Gene MEKK15 (Human)

MEKK15

Species: Human
Alias: YSK4, FLJ23074, MEKK15, RCK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , GeneCards
Annotation: Consensus chromosomal location: 2q21.3,

Classification

Group: STE
Family: STE11
Subfamily: MEKK15

Sequence

Name Sequence Type Origin Length Description Download
MEKK15.NA RNA Sugen Kinome 4955 None Fasta, JSON
MEKK15.AA Protein Sugen Kinome 1430 None Fasta, JSON
MEKK15.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of MEKK15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MEKK15.AA MEKK15 1163-1426 82 5.8e-221 740.36 In-house 1-264 (264) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-264/264
Sequence Identity: 82% (218 aa)

WTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPE
|.||.|||||||||||||||..|||||||||.||...|..|...||||||||||||.|||.|||||||.||..|.|.|||.|||||||||||||||||.|
WKKGNILGKGAYGTVYCGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDE

MVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEM
||||||||||||||.|||||||||||||||||||||||||||||||||.||.|.|.|.|||||||||.|||||||||||.|.||||||||||||||||||
MVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEM

ATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
||.|||.|.||||||||||||||..||.||..|||.|..||||||||||||||.|.|||||.|.
ATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK15.AA STE11 1163-1426 49 6.6e-168 564.11 In-house 1-303 (303) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-303/303
Sequence Identity: 49% (150 aa)

WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKL--AAEKEYRK------LQEEVDLLKALKHVNIVAYLGTCL---QENTVSIFMEFVPGGSI
|.||||.||||.|||| |  .. |.|.||||.... .|..   .||||..      .|||. |.| |.| ||| |.|.||   |...|.||||..||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSIIN-RFGP--LPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGI-IKLIDFGCARRLAWAGLNGTHSDM----LKSMHGTPY--------
||... ..||  ..|||..|||||||.|..|||.....|||||| |..|. .|. .||.|||||.|||| ........|    .||| ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVINESG---YGRKSDIWSIGCTVFEMATGKPPLASMDR--MAAMFYIGAHRGLMPPLPDHFS------ENAADFVRMCLTRDQHERPSALQLLKH
|||||||...|   ||||.||||.||||.|||||||| . .|.  |||||.||.... .||.|.|.|      |.. ||.| |...|...||.| |||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

SFL
.|.
PFI
Kinase MEKK15.AA STE 1163-1426 31 1.8e-118 399.91 In-house 1-359 (359) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-359/359
Sequence Identity: 31% (114 aa)

WTKGEILGKGAYGTVYCGLTS----------------QGQLIAVKQVALDTSNKLAAE------------KEYRKLQEEVDLLKALK--HVNIVAYLGTC
|.. |..||||.||||...                  .|...|.||. |...|.   |            .|  ....|....| ..  | ||| |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LQE-------NTVSIFMEFVPGGSISSIIN-RF-------------GPLPEMVFCKYTKQILQG-VAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCA
..|       ... |.||...|||...||. ..             ...|| . .....|||.|  .|||.. ..|||||. |..|     .||.|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

RRLAWAGLNG----------THSDMLKSMHGTPYWMAPEVINE------SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHR---------
 .|.  . |.          | . . ... ||| |||||||.       .||..|.||||.|||. ||||||||.. |  | |||.|             
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GLMPPLPD-------------------HFSENAADFVRMCLTRDQHERPSALQLLK--HSFL
    |  |||||                   ..|..  ||.. ||..| ..||.| ||||  |.|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK15.AA STE11-Unclassified 1163-1426 41 1.8e-116 393.23 In-house 1-308 (308) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-308/308
Sequence Identity: 41% (127 aa)

WTKGEILGKGAYGTVYCGL-TSQGQLIAVKQVALDTSN--KLAAEKE-YRKLQEEVDLLKALKHVNIVAYLGTC--LQENTVSIFMEFVPGGSISSIINR
| |||..|||..|.|| .. .. |...||||.    .|    ...|| .  .|.|. .|| | | ||| |.|.    .|. ..|||| .|||||.| .|.
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLA----------------WAGLN-GTHS--DMLKSMHGTPY---
.|.. |||  |||||||.|.||||.. ..|||||| |. .   ||.|| |||||.  .                   .   . |   ..||| ||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMAPEVIN---ESGYGRKSDIWSIGCTVFEMATGKPPLASMDR---MAAMFYIGAHRGLMPPLPDHFS-----------ENAADFVRMCLTRDQHERPSA
|||||||.   . |..|||||||.|||| ||||||.| .  .    |.|...|..  .  |..| | |           . . || | |...| ..||.|
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVM-SNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

LQLLKHSFL
 |||.|.|.
NQLLQHPFI
Kinase MEKK15.AA MEKK2 1163-1426 48 8.9e-98 331.14 In-house 1-262 (262) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-262/262
Sequence Identity: 48% (130 aa)

WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENT---VSIFMEFVPGGSISSIINRFG
| .| .||.||.| || |     |  .|||||  | .|   . || . |. |..||| |.|  || | | ||..|    .|||||..||||.   .  .|
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNP-ETRKEVQALECEIQLLKNLQHERIVQYYG-CLRDNQEKTLSIFMEYMPGGSVKDQLKAYG

PLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCT
.| | |  |||.||| |..|||.. .||||||| |..   .| .|| ||| ..||    . .|    .||. ||||||.|||||  ||||| |.||||||
ALTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHIT---GMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCT

VFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
| || | ||| |  . |||.| | | .   | ||.| |..| ||.. |  . . .||||  ||.| | 
VVEMLTEKPPWAEYEAMAAIFKI-ATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKK15.AA S_TKc 1163-1426 29 7.9e-92 312.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

WTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPG--GSISSIINRFGP
.......||||.|.||..     |.. |.|..              .... |...||  .| ||| .....   . . ..||...|  |.  ..| . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGR-KSDI
      .|| . ..|..||.....|.|.. ..|||.|  |..|     ||..||| ||.|             ... |||..|||||.   |||. |.|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW

WSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK-------HSFL
||.||...||..|.||      |..|| .              |. | ||.| ||..|  .||.| ..|.       | ..
WSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK15.AA STE20 1163-1426 35 5.9e-81 275.27 In-house 1-288 (288) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-288/288
Sequence Identity: 35% (105 aa)

WTKGEILGKGAYGTVYCGLT-SQGQL----IAVKQVALDTSN--KLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQE----NTVSIFMEFVPGGSIS
... | .|.|.||.|| .   . |..    .|.|.. |.. .  .    .| . .| |.. .| .|| |||.|.|. | .    .   | ||.  |||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLT

SIINRFG---------PLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDM--LKSMHGTPYWMAPEV
 |....          |. |      ....||| .|||.| ..|||||..|..|   | .||.||| .  |   |   . ..    ... ||||||||||
DIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEV

INE-----SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPD----HFSENAADFVRMCLTRDQHERPSALQLLKHSFL
|..     .||. |.|||| | |  |||.|.||.. | .| |||.|   .   |.| |    ..| .  |||  ||..| ..||.| |||||.|.
IQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEKK15.AA Pkinase 1163-1426 28 8.7e-81 279.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGG----SISSIIN--
...|...|.|..|.|| |   . |.. |||.. .. ..|   ... |.|  |. ..| |.| ||| .....  .. . . ||...||    . ...|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RFGPL--PEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGII----KLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN-ESGYGR
| |..  .| . ..| .|||.|..|.|.. ..|||.|  |...  .| |    |..|||.|. .        ..  ...  |||..||||||.  ..||.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDIWSIGCTVFEMATGKPPLA------SMDRMAAMFYIGAHRGLMPPLPDHFS-------------------ENAADFVRMCLTRDQHERPSALQLLKH
|.|.||.||...||..|.||        . ... .|..   .. |. . |   |                   |.. ||.. ||..| ..||.| |.|.|
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

SFL
 ..
PWF
Kinase MEKK15.AA ASK 1168-1426 43 3.9e-80 266.21 In-house 1-254 (254) Show / Hide 
Range on Protein: 1168-1426
Range on HMM: 1-254/254
Sequence Identity: 43% (116 aa)

ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIIN-RFGPLP--EM
.||||.||.|| |   . |  ||.| .    |.      . . |.||. | | |.| ||| |||.| ... . |||| |||||.|...  ..||.   | 
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNEN

VFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINES--GYGRKSDIWSIGCTVF
    ||||||.|. ||||| .||||||| ||..    |..|. ||| ..||  ||.|     . ..  ||  .|||||| .   |||.  ||||.|||. 
TMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL--AGIN----PCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMV

EMATGKPPLASMDR-MAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
||||||||   ..   |||| .| ..   |..|. .|... .|.. |   | ..|.|| .||.  ||
EMATGKPPFHELGEPQAAMFKVGMYK-KHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK15.AA Dicty2 1163-1426 39 4.1e-77 262.49 In-house 1-264 (264) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-264/264
Sequence Identity: 39% (108 aa)

WTKG-EILGKGAYGTVYCGL-TSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPL
 . | |..|||| |||| || .  |.  | ||. .    ..  |.    .  |..||| |.| ||| |..    ||   |..|.. .|| | ||..||..
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGCF

PEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGI---IKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESG--YGRKSDIWSI
||   | | .|.|.| .|||.. |.|||||. |      |    ||| ||| |  ..        .|   .  |||||||||||  ||     ..|||| 
PESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDY-----SDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSL

GCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
|||. |. || ||      |.||| .       ||||.  |   .||   |  .|  .|..| |||.|  .
GCTIIELLTGNPPYWDLNPMHAMFRMVQDD--HPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MEKK15.AA YSK 1163-1426 36 1.1e-73 221.19 In-house 1-257 (257) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-257/257
Sequence Identity: 36% (99 aa)

WTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINR--FGP
.|| |  |.| .| || |   . .. .|.| . |.      || |   .| |.  |  ..  .|  |.|. |.     | ||.  |||... . .   |.
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLE-----HAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQ

LPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGT-HSDMLKSMHGTPYWMAPEVINE--SGYGRKSDIWSIG
..|.      . ||.|  |||.. ..|||||  || |   | .|| ||| | ..       |  .  .  . ||||||||||| .  |.|  | ||||.|
FDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQI-------TDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLG

CTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPD-HFSENAADFVRMCLTRDQHERPSALQLLKHSFL
 |  |||.| ||.. .. | .|| |       | | . ..| .. .|| .||  |  .|||| .||||.| 
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNP--PKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MEKK15.AA STE-Unique 1236-1426 31 5.4e-52 179.05 In-house 367-616 (616) Show / Hide 
Range on Protein: 1236-1426
Range on HMM: 367-616/616
Sequence Identity: 31% (78 aa)

NTVSIFMEFVPGGSISSIINRFGP---------LPEMVFCKYTKQILQGVAYLHENC--VVHRDIKGNNVMLMPTG-----IIKLIDFGCARRLAWAGL-
|.| ||||. ..|. . ||.| |.         .||    .||.||| |  |||     ..|||.| .|...|  |      .|. ||| | ...  .. 
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

------------NGTHS-------------------DMLKSMHGTPYWMAPEVINES-----GYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIG
            | . .                     .|.. ||| .|.|||||       .|..|.||||.||..|.|..| ||     .| | ... 
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

AHRGLMPP------LPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
 |    ||       |. ..   ..| . || |. | |||| |||.| .|
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase MEKK15.AA TyrKc 1163-1426 25 8.5e-27 96.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 1163-1426
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

WTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL--KHVNIVAYLGTCLQE-------NTVSIFMEFVPGGSISSI
 |.|..|| ||.|.|| |  .  .  ||| .  |.          . . .|  ... |  .| |||. .| |.|.         . | ||..|.|.  . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

INRFGP-LPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWA---GLNGTHSDMLKSMH--GTP-----YWMAPEVIN
. . .| |.   ....  || .| .|||.....|||.   |...   ...|  ||| .| .      |     .|. ...   |.       |||||.||
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECIN

ESGYGRKSDIWSIGCTVFEMAT-GKPPLASM----DRMAAMFYIGAHRGLMPPLPD-------HFSENAADFVRMCLTRDQHERPSALQLLKHSFL
.. .  |||.|| | . .|. | |..|   |       . ..    ... ||. |.       . ..   .  ..|  .| ..||.  ..  |...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MEKK15.AA Pkinase_Tyr 1163-1289 27 1.9e-21 73.23 Pfam 1-137 (270) Show / Hide 
Range on Protein: 1163-1289
Range on HMM: 1-137/270
Sequence Identity: 27% (39 aa)

WTKGEILGKGAYGTVYCGLTS-----QGQLIAVKQVALDTSNKLAAEKE--YRKLQEEVDLLKAL-KHVNIVAYLGTCL-QENT--VSIFMEFVPGGSIS
 |.|. ||.||.|.|| |        ...  ||| .  .     | ...   ... .|. ..| | .| ||| ..| |. |.    . | ||..|.|.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SIINR----FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDI
.   .     .||.    ...  || .| .||...  .|||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MEKK15.AA Pkinase_Tyr 1335-1426 31 1.3e-10 36.54 Pfam 180-270 (270) Show / Hide 
Range on Protein: 1335-1426
Range on HMM: 180-270/270
Sequence Identity: 31% (30 aa)

WMAPEVINESGYGRKSDIWSIGCTVFEMAT-GKPP-LASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
|||||.||.. .  |||.|| | . .|. | |. |  . |.    . ||. ... ||. |.. ..   |  ..|   |  .||.  ..  |..|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase MEKK15.AA STE-Unique 1164-1235 24 5.1e-08 23.96 In-house 1-73 (616) Show / Hide 
Range on Protein: 1164-1235
Range on HMM: 1-73/616
Sequence Identity: 24% (18 aa)

TKGEILGKGAYGTVYCGL-TSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQE
.  ...|.|. |.|.     . .   |.| . |..      |    ....|. ..|.|.| ||| |.|. |..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG