Gene FRAP (Human)

FRAP

Species: Human
Alias: RAFT1, FLJ44809, FRAP, FRAP1, FRAP2, Hs.FRAP1, MTOR, RAPT1, Hs.155952
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p36.22-p36.3,

Classification

Group: Atypical
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
FRAP.NA RNA Sugen Kinome 8733 None Fasta, JSON
FRAP.AA Protein Sugen Kinome 2549 None Fasta, JSON
FRAP.kin_dom Protein Kinase Domain None 337 None Fasta, JSON

Protein domain

Protein domains of FRAP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF3385 FRAP.AA DUF3385 854-1024 50 8.9e-90 309.36 Pfam 1-181 (181) Show / Hide 
Range on Protein: 854-1024
Range on HMM: 1-181/181
Sequence Identity: 50% (92 aa)

VVEPYRKYPTLLEVLLNFLKTE-QNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLP--LDEFYPAV
|..|| .|| ||.||.|.|||| ||. .|||.|...| ||||||||||.|  .|... |...... . ...|.... .|..||...|. |  .||.||.|
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMN--EIERHSDKHHIKF-RDDQHQNQNNPCTDIMLMMQGYSPLSNDEYYPTV

SMVALMR-IFRDQSLSHHHT-MVVQAI----TFIF--KSLGLKC-VQFLPQVMPTFLNVIRVCDG-AIREFLFQQLGMLVSFVK
 ...||| | .|.|||.||| ||||||    ..||  |..|||| |.||||..|.||.|.| |.   .|||.||||..|||.||
VINSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK
FAT FRAP.AA FAT 1513-1908 34 4.3e-163 546.31 Pfam 1-408 (408) Show / Hide 
Range on Protein: 1513-1908
Range on HMM: 1-408/408
Sequence Identity: 34% (163 aa)

ARMAAAAAWGLGQWDS--MEEYTCMIP------------RDTH-----DGAFYRAVLAL--HQDLFS--LAQQCIDKARDLLDAELTA-MAGESYSRAYG
|..||.|||.|||||.  |.||.....            .|.      |..|..|.|.|  |.. |.   |...|||||.||| |.|| ..|||| |.|.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

AMVSCHMLSELEEVIQYK-LV-----------PERREIIRQIWWERLQGC-QRIVEDWQKILMVRSLVVS--------------PHEDMRTWLKYASLCG
.||...||.||||.||||              ||.....|| ||.||.|| || ||.|| ||..|..|.|              |||||..|.|.|.|| 
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCR

KSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQ-TMQQQAQHAIATEDQQH------------KQELHKLMA
|.||. |..|||. |...|||.. .||  . .||.||||.| ||.. ....||||.. |.. .||...... . | ..             ...  ||.|
KHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLA

-RCFLKLGEWQLNL------QGINESTIPKVLQYYSAATEHDRSWYK-AWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATT
 ||..|.|.|| .|      .  |. ... .||.|..||..|..||| |||.||..|||.. ||..|.|.  ..                          
MRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN--------------------------

TASTEGSNSESEAESTENSPTPSPLQKKVTEDLS-KTLLMYTVPAVQGFFRSISLSRG-NNLQDTLRVLT
                                 .    . . ||||..||.||.|| | |..|||||.|.
---------------------------------YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Rapamycin_bind FRAP.AA Rapamycin_bind 2015-2114 68 2.1e-76 243.17 Pfam 1-100 (100) Show / Hide 
Range on Protein: 2015-2114
Range on HMM: 1-100/100
Sequence Identity: 68% (68 aa)

ELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ
||||||||||||||||||||||.|||..|...||..|||||.|.|.||.|..|.|| |..|||| ||.|||.|| ..|....| ||||.||.|||||.||
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase FRAP.AA FRAP 2181-2431 75 1.4e-212 712.53 In-house 1-251 (251) Show / Hide 
Range on Protein: 2181-2431
Range on HMM: 1-251/251
Sequence Identity: 75% (190 aa)

EFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
|..||||||||.||||||||||||.|.||.|.|....||||||||..||||.|.||||||.||||||.||||||.|..|..|||..||.||..|||||.|
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL

MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLT
|.|||.|....|||.|.||.||||||||.||.||.||||||||||.|||.|||||||||||||.||.|..|||.||||||||||||.|||||||||||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRL
|||.||||..|..||||.||..||.|.||||.||||||||||||||..|||
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase FRAP.AA PIKK 2152-2421 45 9.60000000001e-167 560.24 In-house 1-290 (290) Show / Hide 
Range on Protein: 2152-2421
Range on HMM: 1-290/290
Sequence Identity: 45% (132 aa)

RIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIR
||........|...||.|.|....|..|.|...|.|||||||||.||||||.|.||.|..||.. ...|.|..|.|||.|...|||.||..|.||.....
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DYREKKKILLNIE--------------------HRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVG
....||.|. ..|                    ...|......|.|..|..|||||.....||..|...|..|.|.|..| |..||.|||||.|||.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAF
||||||||||.|.|.|...|.|.|||||.|||.||.|...|||.||||||...|||...|..|..| .|..||...|.|....|.|.|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase FRAP.AA PI3Kc 2183-2484 29 3.5e-123 416.47 SMART 1-336 (336) Show / Hide 
Range on Protein: 2183-2484
Range on HMM: 1-336/336
Sequence Identity: 29% (100 aa)

VFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRM-----------
 ...|...|||||.|.||.|.|.|.....|  . | .| ...|..||.. ..|.|.|||.|.||| . . |...||. .......|..|           
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------APDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSS-EVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGD
          ...|.|.|.|.....||.|.... ...|.. .| ..|.. |.|...|.|.|||.|...||.||||.||||..|.|||. .|...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVAMTREKFP----EKIPFRLTRMLTNAME----VTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPL-LNWRLMDTNTKGNKRSRTRTDSYSA
.|. ......|.    |. |||||... ..|.    ..|..|..| .|.......|.|....|...|..||||.  .|| |  ... . |.| | |..| 
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD

GQSVEILDG----VELGEPAHKKTGTTVPESIHSFIG
 .. .  .       ... .. .| ... .  .   .
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase FRAP.AA PI3_PI4_kinase 2181-2431 34 6.1e-113 386.31 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2181-2431
Range on HMM: 1-300/300
Sequence Identity: 34% (104 aa)

EFVFLLKGHEDLR--QDERVMQLF-----------------------GLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYRE
.  |..||..|||  ||.|.||..                       .|.|... .|  ..|.|...| | .||.....|.|.|||.|.|.| ..| |..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

KKK-ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSS-EVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLML--DRLSG
|.| . .|.||. ...|.||..||..||||||||.. ..| ...| ...| ..|.  | |...|.|..||.|.|..|.||||.||||..|.|.  |. .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

KILHIDFGDCFE-VAMTREKFPEKIPFRLTR------MLTNAM------EVTGLDGNYRITCHTVMEVLREHKDSVMAVL-------EAFVYDPLLNWRL
.. |||||.||. ..| ....||..|||.|.      .. .||      ...| .| .| .|......||.|....|..|       |..|.|.|..|| 
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase FRAP.AA ATR 2152-2421 31 2.8e-55 186.67 In-house 2-267 (267) Show / Hide 
Range on Protein: 2152-2421
Range on HMM: 2-267/267
Sequence Identity: 31% (85 aa)

RIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIR
 |  .   .....| |.|.|..| ||.|. .. . | ..|||.| | |.   |.| ..  |  . |. . .. ||||||  ....| ||    ||.... 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

D-YREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLS
  ..|||.     .    ||.  |     . .|  ||   .              . | .. |.  | || || ||..|||||.||||||  |...|.. 
KLWKEKKQYMQFYQ----LRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAF
| . |.|.   |    . |  || .|||||. . ..|   . .| .|  |  .| ..|.|.| .|.|...|
GECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase FRAP.AA ATM 2312-2429 44 2.6e-37 116.48 In-house 132-248 (304) Show / Hide 
Range on Protein: 2312-2429
Range on HMM: 132-248/304
Sequence Identity: 44% (52 aa)

VWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHK
.||..|  |||| |  |.|||||||||||  |...   |  . ||| |  ||        || .|||||| .   | .|| .| .|  |   |||.|  .
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

DSVMAVLEAFVYDPLLNW
. .. . |  .||||  |
ETLLTIVEVLLYDPLFDW
Kinase FRAP.AA SMG1 2160-2240 40 2.7e-19 60.45 In-house 1-81 (242) Show / Hide 
Range on Protein: 2160-2240
Range on HMM: 1-81/242
Sequence Identity: 40% (33 aa)

LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWV
. ..  | .|.||  .|| |  . .| || |||  |||.||   .|||. |              |.| || | |||| ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV
Kinase FRAP.AA DNAPK 2151-2240 36 1.7e-18 63.8 In-house 2-91 (301) Show / Hide 
Range on Protein: 2151-2240
Range on HMM: 2-91/301
Sequence Identity: 36% (33 aa)

IRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWV
.||        |. |  ||... . |    |  |. || |||||| |. |||   |  .. ||    . |    | .||.    ||| ||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV
Kinase FRAP.AA SMG1 2286-2363 46 1.9e-18 57.62 In-house 156-233 (242) Show / Hide 
Range on Protein: 2286-2363
Range on HMM: 156-233/242
Sequence Identity: 46% (36 aa)

VFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFE
| |  .  |  . ||| ||      . |.     | || |||||||||.||||||  | ..|   | . |||.  |||
VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase FRAP.AA DNAPK 2307-2431 32 1e-16 57.22 In-house 177-301 (301) Show / Hide 
Range on Protein: 2307-2431
Range on HMM: 177-301/301
Sequence Identity: 32% (40 aa)

SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEV
| . | .   |  . |. ||    ..||| ||||  | |     | |  ||||  |  |      ||  ||||||  .| |   .  | ..      |  
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LREHKDSVMAVLEAFVYDPLLNWRL
.|  .   .   . |. ||.. |  
FRKDRNILTNFCDVFINDPSFDWKN
Kinase FRAP.AA ATM 2185-2239 43 1e-12 36.52 In-house 3-57 (304) Show / Hide 
Range on Protein: 2185-2239
Range on HMM: 3-57/304
Sequence Identity: 43% (24 aa)

LLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGW
| || .|||||  . | | . ||||       .. | |  | |.|||  || . |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
FATC FRAP.AA FATC 2517-2549 60 6.5e-22 73.24 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2517-2549
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

DTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
  |.|. ||. ||..||..|||||.||||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW