Gene MAK (Human)

MAK

Species: Human
Alias: MAK, dJ417M14.2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards ,
Annotation: Consensus chromosomal location: 6p24.1-p25,

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
MAK.NA RNA Sugen Kinome 3905 None Fasta, JSON
MAK.AA Protein Sugen Kinome 648 None Fasta, JSON
MAK.kin_dom Protein Kinase Domain Sugen Kinome 281 None Fasta, JSON

Protein domain

Protein domains of MAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAK.AA MAK 4-284 63 4.1e-245 789.03 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 63% (223 aa)

YTTMRQLGDGTYGSVLMGKS------------------------------NESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANVIKLKEVIR--
|....||||||||.|...|.                              ...||.|||||||.|||||.||||||||||||||| |.|..|||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENDHLYFIFEYMKENLYQLMKDRNK-LFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGP-----------------ELVKIADFGLARELRS
|||||||.||||||||||.||||.. .|||.|||||||||||||||.||||||||||||||..||||                 ||.||||||||||.||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

QPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSD----------------WPEGYQLASSMNF
.|||||||||||||||||||||..||||||.||||.||||||..||||||.||.|.|||||||||||||.|                ||.|||||..|||
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

RFPQCVP---INLKTLIPNASN-EAIQLMTEMLNWDPKKRPTASQALKHPYF
|||||||   ..||.||||.|. .||.||..||.|||.|||||.|..|.|||
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase MAK.AA RCK 4-284 66 3.3e-237 760.73 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 66% (199 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANVIKLKEVIREND--HLYFIFEYMKENLYQLMKD---RNKLF
|....||||||||.|..... |.||.||||.||.|||||.|||||||.|||.||| |.|.||||||||.||  .|||.||||..||||.|||   |.|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PESV--IRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMG---------PELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAV
||..  |.|||||||||||..|||||||||.||||..|.|         ....|||||||.|| ||.||||||||||||||||.|||.  |.||.|.|||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF
| ||.|||||||||||.||.|.|||||.|.|||.| |||.||.|||.|||.||||....||.||||.| ..|.||..||.|||.||.||.|||.||||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase MAK.AA CMGC 4-284 26 1.2e-136 452.03 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 26% (137 aa)

YTTMRQLGDGTYGSVLMGKS--------------NESGELVAIKRMKRKFYSWDEC----------MNLREVKSLKKLN-----------------HANV
|. ....| |||| |  ..               .|..|.||||..|..|| ....          . |||.| ||.||                 | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKLKEVIREND-----------------HLYFIFEYMKENLYQLMKD--------RNKLFPESV------------IRNIM------YQILQGLA--FIH
.||..... ..                 |||..||||  .|||..|.        |.. ..| .            |...|      ||||.||.  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHG--FFHRDMKPENLLCMGPELV--------------------KIADFGLARELRSQP----------------------PYTDYVSTRWYRAPEVLLR
.|.  ..|||.||||.|      .                    ||.|||||| . . .                      |||.||.||||||||.||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SSVYS---------SPIDVWAVGSIMAELYM--------LRPLFPGTSE-----------VDEIFKICQVLGTPK---------------KSDWPE----
.. |.         .|||.|.|| |.||.|.        ..||||| ||           .| .|||..|||||                . .||.    
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

---------------------GYQLASSMNFRFPQCVPINLKTLIPN-----------------------------------ASNEAIQLMTEMLNWDPK
                     ..... ..|.|||.. |...| |.|.                                   .. .|| |.  || .||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRPTASQALKHPYF
||.||.|||.||||
KRITAEQALQHPYF
Kinase MAK.AA Pkinase 4-284 32 9.1e-112 382.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLR---EVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKE-----NLYQLMK-DRN
|.. |..| |..|.|  ..   .|..||.|..|..  ........|   |.. .|.||| |...|... ...||.|...||.        |. ... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KLF--PESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELV----KIADFGLARE--LRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAV
. |  .| .....|||||.||...|..|. |||.||||.|.     .    ||.|||||.   . ... .|... |.||.||||.. .. |....|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GSIMAELYMLRPLFPGT----SEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHP
| |..|..  ||.|||     . .|....||...|.| ..|||. .    .. ||. .   . ..|. .|.| |...... .|..|||||||| |.|.||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase MAK.AA CDK 4-284 34 3.6e-111 356.96 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 34% (110 aa)

YTTMRQLGDGTYGSVLMGKSNESG-----ELVAIKRMK---RKFYSW-DECMN---LREVKSLKKLNHANVIKLKEVIREN-----------DHLYFIFE
|    ..| |||| |  ... ..|     ..||.|. .    .  .  .| ..   .||.. ||.| |.|..||..|.  .             ||..||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPEL-----VKIADFGLARELRS-------QPPYTDYVSTRWYRAP
||   |...|.          |...|.|.|.||...|.... |||.|| |.| .         .|||||||||.  .       . .||  | |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EVLLRSSVYS--SPIDVWAVGSIMAELYM---LRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTE
|.|| |. ||   |||.|.|| |.||...    .|||||.|| | .|||....|||  ..||.  .|                            .|.  
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

MLNWDPKKRPTASQALKHPYF
||  ||||| .|.|||.||||
MLCYDPKKRISAEQALQHPYF
Kinase MAK.AA CDK7 4-284 36 4.90000000001e-105 280.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 36% (106 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK--RKFYSWDECMN---LREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFP
|......| |... |  .   ..|. ||||. |        .  .|   .||.| |. . | ||| |  ..   . .. .|..|   |    ||   .. 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

ESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRS-QPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLR
 . | ..| ..|||| . |..   |||.|| |||      .|||||||||   |    ||  | |||||||| |     | . .|.|.|| |.||| |||
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL-MLR

-PLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR-FPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF
 | .||.|..| . .|.| ||||  ..||.  .... . |. ||    . |. .   ||.... ||  |.  .| || |..|.||.|||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase MAK.AA CDC2 4-284 39 1.6e-102 315.95 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 39% (120 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDE---CMNLREVKSLKKLN-HANVIKLKEVIRENDHLYFIFEYMKENLYQLMK---DRNKL
|.  . .| |||| |  .| ......||.|. . .  . ..      .||   ||.|. | |..||..|| .   || .|||.  .| ..|.     || 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRS-QPPYT--DYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAEL
.|.......|||||||..| | .. .||| || |.|      .|||||||||       .||    | |.||||||.||... || |.|.|..| |.||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

YML---RPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPN---------ASNEAIQLMTEMLNWDPKKRPTASQALKH
.|    .|||.| || |..||| ..||||. ..||. .||    |  ||.  |..|....||         . .|.|.|  .||  || || .| .||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase MAK.AA S_TKc 4-284 32 6.7e-101 342.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 32% (96 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKE---NLYQLMKDRNKL----
|. .|..| |..|.|  .. ...|..||||..|        .. .||.. ||| .| |..||..|... ||||...||.     .|....|.|..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSS-PIDVWAVGSIMAELY
 ||| ..| .||||...|...|.||. ||| ||||.|.     .||.||||||.|      | .. |.||.|||||     |.  ..|.|..| |..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

MLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALK-------HPYF
  .|.||   .....||..                                        | ||....  .|..||.||||| .||.       ||.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAK.AA MOK 4-284 39 4.1e-90 282.6 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPES
| .. ..|.||.  |.  .|   |.  | |.||..| | ..  ||||.. ...|| |.|...|.||.  |    |  | | |  |.| |.. |    |. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLF
 |.. |||... |  .|. | ||||.||||.|    . .|.||||  |   |. |||.|.||||||||| ||    |.  .|.|.|| .  |.  |.|||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQ-DHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF
||  ||| | ||  |.|||..       . . .||. ||      .. |.||..  ....| .|  .||  | || |...||||
PGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase MAK.AA CDK5 4-284 36 5.1e-85 268.51 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-287/287
Sequence Identity: 36% (108 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDE---CMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPES
|  |  .|.|||| |  ..  |..|.||.||   .  | ||   .  .||.  || | | |.. |  ||  .  |  .||.. . |   | ..|      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV--RLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARE----LRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELY-M
.|. .||| |.|||| |.|   |||.|| |||       | |||||||      |    |.  | | |||.| ||. | .|| .||.| .| |.||.   
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

LRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSM--NFRFPQCVPIN-LKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF
.||||||... |. ..| ...|||  . ||   .|         .|   .   .. ..|. . .   |. .||  .|..| .| .||.||||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase MAK.AA MAPK 4-284 32 1.3e-84 287.4 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-328/328
Sequence Identity: 32% (108 aa)

YTTMRQLGDGTYGSVLMGKSNE------SGELVAIKRMKRKFYSWDECMN-LREVKSLKKL-NHANVIKLKEVIRE------NDH-----LYFIFEYMKE
|.  ...| | || | . . ..      .|. ||||.. | | .   |   .||.| |. . .| |.|||.....       |..     .|...|.|  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYQLMKDRNKLFPESVIRNIMYQILQG--LAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPY---------------TDYVSTRWYRA
.|.|..| ..    .  |. .||||| |  | .||  .  ||| ||.|.|.    ..||.|||||| . ..  .               |.||.||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLR--SSVYSSPIDVWAVGSIMAELYM-LRPLFPGTSEVDEIFKICQVLGTPKKSDW-PEG-YQLASSMNFRF---PQCVPINLKTLIPN----ASN
||..|   .  |.  .|.|.|| |.||..   .|||||.. .| ...| .|||||.. ..   . .. | ..  ..   |.. ........||    |. 
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

EAIQLMTEMLNWDPKKRPTASQALKHPYF
.|| |.  || .||.|| |. .|| ||||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MAK.AA CDKL 4-218 40 8e-72 244.84 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-218/286
Sequence Identity: 40% (89 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN---LREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPES
| ..  .| | || |.  .  |.|..||||. |   .  |.  .   .||.| || | | |   |.|| | .  |.  |||.  ..  . . . .  .|.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESED--DPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEH

VIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCM-GPELVKIADFGLARELRSQPP--YTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLR
|.|..|.|||....| |||   ||| ||||.|       ||. |||.|| . ..|   ||||| |||||||| |.    |..|.|.||.| .|||. .  
VVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQ

PLFPGTSEVDEIFKICQVLGT
||.|| |..|  ..| ..||.
PLWPGQSDIDQLYHIQKCLGP
Kinase MAK.AA TyrKc 4-284 22 5e-16 36.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKL--NHANVIKLKEVIREN-------DHLYFIFEYMKE-NLYQLMKDR
 |  ..|| | .| |  |. .   . ||.| .|       . . .|| . ..||  .| |...|  |...        . |. ..|||.  .| .  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-------PPYT------DY--VSTRWYRAPEVLLRSSVYS
 . .. .   ....|| .| ...|.... |||    | |   .  |||.||||.|.. .          |.          .  ||. |||.. . ....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

SPIDVWAVGSIMAELYML-RPLFPG-------TSEVDEIFKICQVLGTPKK----SDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLN
.  |||. |  | |.. .  .  ||        .|| |  |    .  |.     |                            . .. |  |.|..  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------FVCCPDEMYQIMKQCWH

WDPKKRPTASQALKHPYF
 ||..||| |.   | .|
EDPEDRPTFSEI--HECF
Kinase MAK.AA Pkinase_Tyr 4-125 21 1.9e-14 49.57 Pfam 1-136 (270) Show / Hide 
Range on Protein: 4-125
Range on HMM: 1-136/270
Sequence Identity: 21% (30 aa)

YTTMRQLGDGTYGSVLMGKSN----ESGELVAIKRMKRKFYSWDE---CMNLREVKSLKKL-NHANVIKLKEVIR-ENDH--LYFIFEYMKE-NLYQLMK
 | ...|| | .|.| .|. .    . .  ||.| . .  .. ..    . .||.| .|.| .| |...|  |.  . ..  .| ..|||.  .|.   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DR---NKLFPESVIRNIMYQILQGLAFIHKHGFFHRD
..   .. .. . . .. .|| .|... . ... |||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD
Kinase MAK.AA CDKL 243-284 37 5.1e-12 37.37 In-house 244-286 (286) Show / Hide 
Range on Protein: 243-284
Range on HMM: 244-286/286
Sequence Identity: 37% (16 aa)

PINLKTLIPNAS-NEAIQLMTEMLNWDPKKRPTASQALKHPYF
. .|.   ||.|  .|. .|  .|  || .|.|..|...||||
MEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MAK.AA Pkinase_Tyr 139-185 32 0.006915 10.4 Pfam 150-199 (270) Show / Hide 
Range on Protein: 139-185
Range on HMM: 150-199/270
Sequence Identity: 32% (17 aa)

VKIADFGLARELRSQPPYTDYVST------RWYRAPEVLLRSSVYSSPIDVWA
|||.|||||| . .   |  ....      .|. |||..  .  ...  |||.
VKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS