635 9.2 Pfam 24-70 (270) Show / Hide 
Range on Protein: 39-81
Range on HMM: 24-70/270
Sequence Identity: 29% (14 aa)

DSRACRKVAVKKI-ALSDARS--MKHALREIKIIRRL-DHDNIVKVY
..  . .||||..   .. .   ..  .||.|| . | .|.|||. |
PDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY