Gene GCK (Human)

GCK

Species: Human
Alias: GCK, MAP4K2, RAB8IP, BL44
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 11q12.3-q13,

Classification

Group: STE
Family: STE20
Subfamily: KHS

Sequence

Name Sequence Type Origin Length Description Download
GCK.NA RNA Sugen Kinome 2964 None Fasta, JSON
GCK.AA Protein Sugen Kinome 820 None Fasta, JSON
GCK.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of GCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GCK.AA KHS 16-273 77 4.8e-196 657.59 In-house 1-258 (258) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-258/258
Sequence Identity: 77% (200 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAY
.|||||||.|||||||||||....||||||..|..||||....||||.....|||||.|||.|||||.|.||||||.|||||||.|||.||||.|.||||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLF
||||.|.|||.|||.||.||||||||.||| ||||||||||||...||..|||.|||||||||||||||||||||||.|||.||.|||||||.|||||.|
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

HLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
.|||||||.||.||.||||||.||..|.|.||||.|.||||||||||||||||||||.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase GCK.AA STE20 16-273 47 8.20000000001e-159 533.9 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-288/288
Sequence Identity: 47% (137 aa)

FELLQRVGAGTYGDVYKARDTVTSEL----AAVKIVKLDPG----DDISSLQQEITILRECRHPNVVAYIGSYLRN----DRLWICMEFCGGGSLQEIYH
.|||...| |.||.||||... | |.    .|.|...|..     |.. ..|.|| |...|.|||.|.|.||||..    | |||.||.||||||..|..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ATG------PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTA----SVA-KRRSFIGTPYWMAPEVAAVER--
    .|      |..| ||||.|||.|.||..|||...||||||..| ||| .|.||||||||.. ||     . . || .|.|||||||||| . ..  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRD--KTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
..||.. ||.|.|||||||. | .||.| .|||||.... |.. .||.|.|  ...|...||.|... |.|.|.|||||..||.||| 
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GCK.AA STE 16-273 33 9.80000000001e-130 437.31 In-house 1-359 (359) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-359/359
Sequence Identity: 33% (121 aa)

FELLQRVGAGTYGDVYKARDT------VTSEL---------AAVKIVKLDPG-----------------DDISSLQQEITILRECR--HPNVVAYIGSYL
.|.....| |..| ||||..        | |.          |.|...|..                  ... ....|| |...|.  |||.| |.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RN-------DRLWICMEFCGGGSLQEIYHAT--------------GPLEERQIAYVCREALKG-LHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSG
..       | ||||||...|||| .|.. .              ....| ||||.||. ||| |..|||...||||||.|| ||     |||.||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ELTASVA----------------KRRSFIGTPYWMAPEVAAVER---KGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSS----------
 || |.|                || .|.||| ||||||   ..   ..||.. ||.| ||.|.||. . .||.. .|||||.... ...          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---FQPPKLRD-----------------KTRWTQNFHHFLKLALTKNPKKRPTAEKLLQ--HPFT
   ..||.| |                 ...|...|..|... |.|.|.|||||..||.  ||| 
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GCK.AA YSK 16-273 45 9.69999999999e-120 362.3 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-257/257
Sequence Identity: 45% (118 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPG-DDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHAT--GPLEERQ
|  . ..| | .|.|||. | .| .  |.||. |.   |.|  .||||..| .|  |..  |.||||.   ||| ||.|||||.     .   |...| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERK-GGYNELCDVWALGITAIELGELQ
|| . || ||||  |||. ||||||| || ||. .|||||.||||.| .| .. ||  |.||||||||||  .     .|..  |.| |||||.|.   .
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEV--ICQEVSYYDFKADIWSLGITAYEMAKGE

PPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
||.  .||||.. |  |.  .|||| ... .. .|  |  . | |.|..||.|. || | | 
PPYCDYHPMRVMFLIPKN--NPPKLEGRS-YSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase GCK.AA MST 16-273 45 3.9e-113 360.96 In-house 1-254 (254) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-254/254
Sequence Identity: 45% (119 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYL--RNDRLWICMEFCGGGSLQEIYHATG-PLEERQ
|... . | | || |||| .  |... |.|.|. .   |....  ||.|. .|  ...| | |||.   |  .||.||.||.||.  |  .|. .| | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN--EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQP
|| ... .|.||  ||.  ||||||| .| ||   |  |||||||||.||   ||| ..|||||||||||     . .|.   | |.|||||||. |  |
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVI---QEIKYDCKADIWSLGITAIEMAEGMP

PLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
|.. .|||||. .  ..   ||...| ..| |.|  |..  |.||| .|.||| |||||| 
PYSDIHPMRAMFMIPQKP--PPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase GCK.AA PAKA 16-273 39 1e-94 321.0 In-house 1-260 (260) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-260/260
Sequence Identity: 39% (106 aa)

FELLQRVGAGTYGDVYKARDTVTSEL--AAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-----PL
.. .. .| |  | ||.| .. | .    |.|  ...  . .  .  || ...||.|.|.| || ||| .| ||. ||. .||.| ..  ..      ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

EERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELG
.|.|||||||| |.||. .||.. ||||||  | ||  .|.||..|||   .|| .  || .  ||||||||||  . ||  |.|  |.| ||| |||. 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEV--IRRK-QYDEKVDIWSLGIMAIEMI

ELQPPLFHLHPMRALMLMSKSSFQ-PPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
| .||     | ||. | ..   .  |...|...|.|.|. ||.. | .....|..|..||.||| 
EGEPPYLNEPPLRAMYLIAT---NGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase GCK.AA S_TKc 16-273 29 6e-93 316.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGG--GSLQEIYHATGP------
.|.|. .| |..| |||.|.. | .. |.||.|        ....|| ||.. .|||.| .....   |.|...||.|.|  |.| .. .  |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNE-LCDVWALGITAIE
. | ........ ...| ..||.| ||||.| .|.||.    .|..|||.. .|       ..|.|||..|||||       ||.   ||.|..|.. .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYE

LGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQ-------HPFT
.   .||    .... . ..                .. . .|..  |.|.|.||||| ..||       ||. 
MLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GCK.AA SLK 16-273 41 1.5e-91 309.17 In-house 1-259 (259) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-259/259
Sequence Identity: 41% (108 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG-PLEERQIA
.|..  .| | .| ||||..  .. .|| |..... .....    || || || |||.|  ...|  ...||. .|||.|| . .|    . ||.| ||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE--RKGGYNELCDVWALGITAIELGELQP
|||.. . .|..|||.  ||||.|  |.|.|..|||.|||||||  ..  . || .|||||||||||| . |  .   |    |.|.|||| ||. .. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
|   . ||| |. . ||  .||.|    .|...|. ||| .| |.|..|.|...|.||.. 
PHHEMNPMRVLLKIQKS--EPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase GCK.AA MSN 16-273 46 2.7e-90 298.34 In-house 1-265 (265) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-265/265
Sequence Identity: 46% (125 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE-CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--G
||| . || |||| ||| | . |..|||.|....   |.   ..||| .|.    | |...| | ...      ...||. ||||| ||. .. . |   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVR-EDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVER--KGGYNELCDVWALGITA
 | |  |||.||| |.|| |||..  ||||||| | ||| . .||| |||||  |   | .| .|||||||||||| | .   .  |    |.|..||||
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
||. | ||||  .||||||.|. . .  ||||.   .|.. ||.|.   | || ..||..|..|.||| 
IEMAEGQPPLCDMHPMRALFLIPRNP--PPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase GCK.AA NinaC 16-273 42 1.6e-82 280.49 In-house 1-267 (267) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-267/267
Sequence Identity: 42% (114 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDI-SSLQQEITILRE-CRHPNVVAYIGSYLRNDR-----LWICMEFCGGGSLQEI----YHA
.|    .| |||| |.|. .    ..|||||  ... .|.  .   |  |||. | ||||| . | | . |.     ||. ||.| |||  ..       
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKI--QHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKC

TGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE--RKGGYNELCDVWALGI
   ..|  |||. .||. || |||.   ||||.|| | |||  | ||| |||||  |.    .|   .|||.|||||| | .  .   |   ||||.|||
GRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGI

TAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
||||||   ||.. .|||||.         ||.|.  . | | | .|    |.|.  |||.   .|.||| 
TAIELGDGDPPFADMHPMRAMFKIPRNP--PPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase GCK.AA PAKL 16-273 40 2.9e-79 269.62 In-house 1-256 (256) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-256/256
Sequence Identity: 40% (107 aa)

FELLQRVGAGTYGDVYKA--RDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRN-DRLWICMEFCGGGSLQEIYHATG-PLEER
||.    | | || ||||  .|| ..   |.|   . .  .| ... || ||  |. ||.| | ||     . .|| |..|  ||   .   ..  |.| 
FEFQEKLGQGSYGSVYKAIHKDTNFP--LAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEK

QIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVA-KRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGEL
||. . . .||||| |||.. |||||| || ||.  ..||.||||||  |  .      . ||||||||||.     |  ||  ||.| |||||||. . 
QISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII---NKQNYNNKCDIWSLGITAIEMADG

QPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
 ||.  . ||||..        ||.. .   |   |  ||   ..| | ||. .  || ||| 
FPPHYDMPPMRAMYMIPNWP--PPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase GCK.AA Pkinase 16-273 27 1.9e-72 251.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ-----EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGG----SLQEIYH--A
.......|.|..| |||...  |... ||||.|.. ... . .|.     || |.....|||.| ..... ..|.....||.|.||    .| .. .  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

TGPL--EERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDV----KLADFGVSGEL-TASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDV
 |..  .|...  .... |.|| ..||.| ||||.| .|.|.  .|..    |..|||..  . . .     .| |||..|||||  .    .|   .|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDM

WALGITAIELGELQPPLFHL--------HPMRALMLMSKSSFQPPKLRDKT--------------RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFT
|..|.. .|.   .||  .           | .. .. . .|. |.....               .|.... .|.|  |.|.|||||||| .||||. 
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GCK.AA Pkinase_Tyr 16-158 26 3.1e-23 79.3 Pfam 1-158 (270) Show / Hide 
Range on Protein: 16-158
Range on HMM: 1-158/270
Sequence Identity: 26% (42 aa)

FELLQRVGAGTYGDVYKARDT----VTSELAAVKIVKLDPGDD---ISSLQQEITILREC-RHPNVVAYIGSYL-RNDR--LWICMEFCGGGSLQEIYHA
 ....  |.| .|.|||.. .     |    |||..| .  ..   . .. .|. |...  .|||.| ..|  . . .   ..| ||.. .|.| .  ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVS
     .||   ..   |..  ||. .|.|.. ||||.   | |.| .. || .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase GCK.AA TyrKc 16-277 22 2.3e-18 68.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-277
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILREC--RHPNVVAYIGSYLRN-------DRLWICMEFCGGGSLQEIYHATG
 .|..  | | .| |||.. .   .  ||| .| |    .  . .|. |...   .|||.|. .|  .         . |.| ||.. .|.|..  ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

P-LEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTAS-------VAKRRSF-IGTP-----YWMAPEVAAVERKGGYN
| |  ..  . |  . .|  .|||.. ||||.   | |.. .. || .||| | ...           .| .   |.       |||||.    ..| ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT

ELCDVWALGIT---AIELGELQPPL-----FHLHPMRALMLMSKSSFQPPK-----LRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQL
.  |||. |..      .|.  .|           ....    .   |||           . ..  .   |     .|..||| . .       ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase GCK.AA Pkinase_Tyr 177-203 33 0.030235 8.23 Pfam 180-203 (270) Show / Hide 
Range on Protein: 177-203
Range on HMM: 180-203/270
Sequence Identity: 33% (9 aa)

WMAPEVAAVERKGGYNELCDVWALGIT
|||||. .  .   ...  |||. |..
WMAPECINYGK---FTTKSDVWSFGVL
CNH GCK.AA CNH 487-800 28 2.3e-133 450.27 SMART 1-375 (375) Show / Hide 
Range on Protein: 487-800
Range on HMM: 1-375/375
Sequence Identity: 28% (108 aa)

AAVTWIHPVTRDQ----FLVVGAEEGIYTLNLHEL----HEDTLEKLISHR---CSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTN
....|.||.|.||    .|.||.|.|||.||....    ||.|.|.....|   |.|.|..||.|...|||..|...|.|..||...|.|...|. |...
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPH-IQDH

RLTQRIIPRRFALSTKIPDTKG-CLQCRV-VRNPYTGATFLLAALPTSLLLL-QWYEPLQKFLLLK--------------NFSSPLPSPAGMLEPLVLDG
. .....||.....|||||||| |..|.| .....||..|| .|...|  .. |||.|..||...|              .|..|...|. ...... |.
MCNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDS

KELPQVCVGAEG---PEGPGCRVLFH-------------VLPLEAGLTPDILIPPEGIPG--SAQQVIQVDR------DTILVSFERCVRIVNMQG-EPT
.|.|..|.|...   .......|..|             ......  ... .........  ...||.||..      |..|.........||..| |..
FERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWR

ATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEV-TQEITDE----TRIFRVLG----AHRDIILESIP
 ...|.|...|..|..........|||..|.|.|...|.|. ||.|.|.    .|.||.|.     .|.|...|.|
RWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH GCK.AA CNH 492-790 23 2.8e-94 324.33 Pfam 1-336 (336) Show / Hide 
Range on Protein: 492-790
Range on HMM: 1-336/336
Sequence Identity: 23% (82 aa)

IHPVTRDQFLVVG-AEEGIYTLNL----HELHEDTLEKLISHRCSWLYCVN--NVLLSL--SGKSTHIWAHDLPGLFEQR--RLQQQVPLSIPTNRLTQR
..|.|..| | || ..||.|..|.    ...|. ......|.|....|...  |.|...  ..|. |...|.|  |.. .  . |.. | ...|.|. .|
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-ER

IIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPT-----SLLLLQWYEPLQKF-------------LLLKN-FSSPLPSPA-GMLEPLVLDGKE
|.||.||...|.||||.| .....||.|.. ..| .|...     ......||.|..||              ...  |. ||| |   ... ..|. .|
IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLP-PMTECFSMHWLP-QE

LPQVCVGAEGPEGPGCRVLFHVLPLE-AGLTPDILIPPEGI----------PGSAQQVIQVDRD-TILVSFERCVRIVNMQGE-PTATLAPELTFDFPIE
 |..|||         .. ||...|.  | . ....|                 . .......| ..|.....|. .||.||. .. ..  |..... ..
KPKLCVGC--------QKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQ

TVVCLQDSVLAFWSHGMQGRSLDTN-EV---TQEITDETRIFRVLGA
...|.....|||.......|...|. |.   .|.|..... |...|.
SFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS