Gene LRRK2 (Human)

LRRK2

Species: Human
Alias: ROCO2, RIPK7, PARK8, LRRK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 12q11-q12,

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRK2.NA RNA Sugen Kinome 9731 None Fasta, JSON
LRRK2.AA Protein Sugen Kinome 2527 None Fasta, JSON
LRRK2.kin_dom Protein Kinase Domain Sugen Kinome 246 None Fasta, JSON

Protein domain

Protein domains of LRRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRRK2.AA LRR_1 983-1004 25 20.814592 2.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 983-1004
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

YITSLDLSA-N--EL-RDIDAL-SQKC
 ...||||  |   | ..|      ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1034-1057 33 0.000105 22.88 SMART 1-24 (24) Show / Hide 
Range on Protein: 1034-1057
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKSLTHLDLHSNKFTSFPSYLLKM
| .|..|||..|..|. |. ..  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRRK2.AA LRR_TYP 1010-1033 33 0.001076 19.52 SMART 1-24 (24) Show / Hide 
Range on Protein: 1010-1033
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LEHLEKLELHQNALTSFPQQLCET
| .|..| |. |.||. |..... 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRRK2.AA LRR_1 1036-1057 29 0.004075 15.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1036-1057
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLTHLDLHS-N--KFT-SFPSY-LLKM
.|.|||| . |  ..| ..|.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1012-1034 29 0.235918 8.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1012-1034
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

HLEKLELHQ-N--ALT-SFPQQLCETL
.|..| |   |   || ..|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1084-1105 22 0.17162 9.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1084-1105
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

TLKQFNLSY-N--QLS-FVPEN-LTDV
.|.  .||. |  .|.  .|.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1082-1105 33 0.293157 4.22 SMART 1-24 (24) Show / Hide 
Range on Protein: 1082-1105
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

CPTLKQFNLSYNQLSFVPENLTDV
 | |.  .||.|||. .|... . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRRK2.AA LRR_TYP 1128-1151 29 0.000833 19.89 SMART 1-24 (24) Show / Hide 
Range on Protein: 1128-1151
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LKELKILNLSKNHISSLSENFLEA
| .|. |.|| |....| .. .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRRK2.AA LRR_1 1130-1152 18 0.011005 13.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1130-1152
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

ELKILNLSK-N--HIS-SLSENFLEAC
 |..|.||  |  ... ..... . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1108-1128 25 11.45709 2.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1108-1128
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLEQLILEG-N--KIS-GICS--PLRL
.|. | | | |  ...  | .     |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1195-1219 44 0.022982 13.28 SMART 1-24 (24) Show / Hide 
Range on Protein: 1195-1219
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LPHLRSLDMSSNDIQYLPGPAHWKS
||.||.|| |.| .. || |  . .
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_1 LRRK2.AA LRR_1 1197-1217 22 0.096914 10.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1197-1217
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

HLRSLDMSS-N--DIQ-YLPG--PAHW
.|..||.|. |   .. ..|     . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1174-1195 29 0.115487 10.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1174-1195
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SMTILKLSQ-N--KFS-CIPEA-ILNL
. ..| ||  |  ... .||.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1221-1233 31 5.089292 4.24 Pfam 1-16 (26) Show / Hide 
Range on Protein: 1221-1233
Range on HMM: 1-16/26
Sequence Identity: 31% (5 aa)

NLRELLFSH-N--QIS
||..| .|. |  ...
NLQHLDLSGCNCCNLT
LRR_1 LRRK2.AA LRR_1 1246-1267 33 0.004824 14.96 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1246-1267
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RVEKLHLSH-N--KL-KEIPPE-IGCL
. ..|.||. |  .| ..|||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1269-1291 33 0.046829 11.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1269-1291
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLTSLDVSY-N-LEL-RSFPNE-MGKL
||..||.|. |   | ...|..   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1244-1266 29 0.103648 7.92 SMART 1-24 (24) Show / Hide 
Range on Protein: 1244-1266
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

WSRVEKLHLSHNKLKEIPPEI-GC
 .  ..|.||.|.|...||.. ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRRK2.AA LRR_TYP 1267-1291 36 0.134227 7.0 SMART 1-24 (24) Show / Hide 
Range on Protein: 1267-1291
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LENLTSLDVSYNLELRSFPNEMGKL
| ||..|| |.|  |.. |...   
LPNLRELDLSNNQ-LTHLPPGAFQG
COR LRRK2.AA COR 1504-1854 20 1.2e-111 363.44 In-house 1-434 (434) Show / Hide 
Range on Protein: 1504-1854
Range on HMM: 1-434/434
Sequence Identity: 20% (91 aa)

IINESLNFKIRDQLV--VGQLIPDCYVELEKIILSER--KNVPIEFPVIDRKRLLQLVRENQ---------LQLDENELPHAVHFLNESGVLLHFQ--DP
|.......|......  ..| .| ......... ..|  .|...|.|....|...|...|..         ...||.|| .....|...|...||.  |.
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH

ALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK--HPKGI-ISRRDVEKFLSKK---------RKFPKNYMSQYFKLLEKFQIALPIGE----------EY
. .|.|.....|.|.|..|..|...| . |..  |.||| ....|.||.....         |..|.... ....|.|||....||..          ..
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTT

LLVPSSLSDHRPVIE-LPHC-------ENSEIIIRLYEM------PYFPMGFWSRLINRLLEISPYMLS-GRERALRPNRMYWRQGIYLNWSPE--AYCL
.|.|. |.|.|| .  ....       .... . | |..      ...|.|||.|.. ||.... .|.. ..||.. ...||||.|..|.|. .  ...|
YLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSC-CEWMYWRNGMVLKWEGHNKNEAL

VGSEVLDNHPESFLKITVPSCRK-----GCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFN---DGE-EHQ--KILLDDLMKKAEEG-
| ...     .. ..||| .|..     .| |.... .||......|.|.   ...|...  ....| ..  .   . .  ..   . .|......|.| 
VKCDN----HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW--VCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGM

DLLVNPDQPR-----------------------LTI-PISQ
| ...| . .                        .| .||.
DSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
ROC LRRK2.AA ROC 1332-1503 30 1.7e-73 244.94 In-house 1-215 (215) Show / Hide 
Range on Protein: 1332-1503
Range on HMM: 1-215/215
Sequence Identity: 30% (67 aa)

YNRMKLMIVGNTGSGKTTLLQQLMKTKKS-------DLGMQSATVGID-VKDWPIQIRDK----RKRDLVLNVWDFAGREEFYSTHPHFMTQ-RALYLAV
.|.||||..|. |.|||.|..|||..|.|       |.|....|.||. ...|.....|.    ..... .|||||.|.|....|| .|.|. |..||.|
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

YDLSK----GQAE----VDA--MKPWLFNIKARASS--------SPVILVGTHLDVSDEKQ-----RKACMSKITKELLNKRGFPAIR---------DYH
.|...    || |      .  ...|| .||.|..         ||||.||||.|......     .|.|. .....|  .  ||.|.         ...
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKL--RNKFPNICHSWMQIEHYQGF

FVNATEES-DALAKLRKT
|. ..|..   . |||..
FHVDCETGCKGIDKLRHH
Miro LRRK2.AA Miro 1336-1455 22 2e-35 128.69 Pfam 1-140 (140) Show / Hide 
Range on Protein: 1336-1455
Range on HMM: 1-140/140
Sequence Identity: 22% (32 aa)

KLMIVGNTGSGKTTLLQQLMKTKKS------------DLGMQSATVGIDVKDWPIQIRDKRKRDLV-------LNVWDFAGREEFYSTHPHF--MTQRAL
|....|..|.||.....|... ...             . |.. |...|     .|.. ... ..|       ...||..|||.....|.||  |...  
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVD----TMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADA

YLAVYDLSKGQ--AEVDAMKPWLFNIKARASS-SPVILVGTHLD
.. |||.....  ..|.....||......... .|||.||...|
ICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
RAB LRRK2.AA RAB 1335-1504 22 6.5e-08 -43.82 SMART 1-172 (172) Show / Hide 
Range on Protein: 1335-1504
Range on HMM: 1-172/172
Sequence Identity: 22% (41 aa)

MKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPW
.|....|. | ||. ||.. .. | |.   ...|.|.| |   |....|| .   | .|| || | | |  ...    .  . |||... .      . |
FKIILIGDSGVGKSCLLHRFTDDKFSE--QYKHTIGVDFKTKTIEVDGKRVK---LQIWDTAGQERFRSITSSYYRGAHGCILVYDITNRESFENVKN-W

LFNIKARASS----SPVILVGTHLDVSDEKQRKACMSKITKEL----LNKRGFPAI-----RDYHFVNATEESDALAKLRKTI
|  |.  |..     ...|||   | ..     .  ..  ...      | |.| .     ..  .|.      .||.  . .
LKEIRMHANPPPENVVIMLVGNKCDLEH---QRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEE--AFQCLARKIYQR
Kinase LRRK2.AA LRRK 1875-2134 29 2.6e-123 415.95 In-house 1-351 (351) Show / Hide 
Range on Protein: 1875-2134
Range on HMM: 1-351/351
Sequence Identity: 29% (104 aa)

LEFEQAPEFLLGDGSFG-SVYRAAYEG----------------------------EEVAVKIFNKH----------------------------------
|..|.     .|.|.|| .|||| ..|                            ..||.|..|..                                  
LKIEEQ----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHED

--TSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQ---QDK-----ASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHN
  ...|..|.|.....||.||...||.  .|.|...|||.|. |.|...|.   ||.     |.....|...|||..|.|..||||..  ||.||||..|
CCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

VLLFTL-------YPNAAIIAKIADYGIAQ--YCCRMG-IKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFP-----NE
.||...       ||||...|||||.|| .  .|..|| .|...|.||..|||. |  |.. |....|.||||..|...||..... ....|.     .|
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

FDELEIQGKLPDPVK---EYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS
..|..|...|.....   ...|.||.|...||..| ...|..||.. |....| .
QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRK2.AA TKL 1885-2132 21 4.7e-70 239.04 In-house 1-364 (364) Show / Hide 
Range on Protein: 1885-2132
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

LGDGSFGSVYRAAYEG----------EEVAVKIFNKHTSL-----------------------------RLLRQELVVLCHLHHPSLISLLAAGIRPR--
.| |.|| ||.. . |          ..||||.|..| .                                ...|....  |.|| ....... ..|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------MLVMELASKGS-LDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM--------IIYRDLKPHNVLLFTL---------YPNAAII
             ..|||....|| |..|.          . .|.|| .| |. ||||          ||.||||..|.|..           .||| . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKIADYGIAQYCCRMG--------------------IKTSEG-TPGFRAPEVARGN---------------VIYNQQADVYSFGLLLYDILTTGGRIVEG
.||.|.|...  ...|                     . ... ||.. |||| ||.                 |....||||||..|. |||      . 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

LKFPNEFD-------ELEIQGKLPDPVK---------EYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL
  .| .|        .. .. .|. |..               .| . ||...| ...|..||.  .. ..|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRRK2.AA TK 1879-2132 15 1.1e-42 140.44 In-house 1-486 (486) Show / Hide 
Range on Protein: 1879-2132
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

QAPEFLLGDGSFG---SVYRAAYEG---------------------------EEVAVKIFNK--HTSLRL-----------------LRQELVVLCH--L
   .  || | ||    ||.. ..|                           ..||||.  .  ..| .                  . .|. ..||  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPSLISLLA--------------AGIRPRMLVMELASKGS----LDRLLQQDKA---------------------------------------------
||| ...|..               . .| |.|||....|.    |.  |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLTRTLQHR-------------------IALHVADGLRYLHSA------MIIYRDLKPHNVLLFTLYPNAAI------IAKIADYGIA--
          .|| . ...                   ... .|.|..||||        .. |||  .|.|..  .... .      ..||||.| .  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------------QYCCRMGIKTSEGTPGF-----------------------RAPEVARGNV--------IYNQQADVYSFGLLLYDILTTG-GRIVEGL
            .. .|.. ..  . .                          |||. ...|        ..  . ||.||| |.. |.| | .   .|.
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KF--------PNEFDELEIQG-------------KLPDPVKEYGC-----------APWPMVEKLIKQCLKENPQERPTSAQVFDIL
          . |. |.  .|             ... |  .. .           .| .... |..|| ...|..||| .|. . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRRK2.AA S_TKc 1884-2137 24 1.2e-40 142.22 SMART 6-231 (231) Show / Hide 
Range on Protein: 1884-2137
Range on HMM: 6-231/231
Sequence Identity: 24% (67 aa)

LLGDGSFGSVYRAAYEG--EEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGI-RPRMLVMELASK--GSLDRLLQQDKAS-----LTRTLQHR
..| |.||.||..   .  ..||.|| .     . .|.|. .| . ||| .. |. .       .|||...   |.| ..... .       ..     .
KIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-QADVYSFGLLLYDILTTGGR
..  ....| |.||  ||.||||| |.|| .         ||.| |.|        .|  ||| ..||||      |.   .|..|.| .||  |. |  
YMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC-GYP

IVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFD----ILNSAEL
  .     ...  ... |              | .  .|..||. .|..|||  ...     | .   .
PFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRRK2.AA Dicty4 1880-2068 33 1.4e-37 123.01 In-house 2-212 (277) Show / Hide 
Range on Protein: 1880-2068
Range on HMM: 2-212/277
Sequence Identity: 33% (72 aa)

APEFLLGDGSFGSVYRAAYEGEEVAVKIF--NKHTS----LRLLRQELVVLCHLHHPSLISLLAAGI----RP--RMLVMELASKGSLDRLLQQ------
. | ..|.||||.||..   | |||||..  .. ..    |  .|.|   .| . || .. .. | .     |   . |.|. .||.| .||        
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

DKASLTRTLQHR---IALHVADGLRYLHS--AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG-----IKTSEGTPGFRAPEVARGNVIYN
.. .|  .|  |   .|. .| |. .||.    || ||||.|| |       .   .|..| |..||  .        .|  |||.  |||| ...  ||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV-----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YN

QQADVYSFGLLLYDILT
. |||||||..|. |||
EKADVYSFGIVLWEILT
Kinase LRRK2.AA Pkinase 1885-2132 26 9.1e-37 131.09 Pfam 7-293 (293) Show / Hide 
Range on Protein: 1885-2132
Range on HMM: 7-293/293
Sequence Identity: 26% (78 aa)

LGDGSFGSVYRAAYEGEE--VAVKIFNKHTSLRLLRQ------ELVVLCHLHHPSLISLLAAGIRPRMLV--MELASKG----SLDRLLQ-QDKASL--T
.| ||||.||..   |..  |||||..|..     .|      |. .. .|.||  . |. .  ... .   ||.. .|    .| .... ... ..  .
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

RTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF-TLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL
     .... .. || |.||  ||.||||| |.|.  . ...|  . ||.| |.|    |      .|  |||...|||| ||.  | . .|..|.|..|
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

YDILTTGGRIVEGLKFPNE-----FDELEIQGKLPDPVKEYGCAPW---------------------PMVEKLIKQCLKENPQERPTSAQVFDI--L
|  |.  ||    . ||..      |....  .  .|  .. .  |                     .   ..|| ||. .|..||| .|..    .
YEMLC--GR----PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LRRK2.AA MLK 1875-2068 27 4.9e-36 122.55 In-house 1-231 (291) Show / Hide 
Range on Protein: 1875-2068
Range on HMM: 1-231/291
Sequence Identity: 27% (64 aa)

LEFEQAPEFLLGDGSFGSVYRAAYEGEE-----VAVKIFN--------KHTSLRLLRQELVVLCHLHHPS----LISLLAAGIRP-RM--LVMELASKGS
..|..     .| ||||.|... . ...     ||||...        . .. . ...|   | .| ||      | .... ..|     .||| ...||
IQFHE----WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LDRLL--QQDKAS-----------LTRTLQHRIALHVADGLRYLHS-A--MIIYRDLKPHNVLLFT--LYPNAAIIAKIADYGIAQYCCRMGI-KTS-EG
| ..|  ...| .            .  .  ..|| .| |. |||| |  .|| ||||.||.|.      . .  ..||.| |..   ..|.  ..|  |
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAG

TPGFRAPEV-AR-GNVIYNQQADVYSFGLLLYDILT
|. ..||||  .  .  |.  .||.|.|..|. .||
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLT
Kinase LRRK2.AA TKL-Unique 1881-2069 27 3e-31 107.51 In-house 1-224 (290) Show / Hide 
Range on Protein: 1881-2069
Range on HMM: 1-224/290
Sequence Identity: 27% (61 aa)

PEFLLGDGSFGSVYRAAYEGEEVAVKIFNK-----HTSLRLLRQELVVLCHLH-HPSLISLLAAGI----RPR--MLVMELASKGSLDRLLQ--------
.  ..| |..|.||.. . |..||.|.|..      .... .. |. ..  || || .  . .. .     |    .|||  . |||. .|.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-QDKASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSE-----------GTPGFRAPEVARG
  ..  |.  .. ..|. .|.|. |||.    || ||||. |.|.    . | . .||.| |..    ..  .|.            |..  .|||| |.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

N-VIYNQQADVYSFGLLLYDILTT
|   |....||||||  |. |.|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase LRRK2.AA CAMK 1884-2068 18 1.4e-30 95.15 In-house 1-329 (425) Show / Hide 
Range on Protein: 1884-2068
Range on HMM: 1-329/425
Sequence Identity: 18% (61 aa)

LLGDGSFGSVYRAAYE-G-------------EEVAVKIFNK------------------------------HTSLRLLRQELVVLCH-------LHHPSL
 || |||| |...                  ..||.|| .|                                ... .|.|. .. .       |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISLLAAGI------------RPRM----------LVM---ELASKG----S-LDRLLQQDK-------------ASLTRTLQHRIALHVADGLRYLHSAM
|.|. .                ..          .||   |..| |      .|.. .. .               .|    .|.   ......|.||  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYRDLKPHNVLLFTLYPNAA------------IIAKIADYGIAQYCCRMG-------------------------IKTSEGTPGFRA-PEVARG-----
|. ||||| |.|| . ...                 ||.| | |... .                            ||. |||.. | ||| .|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------NVIYNQQADVYSFGLLLYDILT
        .  |....|. | | .||  |.
MQNATDEEKPYYGPKCDMWSCGVILYIMLC
Kinase LRRK2.AA Dicty4-Unclassified 1884-2068 29 4.3e-30 100.22 In-house 6-203 (263) Show / Hide 
Range on Protein: 1884-2068
Range on HMM: 6-203/263
Sequence Identity: 29% (61 aa)

LLGDGSFGSVYRAAYEGEEVAVKIFNK-HTSLR-----LLRQELVVLCHLHHPSLISLLAAGIRP------RMLVMELASKGSLDRLLQ-----QDKA-S
 .| | |  |..    | .||||.||    . |       . |  .|  . || |. .  . | |       . |||.  || |  .       |..  .
FIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIK

LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEG-TPGFRAPEVARGNVIYNQQADVYSFGLLLY
|  ||  ..|. .| |. .||.  .| ||.|  |.|.          .|||| ||.         |  . ||   .||. ..   ||| .||||....||
LDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILM-----DKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSYAMMLY

DILT
  .|
ELAT
Kinase LRRK2.AA TyrKc 1875-2132 24 2.4e-26 94.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 1875-2132
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

LEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHL--HHPSLISLLAAGI---------RPRMLVMELASKGSLDRLLQQDK
.....     || | || ||.. .  ..||||  .... .. ...|. ..|.|  ||| .. |... .          | |.|||....|.|.  |.  .
ITLGK----KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

ASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRM-------GIKTSEGTPGFR--------APEVARGNV
  |.    . ... .|.| .||||  .| |||   |.|.   .     ..||.| | . .             ... .. | .        |||. . . 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-

IYNQQADVYSFGLLLYDILTTGGRIVEGL----KFPNEFDELEIQGKLPDPVKE-----YGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL
... . ||.||| ... |.| |.   .|     . . |  |.  ||. ... ..     . |.|  | . ..||| .|.| .||| ... ...
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LRRK2.AA HH498 1882-2068 25 4.3e-26 79.37 In-house 2-221 (284) Show / Hide 
Range on Protein: 1882-2068
Range on HMM: 2-221/284
Sequence Identity: 25% (57 aa)

EFL--LGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLR----------QELVVLCHLHHPSLISLLAAGIRPR---MLVMELASKGSLDRLL-------
||.   | |||| ||.  . .  |||| .   . .               | ...| | ||. .  . | .       .| .  . ||| ..|       
EFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGG

-------QQDK---ASLTRTLQHRIALHVADGLRYLHS---AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIK--TS-EGTPGFRAPEV
        ..|     .      .|.. || | .|||.     || |||  ||.|.      .  .|..||.|.  . | |. .  |.  | . ..||||
AGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-----EDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEV

ARGNVIYNQQADVYSFGLLLYDILT
   .  |   .||.|... .. ..|
FSQCQKYSIKVDVFSYAMCIWEMHT
Kinase LRRK2.AA STE 1885-2063 20 3.4e-25 85.99 In-house 7-258 (359) Show / Hide 
Range on Protein: 1885-2063
Range on HMM: 7-258/359
Sequence Identity: 20% (55 aa)

LGDGSFGSVYRAAYE-----------------GEEVAVKIFNKHTS-------------------LRLLRQELVVLCHLH--HPSLISLLAAGIRP----
.| |.||.||.|..                  || .|.|. |. ..                   .  . .|. .. ...  ||  .  . . ..     
IGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNH

-----RMLVMELASKGSLDRLLQ---QDKASLT----------RTLQHRIALHVADG-LRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQY
       ..||. . |||| ...     . .|.           ..  .|.  .  | | ||||  || ||.|| |.||          .|..| |..  
KNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFGVCGQ

CCR----------------MGIK--TSEGTPGFRAPEVARG-----NVIYNQQADVYSFGLLL
                   |. |  |  ||| . |||| ..     .  |. ..|..|.|...
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase LRRK2.AA Pkinase_Tyr 1875-1987 24 3.9e-24 82.36 Pfam 1-129 (270) Show / Hide 
Range on Protein: 1875-1987
Range on HMM: 1-129/270
Sequence Identity: 24% (33 aa)

LEFEQAPEFLLGDGSFGSVYRAAYE------GEEVAVKIFNKHTSLRL-----LRQELVVLCHL-HHPSLISLLAAGI---RP--RMLVMELASKGSLDR
..| .     || |.||.||.. .       . .||||. . ... .      . .|. ....| ||| ...|... .   .|   ..|||.. .|.|. 
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LLQQD---KASLTRTLQHRIALHVADGLRYLHS
 |..    | .||      ... .|.|. ||.|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase LRRK2.AA MLK 2108-2132 40 2.1e-07 21.87 In-house 267-291 (291) Show / Hide 
Range on Protein: 2108-2132
Range on HMM: 267-291/291
Sequence Identity: 40% (10 aa)

EKLIKQCLKENPQERPTSAQVFDIL
.||.||| ...| .||...|.  .|
KKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LRRK2.AA Dicty4 2109-2134 28 2e-06 17.41 In-house 250-277 (277) Show / Hide 
Range on Protein: 2109-2134
Range on HMM: 250-277/277
Sequence Identity: 28% (8 aa)

KLIKQCLKENPQERPTSAQVFDI--LNS
.||. |. ..|| ||. ...  .  |..
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase LRRK2.AA Dicty4-Unclassified 2105-2132 39 1.6e-05 14.87 In-house 236-263 (263) Show / Hide 
Range on Protein: 2105-2132
Range on HMM: 236-263/263
Sequence Identity: 39% (11 aa)

PMVEKLIKQCLKENPQERPTSAQVFDIL
. . |||| |. . |. |||  |. . |
NFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase LRRK2.AA HH498 2110-2132 39 0.000261 9.13 In-house 262-284 (284) Show / Hide 
Range on Protein: 2110-2132
Range on HMM: 262-284/284
Sequence Identity: 39% (9 aa)

LIKQCLKENPQERPTSAQVFDIL
|| .|   .| .||. .|.  ||
LIQMCWHPCPENRPDFDQIVTIL
Kinase LRRK2.AA TKL-Unique 2109-2132 33 0.000748 9.68 In-house 267-290 (290) Show / Hide 
Range on Protein: 2109-2132
Range on HMM: 267-290/290
Sequence Identity: 33% (8 aa)

KLIKQCLKENPQERPTSAQVFDIL
.||.|| . .|..||.  ..   |
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase LRRK2.AA Pkinase_Tyr 2040-2071 37 0.004209 11.13 Pfam 182-212 (270) Show / Hide 
Range on Protein: 2040-2071
Range on HMM: 182-212/270
Sequence Identity: 37% (12 aa)

APEVARGNVIYNQQADVYSFGLLLYDILTTGG
|||. . .. .. . ||.||| |.. |.| |.
APECINYGK-FTTKSDVWSFGVLMWEIFTYGE
Kinase LRRK2.AA CAMK 2110-2128 36 0.006796 4.36 In-house 401-419 (425) Show / Hide 
Range on Protein: 2110-2128
Range on HMM: 401-419/425
Sequence Identity: 36% (7 aa)

LIKQCLKENPQERPTSAQV
||...|. .|..|.| .|.
LIRKMLQVDPEKRMTIEQC
Kinase LRRK2.AA STE 2111-2127 47 0.007593 6.03 In-house 334-350 (359) Show / Hide 
Range on Protein: 2111-2127
Range on HMM: 334-350/359
Sequence Identity: 47% (8 aa)

IKQCLKENPQERPTSAQ
|..||. .|..|||. |
INKCLQKDPNKRPTASQ
Kinase LRRK2.AA Pkinase_Tyr 2104-2132 31 0.085558 6.7 Pfam 242-270 (270) Show / Hide 
Range on Protein: 2104-2132
Range on HMM: 242-270/270
Sequence Identity: 31% (9 aa)

WPMVEKLIKQCLKENPQERPTSAQVFDIL
.. . .|.||| ...|..||| ...  .|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
WD40 LRRK2.AA WD40 2231-2276 27 0.000911 19.55 SMART 1-46 (46) Show / Hide 
Range on Protein: 2231-2276
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

DGKKRHTLEKMTD--SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFE
. |  ||..  |.  .|||.  .. .. ....|.|..|  ||.. |..
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD