Gene MAP2K2 (Human)

MAP2K2

Species: Human
Alias: MAPKK2, MAP2K2, MKK2, PRKMK2, MEK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.3,

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
MAP2K2.NA RNA Sugen Kinome 1759 None Fasta, JSON
MAP2K2.AA Protein Sugen Kinome 400 None Fasta, JSON
MAP2K2.kin_dom Protein Kinase Domain Sugen Kinome 298 None Fasta, JSON

Protein domain

Protein domains of MAP2K2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K2.AA MEK1 72-369 82 1.6e-223 748.82 In-house 1-297 (297) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-297/297
Sequence Identity: 82% (245 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILG
||.|.|||.||||||.|..||..|.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||.|.||||.|||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPD
|||.||||||.|||.||.|||||||||||||||||||||||||||||||||||||||||||||.|||||||||.||||||||||||||.|.|||||||||
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPPPD

AKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
.||.|..||..|.. .|||||.|.||.||...|.| |||||..||||||.|||||||||||||..||. .||.||.|||||||.||||||.|..||||
QKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPIS-HGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K2.AA STE7 72-369 50 1.2e-184 619.66 In-house 1-288 (288) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-288/288
Sequence Identity: 50% (163 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIK-PAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKEA-----
.|.|.|||.||.|||.|..|.||| |||.|.|.|... |....||..||.|||.|| .||||.||||||..|.  |.||||.||||.||...|..     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----KRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERLQG--THYSVQSDIWSMG
    .|||| ||||...||..|| ||.|||.|.|||||||||||||||..||||||..|||.|||  |..|||...||||||..|  .||.|.||.||.|
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LSL-VELAVGRYPIP-----PPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNE-PPPKLPNGVFTPDFQEFVN
... .|.|.||||.|     |||.|... .|.                                .. |||||.|..|||| |||.||   |.|.||.|||
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ--------------------------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFVN

KCLIKNPAERADLKMLTN-HTFI
|||.|.| ||.....|.. | ||
KCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K2.AA STE7-Unclassified 72-369 37 6.4e-134 451.21 In-house 1-301 (301) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-301/301
Sequence Identity: 37% (129 aa)

FERISELGAGNGGVVTKVQHRP------SGLIMARKLIHLEIK-PAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE---ISICMEHMDGGSLD---Q
.||...||.|..|.| |. | .      .| ||| | | ...  .....||.|||..||.|. .||||..|||.|...    | |||| ||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VLKEA--------KRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERLQGT-----
..|..        ..||| .|||. ..|..|| || |||.| |||.||.||||||.|..|.|||||.|||....  |...||. .||.|||.||      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

HYSVQSDIWSMGLSLVELAVGRYPIP-------------PPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEP
 |||.||||| ||.. |.| |.||..             |                                              | ..|||..|||.|
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP--------------------------------------------ENMSFWELLSCIVNFP

PPKLPN-G---VFTPDFQEFVNKCLIKNPAERADLKMLTN-HTFI
 | ||. .    . ..|. |..||..|.| ||.|   |.| | .|
VPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase MAP2K2.AA STE 72-369 28 1.9e-114 386.55 In-house 1-359 (359) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-359/359
Sequence Identity: 28% (115 aa)

FERISELGAGNGG-VVTKVQHRPS--------------GLIMARKLIHLEIK----------------PAIRNQIIRELQVLHECN--SPYIVGFYGAFY
.|.|...| |..| |.... | ..              | ||| | ..|| .                . ...||..|......||  .|.|| .||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDG-------EISICMEHMDGGSLDQVLKEA--------------KRIPEEILGKVSIAVLRG-LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS
 .|       |. ||||.|||||||...|.               .|.||......  ..|.| |.|| ..| |.|||.||.|||.     .|||||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GQLIDS------------------MANSFVGTRSYMAPERLQG------THYSVQSDIWSMGLSLVELAVGRYPI---PPPDAKELEAIFGRPVVDGEEG
|||.||                  . |.||||  .||||..|.       .|....|||| |. ..|.| |..|    .|. |  . .. ....   .  
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ--Q--

EPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNG------------------VFTPDFQEFVNKCLIKNPAERADLKMLTN--HTFI
                             ||.| .|||.|||.||.                    ..|.|..|.||||.|.| .|.. . | .  | ||
-----------------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K2.AA MEK5 73-268 53 6.9e-85 288.32 In-house 2-192 (254) Show / Hide 
Range on Protein: 73-268
Range on HMM: 2-192/254
Sequence Identity: 53% (104 aa)

ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGK
     || |||| | |  | ||| |.| |.| |.|   .. ||. ||..|. | ||||.||||||. .  |||| | |||||||      ..|||.|||.
RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMY----RCIPEHILGR

VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIP
...|. .|| || .  .||||||||||.||| .|.||||||||| ||..|..  ..||  ||||||. | .| . ||.||.|....|.|.||.| |
MTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYP
Kinase MAP2K2.AA S_TKc 72-369 25 7.1e-82 279.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-231/231
Sequence Identity: 25% (80 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDG--GSLDQVLKEAKR-----
.| . ..| |  |.| |..|. .| |.| | |.        ..|.||.|.|.. . |.|| .|..|.. ... ..||..||  |.| ...|. .|     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSV-QSDIWSMGLSLVELAV
 .||    ..   ....|.|. .. .|.|||.||.|||...  .||.||||.. ||     ..|.||. ||||| |   .|.   .|.|| |  | |...
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKM
|. | |     .....| . .                                                       .|.. .|..||| |.|..|     
GYPPFP-----QMQMMFKKIG-------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

LTN-------HTFI
. .       | ..
ALQDEWDIKCHPWF
Kinase MAP2K2.AA Pkinase 72-369 24 2e-70 245.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-293/293
Sequence Identity: 24% (78 aa)

FERISELGAGNGGVVTKVQHRPSGL-IMARKLIHLEIKPAIRNQIIR--ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGG----SLDQVLK--EA
..... .|.|. |.| | .|. .|      ..   ..|.  . . .|  |.|.....|.|.|| .|..|.....| ..||...||    .|  ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRI--PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI----KLCDFGVSG---QLIDSMANSFVGTRSYMAPERLQ-GTHYSVQSDIWS
...  .|. . ..   .||||.|. . . |.|||.||.|||....|.|    |.||||..       .| ...|.||. ||||| .. |..|.  .|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGLSLVELAVGRYPIPPP----DAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNK
.|. | |.. || | |      .. ... |. .   . .. .| ..|.....  |.   |                    . ...     ......|...
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------------F-HWTF-HNWSEECKDFIKW

CLIKNPAERADLKMLTNHTFI
|| |.|..|   . . .| ..
CLCKDPKKRPTAEQILQHPWF
Kinase MAP2K2.AA MEK4 72-266 41 3.6e-70 228.18 In-house 1-211 (275) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-211/275
Sequence Identity: 41% (88 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIH-LEIK-----PAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEA--
 . ..|.|.|. |.| | .|..|| ||| | |    .           .  .|. |     | |||| |||| .. |   |||| ||  |.|   | .  
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

---KRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPERLQG----THYSVQSDIWSMG
   .||||.|.|.. ... . | || |.|.| ||||||||||.. .| .||||||..||| ||.| .  .| | ||||||..       | . ||.|| |
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

LSLVELAVGRYP
  ..|.| |..|
ITMYEVATGKFP
Kinase MAP2K2.AA MEK3 72-266 42 8.4e-70 236.56 In-house 1-205 (264) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-205/264
Sequence Identity: 42% (88 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLK-EAKRI
 . |.||| |  |.| |..||.|| ||| | |   .      ... .. .       || | |||| .  | . |||| ||  .||    .|.|   ..|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHI

PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPERLQG----THYSVQSDIWSMGLSLVEL
||.||||... . ..| |..|. .. ||||||||.|.|  | .|.||||.||.|.||||     | . ||||||  .      |.| ||.||.|  ..|.
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

AVGRYP
|.||||
AIGRYP
Kinase MAP2K2.AA MEK7 72-266 43 4.5e-68 230.05 In-house 1-206 (269) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-206/269
Sequence Identity: 43% (91 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI-----
 . |...| |  | |.|. |. || ||| |             | . | |   |. .||||  .|.|  | .. |||| | .  .|  ||  |       
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMAPERLQG-----THYSVQSDIWSMGLSLVE
|| |.||...|.   | || |||.||||||||||||   || |||||||.|| ..||.|..   |   ||||||.         | . .|.||.| .|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

LAVGRYP
|| |.||
LATGQYP
Kinase MAP2K2.AA STE20 72-266 34 4.7e-55 189.21 In-house 1-226 (288) Show / Hide 
Range on Protein: 72-266
Range on HMM: 1-226/288
Sequence Identity: 34% (79 aa)

FERISELGAGNGGVVTKVQHRPSGLI----MARKLIHLEIKP---AIRNQIIRELQVLHECNSPYIVGFYGAFYSD----GEISICMEHMDGGSLDQVLK
.| . ..| |. |.| |. |.|.| .     | | . || .      .. |. | ... .|..|.|| .||... |     |. |.||...|||| ...|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---EAK------RIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMA---NSFVGTRSYMAPERLQG---
   . .      .. ||    .   ||.||.|| ..|.| |||.|  |||....||.||.||||..||..    .|.   |.||||  .|||| .|.   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHII-HRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--THYSVQSDIWSMGLSLVELAVGRYP
    |   .|||| |  . |.| |. |
PDKGYDYKCDIWSLGITAIEMAEGEPP
Kinase MAP2K2.AA Ciliate-E2 72-369 18 8e-50 169.21 In-house 1-365 (365) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-365/365
Sequence Identity: 18% (76 aa)

FERISELGAGNGGVVTKVQHRPSG-----------------------------LIMARKLIHLEIKPAIRN-------QIIRELQVLHECNSPYIVGFYG
.. |  .| || |.| |....  .                              .. ....... .  | .       .|  |...| . |.|.|. .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

AFY--SDGEISICMEHMDGGSLDQVLK------------EAKRIPEEILGKVSIAVLR---------------GLAYLREKHQIMHRDVKPSNILVNSRG
.|.  .|  | . ||  .||.| . .|            . |.. |.  ....  .|.               .| || .|. |.||| ||.|||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

EIKLCDFGVSGQLIDS---------------------------------MANSFVGTRSYMAPERLQGTH---------YSVQSDIWSMGLSLVELAVGR
 ||..||| | .. |.                                 |.|...||  ||||| |.|           |. ..||||.|  | |.  |.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLP----------NGVFTPDFQEFVNK----CL
.|                                                 . . .  ..  ..| . ..          .   ... . . .|    .|
PPF------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRML

IKNPAERAD-LKMLTNHTFI
 |.| .| .  . . || ..
QKDPEKRITGWEQILNHPWF
Kinase MAP2K2.AA MEK3 319-369 46 3.4e-17 55.02 In-house 213-264 (264) Show / Hide 
Range on Protein: 319-369
Range on HMM: 213-264/264
Sequence Identity: 46% (24 aa)

FELLDYIVNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
|. |  .| ||||.|| .  | ||.| |.|.|| ||..||   . |  | |.
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K2.AA MEK7 319-369 42 1.9e-15 48.83 In-house 214-269 (269) Show / Hide 
Range on Protein: 319-369
Range on HMM: 214-269/269
Sequence Identity: 42% (24 aa)

FELLDYIVNE--PPPKLPNGV---FTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
|| .  | |.  .|| || .    | |||..||.||| |.. .| . .||  | ||
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K2.AA TyrKc 72-369 17 3.3e-14 6.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-369
Range on HMM: 1-280/280
Sequence Identity: 17% (59 aa)

FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC--NSPYIVGFYGAFYSD-------GEISICMEHMDGGSLDQVLKEA
 . . .|| |. |.| | . .   .  | | .. .     |  ..||......   . | || .||.  ..       . . | ||.|..|.|.. |.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KR-IPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM------ANSFV-----GTRS-----YMAPERLQGTHYS
.. .. . | . .. . .| .|| .| .. |||    |.||.... .| .||| |   |..           .     |...      |||| ..   ..
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VQSDIWSMGLSLVELAVGRYPIPPPDA-----KELEAIFGRPVVDGEEGEPHS---ISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGV
 .||.|| |  . |.    |  .|.       .. . .. .    .    |..   .|                                          
TKSDVWSFGVCMWEIF--TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------F--VC

FTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
 ...  .   .|   .|..|   . .  | ..
CPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP2K2.AA STE20 324-369 37 1.1e-12 43.0 In-house 238-288 (288) Show / Hide 
Range on Protein: 324-369
Range on HMM: 238-288/288
Sequence Identity: 37% (19 aa)

YIV--NEPPPKLP---NGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
.|   ..|||.|       ..|.|..||.||| |.|..|.  . | .| ||
MIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K2.AA MEK5 320-369 42 8.5e-12 39.4 In-house 205-254 (254) Show / Hide 
Range on Protein: 320-369
Range on HMM: 205-254/254
Sequence Identity: 42% (21 aa)

ELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
.||  ||.| ||.|| . |   | .|.|.|. | | .|   . | .| ||
QLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K2.AA Pkinase_Tyr 111-252 26 1.4e-11 39.83 Pfam 46-199 (270) Show / Hide 
Range on Protein: 111-252
Range on HMM: 46-199/270
Sequence Identity: 26% (41 aa)

IRNQIIRELQVLHEC-NSPYIVGFYGAFY-SDGE--ISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILV
.|   .||......  . | || .||. .  ..   | | ||.| .|.|.  |..     .... . | . .. . .|..|| .|. . |||.   |.||
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLV

NSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMAPERLQGTHYSVQSDIWS
.. . .| |||| .  .  .  .  . .|.        |||| ..   ....||.||
TENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS
Kinase MAP2K2.AA MEK4 316-369 21 3.6e-10 29.19 In-house 216-275 (275) Show / Hide 
Range on Protein: 316-369
Range on HMM: 216-275/275
Sequence Identity: 21% (13 aa)

M--AIFELLDYIVNEPPPKLPNGVF----TPDFQEFVNKCLIKNPAERADLKMLTNHTFI
.   .|. .  .|.  ||.| .  .    .... .|.|.||.|.  .|.  . |  . |.
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY