Gene ICK (Human)

ICK

Species: Human
Alias: ICK, KIAA0936, MGC43611, MGC131603, ROCK1, P160ROCK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards ,
Annotation: Consensus chromosomal location: 6p11.1-p12.2,

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
ICK.NA RNA Sugen Kinome 6238 None Fasta, JSON
ICK.AA Protein Sugen Kinome 632 None Fasta, JSON
ICK.kin_dom Protein Kinase Domain Sugen Kinome 281 None Fasta, JSON

Protein domain

Protein domains of ICK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ICK.AA MAK 4-284 63 3.8e-247 795.63 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 63% (224 aa)

YTTIRQLGDGTYGSVLLGRS------------------------------IESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANVVKLKEVIR--
|..|.||||||||.|.|...                              |..||..|||.||.||||||||||||||||||||| |.|.||||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENDHLYFIFEYMKENLYQLIKERNK-LFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGP-----------------ELVKIADFGLAREIRS
|||||||.||||||||||..|.|.. .|||..||||||||||||||.|||||||||.||||..||||                 ||.|||||||||||||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTD----------------WPEGYQLSSAMNF
|||||||||||||||||||||||.||||||.|||||||||.||.||||||.||||.|||||||||||||.|                ||.||||...|||
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

RWPQCVP---NNLKTLIPNASS-EAVQLLRDMLQWDPKKRPTASQALRYPYF
|.|||||   ..||.||||.|. .|..|..|||||||.|||||.|...||||
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase ICK.AA RCK 4-284 66 3.4e-240 770.33 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 66% (198 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANVVKLKEVIREND--HLYFIFEYMKENLYQLIKE---RNKLF
|..|.||||||||.|......|.||..||||||.|||||||||||||.|||.||| |.|..|||||||.||  .|||.||||..||||..|.   |.|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PESA--IRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG---------PELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAV
||.   |.|||||||||||..||||||||||||||..|.|         ....|||||||.||||||||||||||||||||||.|||.|.|.||.|.|||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF
||||.|.|.|||||||.|||| |||||.|.|||.|.|||.||.|.|.|||..|||....||.||||.|.....|...||||||.||.||.|||..|||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase ICK.AA CMGC 4-284 28 2.4e-139 461.06 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 28% (146 aa)

YTTIRQLGDGTYGSVLLGRS--------------IESGELIAIKKMKRKFYSWEEC----------MNLREVKSLKKLN-----------------HANV
|. |...| |||| |  .|               .|..|..||||.|..|| ....          . |||.| ||.||                 | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLKEVIREND-----------------HLYFIFEYMKENLYQLIKERN---------------------------KLFPESAIRNIMYQILQGLA--FI
|||..... ..                 |||..||||  .|||.||. .                           | |.  .|| .|||||.||.  ..
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HKHG--FFHRDLKPENLLCMGPELV--------------------KIADFGLAR--EIRSKP--------------------PYTDYVSTRWYRAPEVLL
|.|.  ..||||||||.|      .                    ||.||||||  ...|..                    |||.||.||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

RSTNYS---------SPIDVWAVGCIMAEVYT--------LRPLFPGASE-----------IDTIFKICQVLGTPK---------------KTDWPE---
....|.         .|||.|.||||.|| ||        ..||||| ||           || .|||..|||||                . .||.   
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

----------------------GYQLSSAMNFRWPQCVPNNLKTLIPN-----------------------------------ASSEAVQLLRDMLQWDP
                      ....   .|.| |.. |...| |.|.                                   ....|. ||  |||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KKRPTASQALRYPYF
.||.||.|||. |||
DKRITAEQALQHPYF
Kinase ICK.AA CDK 4-284 35 9.3e-113 362.12 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 35% (114 aa)

YTTIRQLGDGTYGSVLLGRSIESG-----ELIAIKKMK------RKFYSWEECMNLREVKSLKKLNHANVVKLKEVIREN-----------DHLYFIFEY
|  . ..| |||| |  .|. ..|     ...|.|| .      ..      .  .||.. ||.| |.|.|||..|.  .             ||..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPEL-----VKIADFGLAREIRS-------KPPYTDYVSTRWYRAPE
|   |.....          |...|.|.|.||...|.... |||||| |.| .         .|||||||||.  .         .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLRSTNYS--SPIDVWAVGCIMAEVYT---LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDM
.|| |..||   |||.|.||||.|| .|    .||||| |||| .|||....|||   .||.  .|                            .||  |
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LQWDPKKRPTASQALRYPYF
|. ||||| .|.|||  |||
LCYDPKKRISAEQALQHPYF
Kinase ICK.AA Pkinase 4-284 33 4.5e-112 383.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 33% (102 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLR---EVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKE-----NLYQLIK-ERN
|...|..| |..|.| ... . .|.. |.|..|..  ........|   |.. .|.||| |.|.|... ...||.|...||.        |. .|. .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KLF--PESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELV----KIADFGLARE--IRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAV
. |  .|  ....|||||.||...|..|. ||||||||.|.     .    ||.|||||.   . ... .|... |.||.||||.. .. |....|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMAEVYTLRPLFPGA----SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYP
|||..|... ||.|||.    . .| ...||...|.| . |||. .  |  . ||  .     ..|. .|.|.|. ......|..|||||||| |.|  |
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase ICK.AA CDC2 4-284 40 1e-105 325.92 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 40% (122 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE---CMNLREVKSLKKLN-HANVVKLKEVIRENDHLYFIFEYMKENLYQLIK---ERNKL
|. |. .| |||| |  ..  ......|.|| . .  . ..      .||   ||.|. | |.|||..|| .   || .|||.  .| .. .     || 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRS-KPPYT--DYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEV
.|.......|||||||..| | .. .|||||| |.|      .||||||||| .   . .||    | |.||||||.||..  || |.|.|..|||.|| 
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---YTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLS-SAMNFRWPQCVPNNLKTLIPN---------ASSEAVQLLRDMLQWDPKKRPTASQALR
    | .|||.| |||| .||| ..||||.  .||. .||    . |  |.  |..|....||         .  |...||. ||| || || .| .||.
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTF--PRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

YPYF
 |||
HPYF
Kinase ICK.AA S_TKc 4-284 33 3.4e-104 353.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 33% (100 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKE---NLYQLIKERNKL----
|. .|..| |..|.| ..| ...|.. |||..|        .. .||.. ||| .| |.|||..|... ||||...||.     .|...||.|..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSS-PIDVWAVGCIMAEVY
 |||  .| .||||...|...|.||. ||||||||.|.     .||.||||||..      | .. |.||.|||||     |.  ..|.|..|||..| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALR-------YPYF
. .|.||   .....||..                                        |.|| ...| .||.||.||||| .||.        |.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ICK.AA CDK7 4-284 35 2e-100 268.18 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 35% (103 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN------LREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLF
|..|...| |... | ...  ..|. .|||| | |  . .|         .||.| |. . | ||. |  ..   . .. .|..|   |   ||    ..
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIK-KLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIIL

PESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRS-KPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTL
  . | ..| ..|||| . |..   |||||| |||      .||||||||| . |    ||  | |||||||| |     | . .|.|.||||.||    
TPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

RPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR-WPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF
 | .|| |.|| . .|.| ||||   .||.  .. . . |. .|      |. .   || ... |.  |.  .| || |..|.|  |||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase ICK.AA MOK 4-284 40 4.3e-95 298.48 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-283/283
Sequence Identity: 40% (116 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANVVKLKEVI--RENDHLYFIFEYMKENLYQLIKERNKLFPES
| .| ..|.||.  |.  .|.  |.  | |.||..| | |.  ||||.. ...|| |.|...|.||.  |    |  | | |  |.| ||. |    |. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

AIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLF
 |.. |||... |  .|. | |||| ||||.|    . .|.||||  | . || |||.|.||||||||| ||    |.  .|.|.|||.  |.  |.|||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQ-DHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF
||. |.| | ||  |.|||...      . | |||. .|      .. |.||..  .....  |  .||  | || |... |||
PGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase ICK.AA MAPK 4-284 33 7e-84 284.98 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-328/328
Sequence Identity: 33% (111 aa)

YTTIRQLGDGTYGSVLLGRSIE------SGELIAIKKMKRKFYSWEECMN-LREVKSLKKL-NHANVVKLKEVIRE------NDH-----LYFIFEYMKE
|. ....| | || |   .  .      .|. .||||. | | .   |   .||.| |. . .| |..||.....       |..     .|...|.|  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYQLIKERNKLFPESAIRNIMYQILQG--LAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPY---------------TDYVSTRWYRA
.|.|.|| ..    .  |. .||||| |  | .||  .  ||||||.|.|.    ..||.|||||| | ..  .               |.||.||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLR--STNYSSPIDVWAVGCIMAEVYT-LRPLFPGASEIDTIFKICQVLGTPKKTDW---P-EGYQLSSAMNFR-WPQCVPNNLKTLIPN----ASS
||..|   ...|.  .|.|.||||.|| .|  .||||| . || ...| .|||||.. ..   .      .   ..   |.. . ......||    |..
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

EAVQLLRDMLQWDPKKRPTASQALRYPYF
.|. ||  ||..||.|| |. .||. |||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ICK.AA CDK5 4-284 36 9.1e-83 261.28 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-287/287
Sequence Identity: 36% (108 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE---CMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPES
|  .  .|.|||| |  .|  |..|..|.|.   .  |  |   .  .||.  || | | |.| |  ||  .  |  .||.. . |   . ..|      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV--RLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

AIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLARE----IRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVY-T
 |. .||| |.|||| |.|   |||||| |||       | |||||||     .|    |.  | | |||.| ||. |  || .||.| .|||.||.  .
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAM--NFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF
.||||||... |  ..| ...|||    ||   .|.        .|   ..  .. ..|. ...   ||  ||| .|..| .| .||. |||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase ICK.AA CDKL 4-218 42 4.4e-76 259.08 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-218/286
Sequence Identity: 42% (94 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKR-KFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAI
| ..  .| | || |.  |  |.|...|||| |  .    .    .||.| || | | | | |.|| | .  |.  |||.  ..  . .|. .  .|. .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RNIMYQILQGLAFIHKHGFFHRDLKPENLLCM-GPELVKIADFGLAREIRSKPP--YTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPL
|..|.|||....| |||   ||| ||||.|       ||. |||.|| . .||   ||||| |||||||| |.  | |..|.|.||.||.|||  .  ||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGASEIDTIFKICQVLGT
.|| |.||  ..| ..||.
WPGQSDIDQLYHIQKCLGP
Kinase ICK.AA Pkinase_Tyr 4-196 26 9.6e-22 74.26 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-210/270
Sequence Identity: 26% (56 aa)

YTTIRQLGDGTYGSVLLGRSI----ESGELIAIKKMKRKFYSWEE---CMNLREVKSLKKL-NHANVVKLKEVIR-ENDH--LYFIFEYMKE-NLYQLIK
 | ...|| | .|.| .|.      . .   |.|.. .  .. |.    . .||.| .|.| .| |.|.|  |.  . ..  .| ..|||.  .|.   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ER---NKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVST------RWYRAPEVLLRSTNYSSPID
..   .. .. . . .. .|| .|... . ... ||||   | |   .  |||.|||||| | ..  |  ....      .|. |||..  .  ...  |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSD

VWAVGCIMAEVYTL
||. |  | |..|.
VWSFGVLMWEIFTY
Kinase ICK.AA TyrKc 4-284 21 1.5e-16 45.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKL--NHANVVKLKEVIREN-------DHLYFIFEYMKE-NLYQLIKER
 | ...|| | .| | .|. .   .  |.|..|       . . .|| . ..||  .| |.|.|  |...        . |. ..|||.  .| . ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSK-------PPYT------DY--VSTRWYRAPEVLLRSTNYS
 . .. .   ....|| .| ...|.... ||||   | |   .  |||.||||.|.| ..         |.          .  ||. |||.. .   ..
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

SPIDVWAVGCIMAEVYTL-RPLFPG---ASEIDTIFKICQVLGTPKKTDWPEG----YQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPK
.  |||. |  | |..|.  .  ||        . . . . . . .  . |.                            . ...|  |. ..  . ||.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------FVCCPDEMYQIMKQCWHEDPE

KRPTASQALRYPYF
.||| |.   . .|
DRPTFSEI--HECF
Kinase ICK.AA CDKL 243-284 32 1.9e-10 31.95 In-house 244-286 (286) Show / Hide 
Range on Protein: 243-284
Range on HMM: 244-286/286
Sequence Identity: 32% (14 aa)

PNNLKTLIPNAS-SEAVQLLRDMLQWDPKKRPTASQALRYPYF
...|.   ||.| ..|  ... .|. || .|.|..|... |||
MEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF