Gene HPK1 (Human)

HPK1

Species: Human
Alias: MAP4K1, Hs.86575, HPK1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13.1,

Classification

Group: STE
Family: STE20
Subfamily: KHS

Sequence

Name Sequence Type Origin Length Description Download
HPK1.NA RNA Sugen Kinome 2786 None Fasta, JSON
HPK1.AA Protein Sugen Kinome 833 None Fasta, JSON
HPK1.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of HPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HPK1.AA KHS 17-274 70 2.8e-191 641.73 In-house 1-258 (258) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-258/258
Sequence Identity: 70% (183 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISY
|.||||.|.||||.|.||||..|..|.|.|..||||.||....|.||...|.|||.|||||.||||. .|||||||.||.|||||||.|||.||||||.|
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF
||||.||||.||||..|.||||||||||..|.|.|.|||||.||||.||.|.| ||||||||||||||||. |||||.|||||..|||||||||||||.|
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

DVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
|.||.|.|||||||..|||.||.| |||..||.|.|..|||.|||||.|.|.|.|..|
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase HPK1.AA STE20 17-274 47 1.1e-153 516.82 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-288/288
Sequence Identity: 47% (138 aa)

YDLLQRLGGGTYGEVFKARDKVSGDL----VALKMVKMEPD----DDVSTLQKEILILKTCRHANIVAYHGSYLWL----QKLWICMEFCGAGSLQDIYQ
|.||...| |.||.|.||..| .|..    || |....|..    |.. ..||||.|.| |.| |||.|.||||      ..|||.||.||.|||.||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---VTG------SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGA----TLA-RRLSFIGTPYWMAPEVAAVAL--
   ..|      ...| ||.|.||||||||.||||...||||||..|||... ||| ||||| .||.      | . .| .|.|||||||||| .     
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKE--KGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
..||.. ||||||||||||.|| .||.||.||.|..|...|.. .||.||.  . |||  ||.|... |.| |.|||.|...|.|. .
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase HPK1.AA STE 17-274 31 1.3e-122 413.65 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-359/359
Sequence Identity: 31% (114 aa)

YDLLQRLGGGTYGEVFKARDKV---------------SGDLVALKMVKMEPD-----------------DDVSTLQKEILILKTCR--HANIVAYHGSYL
.......| |..|.|.||...                .|...| | ...|..                 ...  ..||| |.| |.  | ||| |.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

WL-------QKLWICMEFCGAGSLQDIYQ---VTGS-----------LSELQISYVCREVLQG-LAYLHSQKKIHRDIKGANILINDAGEVRLADFGISA
         ..||||||....||| ||..    .|            ..| ||.|.||..|.| |.||||...||||||.||||.     | |.|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QIGATLA----------------RRLSFIGTPYWMAPEVAAVAL---KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG----------
|.  ..|                .| .|.||| ||||||        ..||.. |||||||.|.||.|. .||..| ||.|..|......          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---YQPPRLKE-----------------KGKWSAAFHNFIKVTLTKSPKKRPSATKMLS--HQLV
    .||.|..                 . |||  |..||.  |.| |.|||.|...|.  |  .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase HPK1.AA MST 17-274 45 1.2e-117 375.49 In-house 1-254 (254) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-254/254
Sequence Identity: 45% (120 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYL--WLQKLWICMEFCGAGSLQDIYQVTG-SLSELQ
.|.. .|| | || |.|| .| .| .|| |||.   . | . . ||| |.. |   .|| | |||.    . .||.||.||.||. ||   |.  |.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP
|. ... .||||.|||. |||||||| .|||.|  ||  ||||| |.|   | | | ..|||||||||||     . .|.   |||||||||||.||  |
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ---EIKYDCKADIWSLGITAIEMAEGMP

PLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
|..|.|| |..|.  ..   || .|.  .||  | .|..  |.|.| .|..|.  |.|  .
PYSDIHPMRAMFMIPQKP--PPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase HPK1.AA YSK 17-274 44 1.6e-113 343.23 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-257/257
Sequence Identity: 44% (115 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT--GSLSELQ
.  . . | | .|||.|. |.. .  || | .  |  .|..  .|.|| .|  |   .|  | ||||   |||| ||.|| ||. |       |.. | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP
|. . ||.|.|| ||||..||||||| ||.|..  |.| |.|||...||  |  .|  |.||||||||||    .  .|..  |||||||||.|.|  .|
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV-SYYDFKADIWSLGITAYEMAKGEP

PLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
|. |.||.||.||  |.  .||.| |. ..| .| .|. . | | |..||||   |.|. .
PYCDYHPMRVMFLIPKN--NPPKL-EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase HPK1.AA PAKA 17-274 39 3.5e-92 312.56 In-house 1-260 (260) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-260/260
Sequence Identity: 39% (105 aa)

YDLLQRLGGGTYGEVFKARDKVSGDL--VALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGS-----L
|. .. .| |  |||..| ..  ..   || |  .|. ..   ..  |||..|.|.| ||| |  |||   .||. ||. ..|.| |. . . .     .
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELA
.| ||.|||||.|||| ..||.. ||||||  |||..  |.| ..|||  ||.     .| .  |||||||||   | ..  |.|  ||||||| |||..
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPE---VIRRKQYDEKVDIWSLGIMAIEMI

ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
| .||  .  ||| ..| .. |   | .|.. |||  |..| .  | . ...|.||.. |.|   
EGEPPYLNEPPLRAMYLIATNGK--PDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase HPK1.AA MSN 17-274 46 4.6e-90 297.6 In-house 1-265 (265) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-265/265
Sequence Identity: 46% (126 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL-KTCRHANIVAYHGSYLWL------QKLWICMEFCGAGSLQDIYQVT--G
..| . .| ||||.|.| | .  | |.|.|..... .|.   ...|| .| |   | ||..|.| .. .      ..||. ||||||||. |. . |   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVR-EDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV--ALKGGYNELCDIWSLGITA
|| |  | |.|||.|.|||.||..| ||||||| |.|. .  ||.| |||.|||.  |  || .|||||||||||| |     .  |    |.||.||||
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
||.|| |||| |.||.| |||. .    ||.|| | |||  ||||.   | |  ..||.. .|| |  .
IEMAEGQPPLCDMHPMRALFLIPRN--PPPKLKSK-KWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase HPK1.AA PAKL 17-274 40 2e-87 296.73 In-house 1-256 (256) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-256/256
Sequence Identity: 40% (105 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWL-QKLWICMEFCGAGSLQDIYQVTG-SLSELQI
. .   || | || |.||  | ..   | |   . .  ..  ..||| ||| |.  ||| | ||      ..|| |..| .||  |. .... .| | ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

SYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLA-RRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP
| . . .| || ||||.  |||||| ||||.|  . | .||||.| |.  ..     . ||||||||||   . .|  ||  ||||||||||||.|.  |
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPE---IINKQNYNNKCDIWSLGITAIEMADGFP

PLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
|. |. | | .         || ...  .||  | .|.   ..| | ||.|.   |.|   
PHYDMPPMRAMYMIPNWP--PPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase HPK1.AA S_TKc 17-274 28 4.8e-87 296.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGA--GSLQDIYQVTGS------
|..|. .| |..|.|.|.|.| .| .||.|..|        ....|| |||  .| ||| .....   ..|...||.|.   |.| |. .  |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNE-LCDIWSLGITAIE
..| .. .........|.|.||.. ||||.| .|||...  .. ..|||...|.        .|.|||..|||||       ||.   ||.||.|.. .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYE

LAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLS-------HQLV
..  .||    .. ... ..                |  . .||.  |.| |.|||.| . |        |. .
MLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HPK1.AA SLK 17-274 41 6.3e-84 283.01 In-house 1-259 (259) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-259/259
Sequence Identity: 41% (108 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQIS
....  || | .| | ||..|  . . | ||.... .....    || || .| | |||   ..| . .|||. .|||. | .  |   .  .| | || 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAA--VALKGGYNELCDIWSLGITAIELAELQP
|||......| .|||.| ||||.|  |||.   |.|||||||.||.   |. .| .|||||||||||| .        |    |||||||| ||.|.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
|  .. |.|||. . ||  .||.|..  .||  |..|.| .| | |..|... ... || |
PHHEMNPMRVLLKIQKS--EPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase HPK1.AA Ste20-DD1 17-274 41 4e-76 259.22 In-house 1-268 (268) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-268/268
Sequence Identity: 41% (113 aa)

YDLLQRLGGGTYGEVFKA-------RDKVSGDLVALKMVKMEPDD--DVSTLQKEILILK-TCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT
.  .   | | .| |          |. .   ..| | | |. ||  . | | ||| ||| | .   || ||| |.    | | ||.|  ||. || |  
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

G-SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV-ALKGGYNELCDIWSLGIT
.  | | ||  .|  . .|| ||||.. .|||||  |.|.|  |  .|||||.|. .  .  .    || ||||.||.        ||    ||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

AIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
|||.||. ||.|.| | || |       ||| ||  . ||  |  |||. | . | |||||  .|.|  .
AIEMAESKPPRFNVNPVRVIFVIPH--QQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase HPK1.AA Pkinase 17-274 27 2.7e-68 237.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK-----EILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAG----SLQDIYQ--V
| .....| |..|.|.|...| .|..||.| .| . ... . .|      || |.| ..| ||| .....   ......||.|. |    .| |. .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

TGSL--SELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEV----RLADFGISAQI-GATLARRLSFIGTPYWMAPEVAAVALK--GGYNELC
 |..  || ..  .....|.||.|.||.. ||||.| .||||.. |..    ...|||...|.         .| |||..|||||    ..   .|   .
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IRGGQYYGPKV

DIWSLGITAIELAELQPPLFDV----HPLRVLFLMTKSGYQPPRLKEKGK-------------------WSAAFHNFIKVTLTKSPKKRPSATKMLSHQL
|.||.|.. .|..  .||  .     . .. .... . .. |..  .  .                   || ..  |||  |.| |||||.|.  | |  
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

V
.
F
Kinase HPK1.AA Pkinase_Tyr 17-159 27 3.2e-23 79.28 Pfam 1-158 (270) Show / Hide 
Range on Protein: 17-159
Range on HMM: 1-158/270
Sequence Identity: 27% (43 aa)

YDLLQRLGGGTYGEVFKARDK----VSGDLVALKMVKMEPDDD---VSTLQKEILILKTC-RHANIVAYHGSYL-WLQK--LWICMEFCGAGSLQDIYQV
  ... || | .|||.|.. |      .  || ||.|   ...      . .|. |.|.  .| ||| ..|  .   .   ..| ||..  |.| |  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGIS
     ..|.  ..   |... .|..||.|.. ||||.   |.|... . |. .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase HPK1.AA TyrKc 17-273 23 5.4e-17 52.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-273
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTC--RHANIVAYHGSYLWL-------QKLWICMEFCGAGSLQDIYQVTG
  |.. || | .|||.|.. |     || ||.| .    .  . .|. |..    .| |||. .|  .         . |.| ||..  |.|.|  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

S-LSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAT--------LARRLSFIGTP-----YWMAPEVAAVALKGGYN
  |.  .  . |  . .| .||||.. ||||.   |.|... . |. .||| |  |.            |  .  |.       |||||.     .| ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT

ELCDIWSLGITAIELAEL-QPPLFDV----HPLRVLFLMTKSGYQPPRLKE--------KGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQL
.  |.|| |..  |.  . |.|  ..     . . ..   |.|| .|. ..            ... .. .|      |..||. .    ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCC---PDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase HPK1.AA Pkinase_Tyr 178-236 24 0.034875 8.02 Pfam 180-237 (270) Show / Hide 
Range on Protein: 178-236
Range on HMM: 180-237/270
Sequence Identity: 24% (15 aa)

WMAPEVAAVALKGGYNELCDIWSLGITAIELAEL-QPP-LFDVHPLRVLFLMTKSGYQPPR
|||||. .      ...  |.|| |..  |.  . . |   .. . .|. . ...||. |.
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
CNH HPK1.AA CNH 500-807 31 7.1e-130 438.69 SMART 1-375 (375) Show / Hide 
Range on Protein: 500-807
Range on HMM: 1-375/375
Sequence Identity: 31% (118 aa)

STAAWTHPSTKDQ----HLLLGAEEGIFILNRNDQ-----EATLEMLFPSR---TTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPI--AHI
.|..|.|| |.||    .||.|.|.||..||.|.|     |.|.|.....|   ..|||..||.||..|||.||||||.. .|.....|....|.  .|.
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

SPHRLLARKNMVSTKIQDTKG-CRACCV-AEGASSGGPFLCGALETSVVLL-QWYQPMNKFLLVR--------------QVLFPLPTPLSVFALLTGPGS
..|.|..|||...|||.|||| |..||| ..|...| .|||.|...||... |||.||.||....              ...||...|..||.... ...
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

ELPAVCIGVSP----GRPGKSVLFH-------------TVRFGALSCWLGEMSTEHR----GPVQVTQVEE------DMVMVLMDGSVKLVTPEGSPVRG
|.|..|||...    ..... |..|             ||.. ..|.|. ...|.|.     |.||.||..      ||... .| ....|...||..| 
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

LRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQL-LQELRDP----TLTFRLLG----SPRLECSGTIS
 |.|........|..|.......|||..|.|.... .... .|...|.    . .||||.    ..|  .  ...
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH HPK1.AA CNH 505-797 21 4.9e-73 253.75 Pfam 1-336 (336) Show / Hide 
Range on Protein: 505-797
Range on HMM: 1-336/336
Sequence Identity: 21% (75 aa)

THPSTKDQHLLLG-AEEGIFILNR-----NDQEATLEMLFPSRTTWVYSIN--NVLMSL--SGKTPHLYSHSILGLLERKETR------AGNPIAHISPH
..| | .|.||.| ..||....|.     .  ..... .|. | |..| |.  |.|...  ..|..|||.|..  | .. ...      .  ....| ..
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-ER

RLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALET-----SVVLLQWYQPMNKF-------------LLVRQ-VLFPLPTPL-SVFALLTGPGS
 ...||.....|. |||.|  .|... . ..| .||.|...     ......||.||.||              ..|. . .||| |.  .| ..  | .
-IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLP-PMTECFSMHWLP-Q

ELPAVCIGVSPGRPGKSVLFHTVRFG--ALSCWL---GEMS--------TEHRGPVQVTQVEED-MVMVLMDGSVKLVTPEGS-PVRGLRTPEIPMTEAV
| | .|.|.       .. || |..   . ..||   .  |        .|.  |........| .... .|  ...|. .|  . |.  . ||   .. 
EKPKLCVGC-------QKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRK-HDWEIMWEGMP

EAVAMVGGQLQAFWKHGVQVWALGSD-QL---LQELRDPTLTFRLLGS
...|.....| ||........ . .  ..   .|........|...||
QSFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS