Gene MAST2 (Human)

MAST2

Species: Human
Alias: Hs.101474, MTSSK, MAST205, KIAA0807, MAST2, FLJ39200, RP4-533D7.1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p34.1,

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST2.NA RNA Sugen Kinome 5799 None Fasta, JSON
MAST2.AA Protein Sugen Kinome 1798 None Fasta, JSON
MAST2.kin_dom Protein Kinase Domain Sugen Kinome 274 None Fasta, JSON

Protein domain

Protein domains of MAST2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST2.AA DUF1908 201-278 66 2.6e-47 168.28 Pfam 1-89 (369) Show / Hide 
Range on Protein: 201-278
Range on HMM: 1-89/369
Sequence Identity: 66% (59 aa)

PLDSPRNFSPNAPAHFSFVPAR-------RTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKL----HQLPFQPTADELHFLTKHFS
|.||||||| .....| |||.|       | ||||||.|||||||||||.|||.|||.|||||.|    ||||||||.|.|||| |||.
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFC
DUF1908 MAST2.AA DUF1908 281-476 68 3.4e-140 476.86 Pfam 167-369 (369) Show / Hide 
Range on Protein: 281-476
Range on HMM: 167-369/369
Sequence Identity: 68% (139 aa)

SVPDEE----GRQSPAMRPRSRSL-SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNT--PDSVLPLADGALSFIHHQVIEMARDCLDKS
|. ||.    |..|| .||||||| ||.||...||.||.||||||||||||||.|||||| .||  .   |.. |.|||. . ||||||.|||||||.||
SCQDEDNNFCGCRSPHHRPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHKS

RSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPL
. .||||.||||.|..||.||..||||||| ||.|. ...|||.|||.|||||||||||||||||||||||||.||..|||| ||||||..||||.|||.
HAKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAKVMQGIKTDIPRYIIHQLGLNRDPI

EEM
|||
EEM
Kinase MAST2.AA MAST 512-785 55 1.3e-232 718.97 In-house 1-337 (337) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-337/337
Sequence Identity: 55% (187 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDT--KRHLCMVMEYVEGGDCATLLKNIG-ALP
||.||.||.||||||.||.||.|..|||||.||.|..|..||..|.||||.|||...|||||.||.|| |  |..|||||||.||||||.||...| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEG---------------HIEKDAREFL------------
..|...|.|||||.|||||.||||||||||||.||.|.||||||||||||.|.|..|||.|||               ||.|....|             
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEE-LFGQVIS--DEIVWPEG-----D
                        .||.||||.||||||||.|| ||||||||.||||.|||||||.||.|||||| .|...|.  .|| |||.     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFF
....|.|||| .|||..||..|||.. |.|.||||||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST2.AA MAST 512-785 52 2.9e-213 694.34 In-house 1-334 (334) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-334/334
Sequence Identity: 52% (174 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDM
||.||.||.||||.|.||.||.|..|||||.|.|...|..|...| .|||.||....|||||.||.|| ||..|||||||.||||||.||...|.....|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

VRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEG---------------HIEKDAREFL---------------
...|.|||||.|||||..|||||||||||.||.|.||||||||||||.|.|......|||               ....|...|                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQVCGTPEYIAPEVILRQG-YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE---IVWPEG-----DEALP
                    .||.||||.||||||||.|| .|||||||.||||.|||||||.||..|||||.|.......   | ||||     |||..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

PDAQDLTSKLLHQNPLERLGTG-SAYEVKQHPFF
|.||||..|||...|..|||..  |.||||||||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST2.AA AGC 512-785 29 1.3e-171 448.03 In-house 1-395 (395) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-395/395
Sequence Identity: 29% (118 aa)

FETIKLISNGAYGAVFLVRHK------STRQRFAMKKINKQN-LILRN--QIQQAFVE------------RDILTFAE----------NPFVVS-MFCSF
|| .|.|. |..| |.|||.|      .| . .|||...|.   ....  ..... .|            |.||. .           .||.|. ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DTKRH--LCMVMEYVE--------GGDCATLLKNIG-----ALPVDMVRLYFAE-------TVLALEYLHN-YGIVHRD-LKPDNLLITSMGHIKLTDFG
 .|.|  |..||||..        ||.| ..| . |      .. ...| |.||       .||||||||.  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGLMS-----------LTTNLYEG---------------HIEKDA----------REFLDKQVCG--TPEYIAPEVILRQGYGKPVDWWA--MGIIL
|.|.| ..           .... ...               .. ...           ... .  ||  ||||.|||..    |||..|||.  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEFLVGCVPFFGDTPE----------ELFGQVI------SDEIVWP-------EGDEALPPDAQDLTSKLLHQNPLERLGTGS-------AYEVKQHPFF
||.|.|. ||.||.|.          |.| ...      .... .|       ..|. . |.|.|| .|||. .| .|||.|        | |.|.||.|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST2.AA S_TKc 512-785 32 5.3e-101 342.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-231/231
Sequence Identity: 32% (94 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEG--GDCATLLKNIGA---
.| ...|  ||.| |...|||.| ...|.|.|.          ...  |..||     |..| .. .|..  ||.|||||..|  ||  ...|. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG
   .|  ..| |......||||.|. ||.||||||.|.|...  |||..||||...                       . .||||.|.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYE----VKQHPFF
| ..|||. |.||||.|.|. ||   .....| ..              .|.| |. .|.|. .| .|..   | .    .|.||.|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST2.AA RSK-Unclassified 512-785 37 1.2e-93 294.54 In-house 1-283 (283) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-283/283
Sequence Identity: 37% (108 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLK--NIGALPV
|. ..||  |  | |.||| | | | .|||  .|. .| .| |. .  |..|.   . ||.| .. || |.  | ..|||  |||    |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG------LMS--LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQG
| || | .|...||||||  ... ||||||| .    ||..||||.||. .       |       . .  |  .   |  .  ||| ||.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSA--YEVKQHPFF
 .| |||| .||..|| |.|| |. |.  .|.|  .   ..  |. |. .  ...||  ||| .||  ||| ..    ..|.||||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST2.AA AktR 512-785 37 2.2e-90 306.61 In-house 1-268 (268) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-268/268
Sequence Identity: 37% (105 aa)

FETIKLISNGAYGAVFLVRHK-STRQRFAMKKINKQNLILRNQIQQAFVERDILT-FAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPV
|. .|.. .||.| |.||..|  . . .||| | |...| |||....  ||.|.   . .|| | .. .| ||..|  .|||..||.  . ||... .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DMVRLYFAETVLALEYLHNY-GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDA-REFLDKQVCGTPEYIAPEVILR-QGYGKPV
...| |||. .|||||||.   |. |||||.|.|. . ||.|.|||||||              ....  .. . . .||||||.|||.|.. .|..|.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWAMGIILYEFLVGCVPFFG-DTPEELFGQVISDEIVWPEGDEALPPDAQDLTS-KLLHQNPLERLG--TGSAYEVKQHPFF
|||| || .|| ..|| ||.  .. .... . |.. .. ..  . . . ..||   ||| .|| .|||  . .. |.| ||.|
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST2.AA RSK 515-785 34 3.7e-84 285.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 515-785
Range on HMM: 1-278/278
Sequence Identity: 34% (102 aa)

IKLISNGAYGAVFLVRHK---STRQRFAMKKINKQNLILRNQ-IQQAFVERDILTFAE-NPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGA---
.|.   |.||.|||.| .    |.| .||| ..|  .. |.  .  .. ||.||   .  ||.|. . .|.|. .| ..|||..||.  | |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITS---MGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAR-EFLDKQVCGTPEYIAPEVIL----
.  | .. |.|| |||.|.||  ||.||||||.| | ..    |||||||||..|..               ... ... .  |.| ||.|||..     
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF---------------RCDHNQWTMTFCYTIEYMAPEMLKRANQ

RQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDEIVWPEGD--EALPPDAQDLTSKLLHQNPLERLG--TGSAYEVKQHPFF
. |..| .|||  |...|| |.||.|| |   ....|.. .. . .   ....  . | ..|.|| .|.|| .|  |||   . | |.||||.|
QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST2.AA Pkinase 512-785 29 4.5e-80 277.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFV--ERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGG----DCATLLK--N
..... |  |..| |.. .||.|....|.|.|.|.  .  .. |...   |  |.     |..| ....| .|.|..|||||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

IGAL--PVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHI----KLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
 |..  . . .. |. ... .|||.|. ||.||||||.|.|| . |||    |..||||.|               .   . .  . .||||.|.|||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-M--TTFCGTPWYMAPEVI

L-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVIS--DEIVWPEGDE----------------ALPPDAQDLTSKLLHQNPLERLG
. .|.||..||.|..|.||||.| |  || |.      .. ... .. .   .  ||. ..                .......|. ...|...| .|..
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

TGSAYEVKQHPFF
   | ...|||.|
---AEQILQHPWF
Kinase MAST2.AA NDR 512-658 47 1.9e-77 238.27 In-house 1-152 (350) Show / Hide 
Range on Protein: 512-658
Range on HMM: 1-152/350
Sequence Identity: 47% (72 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE--NPFVVSMFCSFDTKRHLCMVMEYVEGGDCAT---LLKNIGA
|| ||.|. ||.| |.|||.|.|.. .|||...|.  . .||. .   ||||.. |   ||.||....||  | .|. ||||. |||  |   ||.. . 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
.. |. | | ||.|.|.|..|..|..|||.||||.|| . ||||||||||..
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase MAST2.AA Akt 512-663 40 9.2e-55 173.45 In-house 1-154 (264) Show / Hide 
Range on Protein: 512-663
Range on HMM: 1-154/264
Sequence Identity: 40% (62 aa)

FETIKLISNGAYGAVFLVRHKSTRQRF-AMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVD
|. .|..  |..| ||||. |.| . . ||| . |. .| .||..... || ||    .||.|..  || |. .|..||.|. ||.  ..|.  .  . |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MVRLYFAETVLALEYLHNYGIVHRD-LKPDNLLITSMGHIKLTDFGLSKIGLMS
  | | || .||.|.||. .|. || ||| |.|. . |||.||||||.| ....
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST2.AA SGK 512-658 36 1e-52 160.87 In-house 1-173 (283) Show / Hide 
Range on Protein: 512-658
Range on HMM: 1-173/283
Sequence Identity: 36% (63 aa)

FETIKLISNGAYGAVFLVRHKST------------------RQRFAMKKINKQNLI-------LRNQIQQAFVER-DILTFAENPFVVSMFCSFDTKRHL
|. .|.|  | .| |..|.||..                   . .||| ..||  |        ...      || .||     || |.   .| ||  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
 .||.||.||.    |.  . .| | .| | || |.||||||   |..|||||.|.|  ..||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MAST2.AA PKA 512-658 42 7.4e-52 178.59 In-house 1-149 (263) Show / Hide 
Range on Protein: 512-658
Range on HMM: 1-149/263
Sequence Identity: 42% (64 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV-SMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVD
||.|... .| .| | |.|||.. . .||| ..||  . ..|..    |. ||.  ..||.| .|  .| . |.| ||||||.||.  . | . | .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MVRLYFA-ETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
. ..| | . ||||||||.  |..||||| |.|| . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST2.AA Akt 685-785 37 4e-42 132.39 In-house 162-264 (264) Show / Hide 
Range on Protein: 685-785
Range on HMM: 162-264/264
Sequence Identity: 37% (39 aa)

VCGTPEYIAPEVILRQGYGKPVDWWA-MGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLG--TGSAYEVKQ
.||||||.|||... .|..|.||||.  |...||.. |  ||. .  ...| .  . ..  |.  ... |...|| |.||. .| .|||   . | |.|.
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HPFF
||.|
HPWF
Kinase MAST2.AA NDR 687-785 41 7.9e-41 123.23 In-house 243-350 (350) Show / Hide 
Range on Protein: 687-785
Range on HMM: 243-350/350
Sequence Identity: 41% (45 aa)

GTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVW-----PEGDEA-LPPDAQDLTSKLLHQNPLERLGTGS--AY
|||.|.||||... .||.. .|||  | |.||.|||  ||..|||.| .  ... .. |       . || | |.|.||  .|.. .| .||| .   . 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVKQHPFF
|.|.||||
EIKSHPFF
Kinase MAST2.AA SGK 686-785 40 2.2e-39 118.95 In-house 186-283 (283) Show / Hide 
Range on Protein: 686-785
Range on HMM: 186-283/283
Sequence Identity: 40% (41 aa)

CGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG-SAYEVKQHPF
|||||| ||||.. |.... |||| .|..|||...|  ||.    .... . |. ..  | .     .|| ||   ||. .| .||||   . |.|.|||
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST2.AA PKA 685-785 37 4.1e-35 122.96 In-house 158-263 (263) Show / Hide 
Range on Protein: 685-785
Range on HMM: 158-263/263
Sequence Identity: 37% (41 aa)

VCGTPEYIAPEVILRQ-GYGKPVDWWAMGIILYEFLVGCVPFFGD--TPEELFGQVISDEIVWPEGDEALPPDA---QDLTSKLLHQNPLERLGTGSA--
.||||||.|||.|..  |.||.||||| ||. ||.|.|  ||. .  .| ...   .. .| .|. .    .||    || .|||  .. .|.|. ..  
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFD---SDANYFKDLIKKLLQVDLTKRYGNMKNGV

YEVKQHPFF
  .| |..|
NDIKNHKWF
Kinase MAST2.AA TyrKc 512-785 18 1.2e-11 -34.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 512-785
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA--ENPFVVSMF-CSFDTK------RHLCMVMEYVEGGDCATLLK
 . .| . .||.| |.. . |   .  | |....        ..    |  |..    ..| .| .. .  . .        |..||||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NIGA-LPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMS----LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI
. .  |...    .        ||||  ...||||   | |... ...| .|||||. .         .  |    .|...  |           |||.|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML------PIRWMAPECI

LRQGYGKPVDWWAMGIILYEFLVGCVPFFGD------TPEELFGQVISDEIVWPEGD--EAL-----PPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPF
    .    | |. |. ..| .  . .   .      ...|.. .| . .   .  .  . .     |..  .. ..  | .| .|    .  |.  | .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRP---TFSEI--HEC

F
|
F
Kinase MAST2.AA Pkinase_C 803-848 29 2.6e-08 32.53 Pfam 1-46 (46) Show / Hide 
Range on Protein: 803-848
Range on HMM: 1-46/46
Sequence Identity: 29% (14 aa)

QLESEDDTSYFDTRSERYHHMDS-EDEEEVSEDGCLEIRQFSSCSPR
|..|..|||.||.  .. ..||.  |..  |.   .. |.|. ..| 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MAST2.AA Pkinase_Tyr 584-658 29 1.7e-07 26.0 Pfam 81-159 (270) Show / Hide 
Range on Protein: 584-658
Range on HMM: 81-159/270
Sequence Identity: 29% (23 aa)

HLCMVMEYVEGGDCATLLKN----IGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK
....||||...||  . |..     ..|.. .   . ..   ..|||.. ...||||   | |.|. ...| .||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST2.AA S_TK_X 786-846 20 0.000369 11.66 SMART 1-79 (79) Show / Hide 
Range on Protein: 786-846
Range on HMM: 1-79/79
Sequence Identity: 20% (17 aa)

TGLDWTGLLR----QKAEFIPQLE----SEDDTSYFD---TRSERYHHMDSEDEEEVSEDGCLE----------IRQFSSCS
 |.|| .|..     .. |.|..     |. |||.||   |. .     .. |.. .|.    .           |.|.   
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
PDZ MAST2.AA PDZ 1112-1192 25 4.3e-15 57.39 SMART 1-80 (80) Show / Hide 
Range on Protein: 1112-1192
Range on HMM: 1-80/80
Sequence Identity: 25% (24 aa)

KKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAG------LRQGDLITHVNG-EPVHGLVHTEVVELILKSGN-----KVAISTTPLE
. .||...              .. . .|..||||. ||      || || |. ||| .|| .. | ..|... ..|.     || .   . .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST2.AA PDZ 1139-1189 27 2.3e-07 27.78 Pfam 33-86 (86) Show / Hide 
Range on Protein: 1139-1189
Range on HMM: 33-86/86
Sequence Identity: 27% (15 aa)

HVEDG-GPASEAG-LRQGDLITHVNGEPVHGLVHTEVVELILKSGN-KVAISTT
.|  | |.|  .| .. || |. .||... .. | ..|..| .|.. .|..   
EVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ